Ddit3

Summary

Gene Symbol: Ddit3
Description: DNA-damage inducible transcript 3
Alias: CHOP, CHOP-10, Chop10, Gadd153, RM4, DNA damage-inducible transcript 3 protein, C/EBP homologous protein, C/EBP zeta, CCAAT/enhancer-binding protein homologous protein, DDIT-3, c/EBP-homologous protein 10, growth arrest and DNA-damage-inducible protein GADD153
Species: rat
Products:     Ddit3

Top Publications

  1. Su N, Kilberg M. C/EBP homology protein (CHOP) interacts with activating transcription factor 4 (ATF4) and negatively regulates the stress-dependent induction of the asparagine synthetase gene. J Biol Chem. 2008;283:35106-17 pubmed publisher
    C/EBP homology protein (CHOP), a stress-induced transcription factor, is involved in transcriptional regulation, cell cycle, and apoptosis...
  2. Ron D, Habener J. CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription. Genes Dev. 1992;6:439-53 pubmed
    ..domain "zipper probe" was used to isolate a clone that encodes a new C/EBP-homologous protein: CHOP-10...
  3. Chen B, Wolfgang C, Hai T. Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd153/Chop10. Mol Cell Biol. 1996;16:1157-68 pubmed
    ..We also demonstrate that an ATF3-interacting protein, gadd153/Chop10, forms a nonfunctional heterodimer with ATF3: the heterodimer, in contrast to the ATF3 homodimer, does not ..
  4. Zinszner H, Kuroda M, Wang X, Batchvarova N, Lightfoot R, Remotti H, et al. CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum. Genes Dev. 1998;12:982-95 pubmed
    ..that perturb function of the endoplasmic reticulum (ER stress), is a powerful inducer of the transcription factor CHOP. The role of CHOP in the response of cells to injury associated with ER stress was examined in a murine deficiency ..
  5. Marciniak S, Yun C, Oyadomari S, Novoa I, Zhang Y, Jungreis R, et al. CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum. Genes Dev. 2004;18:3066-77 pubmed
    ..The transcription factor C/EBP homologous protein (CHOP) is activated by ER stress, and CHOP deletion protects against its lethal consequences...
  6. Gachon F, Gaudray G, Thebault S, Basbous J, Koffi J, Devaux C, et al. The cAMP response element binding protein-2 (CREB-2) can interact with the C/EBP-homologous protein (CHOP). FEBS Lett. 2001;502:57-62 pubmed
    ..Here we show that CREB-2 is able to interact with C/EBP-homologous protein (CHOP), a bZIP transcription factor known to inhibit CAAT/enhancer-dependent transcription...
  7. Ubeda M, Wang X, Zinszner H, Wu I, Habener J, Ron D. Stress-induced binding of the transcriptional factor CHOP to a novel DNA control element. Mol Cell Biol. 1996;16:1479-89 pubmed
    CHOP (GADD153) is a mammalian nuclear protein that dimerizes with members of the C/EBP family of transcriptional factors...
  8. Ohoka N, Yoshii S, Hattori T, Onozaki K, Hayashi H. TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death. EMBO J. 2005;24:1243-55 pubmed
    C/EBP homologous protein (CHOP) is a stress-inducible nuclear protein that is crucial for the development of programmed cell death and regeneration; however, the regulation of its function has not been well characterized...
  9. Liu H, Qian J, Wang F, Sun X, Xu X, Xu W, et al. Expression of two endoplasmic reticulum stress markers, GRP78 and GADD153, in rat retinal detachment model and its implication. Eye (Lond). 2010;24:137-44 pubmed publisher
    ..the expression of endoplasmic reticulum (ER) stress-related genes, glucose-regulated protein 78 (GRP78) and growth arrest DNA damage-inducible gene 153 (GADD153)/CPEBP homologous protein (CHOP), in rat retinal detachment (RD) model.

More Information

Publications83

  1. Ubeda M, Vallejo M, Habener J. CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex proteins. Mol Cell Biol. 1999;19:7589-99 pubmed
    The transcription factor CHOP (C/EBP homologous protein 10) is a bZIP protein induced by a variety of stimuli that evoke cellular stress responses and has been shown to arrest cell growth and to promote programmed cell death...
  2. Jiang H, Wek S, McGrath B, Lu D, Hai T, Harding H, et al. Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response. Mol Cell Biol. 2004;24:1365-77 pubmed
    ..ATF3 contributes to induction of the CHOP transcriptional factor in response to amino acid starvation, and loss of ATF3 function significantly lowers stress-..
