Dcn

Summary

Gene Symbol: Dcn
Description: decorin
Alias: decorin, DSPG, PG-S2, PG40, bone proteoglycan II, dermatan sulfate proteoglycan-II (decorin)
Species: rat
Products:     Dcn

Top Publications

  1. Schaefer L, Raslik I, Grone H, Schonherr E, Macakova K, Ugorcakova J, et al. Small proteoglycans in human diabetic nephropathy: discrepancy between glomerular expression and protein accumulation of decorin, biglycan, lumican, and fibromodulin. FASEB J. 2001;15:559-61 pubmed
    Small leucine-rich proteoglycans (SLRPs), for example, decorin, biglycan, fibromodulin, and lumican, are extracellular matrix organizers and binding partners of TGF-b. Decorin is also involved in growth control and angiogenesis...
  2. Williams K, Qiu G, Usui H, Dunn S, McCue P, Bottinger E, et al. Decorin deficiency enhances progressive nephropathy in diabetic mice. Am J Pathol. 2007;171:1441-50 pubmed
    b>Decorin, a proteoglycan that inhibits active transforming growth factor-beta, is increased in diabetic nephropathy; however, its functional significance is unclear...
  3. Wu H, Jiang W, Zhang Y, Liu Y, Zhao Z, Guo M, et al. Regulation of intracellular decorin via proteasome degradation in rat mesangial cells. J Cell Biochem. 2010;111:1010-9 pubmed publisher
    b>Decorin (DCN) is a member of small leucine-rich proteoglycan family that neutralizes the bioactivity of transforming growth factor-beta1 (TGF-?1). It has been proven to be a promising anti-fibrotic agent to treat glomerulonephritis...
  4. Wu F, Yao H, Bader A, Dong F, Zhu F, Wu N, et al. Decorin gene transfer inhibited the expression of TGFbeta1 and ECM in rat mesangial cells. Eur J Med Res. 2007;12:360-8 pubmed
    To explore the regulative role of decorin on the ECM gene-expression in diabetic nephropathy, recombinant adenovirus expressing rat decorin (Ad-decorin) was constructed to further investigate the effects of decorin overproduction on the ..
  5. Steer D, Shah M, Bush K, Stuart R, Sampogna R, Meyer T, et al. Regulation of ureteric bud branching morphogenesis by sulfated proteoglycans in the developing kidney. Dev Biol. 2004;272:310-27 pubmed
    ..that many proteoglycan core proteins change during kidney development (syndecan-1,2,4, glypican-1,2,3, versican, decorin, biglycan)...
  6. Simkhovich B, Marjoram P, Poizat C, Kedes L, Kloner R. Age-related changes of cardiac gene expression following myocardial ischemia/reperfusion. Arch Biochem Biophys. 2003;420:268-78 pubmed
    ..expression associated with early-remodeling including down-regulation of tissue inhibitor of metalloproteinase 1, decorin, collagen, tropoelastin, and fibulin, as well as decreases in hypertrophy-related transcripts...
  7. Goldoni S, Seidler D, Heath J, Fassan M, Baffa R, Thakur M, et al. An antimetastatic role for decorin in breast cancer. Am J Pathol. 2008;173:844-55 pubmed publisher
    b>Decorin, a member of the small leucine-rich proteoglycan gene family, down-regulates members of the ErbB receptor tyrosine kinase family and attenuates their signaling, leading to growth inhibition...
  8. Bhide V, Laschinger C, Arora P, Lee W, Hakkinen L, Larjava H, et al. Collagen phagocytosis by fibroblasts is regulated by decorin. J Biol Chem. 2005;280:23103-13 pubmed
    b>Decorin is a small, leucine-rich proteoglycan that binds to collagen and regulates fibrillogenesis. We hypothesized that decorin binding to collagen inhibits phagocytosis of collagen fibrils...
  9. Zhang J, Wright W, Bernlohr D, Cushman S, Chen X. Alterations of the classic pathway of complement in adipose tissue of obesity and insulin resistance. Am J Physiol Endocrinol Metab. 2007;292:E1433-40 pubmed
    ..we investigated adipose expression and regulation of C1 complement subcomponents and C1 activation regulator decorin in obesity and insulin resistance...

