Dcx

Summary

Gene Symbol: Dcx
Description: doublecortin
Alias: neuronal migration protein doublecortin
Species: rat
Products:     Dcx

Top Publications

  1. Kerjan G, Koizumi H, Han E, Dubé C, Djakovic S, Patrick G, et al. Mice lacking doublecortin and doublecortin-like kinase 2 display altered hippocampal neuronal maturation and spontaneous seizures. Proc Natl Acad Sci U S A. 2009;106:6766-71 pubmed publisher
    Mutations in doublecortin (DCX) are associated with intractable epilepsy in humans, due to a severe disorganization of the neocortex and hippocampus known as classical lissencephaly...
  2. Koizumi H, Tanaka T, Gleeson J. Doublecortin-like kinase functions with doublecortin to mediate fiber tract decussation and neuronal migration. Neuron. 2006;49:55-66 pubmed
    The potential role of doublecortin (Dcx), encoding a microtubule-associated protein, in brain development has remained controversial...
  3. Dellarole A, Grilli M. Adult dorsal root ganglia sensory neurons express the early neuronal fate marker doublecortin. J Comp Neurol. 2008;511:318-28 pubmed publisher
    It has been widely accepted that doublecortin (DCX) may represent a neuronal fate marker transiently expressed by immature neurons during development of the central and peripheral nervous tissue and in neurogenic areas of the adult brain...
  4. Manohar S, Paolone N, Bleichfeld M, Hayes S, Salvi R, Baizer J. Expression of doublecortin, a neuronal migration protein, in unipolar brush cells of the vestibulocerebellum and dorsal cochlear nucleus of the adult rat. Neuroscience. 2012;202:169-83 pubmed publisher
    Doublecortin (DCX) is a microtubule-associated protein that is critical for neuronal migration and the development of the cerebral cortex...
  5. Tint I, Jean D, Baas P, Black M. Doublecortin associates with microtubules preferentially in regions of the axon displaying actin-rich protrusive structures. J Neurosci. 2009;29:10995-1010 pubmed publisher
    Here we studied doublecortin (DCX) in cultured hippocampal and sympathetic neurons during axonal development. In both types of neurons, DCX is abundant in the growth cone, in which it primarily localizes with microtubules...
  6. Schaar B, Kinoshita K, McConnell S. Doublecortin microtubule affinity is regulated by a balance of kinase and phosphatase activity at the leading edge of migrating neurons. Neuron. 2004;41:203-13 pubmed
    Doublecortin (Dcx) is a microtubule-associated protein that is mutated in X-linked lissencephaly (X-LIS), a neuronal migration disorder associated with epilepsy and mental retardation...
  7. Nosten Bertrand M, Kappeler C, Dinocourt C, Denis C, Germain J, Phan Dinh Tuy F, et al. Epilepsy in Dcx knockout mice associated with discrete lamination defects and enhanced excitability in the hippocampus. PLoS ONE. 2008;3:e2473 pubmed publisher
    Patients with Doublecortin (DCX) mutations have severe cortical malformations associated with mental retardation and epilepsy. Dcx knockout (KO) mice show no major isocortical abnormalities, but have discrete hippocampal defects...
  8. Friocourt G, Liu J, Antypa M, Rakic S, Walsh C, Parnavelas J. Both doublecortin and doublecortin-like kinase play a role in cortical interneuron migration. J Neurosci. 2007;27:3875-83 pubmed
    ..Two genes, LIS1 and doublecortin (DCX), have been shown to be responsible for a large proportion of cases of type I lissencephaly...
  9. Corbo J, Deuel T, Long J, LaPorte P, Tsai E, Wynshaw Boris A, et al. Doublecortin is required in mice for lamination of the hippocampus but not the neocortex. J Neurosci. 2002;22:7548-57 pubmed
    Doublecortin (DCX) is a microtubule-associated protein that is required for normal neocortical and hippocampal development in humans...

More Information

Publications50

  1. Des Portes V, Francis F, Pinard J, Desguerre I, Moutard M, Snoeck I, et al. doublecortin is the major gene causing X-linked subcortical laminar heterotopia (SCLH). Hum Mol Genet. 1998;7:1063-70 pubmed
    ..The absence of phenotype-genotype correlations suggests that X-inactivation patterns of neuronal precursor cells are likely to contribute to the variable clinical severity of this disorder in females. ..