  3. Jousse C, Bruhat A, Carraro V, Urano F, Ferrara M, Ron D, et al. Inhibition of CHOP translation by a peptide encoded by an open reading frame localized in the chop 5'UTR. Nucleic Acids Res. 2001;29:4341-51 pubmed
    b>Chop is a ubiquitously expressed mammalian gene encoding a small nuclear protein related to the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors...
  4. McCullough K, Martindale J, Klotz L, Aw T, Holbrook N. Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state. Mol Cell Biol. 2001;21:1249-59 pubmed
    b>gadd153, also known as chop, is a highly stress-inducible gene that is robustly expressed following disruption of homeostasis in the endoplasmic reticulum (ER) (so-called ER stress)...
  5. Tang J, Nakamura M, Okura T, Takata Y, Watanabe S, Yang Z, et al. Mechanism of oxidative stress-induced GADD153 gene expression in vascular smooth muscle cells. Biochem Biophys Res Commun. 2002;290:1255-9 pubmed
    ..Growth arrest and DNA damage-inducible gene 153 (GADD153), which is upregulated by oxidative stress, regulates the cell cycle and apoptosis...
  6. Oyadomari S, Koizumi A, Takeda K, Gotoh T, Akira S, Araki E, et al. Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes. J Clin Invest. 2002;109:525-32 pubmed
    ..development of diabetes in Akita mice, mRNAs for the ER chaperone Bip and the ER stress-associated apoptosis factor Chop were induced in the pancreas...
  7. Singh V, Pacheco I, Uversky V, Smith S, Macleod R, Jia Z. Intrinsically disordered human C/EBP homologous protein regulates biological activity of colon cancer cells during calcium stress. J Mol Biol. 2008;380:313-26 pubmed publisher
    ..The C/EBP homologous protein (CHOP) is a proto-oncogene, traditionally shown as a dominant-negative inhibitor of C/EBPs and a transcriptional ..
  8. Chami M, Oulès B, Szabadkai G, Tacine R, Rizzuto R, Paterlini Brechot P. Role of SERCA1 truncated isoform in the proapoptotic calcium transfer from ER to mitochondria during ER stress. Mol Cell. 2008;32:641-51 pubmed publisher
    ..variant of the sarcoendoplasmic reticulum Ca(2+)-ATPase 1 (S1T) amplifies ER stress through the PERK-eIF2alpha-ATF4-CHOP pathway...
  9. Wan S, Shi P, Zhang X, Gu C, Fan S. Stronger expression of CHOP and caspase 12 in diabetic spinal cord injury rats. Neurol Res. 2009;31:1049-55 pubmed publisher
    ..then, rats were killed at 24 hours and 7 days, and the level of C/EBP homologous transcription factor protein (CHOP), a proapoptotic protein, and caspase 12 were determined by immunohistochemistry staining and real-time reverse ..
  10. Aman P, Ron D, Mandahl N, Fioretos T, Heim S, Arheden K, et al. Rearrangement of the transcription factor gene CHOP in myxoid liposarcomas with t(12;16)(q13;p11). Genes Chromosomes Cancer. 1992;5:278-85 pubmed
    ..We have used Southern blot technique to test whether a gene of the CCAAT/enhancer binding protein (C/EBP) family, CHOP, which maps to 12q13 and is assumed to be involved in adipocyte differentiation, could be the 12q gene in question...
  11. Cheng W, Wang B, Shyu K. Regulation of GADD153 induced by mechanical stress in cardiomyocytes. Eur J Clin Invest. 2009;39:960-71 pubmed publisher
    Growth arrest and DNA damage-inducible gene 153 (GADD153), an apoptosis regulated gene, increased during endoplasmic reticulum stress. However, the expression of GADD153 in cardiomyocytes under mechanical stress is little known...
  12. Lee W, Chakraborty P, Roussa E, Wolff N, Thevenod F. ERK1/2-dependent bestrophin-3 expression prevents ER-stress-induced cell death in renal epithelial cells by reducing CHOP. Biochim Biophys Acta. 2012;1823:1864-76 pubmed publisher
    ..Chronic ER stress culminates in apoptotic cell death, which involves induction of pro-apoptotic CHOP. Here, we show that bestrophin-3 (Best-3), a protein previously associated with Ca(2+)-activated Cl(-) channel ..
  13. Kodama K, Nishio Y, Sekine O, Sato Y, Egawa K, Maegawa H, et al. Bidirectional regulation of monocyte chemoattractant protein-1 gene at distinct sites of its promoter by nitric oxide in vascular smooth muscle cells. Am J Physiol Cell Physiol. 2005;289:C582-90 pubmed
    ..We found that SNP induced C/EBP homologous protein (CHOP) expression, which inhibited C/EBP binding activity and reduced the C/EBP activity induced by chronic activation of ..