More Information

Publications36

  1. Nishimura T, Oyama K, Kishioka Y, Wakamatsu J, Hattori A. Spatiotemporal expression of decorin and myostatin during rat skeletal muscle development. Biochem Biophys Res Commun. 2007;361:896-902 pubmed
    b>Decorin, a small leucine-rich proteoglycans, plays an important role in tissue morphogenesis through the regulation of collagen fibrillogenesis and the modulation of some growth factors...
  2. Chen C, Chang S, Vivian Yang W. High glucose alters proteoglycan expression and the glycosaminoglycan composition in placentas of women with gestational diabetes mellitus and in cultured trophoblasts. Placenta. 2007;28:97-106 pubmed
    ..that the increased CS/DS PGs in GDM placentas were predominantly the small leucine-rich proteoglycans (SLRPs), decorin and biglycan. Increased mRNA expression level was consistently shown by quantitative real-time PCR...
  3. Tang M, Mao J. Matrix and gene expression in the rat cranial base growth plate. Cell Tissue Res. 2006;324:467-74 pubmed
    ..osteocalcin, osteopontin, and fetal liver kinase 1, were expressed in the CBGP with a reproducible absence of decorin mRNA...
  4. De Cosmo S, Tassi V, Thomas S, Piras G, Trevisan R, Cavallo Perin P, et al. The Decorin gene 179 allelic variant is associated with a slower progression of renal disease in patients with type 1 diabetes. Nephron. 2002;92:72-6 pubmed
    ..b>Decorin, a proteoglycan which is a component of the extracellular matrix, regulates TGF-beta1 activity and expression...
  5. Henke A, Grace O, Ashley G, Stewart G, Riddick A, Yeun H, et al. Stromal expression of decorin, Semaphorin6D, SPARC, Sprouty1 and Tsukushi in developing prostate and decreased levels of decorin in prostate cancer. PLoS ONE. 2012;7:e42516 pubmed publisher
    ..of developmental prostate mesenchyme were selected using a wholemount in situ hybridisation screen and studied Decorin (Dcn), Semaphorin6D (Sema6D), SPARC/Osteonectin (SPARC), Sprouty1 (Spry-1) and Tsukushi (Tsku)...
  6. Gornstein E, Schwarz T. The paradox of paclitaxel neurotoxicity: Mechanisms and unanswered questions. Neuropharmacology. 2014;76 Pt A:175-83 pubmed publisher
    ..This article is part of the Special Issue entitled 'The Synaptic Basis of Neurodegenerative Disorders'. ..
  7. Suzuki K, Wang R, Kubota H, Shibuya H, Saegusa J, Sato T. Kinetics of biglycan, decorin and thrombospondin-1 in mercuric chloride-induced renal tubulointerstitial fibrosis. Exp Mol Pathol. 2005;79:68-73 pubmed
    We investigated the kinetics of decorin, biglycan and thrombospondin-1 in mercuric chloride-treated Brown Norway (BN) rats. BN rats were injected subcutaneously with 1 mg/kg b.w. of mercuric chloride one or three times...
  8. Bolton K, Segal D, McMillan J, Jowett J, Heilbronn L, Abberton K, et al. Decorin is a secreted protein associated with obesity and type 2 diabetes. Int J Obes (Lond). 2008;32:1113-21 pubmed publisher
    To characterize the expression of the small leucine-rich glycoprotein decorin in adipose tissue...
  9. Jones M, Ravid K. Vascular smooth muscle polyploidization as a biomarker for aging and its impact on differential gene expression. J Biol Chem. 2004;279:5306-13 pubmed
    ..These mRNAs correspond to guanine deaminase, to the matrix proteins rat glypican 3 (OCI-5) and decorin, as well as to the inflammation-associated transcripts, insulin-like growth factor-binding protein 6, macrophage ..
  10. Roberts H, Moseley R, Sloan A, Youde S, Waddington R. Lipopolysaccharide alters decorin and biglycan synthesis in rat alveolar bone osteoblasts: consequences for bone repair during periodontal disease. Eur J Oral Sci. 2008;116:207-16 pubmed publisher
    ..In the presence of P. gingivalis LPS, decorin expression by the alveolar bone cells was reduced during periods of culture relating to collagen fibrillogenesis ..
  11. Zhang Y, Hu R, Wu H, Jiang W, Sun Y, Wang Y, et al. OTUB1 overexpression in mesangial cells is a novel regulator in the pathogenesis of glomerulonephritis through the decrease of DCN level. PLoS ONE. 2012;7:e29654 pubmed publisher
    ..But its concrete cellular location and function in the kidney remain unclear. Decorin (DCN) in mesangial cells (MC) is considered to be a potentially important factor for antagonizing ..
  12. Jeansson M, Granqvist A, Nyström J, Haraldsson B. Functional and molecular alterations of the glomerular barrier in long-term diabetes in mice. Diabetologia. 2006;49:2200-9 pubmed
    ..In addition, protein and mRNA levels for versican and decorin were downregulated after 40 weeks of diabetes...
  13. Toeda K, Nakamura K, Hirohata S, Hatipoglu O, Demircan K, Yamawaki H, et al. Versican is induced in infiltrating monocytes in myocardial infarction. Mol Cell Biochem. 2005;280:47-56 pubmed
    ..Versican mRNA then gradually decreased, while the mRNA of decorin, another small proteoglycan, increased thereafter...
  14. Knoll K, Pietrusz J, Liang M. Tissue-specific transcriptome responses in rats with early streptozotocin-induced diabetes. Physiol Genomics. 2005;21:222-9 pubmed
