Gene Symbol: Dapk2
Description: death-associated protein kinase 2
Alias: death-associated protein kinase 2, death-associated kinase 2
Inbal B, Shani G, Cohen O, Kissil J, Kimchi A. Death-associated protein kinase-related protein 1, a novel serine/threonine kinase involved in apoptosis. Mol Cell Biol. 2000;20:1044-54 pubmed
..Possible functional connections between DAP kinase and DRP-1 are discussed. ..
Li H, Ray G, Yoo B, Erdogan M, Rosen K. Down-regulation of death-associated protein kinase-2 is required for beta-catenin-induced anoikis resistance of malignant epithelial cells. J Biol Chem. 2009;284:2012-22 pubmed publisher
Geering B, Stoeckle C, Rozman S, Oberson K, Benarafa C, Simon H. DAPK2 positively regulates motility of neutrophils and eosinophils in response to intermediary chemoattractants. J Leukoc Biol. 2014;95:293-303 pubmed publisher
..Here, we show that DAPK2, a Ca(2+)/CaM-sensitive serine/threonine kinase known to modulate cell death in various cell types, is a novel ..
Kawai T, Nomura F, Hoshino K, Copeland N, Gilbert D, Jenkins N, et al
. Death-associated protein kinase 2 is a new calcium/calmodulin-dependent protein kinase that signals apoptosis through its catalytic activity. Oncogene. 1999;18:3471-80 pubmed
..a new calcium/calmodulin (Ca2+/CaM) dependent protein kinase termed death-associated protein kinase 2 (DAPK2) that contains an N-terminal protein kinase domain followed by a conserved CaM-binding domain with significant ..
Shani G, Henis Korenblit S, Jona G, Gileadi O, Eisenstein M, Ziv T, et al
. Autophosphorylation restrains the apoptotic activity of DRP-1 kinase by controlling dimerization and calmodulin binding. EMBO J. 2001;20:1099-113 pubmed
..This mechanism of negative autophosphorylation provides a safety barrier that restrains the killing effects of DRP-1, and a target for efficient activation of the kinase by various apoptotic stimuli. ..
Li S, Xiao F, Shan P, Su L, Chen D, Ding J, et al
. Overexpression of microRNA-133a inhibits ischemia-reperfusion-induced cardiomyocyte apoptosis by targeting DAPK2. J Hum Genet. 2015;60:709-16 pubmed publisher
..MiR-133a and Death Associated Protein Kinase 2 (DAPK2) mRNA expression was measured using real-time-PCR, and DAPK2 protein expression was detected ..