Gene Symbol: Ddx58
Description: DEXD/H-box helicase 58
Alias: DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
Species: rat
Products:     Ddx58

Top Publications

  1. Cui S, Eisen├Ącher K, Kirchhofer A, Brz├│zka K, Lammens A, Lammens K, et al. The C-terminal regulatory domain is the RNA 5'-triphosphate sensor of RIG-I. Mol Cell. 2008;29:169-79 pubmed publisher
    ..Structure-guided mutagenesis identifies a positively charged groove as likely 5'-triphosphate-binding site of RIG-I. This groove is distinct in MDA5 and LGP2, raising the possibility that RD confers ligand specificity. ..
  2. Ablasser A, Bauernfeind F, Hartmann G, Latz E, Fitzgerald K, Hornung V. RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate. Nat Immunol. 2009;10:1065-72 pubmed publisher
    ..This pathway was important in the sensing of Epstein-Barr virus-encoded small RNAs, which were transcribed by RNA polymerase III and then triggered RIG-I activation. Thus, RNA polymerase III and RIG-I are pivotal in sensing viral DNA. ..
  3. Chiu Y, Macmillan J, Chen Z. RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway. Cell. 2009;138:576-91 pubmed publisher
    ..These results suggest that RNA Pol-III is a cytosolic DNA sensor involved in innate immune responses. ..
  4. Schlee M, Roth A, Hornung V, Hagmann C, Wimmenauer V, Barchet W, et al. Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus. Immunity. 2009;31:25-34 pubmed publisher
  5. Hao Q, Jiao S, Shi Z, Li C, Meng X, Zhang Z, et al. A non-canonical role of the p97 complex in RIG-I antiviral signaling. EMBO J. 2015;34:2903-20 pubmed publisher
    ..Overall, our study uncovered a previously unrecognized role for the p97 complex in protein ubiquitination and revealed the p97 complex as a potential drug target in antiviral therapy. ..
  6. Zhang Z, Yuan B, Lu N, Facchinetti V, Liu Y. DHX9 pairs with IPS-1 to sense double-stranded RNA in myeloid dendritic cells. J Immunol. 2011;187:4501-8 pubmed publisher
    ..Knockdown of DHX9 expression in mDCs blocked the activation of NF-?B and IFN regulatory factor 3 by dsRNA. Collectively, these results suggest that DHX9 is an important RNA sensor that is dependent on IPS-1 to sense pathogenic RNA. ..
  7. Saito T, Hirai R, Loo Y, Owen D, Johnson C, Sinha S, et al. Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2. Proc Natl Acad Sci U S A. 2007;104:582-7 pubmed
    ..Modulation of RIG-I/LGP2 interaction dynamics may have therapeutic implications for immune regulation. ..
  8. Sathe A, Reddy K. TLR9 and RIG-I signaling in human endocervical epithelial cells modulates inflammatory responses of macrophages and dendritic cells in vitro. PLoS ONE. 2014;9:e83882 pubmed publisher
    ..In summary, the results of our study indicate that EEC's play an indispensable role in modulating anti-viral immune responses at the female lower genital tract. ..
  9. Li Y, Chen R, Zhou Q, Xu Z, Li C, Wang S, et al. LSm14A is a processing body-associated sensor of viral nucleic acids that initiates cellular antiviral response in the early phase of viral infection. Proc Natl Acad Sci U S A. 2012;109:11770-5 pubmed publisher
    ..These findings suggest that LSm14A is a sensor for both viral RNA and DNA and plays an important role in initiating IFN-? induction in the early phase of viral infection. ..

More Information


  1. Zhang Z, Kim T, Bao M, Facchinetti V, Jung S, Ghaffari A, et al. DDX1, DDX21, and DHX36 helicases form a complex with the adaptor molecule TRIF to sense dsRNA in dendritic cells. Immunity. 2011;34:866-78 pubmed publisher
    ..This sensor was localized within the cytosol, independent of the endosomes. Thus, the DDX1-DDX21-DHX36 complex represents a dsRNA sensor that uses the TRIF pathway to activate type I IFN responses in the cytosol of mDCs. ..
  2. Kato T, Ueda Y, Kinoh H, Yoneyama Y, Matsunaga A, Komaru A, et al. RIG-I helicase-independent pathway in sendai virus-activated dendritic cells is critical for preventing lung metastasis of AT6.3 prostate cancer. Neoplasia. 2010;12:906-14 pubmed
    ..These results indicate the essential role of RIG-I-independent signaling on antimetastatic effect induced by rSeV-activated DCs and may provide important insights to DC-based immunotherapy for advanced malignancies. ..
  3. Bamming D, Horvath C. Regulation of signal transduction by enzymatically inactive antiviral RNA helicase proteins MDA5, RIG-I, and LGP2. J Biol Chem. 2009;284:9700-12 pubmed publisher
    ..In addition, neither enzymatic activity nor RNA binding was required for negative regulation of antiviral signaling by LGP2, supporting an RNA-independent interference mechanism. ..
  4. Mukherjee A, Morosky S, Shen L, Weber C, Turner J, Kim K, et al. Retinoic acid-induced gene-1 (RIG-I) associates with the actin cytoskeleton via caspase activation and recruitment domain-dependent interactions. J Biol Chem. 2009;284:6486-94 pubmed publisher
  5. Loo Y, Fornek J, Crochet N, Bajwa G, Perwitasari O, Martinez Sobrido L, et al. Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity. J Virol. 2008;82:335-45 pubmed
  6. Wang Y, Ludwig J, Schuberth C, Goldeck M, Schlee M, Li H, et al. Structural and functional insights into 5'-ppp RNA pattern recognition by the innate immune receptor RIG-I. Nat Struct Mol Biol. 2010;17:781-7 pubmed publisher
  7. Berke I, Modis Y. MDA5 cooperatively forms dimers and ATP-sensitive filaments upon binding double-stranded RNA. EMBO J. 2012;31:1714-26 pubmed publisher
    ..We propose a signalling model in which the CARDs on MDA5-RNA filaments nucleate the assembly of MAVS filaments with the same polymeric geometry. ..
  8. Hayakawa S, Shiratori S, Yamato H, Kameyama T, Kitatsuji C, Kashigi F, et al. ZAPS is a potent stimulator of signaling mediated by the RNA helicase RIG-I during antiviral responses. Nat Immunol. 2011;12:37-44 pubmed publisher
    ..These results indicate that ZAPS is a key regulator of RIG-I signaling during the innate antiviral immune response, which suggests its possible use as a therapeutic target for viral control...
  9. Peisley A, Wu B, Xu H, Chen Z, Hur S. Structural basis for ubiquitin-mediated antiviral signal activation by RIG-I. Nature. 2014;509:110-4 pubmed publisher
    ..Our work provides unique insights into the novel types of ubiquitin-mediated signal-activation mechanism, and previously unexpected synergism between the covalent and non-covalent ubiquitin interaction modes. ..
  10. Mibayashi M, Martinez Sobrido L, Loo Y, Cardenas W, Gale M, Garcia Sastre A. Inhibition of retinoic acid-inducible gene I-mediated induction of beta interferon by the NS1 protein of influenza A virus. J Virol. 2007;81:514-24 pubmed
    ..Our results indicate that, in addition to sequestering dsRNA, the NS1 of influenza A virus binds to RIG-I and inhibits downstream activation of IRF-3, preventing the transcriptional induction of IFN-beta. ..