  2. Bai J, Ramos R, Ackman J, Thomas A, Lee R, LoTurco J. RNAi reveals doublecortin is required for radial migration in rat neocortex. Nat Neurosci. 2003;6:1277-83 pubmed
    Mutations in the doublecortin gene (DCX) in humans cause malformation of the cerebral neocortex. Paradoxically, genetic deletion of Dcx in mice does not cause neocortical malformation...
  3. Deuel T, Liu J, Corbo J, Yoo S, Rorke Adams L, Walsh C. Genetic interactions between doublecortin and doublecortin-like kinase in neuronal migration and axon outgrowth. Neuron. 2006;49:41-53 pubmed
    Although mutations in the human doublecortin gene (DCX) cause profound defects in cortical neuronal migration, a genetic deletion of Dcx in mice produces a milder defect...
  4. Wakabayashi T, Kosaka J, Mori T, Takamori Y, Yamada H. Doublecortin expression continues into adulthood in horizontal cells in the rat retina. Neurosci Lett. 2008;442:249-52 pubmed publisher
    The doublecortin (DCX) protein is associated with microtubules, and is essential for neuronal migration, differentiation, and plasticity...
  5. Jean D, Baas P, Black M. A novel role for doublecortin and doublecortin-like kinase in regulating growth cone microtubules. Hum Mol Genet. 2012;21:5511-27 pubmed publisher
    Doublecortin (DCX) and doublecortin-like kinase (DCLK), closely related family members, are microtubule-associated proteins with overlapping functions in both neuronal migration and axonal outgrowth...
  6. Stegeman S, Jolly L, Premarathne S, Gecz J, Richards L, Mackay Sim A, et al. Loss of Usp9x disrupts cortical architecture, hippocampal development and TGF?-mediated axonogenesis. PLoS ONE. 2013;8:e68287 pubmed publisher
    ..This study establishes that Usp9x is critical for several aspects of CNS development, and suggests that its regulation of Tgf-? signaling extends to neurons. ..
  7. Xu X, Zheng J, Zhang J, Chne X, Yang P, Liu J, et al. [Neurogenesis in the dentate gyrus of the hippocampus in a rat model of intracerebral hemorrhage]. Nan Fang Yi Ke Da Xue Xue Bao. 2013;33:1437-41 pubmed
    ..The expression of DCX protein in the ipsilateral DG of the hippocampus was enhanced in the rats 1 day after ICH (0.202?0...
  8. Manent J, Wang Y, Chang Y, Paramasivam M, LoTurco J. Dcx reexpression reduces subcortical band heterotopia and seizure threshold in an animal model of neuronal migration disorder. Nat Med. 2009;15:84-90 pubmed publisher
    ..Here we show, in a rat model of subcortical band heterotopia (SBH) generated by in utero RNA interference of the Dcx gene, that aberrantly positioned neurons can be stimulated to migrate by reexpressing Dcx after birth...
  9. Engelhardt M, Bogdahn U, Aigner L. Adult retinal pigment epithelium cells express neural progenitor properties and the neuronal precursor protein doublecortin. Brain Res. 2005;1040:98-111 pubmed
    ..A subpopulation of RPE- and CB-derived progenitor cells expressed the neurogenesis-specific protein doublecortin (DCX)...
  10. Bregy A, Nixon R, Lotocki G, Alonso O, Atkins C, Tsoulfas P, et al. Posttraumatic hypothermia increases doublecortin expressing neurons in the dentate gyrus after traumatic brain injury in the rat. Exp Neurol. 2012;233:821-8 pubmed publisher
  11. Zhang C, Chopp M, Cui Y, Wang L, Zhang R, Zhang L, et al. Cerebrolysin enhances neurogenesis in the ischemic brain and improves functional outcome after stroke. J Neurosci Res. 2010;88:3275-81 pubmed publisher
    ..number of bromodeoxyuridine-positive (BrdU(+)) subventricular zone (SVZ) neural progenitor cells and doublecortin (DCX) immunoreactivity (migrating neuroblasts) in the ipsilateral SVZ and striatal ischemic boundary 28 days after ..