  14. Chen Y, Gui D, Chen J, He D, Luo Y, Wang N. Down-regulation of PERK-ATF4-CHOP pathway by Astragaloside IV is associated with the inhibition of endoplasmic reticulum stress-induced podocyte apoptosis in diabetic rats. Cell Physiol Biochem. 2014;33:1975-87 pubmed publisher
    ..Here, we tested the hypothesis that suppression of PERK-ATF4-CHOP pathway by Astragaloside IV (AS-IV) is associated with inhibition of ER stress-induced podocyte apoptosis in ..
  15. Ma J, Yang Y, Chen W, Chen M, Wang H, Wang X, et al. Fluoxetine synergizes with temozolomide to induce the CHOP-dependent endoplasmic reticulum stress-related apoptosis pathway in glioma cells. Oncol Rep. 2016;36:676-84 pubmed publisher
    ..Further study showed that FLT activated the ERS marker, CHOP. This induction was associated with activation of the PERK-eIF2?-ATF4 and ATF6 cascade...
  16. Liu H, Qian J, Wang F, Xu X, Zhang X, Zhang X, et al. [Endoplasmic reticulum stress participates in the cell apoptosis process in experimental retinal detachment]. Zhonghua Yan Ke Za Zhi. 2008;44:800-6 pubmed
    ..process of the retina during experimental retinal detachment-by detecting the level of mRNA and protein of the GADD153, the marker of endoplasmic reticulum stress. Completely random design is applied...
  17. Shen M, Wang L, Wang B, Yang G, Shen L, Wang T, et al. Activation of volume-sensitive outwardly rectifying chloride channel by ROS contributes to ER stress and cardiac contractile dysfunction: involvement of CHOP through Wnt. Cell Death Dis. 2014;5:e1528 pubmed publisher
    ..XBP1 pathways, and promotes survival of cardiomyocytes by inverting tunicamycin-induced decrease of Wnt through the CHOP pathway...
  18. Liu Z, Shi Q, Song X, Wang Y, Wang Y, Song E, et al. Activating Transcription Factor 4 (ATF4)-ATF3-C/EBP Homologous Protein (CHOP) Cascade Shows an Essential Role in the ER Stress-Induced Sensitization of Tetrachlorobenzoquinone-Challenged PC12 Cells to ROS-Mediated Apoptosis via Death Receptor 5 (DR5). Chem Res Toxicol. 2016;29:1510-8 pubmed publisher
    ..initiation factor 2? (PERK/eIF2?)-mediated activating transcription factor 4 (ATF4)-ATF3-C/EBP homologous protein (CHOP) signaling pathway contributed to the process of TCBQ-induced ER stress...
  19. Lu H, Zhang J, Wang Q, Tang W, Zhang L. Activation of the endoplasmic reticulum stress pathway involving CHOP in the lungs of rats with hyperoxia?induced bronchopulmonary dysplasia. Mol Med Rep. 2015;12:4494-4500 pubmed publisher
    ..glucose?regulated/binding immunoglobulin protein (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in the lung tissues were examined using immunohistochemistry, and the mRNA and protein levels of GRP78 and CHOP ..
  20. Oh Y, Yue P, Zhou W, Balko J, Black E, Owonikoko T, et al. Oncogenic Ras and B-Raf proteins positively regulate death receptor 5 expression through co-activation of ERK and JNK signaling. J Biol Chem. 2012;287:257-67 pubmed publisher
    ..of ERK/RSK and JNK signaling pathways and subsequent cooperative effects among the transcriptional factors CHOP, Elk1, and c-Jun to enhance DR5 gene transcription...
  21. Tchkonia T, Pirtskhalava T, Thomou T, Cartwright M, Wise B, Karagiannides I, et al. Increased TNFalpha and CCAAT/enhancer-binding protein homologous protein with aging predispose preadipocytes to resist adipogenesis. Am J Physiol Endocrinol Metab. 2007;293:E1810-9 pubmed
    ..which inhibits adipogenesis, and the expression of CCAAT/enhancer-binding protein (C/EBP) homologous protein (CHOP), which blocks activity of adipogenic C/EBP family members, in preadipocytes cultured from young, middle-aged, and ..
  22. Li F, Hayashi T, Jin G, Deguchi K, Nagotani S, Nagano I, et al. The protective effect of dantrolene on ischemic neuronal cell death is associated with reduced expression of endoplasmic reticulum stress markers. Brain Res. 2005;1048:59-68 pubmed
    ..initiation factor 2alpha (p-eIF2alpha), activating transcription factor-4 (ATF-4), and C/EBP-homologous protein (CHOP), as well as terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) in the peri-ischemic ..
