Gene Symbol: Dctn2
Description: dynactin subunit 2
Alias: dynactin subunit 2, dynactin 2 (p50)
McKenney R, Weil S, Scherer J, Vallee R. Mutually exclusive cytoplasmic dynein regulation by NudE-Lis1 and dynactin. J Biol Chem. 2011;286:39615-22 pubmed publisher
..Together these results reveal an unanticipated mechanism for preventing dual regulation of individual dynein molecules, and identify the IC as a nexus for regulatory interactions within the dynein complex. ..
Ohbayashi N, Maruta Y, Ishida M, Fukuda M. Melanoregulin regulates retrograde melanosome transport through interaction with the RILP-p150Glued complex in melanocytes. J Cell Sci. 2012;125:1508-18 pubmed publisher
..These findings reveal a new mechanism by which the dynein-dynactin motor complex recognizes Mreg on mature melanosomes through interaction with RILP and is involved in the centripetal movement of melanosomes. ..
Echeverri C, Paschal B, Vaughan K, Vallee R. Molecular characterization of the 50-kD subunit of dynactin reveals function for the complex in chromosome alignment and spindle organization during mitosis. J Cell Biol. 1996;132:617-33 pubmed
..The data also provide direct in vivo evidence for a role for vertebrate dynactin in modulating cytoplasmic dynein binding to an organelle, and implicate both dynactin and dynein in chromosome alignment and spindle organization. ..
Abe T, Tanaka H, Iwanaga T, Odani S, Kuwano R. The presence of the 50-kDa subunit of dynactin complex in the nerve growth cone. Biochem Biophys Res Commun. 1997;233:295-9 pubmed
..However, the amount of gmp23-48k in the membrane fraction greatly decreased in adult brain. These results suggest a special role of membrane-associated gmp23-48k/p50 in synapse formation during brain development. ..
Schroer T. Dynactin. Annu Rev Cell Dev Biol. 2004;20:759-79 pubmed
Choi W, Khurana A, Mathur R, Viswanathan V, Steele D, Fedida D. Kv1.5 surface expression is modulated by retrograde trafficking of newly endocytosed channels by the dynein motor. Circ Res. 2005;97:363-71 pubmed
..This work has significant implications for understanding the way Kv channel surface expression is regulated. ..
Fumoto K, Hoogenraad C, Kikuchi A. GSK-3beta-regulated interaction of BICD with dynein is involved in microtubule anchorage at centrosome. EMBO J. 2006;25:5670-82 pubmed
..These results imply that GSK-3beta may function in transporting centrosomal proteins to the centrosome by stabilizing the BICD1 and dynein complex, resulting in the regulation of a focused microtubule organization. ..
Chung C, Koprich J, Siddiqi H, Isacson O. Dynamic changes in presynaptic and axonal transport proteins combined with striatal neuroinflammation precede dopaminergic neuronal loss in a rat model of AAV alpha-synucleinopathy. J Neurosci. 2009;29:3365-73 pubmed publisher
..These findings can provide ideas for antecedent biomarkers and presymptomatic interventions in PD. ..
Staples C, Myers K, Beveridge R, Patil A, Howard A, Barone G, et al
. Ccdc13 is a novel human centriolar satellite protein required for ciliogenesis and genome stability. J Cell Sci. 2014;127:2910-9 pubmed publisher