  12. Decimo I, Bifari F, Rodríguez F, Malpeli G, Dolci S, Lavarini V, et al. Nestin- and doublecortin-positive cells reside in adult spinal cord meninges and participate in injury-induced parenchymal reaction. Stem Cells. 2011;29:2062-76 pubmed publisher
    ..Meninges may be considered as a new source of adult stem/precursor cells to be further tested for use in regenerative medicine applied to neurological disorders, including repair from spinal cord injury. ..
  13. Liu X, Chopp M, Zhang X, Zhang R, Buller B, Hozeska Solgot A, et al. Gene profiles and electrophysiology of doublecortin-expressing cells in the subventricular zone after ischemic stroke. J Cereb Blood Flow Metab. 2009;29:297-307 pubmed publisher
    ..rat and transgenic mice that expressed enhanced green fluorescent protein (EGFP) concomitantly with doublecortin (DCX), a marker for migrating neuroblasts, we recorded electrophysiological characteristics while simultaneously ..
  14. D Alessio L, Konopka H, López E, Seoane E, Consalvo D, Oddo S, et al. Doublecortin (DCX) immunoreactivity in hippocampus of chronic refractory temporal lobe epilepsy patients with hippocampal sclerosis. Seizure. 2010;19:567-72 pubmed publisher
    ..Doublecortin (DCX) has been validated to determine alterations in the production of new neurons in the human hippocampus...
  15. Kato M, Kimura T, Lin C, Ito A, Kodama S, Morikawa T, et al. A novel mutation of the doublecortin gene in Japanese patients with X-linked lissencephaly and subcortical band heterotopia. Hum Genet. 1999;104:341-4 pubmed
    The doublecortin (DCX) gene was recently found to be involved in patients with X-linked lissencephaly and subcortical band heterotopia or double cortex syndrome...
  16. Santra M, Zhang X, Santra S, Jiang F, Chopp M. Ectopic doublecortin gene expression suppresses the malignant phenotype in glioblastoma cells. Cancer Res. 2006;66:11726-35 pubmed
    Doublecortin (DCX) is one of the three genes found from Affymetrix gene chip analysis related to glioma patient survival. Two other genes (e.g...
  17. Tsai M, Kuo P, Myers C, Li S, Lin W, Fu T, et al. A novel DCX missense mutation in a family with X-linked lissencephaly and subcortical band heterotopia syndrome inherited from a low-level somatic mosaic mother: Genetic and functional studies. Eur J Paediatr Neurol. 2016;20:788-94 pubmed publisher
    ..Sanger sequencing of DCX gene, allele specific PCR and molecular inversion probe technique were performed...
  18. Santra M, Zheng X, Roberts C, Santra S, Lu M, Panda S, et al. Single doublecortin gene therapy significantly reduces glioma tumor volume. J Neurosci Res. 2010;88:304-14 pubmed publisher
    We employed lentivirus-based doublecortin (DCX), as a glioma suppressor gene therapy in an intracranial glioma tumor xenograft model in nude rats...
  19. Haverfield E, Whited A, Petras K, Dobyns W, Das S. Intragenic deletions and duplications of the LIS1 and DCX genes: a major disease-causing mechanism in lissencephaly and subcortical band heterotopia. Eur J Hum Genet. 2009;17:911-8 pubmed publisher
    ..Abnormalities of the LIS1 and DCX genes are implicated in the majority of patients with these disorders and account for approximately 75% of patients ..
  20. Kremer T, Jagasia R, Herrmann A, Matile H, Borroni E, Francis F, et al. Analysis of adult neurogenesis: evidence for a prominent "non-neurogenic" DCX-protein pool in rodent brain. PLoS ONE. 2013;8:e59269 pubmed publisher
    Here, we have developed a highly sensitive immunoassay for Dcx to characterize expression in brain and cerebrospinal fluid (CSF) of rodents...
  21. Yi S, Hwang I, Yoo K, Park O, Yu J, Yan B, et al. Effects of treadmill exercise on cell proliferation and differentiation in the subgranular zone of the dentate gyrus in a rat model of type II diabetes. Neurochem Res. 2009;34:1039-46 pubmed publisher
    ..study, we investigated the effects of a treadmill exercise on serum glucose levels and Ki67 and doublecortin (DCX) immunoreactivity, which is a marker of cell proliferation expressed during cell cycles except G0 and early G1 and ..