  23. Yamaguchi H, Wang H. CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells. J Biol Chem. 2004;279:45495-502 pubmed
    ..Here, we provide evidence that CHOP is involved in THG up-regulation of DR5, which is a critical step for ER stress-induced apoptosis in human cancer ..
  24. Zhou H, Kato A, Yasuda H, Miyaji T, Fujigaki Y, Yamamoto T, et al. The induction of cell cycle regulatory and DNA repair proteins in cisplatin-induced acute renal failure. Toxicol Appl Pharmacol. 2004;200:111-20 pubmed
  25. Copanaki E, Schürmann T, Eckert A, Leuner K, Muller W, Prehn J, et al. The amyloid precursor protein potentiates CHOP induction and cell death in response to ER Ca2+ depletion. Biochim Biophys Acta. 2007;1773:157-65 pubmed
    ..Interestingly, the induction of the ER stress-responsive pro-apoptotic transcription factor CHOP was significantly upregulated in APP-overexpressing cells in comparison to vector-transfected controls...
  26. Ohoka N, Hattori T, Kitagawa M, Onozaki K, Hayashi H. Critical and functional regulation of CHOP (C/EBP homologous protein) through the N-terminal portion. J Biol Chem. 2007;282:35687-94 pubmed
    C/EBP homologous protein (CHOP) is an endoplasmic reticulum stress-inducible protein that plays a critical role in the regulation of programmed cell death; however, the regulation of its function has not been well characterized...
  27. Matsuo R, Murayama A, Saitoh Y, Sakaki Y, Inokuchi K. Identification and cataloging of genes induced by long-lasting long-term potentiation in awake rats. J Neurochem. 2000;74:2239-49 pubmed
    ..from expressed sequence tags (RM1-3), two were known genes whose up-regulation by LTP has not been described (GADD153/CHOP and ler5), and five were known genes whose up-regulation by LTP has already been reported (MAPK phosphatase, ..
  28. Pirot P, Ortis F, Cnop M, Ma Y, Hendershot L, Eizirik D, et al. Transcriptional regulation of the endoplasmic reticulum stress gene chop in pancreatic insulin-producing cells. Diabetes. 2007;56:1069-77 pubmed
    ..endoplasmic reticulum stress-mediated cell death is the CCAAT/enhancer binding protein (C/EBP) homologous protein (Chop)...
  29. Xu B, Wang F, Wu S, Deng Y, Liu W, Feng S, et al. ?-Synuclein is involved in manganese-induced ER stress via PERK signal pathway in organotypic brain slice cultures. Mol Neurobiol. 2014;49:399-412 pubmed publisher
    ..increase in the protein expression of 78, 94-kDa glucose-regulated protein (GRP78/94), C/EBP homologous protein (CHOP), and caspase-12...
  30. Park S, Choi H, Yang H, Do K, Kim J, Lee D, et al. Endoplasmic reticulum stress-activated C/EBP homologous protein enhances nuclear factor-kappaB signals via repression of peroxisome proliferator-activated receptor gamma. J Biol Chem. 2010;285:35330-9 pubmed publisher
    ..ER stress mediators, including CCAAT enhancer-binding protein (C/EBP) homologous protein (CHOP), are elevated in intestinal epithelia from patients with inflammatory bowel diseases...
  31. Alam S, Abdullah C, Aishwarya R, Orr A, Traylor J, Miriyala S, et al. Sigmar1 regulates endoplasmic reticulum stress-induced C/EBP-homologous protein expression in cardiomyocytes. Biosci Rep. 2017;37: pubmed publisher
    C/EBP-homologous protein (CHOP) is a ubiquitously expressed stress-inducible transcription factor robustly induced by maladaptive endoplasmic reticulum (ER) stresses in a wide variety of cells...
  32. Cheng W, Hung H, Wang B, Shyu K. The molecular regulation of GADD153 in apoptosis of cultured vascular smooth muscle cells by cyclic mechanical stretch. Cardiovasc Res. 2008;77:551-9 pubmed
    The expression of GADD153 (growth arrest and DNA damage-inducible gene 153), an apoptosis-regulated gene, increases during endoplasmic reticulum (ER) stress...
  33. Fabre O, Salehzada T, Lambert K, Boo Seok Y, Zhou A, Mercier J, et al. RNase L controls terminal adipocyte differentiation, lipids storage and insulin sensitivity via CHOP10 mRNA regulation. Cell Death Differ. 2012;19:1470-81 pubmed publisher
    ..Here, we identify C/EBP homologous protein 10 (CHOP10), a dominant negative member of the CCAAT/enhancer-binding protein family, as a specific RNase L target...
