Gene Symbol: Dcp1a
Description: decapping mRNA 1A
Alias: RGD1561298, mRNA-decapping enzyme 1A, test2
Zheng D, Ezzeddine N, Chen C, Zhu W, He X, Shyu A. Deadenylation is prerequisite for P-body formation and mRNA decay in mammalian cells. J Cell Biol. 2008;182:89-101 pubmed publisher
..These results support a dynamic interplay among deadenylation, mRNP remodeling, and P-body formation in selective decay of mammalian mRNA...
Oh J, Kwon A, Jo A, Kim H, Goo Y, Lee J, et al
. Activity-dependent synaptic localization of processing bodies and their role in dendritic structural plasticity. J Cell Sci. 2013;126:2114-23 pubmed publisher
..and Arp2 mRNA from the P-bodies and, consequently, reversed the decrease of F-actin (induced by overexpression of Dcp1a) in the dendrites...
Fenger Grøn M, Fillman C, Norrild B, Lykke Andersen J. Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping. Mol Cell. 2005;20:905-15 pubmed
..These observations suggest that multiple proteins involved in human decapping are important subunits of PBs and are activated on ARE-mRNAs by the protein TTP. ..
Yamaji M, Tanaka T, Shigeta M, Chuma S, Saga Y, Saitou M. Functional reconstruction of NANOS3 expression in the germ cell lineage by a novel transgenic reporter reveals distinct subcellular localizations of NANOS3. Reproduction. 2010;139:381-93 pubmed publisher
..initiation factor 2alpha, markers for the stress granules, whereas a fraction of it showed co-localization with DCP1A, a marker for the processing bodies...
Tritschler F, Braun J, Motz C, Igreja C, Haas G, Truffault V, et al
. DCP1 forms asymmetric trimers to assemble into active mRNA decapping complexes in metazoa. Proc Natl Acad Sci U S A. 2009;106:21591-6 pubmed publisher
..Our results reveal an unexpected connectivity and complexity of the mRNA decapping network in multicellular eukaryotes, which likely enhances opportunities for regulating mRNA degradation. ..
Li Y, Chen R, Zhou Q, Xu Z, Li C, Wang S, et al
. LSm14A is a processing body-associated sensor of viral nucleic acids that initiates cellular antiviral response in the early phase of viral infection. Proc Natl Acad Sci U S A. 2012;109:11770-5 pubmed publisher
..These findings suggest that LSm14A is a sensor for both viral RNA and DNA and plays an important role in initiating IFN-? induction in the early phase of viral infection. ..