Gene Symbol: Dbp
Description: D-box binding PAR bZIP transcription factor
Alias: D site-binding protein, D site albumin promoter binding protein, D site of albumin promoter (albumin D-box) binding protein, albumin D box-binding protein, albumin D-element-binding protein, d site albumin promoter-binding protein 1
Species: rat
Products:     Dbp

Top Publications

  1. Klugmann M, Leichtlein C, Symes C, Klaussner B, Brooks A, Young D, et al. A novel role of circadian transcription factor DBP in hippocampal plasticity. Mol Cell Neurosci. 2006;31:303-14 pubmed
    ..which is associated with improved learning and neuroprotection, results in suppression of the transcription factor DBP (albumin D-site-binding protein)...
  2. Xu Z, Kaga S, Tsubomizu J, Fujisaki J, Mochiduki A, Sakai T, et al. Circadian transcriptional factor DBP regulates expression of Kiss1 in the anteroventral periventricular nucleus. Mol Cell Endocrinol. 2011;339:90-7 pubmed publisher
    ..Here we report that a circadian transcriptional factor, albumin D-site binding protein (Dbp), was able to trigger mKiss1 transcription via the D-box, and this effect was combined with those of estrogen ..
  3. Herichova I, Zeman M, Stebelova K, Ravingerova T. Effect of streptozotocin-induced diabetes on daily expression of per2 and dbp in the heart and liver and melatonin rhythm in the pineal gland of Wistar rat. Mol Cell Biochem. 2005;270:223-9 pubmed
    ..mellitus on function of the circadian system at the level of melatonin synthesis and expression of per2 and dbp in the heart and liver in 8-week-old Wistar rats...
  4. Huang X, Chen W, Yuan J, Yang Y, Mei Q, Huang L. Altered diurnal variation and localization of clock proteins in the remnant kidney of 5/6 nephrectomy rats. Nephrology (Carlton). 2013;18:555-62 pubmed publisher
    To investigate the localization and diurnal variation of clock proteins (BMAL1, PER2) and clock output protein (DBP) in the remnant kidney of 5/6 nephrectomy rats (STNx)...
  5. Mueller C, Maire P, Schibler U. DBP, a liver-enriched transcriptional activator, is expressed late in ontogeny and its tissue specificity is determined posttranscriptionally. Cell. 1990;61:279-91 pubmed
    The full-length cDNA for a transcriptional activator, DBP, that binds to the D site of the albumin promoter has been cloned...
  6. Brown S, Schibler U. The ins and outs of circadian timekeeping. Curr Opin Genet Dev. 1999;9:588-94 pubmed
    ..Taken together, these observations are reshaping thinking about inputs and outputs of metazoan circadian clocks. ..
  7. Brown S, Zumbrunn G, Fleury Olela F, Preitner N, Schibler U. Rhythms of mammalian body temperature can sustain peripheral circadian clocks. Curr Biol. 2002;12:1574-83 pubmed
    ..We postulate that both endogenous and environmental temperature cycles can participate in the synchronization of peripheral clocks in mammals. ..
  8. Saito H, Terada T, Shimakura J, Katsura T, Inui K. Regulatory mechanism governing the diurnal rhythm of intestinal H+/peptide cotransporter 1 (PEPT1). Am J Physiol Gastrointest Liver Physiol. 2008;295:G395-402 pubmed publisher
    ..on the clock genes (Clock, Bmal1, Per1-2, and Cry1) and clock-controlled gene, albumin D site-binding protein (DBP)...
  9. Ando H, Ushijima K, Yanagihara H, Hayashi Y, Takamura T, Kaneko S, et al. Clock gene expression in the liver and adipose tissues of non-obese type 2 diabetic Goto-Kakizaki rats. Clin Exp Hypertens. 2009;31:201-7 pubmed publisher
    ..In this study, we show that the rhythmic mRNA expression of clock genes (Clock, Bmal1, Cry1, and Dbp) is not attenuated in the liver and visceral adipose tissues of Goto-Kakizaki rats, a model of nonobese, type 2 ..

More Information


  1. Takahashi S, Inoue I, Nakajima Y, Seo M, Nakano T, Yang F, et al. A promoter in the novel exon of hPPARgamma directs the circadian expression of PPARgamma. J Atheroscler Thromb. 2010;17:73-83 pubmed
    ..Herein, we show that expression levels of the novel PPARgamma transcript exhibit circadian oscillation. To study the mechanisms controlling PPARgamma expression, a novel PPARgamma gene promoter was cloned and characterized...
  2. Yamajuku D, Shibata Y, Kitazawa M, Katakura T, Urata H, Kojima T, et al. Cellular DBP and E4BP4 proteins are critical for determining the period length of the circadian oscillator. FEBS Lett. 2011;585:2217-22 pubmed publisher
    ..We found that knockdown of DBP, D-box positive regulator, in our model led to a short-period phenotype, whereas overexpressing of DBP produced a ..
  3. Harbour V, Weigl Y, Robinson B, Amir S. Phase differences in expression of circadian clock genes in the central nucleus of the amygdala, dentate gyrus, and suprachiasmatic nucleus in the rat. PLoS ONE. 2014;9:e103309 pubmed publisher
    ..analysis of the transcript level of two core clock genes, Period2 (Per2) and Bmal1, and a clock output gene, Dbp, in the suprachiasmatic nucleus (SCN), the master circadian clock, and in two forebrain regions, the lateral part ..
  4. Xiong D, Shen H, Zhao L, Xiao P, Yang T, Guo Y, et al. Robust and comprehensive analysis of 20 osteoporosis candidate genes by very high-density single-nucleotide polymorphism screen among 405 white nuclear families identified significant association and gene-gene interaction. J Bone Miner Res. 2006;21:1678-95 pubmed
    ..We detected four genes (DBP, LRP5, CYP17, and RANK) that showed highly suggestive associations (10,000-permutation derived empirical global p &..