    ..Particularly interesting cases of common or tissue-specific regulation included decorin and CD36, which were upregulated in several tissues, and serum/glucocorticoid-regulated kinase and four and a ..
  15. Shi Y, Massague J. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell. 2003;113:685-700 pubmed
    ..This article reviews these latest advances and presents our current understanding on the mechanisms of TGF-beta signaling from cell membrane to the nucleus. ..
  16. Batbayal T, Ishii Y, Nomura Y, Watanabe M, Yasuko T, Nakamura S. Change in decorin during aging of rat placenta. Connect Tissue Res. 2006;47:235-41 pubmed
    By immunohistochemistry, with or without chondroitinases, decorin was found to be distributed in the extracellular matrix of chorionic villi and amnia. The strength of staining intensified with increasing gestational age...
  17. Abramson S, Woessner J. cDNA sequence for rat dermatan sulfate proteoglycan-II (decorin). Biochim Biophys Acta. 1992;1132:225-7 pubmed
    A cDNA clone for dermatan sulfate proteoglycan-II, or decorin, has been isolated from a rat uterus library and sequenced...
  18. Biglari A, Bataille D, Naumann U, Weller M, Zirger J, Castro M, et al. Effects of ectopic decorin in modulating intracranial glioma progression in vivo, in a rat syngeneic model. Cancer Gene Ther. 2004;11:721-32 pubmed
    ..b>Decorin, a small proteoglycan which can bind to and inactivate TGF-beta, has been successfully used as an antitumor ..
  19. Buraschi S, Neill T, Goyal A, Poluzzi C, Smythies J, Owens R, et al. Decorin causes autophagy in endothelial cells via Peg3. Proc Natl Acad Sci U S A. 2013;110:E2582-91 pubmed publisher
    Soluble decorin affects the biology of several receptor tyrosine kinases by triggering receptor internalization and degradation...
  20. Asundi V, Dreher K. Molecular characterization of vascular smooth muscle decorin: deduced core protein structure and regulation of gene expression. Eur J Cell Biol. 1992;59:314-21 pubmed
    Two overlapping clones containing sequences homologous to bovine, human and chicken decorin have been recovered from poly A+ RNA isolated from rat vascular smooth muscle cells (VSMC) using cDNA cloning and reverse transcription-..
  21. Nishimura T, Nozu K, Kishioka Y, Wakamatsu J, Hattori A. Decorin expression in quiescent myogenic cells. Biochem Biophys Res Commun. 2008;370:383-7 pubmed publisher
    ..Here, we demonstrated that decorin mRNA expression was high in cell cultures containing a higher ratio of quiescent satellite cells when satellite ..
  22. Ohno T, Hirano S, Rousseau B. Extracellular matrix gene expression during wound healing of the injured rat vocal fold. Otolaryngol Head Neck Surg. 2009;140:757-61 pubmed publisher
    To measure the expression of procollagen-I and -III, decorin, and hyaluronan synthase (HAS)-1, -2, and -3 during the inflammatory, proliferative, and remodeling phases of rat vocal fold injury. Prospective, animal model...
  23. Wiberg C, Klatt A, Wagener R, Paulsson M, Bateman J, Heinegard D, et al. Complexes of matrilin-1 and biglycan or decorin connect collagen VI microfibrils to both collagen II and aggrecan. J Biol Chem. 2003;278:37698-704 pubmed
    ..The small leucine-rich repeat (LRR) proteoglycans biglycan and decorin were bound to the N-terminal region of collagen VI...
  24. Pini L, Torregiani C, Martin J, Hamid Q, Ludwig M. Airway remodeling in allergen-challenged Brown Norway rats: distribution of proteoglycans. Am J Physiol Lung Cell Mol Physiol. 2006;290:L1052-8 pubmed
    ..Tissue sections were incubated with antibodies to the small, leucine-rich PG, decorin, and biglycan and collagen type I...
  25. Wu H, Wang S, Xue A, Liu Y, Liu Y, Wang H, et al. Overexpression of decorin induces apoptosis and cell growth arrest in cultured rat mesangial cells in vitro. Nephrology (Carlton). 2008;13:607-15 pubmed publisher
    b>Decorin (DCN) is a small leucine-rich proteoglycan that plays an important role in the regulation of intercellular contact, cell migration and proliferation. DCN suppresses cell growth and induces apoptosis in various tumour cells...
  26. Orgel J, Eid A, Antipova O, Bella J, Scott J. Decorin core protein (decoron) shape complements collagen fibril surface structure and mediates its binding. PLoS ONE. 2009;4:e7028 pubmed publisher
    b>Decorin is the archetypal small leucine rich repeat proteoglycan of the vertebrate extracellular matrix (ECM). With its glycosaminoglycuronan chain, it is responsible for stabilizing inter-fibrillar organization...
  27. Kokenyesi R, Woessner J. Purification and characterization of a small dermatan sulphate proteoglycan implicated in the dilatation of the rat uterine cervix. Biochem J. 1989;260:413-9 pubmed
    A small dermatan sulphate proteoglycan (DSPG) was extracted from rat cervices and was purified by using DEAE-Sephacel ion-exchange chromatography, gel filtration on Sepharose CL-2B and CsCl-density-gradient centrifugation...