  22. Aigner L, Fluegel D, Dietrich J, Ploetz S, Winkler J. Isolated lissencephaly sequence and double-cortex syndrome in a German family with a novel doublecortin mutation. Neuropediatrics. 2000;31:195-8 pubmed
    ..The molecular and genetic basis of DC/ILS is associated with mutations in the X-linked doublecortin gene (DCX)...
  23. Huang W, She L, Chang X, Yang R, Wang L, Ji H, et al. Protein kinase LKB1 regulates polarized dendrite formation of adult hippocampal newborn neurons. Proc Natl Acad Sci U S A. 2014;111:469-74 pubmed publisher
    ..Thus, besides its known function in axon formation in embryonic pyramidal neurons, LKB1 plays an additional role in regulating polarized dendrite morphogenesis in adult-born granule cells in the hippocampus. ..
  24. Oliver P, Chodroff R, Gosal A, Edwards B, Cheung A, Gomez Rodriguez J, et al. Disruption of Visc-2, a Brain-Expressed Conserved Long Noncoding RNA, Does Not Elicit an Overt Anatomical or Behavioral Phenotype. Cereb Cortex. 2015;25:3572-85 pubmed publisher
    ..A high-throughput knockout program focussing on lncRNAs, similar to that currently underway for protein-coding genes, will be required to establish the distribution of their organismal functions. ..
  25. Wang Y, Zhong J, Xu H, Wei W, Dong J, Yu F, et al. Perinatal iodine deficiency and hypothyroidism increase cell apoptosis and alter doublecortin and reelin protein expressions in rat cerebellum. Arch Med Res. 2012;43:255-64 pubmed publisher
    ..investigated effects of perinatal iodine deficiency and hypothyroidism on cerebellar cell apoptosis, doublecortin (Dcx) and reelin. Apoptosis is an essential part of neural development...
  26. Geoghegan D, Carter D. A novel site of adult doublecortin expression: neuropeptide neurons within the suprachiasmatic nucleus circadian clock. BMC Neurosci. 2008;9:2 pubmed publisher
    ..In the present study we have identified and characterized a quite novel aspect of SCN neurobiology, doublecortin (DCX) protein expression within a defined group of adult rat SCN neurons...
  27. Fournier N, Andersen D, Botterill J, Sterner E, Lussier A, Caruncho H, et al. The effect of amygdala kindling on hippocampal neurogenesis coincides with decreased reelin and DISC1 expression in the adult dentate gyrus. Hippocampus. 2010;20:659-71 pubmed publisher
  28. Guerrini R, Moro F, Andermann E, Hughes E, D Agostino D, Carrozzo R, et al. Nonsyndromic mental retardation and cryptogenic epilepsy in women with doublecortin gene mutations. Ann Neurol. 2003;54:30-7 pubmed
    b>DCX mutations cause mental retardation in male subjects with lissencephalypachygyria and in female subjects with subcortical band heterotopia (SBH)...
  29. Yap C, Vakulenko M, Kruczek K, Motamedi B, Digilio L, Liu J, et al. Doublecortin (DCX) mediates endocytosis of neurofascin independently of microtubule binding. J Neurosci. 2012;32:7439-53 pubmed publisher
    Doublecortin on X chromosome (DCX) is one of two major genetic loci underlying human lissencephaly, a neurodevelopmental disorder with defects in neuronal migration and axon outgrowth...
  30. Kutsuna N, Eriguchi T, Oshima H, Suma T, Sakatani K, Yoshino A, et al. Acute stress exposure preceding global brain ischemia accelerates decreased doublecortin expression in the rat retrosplenial cortex. Adv Exp Med Biol. 2013;789:65-71 pubmed publisher
    ..GBI) or acute stress exposure can induce a decrease in expression of the immature neuronal marker, doublecortin (DCX), in the RS. However, little is known about the DCX expression in the RS after stress exposure prior to GBI...
  31. Juhásová J, Juhás S, Hruska Plochan M, Dolezalova D, Holubova M, Strnádel J, et al. Time course of spinal doublecortin expression in developing rat and porcine spinal cord: implication in in vivo neural precursor grafting studies. Cell Mol Neurobiol. 2015;35:57-70 pubmed publisher
    Expression of doublecortin (DCX), a 43-53 kDa microtubule binding protein, is frequently used as (i) an early neuronal marker to identify the stage of neuronal maturation of in vivo grafted neuronal precursors (NSCs), and (ii) a neuronal ..