  34. Lee M, Kwak Y, You K, Lee B, Kim D. Involvement of GADD153 and cardiac ankyrin repeat protein in cardiac ischemia-reperfusion injury. Exp Mol Med. 2009;41:243-52 pubmed publisher
    ..induces apoptosis in the cardiac myocytes from neonatal rats and it concomitantly leads to induction of GADD153, an apoptosis-related gene...
  35. Roberts G, Di Loreto M, Marshall M, Wang J, DeGracia D. Hippocampal cellular stress responses after global brain ischemia and reperfusion. Antioxid Redox Signal. 2007;9:2265-75 pubmed
    ..We assessed the relative expression of UPR (ATF4, CHOP, GRP78, XBP-1) and HSR-related (HSP70 and HSC70) mRNAs and proteins after brain I/R...
  36. Ha S, Park S, Han C, Nguyen M, Kim S. Cellular adaptation to anthrax lethal toxin-induced mitochondrial cholesterol enrichment, hyperpolarization, and reactive oxygen species generation through downregulating MLN64 in macrophages. Mol Cell Biol. 2012;32:4846-60 pubmed publisher
    ..This study demonstrates for the first time that MLN64 plays a key role in LeTx/caspase-1-induced mitochondrial dysfunction...
  37. Liu X, Wang M, Chen H, Guo Y, Ma F, Shi F, et al. Hypothermia protects the brain from transient global ischemia/reperfusion by attenuating endoplasmic reticulum response-induced apoptosis through CHOP. PLoS ONE. 2013;8:e53431 pubmed publisher
    ..The expressions of C/EBP-homologous protein (CHOP) and glucose-regulated protein 78 (GRP78) in ischemic hippocampus CA1 were measured at 6, 12, 24 and 48 h after ..
  38. Maier P, Zemoura K, Acu a M, Y venes G, Zeilhofer H, Benke D. Ischemia-like oxygen and glucose deprivation mediates down-regulation of cell surface ?-aminobutyric acidB receptors via the endoplasmic reticulum (ER) stress-induced transcription factor CCAAT/enhancer-binding protein (C/EBP)-homologous protein (CH. J Biol Chem. 2014;289:12896-907 pubmed publisher
    ..associated with the up-regulation of the transcription factor CCAAT/enhancer-binding protein-homologous protein (CHOP)...
  39. Baban B, Liu J, Qin X, Weintraub N, Mozaffari M. Upregulation of Programmed Death-1 and Its Ligand in Cardiac Injury Models: Interaction with GADD153. PLoS ONE. 2015;10:e0124059 pubmed publisher
    ..cardiac PD-1 and PD-L1 in the context of assessment of the growth arrest- and DNA damage-inducible protein 153 (GADD153) which regulates both inflammation and cell death...
  40. Yang J, Yao F, Zhang J, Ji Z, Li K, Zhan J, et al. Ischemia-reperfusion induces renal tubule pyroptosis via the CHOP-caspase-11 pathway. Am J Physiol Renal Physiol. 2014;306:F75-84 pubmed publisher
    ..of the endoplasmic reticulum (ER) stress biomarkers glucose-regulated protein 78 and C/EBP homologous protein (CHOP) preceded the incidence of pyroptosis in cells treated with IRI or HRI...
  41. Silva R, Ries V, Oo T, Yarygina O, Jackson Lewis V, Ryu E, et al. CHOP/GADD153 is a mediator of apoptotic death in substantia nigra dopamine neurons in an in vivo neurotoxin model of parkinsonism. J Neurochem. 2005;95:974-86 pubmed
    ..Such analyses, performed in tissue culture models induced by neurotoxins, have identified up-regulation of CHOP/GADD153, a transcription factor implicated in apoptosis due to endoplasmic reticulum stress or oxidative injury...
  42. Wei H, Zhang R, Jin H, Liu D, Tang X, Tang C, et al. Hydrogen sulfide attenuates hyperhomocysteinemia-induced cardiomyocytic endoplasmic reticulum stress in rats. Antioxid Redox Signal. 2010;12:1079-91 pubmed publisher
    ..Confocal immunofluorescent analysis for cardiomyocytic C/EBP homologous protein (CHOP) was performed...
  43. Sylvester S, ap Rhys C, Luethy Martindale J, Holbrook N. Induction of GADD153, a CCAAT/enhancer-binding protein (C/EBP)-related gene, during the acute phase response in rats. Evidence for the involvement of C/EBPs in regulating its expression. J Biol Chem. 1994;269:20119-25 pubmed
    ..b>GADD153, a unique member of the C/EBP family, has been proposed to act as a dominant negative inhibitor of other C/EBPs, ..
  44. Akazawa Y, Saito Y, Nishio K, Horie M, Kinumi T, Masuo Y, et al. Proteomic characterization of the striatum and midbrain treated with 6-hydroxydopamine: alteration of 58-kDa glucose-regulated protein and C/EBP homologous protein. Free Radic Res. 2010;44:410-21 pubmed publisher
    ..Furthermore, 6-OHDA increased the expression level of C/EBP homologous protein (CHOP), a mediator of endoplasmic reticulum (ER) stress response, in the midbrain and striatum...
  45. Alter J, Bengal E. Stress-induced C/EBP homology protein (CHOP) represses MyoD transcription to delay myoblast differentiation. PLoS ONE. 2011;6:e29498 pubmed publisher
    ..the ? subunit of the translation initiation factor 2 (eIF2?) is followed by expression of C/EBP homology protein (CHOP) in some myoblasts...
  46. Yu H, Zhang H, Zhao W, Guo L, Li X, Li Y, et al. Gypenoside Protects against Myocardial Ischemia-Reperfusion Injury by Inhibiting Cardiomyocytes Apoptosis via Inhibition of CHOP Pathway and Activation of PI3K/Akt Pathway In Vivo and In Vitro. Cell Physiol Biochem. 2016;39:123-36 pubmed publisher
    ..results of western blotting revealed that the GP inhibited ER-stress and apoptosis through the blockade of CHOP pathway and activation of PI3K/Akt pathway...
  47. Pino S, O Sullivan Murphy B, Lidstone E, Yang C, Lipson K, Jurczyk A, et al. CHOP mediates endoplasmic reticulum stress-induced apoptosis in Gimap5-deficient T cells. PLoS ONE. 2009;4:e5468 pubmed publisher
    ..We then discovered that ER stress-induced apoptotic signaling through C/EBP-homologous protein (CHOP) occurs in Gimap5(-/-) T cells...
  48. Harding H, Zhang Y, Ron D. Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. Nature. 1999;397:271-4 pubmed
    ..These properties implicate PERK in a signalling pathway that attenuates protein translation in response to ER stress. ..
  49. Bromati C, Lellis Santos C, Yamanaka T, Nogueira T, Leonelli M, Caperuto L, et al. UPR induces transient burst of apoptosis in islets of early lactating rats through reduced AKT phosphorylation via ATF4/CHOP stimulation of TRB3 expression. Am J Physiol Regul Integr Comp Physiol. 2011;300:R92-100 pubmed publisher
    ..heavy chain-binding protein (BiP), activating transcription factor 4 (ATF4), and C/EBP homologous protein (CHOP) in islets from L3 rats...
  50. Nam D, Han J, Lee T, Shishido T, Lim J, Kim G, et al. CHOP deficiency prevents methylglyoxal-induced myocyte apoptosis and cardiac dysfunction. J Mol Cell Cardiol. 2015;85:168-77 pubmed publisher
    ..blot analysis revealed that MGO-induced myocyte apoptosis was inhibited by depletion of CHOP with siRNA against Ddit3, the gene name for rat CHOP...
  51. Bek M, Bayer M, Muller B, Greiber S, Lang D, Schwab A, et al. Expression and function of C/EBP homology protein (GADD153) in podocytes. Am J Pathol. 2006;168:20-32 pubmed
    ..Superoxide anions and H(2)O(2) increased mRNA and protein expression of GAS5 (growth arrest-specific protein 5) and CHOP (C/EBP homology protein)...
  52. Li G, Mongillo M, Chin K, Harding H, Ron D, Marks A, et al. Role of ERO1-alpha-mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress-induced apoptosis. J Cell Biol. 2009;186:783-92 pubmed publisher
    ..Based on roles for C/EPB homologous protein (CHOP) and ER calcium release in apoptosis, we hypothesized that apoptosis involves the activation of inositol 1,4,5-..
  53. Fujinami Y, Mutai H, Kamiya K, Mizutari K, Fujii M, Matsunaga T. Enhanced expression of C/EBP homologous protein (CHOP) precedes degeneration of fibrocytes in the lateral wall after acute cochlear mitochondrial dysfunction induced by 3-nitropropionic acid. Neurochem Int. 2010;56:487-94 pubmed publisher
    ..3-NP is known to induce oxidative stress as well as neuronal apoptosis. C/EBP homologous protein gene (chop) is one of the marker genes induced during endoplasmic reticulum (ER) stress, and is also considered to be involved ..