  32. Kutsuna N, Suma T, Takada Y, Yamashita A, Oshima H, Sakatani K, et al. Decrease in doublecortin expression without neuronal cell death in rat retrosplenial cortex after stress exposure. Neuroreport. 2012;23:211-5 pubmed publisher
    ..A cell population that expresses immature neuronal markers, including doublecortin (DCX), plays a key role in plasticity of the adult brain through formation of new neurons...
  33. Lapray D, Popova I, Kindler J, Jorquera I, Becq H, Manent J, et al. Spontaneous epileptic manifestations in a DCX knockdown model of human double cortex. Cereb Cortex. 2010;20:2694-701 pubmed publisher
    Previous reports indicate that in utero knockdown of doublecortin (DCX) results in the genesis of a subcortical heterotopia reminiscent of the doublecortex observed in female patients with DCX mutations...
  34. Santra M, Santra S, Buller B, Santra K, Nallani A, Chopp M. Effect of doublecortin on self-renewal and differentiation in brain tumor stem cells. Cancer Sci. 2011;102:1350-7 pubmed publisher
    ..with patient Kaplan-Meier survival plots, indicates that expression of a glioma suppressor gene doublecortin (DCX) favors glioma patient survival...
  35. Shimozaki K, Clemenson G, Gage F. Paired related homeobox protein 1 is a regulator of stemness in adult neural stem/progenitor cells. J Neurosci. 2013;33:4066-75 pubmed publisher
    ..These data suggest that Prx1 plays an important role as a key switch for neural cell lineage determination and the maintenance of the self-renewal of adult NSCs at several stages in the adult brain. ..
  36. Cohen D, Segal M, Reiner O. Doublecortin supports the development of dendritic arbors in primary hippocampal neurons. Dev Neurosci. 2008;30:187-99 pubmed
    Doublecortin (DCX) is a microtubule-associated protein necessary for neuronal migration. In spite of its ubiquitous distribution in dendrites, its possible role in dendrite development has not yet been documented...
  37. Urakawa S, Hida H, Masuda T, Misumi S, Kim T, Nishino H. Environmental enrichment brings a beneficial effect on beam walking and enhances the migration of doublecortin-positive cells following striatal lesions in rats. Neuroscience. 2007;144:920-33 pubmed
    ..induction of lesions by striatal injection of 6-OHDA or QA, the number of cells positive for doublecortin (DCX) was strongly increased in the striatum; however, there was no change in the number of DCX-positive cells following ..
  38. Kizhatil K, Wu Y, Sen A, Bennett V. A new activity of doublecortin in recognition of the phospho-FIGQY tyrosine in the cytoplasmic domain of neurofascin. J Neurosci. 2002;22:7948-58 pubmed
    ..The finding that doublecortin associates with FIGQY-phosphorylated neurofascin provides the first connection of doublecortin with the plasma membrane and could be important for a function of doublecortin in directing neuronal migration. ..
  39. Zimatkin S, Karniushko O. [EXPRESSION OF DOUBLECORTIN AND NeuN IN THE DEVELOPING CEREBELLAR NEURONS IN RAT]. Morfologiia. 2016;149:38-42 pubmed
    ..the offspring of 5 outbred female albino rats to give a comparative immunohistochemical evaluation of doublecortin (DCX) and NeuN expression in the neurons of the cerebellar cortex and nucleus interpositus in the early postnatal ..
  40. Wang Y, Yin X, Rosen G, Gabel L, Guadiana S, Sarkisian M, et al. Dcdc2 knockout mice display exacerbated developmental disruptions following knockdown of doublecortin. Neuroscience. 2011;190:398-408 pubmed publisher
    The dyslexia-associated gene DCDC2 is a member of the DCX family of genes known to play roles in neurogenesis, neuronal migration, and differentiation. Here we report the first phenotypic analysis of a Dcdc2 knockout mouse...
  41. Herrick S, Waters E, Drake C, McEwen B, Milner T. Extranuclear estrogen receptor beta immunoreactivity is on doublecortin-containing cells in the adult and neonatal rat dentate gyrus. Brain Res. 2006;1121:46-58 pubmed
    ..proestrus or postnatal day 7 and 14 female rats were dual-labeled for ERbeta and the new-cell marker doublecortin (DCX) and examined by electron microscopy...