  54. Allagnat F, Fukaya M, Nogueira T, Delaroche D, Welsh N, Marselli L, et al. C/EBP homologous protein contributes to cytokine-induced pro-inflammatory responses and apoptosis in ?-cells. Cell Death Differ. 2012;19:1836-46 pubmed publisher
    Induction of the C/EBP homologous protein (CHOP) is considered a key event for endoplasmic reticulum (ER) stress-mediated apoptosis. Type 1 diabetes (T1D) is characterized by an autoimmune destruction of the pancreatic ?-cells...
  55. Svotelis A, Doyon G, Bernatchez G, Desilets A, Rivard N, Asselin C. IL-1 beta-dependent regulation of C/EBP delta transcriptional activity. Biochem Biophys Res Commun. 2005;328:461-70 pubmed
    ..This unusual arrangement of a kinase docking site within a transactivation domain may functionally be important for the regulation of C/EBP delta transcriptional activity. ..
  56. Han X, Chae J, Lee M, You K, Lee B, Kim D. Involvement of GADD153 and cardiac ankyrin repeat protein in hypoxia-induced apoptosis of H9c2 cells. J Biol Chem. 2005;280:23122-9 pubmed
    ..it was found that hypoxia induces apoptosis in rat embryonic heart-derived H9c2 cells leading to the induction of GADD153, which is an apoptosis-related gene...
  57. Pomerance M, Carapau D, Chantoux F, Mockey M, Correze C, Francon J, et al. CCAAT/enhancer-binding protein-homologous protein expression and transcriptional activity are regulated by 3',5'-cyclic adenosine monophosphate in thyroid cells. Mol Endocrinol. 2003;17:2283-94 pubmed
    ..and transcriptional activity of the p38-MAPK substrate CCAAT/enhancer-binding protein-homologous protein (CHOP). CHOP is expressed in the rat thyroid gland and in confluent PCCL3 and FRTL-5 cells...
  58. Zhang J, Singh N, Robinson Taylor K, Dorsett Martin W, Morris M, EARL T, et al. Hepatocyte autophagy is linked to C/EBP-homologous protein, Bcl2-interacting mediator of cell death, and BH3-interacting domain death agonist gene expression. J Surg Res. 2015;195:588-95 pubmed publisher
    ..We hypothesized that gene expression of C/EBP-homologous protein (CHOP) and the BH3 proteins Bcl2-interacting mediator of cell death (BIM) and BH3-interacting domain death agonist (BID) ..
  59. Loinard C, Zouggari Y, Rueda P, Ramkhelawon B, Cochain C, Vilar J, et al. C/EBP homologous protein-10 (CHOP-10) limits postnatal neovascularization through control of endothelial nitric oxide synthase gene expression. Circulation. 2012;125:1014-26 pubmed publisher
    C/EBP homologous protein-10 (CHOP-10) is a novel developmentally regulated nuclear protein that emerges as a critical transcriptional integrator among pathways regulating differentiation, proliferation, and survival...
  60. Rees W, Hay S, Fontanier Razzaq N, Antipatis C, Harries D. Expression of the growth arrest genes (GAS and GADD) changes during organogenesis in the rat fetus. J Nutr. 1999;129:1532-6 pubmed
    ..during the early stages of development, whereas those genes associated with inhibition of protein synthesis [GADD153 (also known as CHOP-10 or Ddit3) and C/EBP-beta] were more highly expressed during the later stages...
  61. Qi Y, Xia P. Cellular inhibitor of apoptosis protein-1 (cIAP1) plays a critical role in ?-cell survival under endoplasmic reticulum stress: promoting ubiquitination and degradation of C/EBP homologous protein (CHOP). J Biol Chem. 2012;287:32236-45 pubmed publisher
    ..cIAP1 functions as an E3 ubiquitin ligase promoting ubiquitination and degradation of C/EBP homologous protein (CHOP), a key mediator of ER stress-induced cell death...
  62. Cai N, McCoy M, Ladenheim B, Lyles J, Ali S, Cadet J. Serial analysis of gene expression in the rat striatum following methamphetamine administration. Ann N Y Acad Sci. 2006;1074:13-30 pubmed
    ..Of these, CAATT enhancer-binding protein homologous protein (CHOP)/GADD153 (growth arrest- and DNA damage-inducible gene 153) was found to be upregulated by about threefold...
  63. Kesterton D. A projectionist speaks. Med Biol Illus. 1977;27:15-9 pubmed
  64. Zhu H, Qian J, Wang W, Yan Q, Xu Y, Jiang Y, et al. RNA interference of GADD153 protects photoreceptors from endoplasmic reticulum stress-mediated apoptosis after retinal detachment. PLoS ONE. 2013;8:e59339 pubmed publisher
    ..Pharmacologic inhibition of photoreceptor cell death may prevent RD. This study investigated the role of GADD153 that participates in endoplasmic reticulum (ER) stress-mediated apoptosis of photoreceptor cells after RD.
  65. Urban P, Bilecová Rabajdová M, Marekova M, Vesela J. Progression of apoptic signaling from mesenteric ischemia-reperfusion injury to lungs: correlation in the level of ER chaperones expression. Mol Cell Biochem. 2012;362:133-40 pubmed publisher
    ..We analyzed changes in mRNA levels of pro-apoptotic genes Gadd153 (Chop) and anti-apoptotic genes Grp78 (Bip) in the small intestine wall and lung parenchyma...
  66. Kroeger H, Messah C, Ahern K, Gee J, Joseph V, Matthes M, et al. Induction of endoplasmic reticulum stress genes, BiP and chop, in genetic and environmental models of retinal degeneration. Invest Ophthalmol Vis Sci. 2012;53:7590-9 pubmed publisher
    ..of tightly induced ER stress genes, Binding of immunoglobulin protein (BiP) and CCAAT/enhancer-binding protein homologous protein (Chop), in seven additional models of retinal degeneration arising from genetic or environmental causes.
  67. Ghosh A, Klocke B, Ballestas M, Roth K. CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress. PLoS ONE. 2012;7:e39586 pubmed publisher
    ..CHOP (C/EBP homologous protein also known as GADD153; gene name Ddit3), a critical initiator of ER stress-induced apoptosis, was found to regulate both PUMA and BIM ..
  68. Jauhiainen A, Thomsen C, Strömbom L, Grundevik P, Andersson C, Danielsson A, et al. Distinct cytoplasmic and nuclear functions of the stress induced protein DDIT3/CHOP/GADD153. PLoS ONE. 2012;7:e33208 pubmed publisher
    DDIT3, also known as GADD153 or CHOP, encodes a basic leucine zipper transcription factor of the dimer forming C/EBP family...
  69. Fradejas N, Pastor M, Burgos M, Beyaert R, Tranque P, Calvo S. Caspase-11 mediates ischemia-induced astrocyte death: involvement of endoplasmic reticulum stress and C/EBP homologous protein. J Neurosci Res. 2010;88:1094-105 pubmed publisher
    ..We have recently shown that the transcription factor C/EBP homologous protein (CHOP), associated with endoplasmic reticulum (ER) stress, plays a key role in the astrocyte death induced by ischemia...
  70. Edagawa M, Kawauchi J, Hirata M, Goshima H, Inoue M, Okamoto T, et al. Role of activating transcription factor 3 (ATF3) in endoplasmic reticulum (ER) stress-induced sensitization of p53-deficient human colon cancer cells to tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis through . J Biol Chem. 2014;289:21544-61 pubmed publisher
  71. Gotoh T, Terada K, Oyadomari S, Mori M. hsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondria. Cell Death Differ. 2004;11:390-402 pubmed
    We reported that the endoplasmic reticulum (ER) stress pathway involving CHOP, a member of the C/EBP transcription factor family, plays a key role in nitric oxide (NO)-mediated apoptosis of macrophages and pancreatic beta cells...
  72. Wang X, Wang Y, Liu X, Wang Q, Zhang C, Zhang L, et al. BRD7 mediates hyperglycaemia-induced myocardial apoptosis via endoplasmic reticulum stress signalling pathway. J Cell Mol Med. 2017;21:1094-1105 pubmed publisher
    ..stress-induced apoptosis by detecting spliced/active X-box binding protein 1 (XBP-1s) and C/EBP homologous protein (CHOP)...
  73. Oshitari T, Yoshida Hata N, Yamamoto S. Effect of neurotrophin-4 on endoplasmic reticulum stress-related neuronal apoptosis in diabetic and high glucose exposed rat retinas. Neurosci Lett. 2011;501:102-6 pubmed publisher
    ..Our results showed that the number of TUNEL-positive, and PERK- and CHOP-positive cells was significantly higher in diabetic and HG exposed retinas than in normal retinas...
  74. Mulhern M, Madson C, Danford A, Ikesugi K, Kador P, Shinohara T. The unfolded protein response in lens epithelial cells from galactosemic rat lenses. Invest Ophthalmol Vis Sci. 2006;47:3951-9 pubmed
    ..of the LECs from these galactose-fed rats showed higher levels of the UPR-specific proteins Bip/GRP78, ATF4, and CHOP. These LECs also demonstrated activation of the UPR-specific procaspase-12 and the increased presence of ROS, ..