Gene Symbol: Dao
Description: D-amino-acid oxidase
Alias: Dao1, D-amino-acid oxidase, D-amino acid oxidase 1, DAAO, DAMOX
Species: rat
Products:     Dao

Top Publications

  1. Katane M, Saitoh Y, Hanai T, Sekine M, Furuchi T, Koyama N, et al. Thiolactomycin inhibits D-aspartate oxidase: a novel approach to probing the active site environment. Biochimie. 2010;92:1371-8 pubmed publisher
    D-Aspartate oxidase (DDO) and D-amino acid oxidase (DAO) are flavin adenine dinucleotide (FAD)-containing flavoproteins that catalyze the oxidative deamination of D-amino acids...
  2. Chumakov I, Blumenfeld M, Guerassimenko O, Cavarec L, Palicio M, Abderrahim H, et al. Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia. Proc Natl Acad Sci U S A. 2002;99:13675-80 pubmed
    ..Yeast two-hybrid experiments with the G72 protein identified the enzyme d-amino acid oxidase (DAAO) as an interacting partner...
  3. Ono K, Shishido Y, Park H, Kawazoe T, Iwana S, Chung S, et al. Potential pathophysiological role of D-amino acid oxidase in schizophrenia: immunohistochemical and in situ hybridization study of the expression in human and rat brain. J Neural Transm (Vienna). 2009;116:1335-47 pubmed publisher
    D-Amino acid oxidase (DAO) is a peroxisomal flavoenzyme that catalyzes oxidative deamination of a wide range of D-amino acids...
  4. Kawazoe T, Tsuge H, Imagawa T, Aki K, Kuramitsu S, Fukui K. Structural basis of D-DOPA oxidation by D-amino acid oxidase: alternative pathway for dopamine biosynthesis. Biochem Biophys Res Commun. 2007;355:385-91 pubmed
    D-amino acid oxidase (DAO) degrades the gliotransmitter D-serine, a potent endogenous ligand of N-methyl-D-aspartate type glutamate receptors...
  5. Konno R. Rat D-amino-acid oxidase cDNA: rat D-amino-acid oxidase as an intermediate form between mouse and other mammalian D-amino-acid oxidases. Biochim Biophys Acta. 1998;1395:165-70 pubmed
    Nucleotide sequence of cDNA encoding rat D-amino-acid oxidase (DAO) was determined. Two species of DAO mRNA were present in rat kidney, liver, and brain. They were probably produced by alternative splicing...
  6. Caldinelli L, Molla G, Sacchi S, Pilone M, Pollegioni L. Relevance of weak flavin binding in human D-amino acid oxidase. Protein Sci. 2009;18:801-10 pubmed publisher
    ..We propose that the absence in vivo of an active site ligand/substrate weakens the cofactor binding, yielding the inactive apoprotein form and thus avoiding excessive D-serine degradation. ..
  7. Mitchell J, Paul P, Chen H, Morris A, Payling M, Falchi M, et al. Familial amyotrophic lateral sclerosis is associated with a mutation in D-amino acid oxidase. Proc Natl Acad Sci U S A. 2010;107:7556-61 pubmed publisher
    We report a unique mutation in the D-amino acid oxidase gene (R199W DAO) associated with classical adult onset familial amyotrophic lateral sclerosis (FALS) in a three generational FALS kindred, after candidate gene screening in a 14...
  8. Caldinelli L, Molla G, Bracci L, Lelli B, Pileri S, Cappelletti P, et al. Effect of ligand binding on human D-amino acid oxidase: implications for the development of new drugs for schizophrenia treatment. Protein Sci. 2010;19:1500-12 pubmed publisher
    ..In conclusion, the different alteration of hDAAO conformation and stability by the ligands used represents a further parameter to take into consideration during the development of new drugs to cope schizophrenia. ..
  9. Konno R, Okamura T, Kasai N, Summer K, Niwa A. Mutant rat strain lacking D-amino-acid oxidase. Amino Acids. 2009;37:367-75 pubmed publisher
    D-amino-acid oxidase (DAO) is known to be associated with schizophrenia. Since the expression of DAO gene had been reported to be very low in LEA rats, we examined LEA/SENDAI rats in detail...

More Information


  1. Zhang H, Qi L, Lin Y, Mao L, Chen Y. Study on the decrease of renal D-amino acid oxidase activity in the rat after renal ischemia by chiral ligand exchange capillary electrophoresis. Amino Acids. 2012;42:337-45 pubmed publisher
    D: -Amino acid oxidase (DAAO) in mammal kidney regulates the renal reactive oxygen species (ROS) levels directly and plays a leading role in the development of ROS-mediated renal pathologic damages based on its crucial role in the ..
  2. Paul P, Murphy T, Oseni Z, Sivalokanathan S, de Belleroche J. Pathogenic effects of amyotrophic lateral sclerosis-linked mutation in D-amino acid oxidase are mediated by D-serine. Neurobiol Aging. 2014;35:876-85 pubmed publisher
    ..We previously reported a coding mutation in D-amino acid oxidase (R199W DAO) associated with familial amyotrophic lateral sclerosis...
  3. Sacchi S, Cappelletti P, Giovannardi S, Pollegioni L. Evidence for the interaction of D-amino acid oxidase with pLG72 in a glial cell line. Mol Cell Neurosci. 2011;48:20-8 pubmed publisher
    ..We also report that newly synthesized cytosolic hDAAO is catalytically active, and therefore pLG72 binding-and ensuing hDAAO inactivation-plays a protective role against d-serine depletion. ..
  4. Popiolek M, Ross J, Charych E, Chanda P, Gundelfinger E, Moss S, et al. D-amino acid oxidase activity is inhibited by an interaction with bassoon protein at the presynaptic active zone. J Biol Chem. 2011;286:28867-75 pubmed publisher
    ..One such susceptibility gene encoding D-amino acid oxidase (DAO), an enzyme that metabolizes the NMDA receptor (NMDAR) co-agonist D-serine, has the potential to modulate NMDAR ..
  5. Molla G, Sacchi S, Bernasconi M, Pilone M, Fukui K, Polegioni L. Characterization of human D-amino acid oxidase. FEBS Lett. 2006;580:2358-64 pubmed
    D-Amino acid oxidase (DAAO) has been proposed to be involved in the oxidation of D-serine, an allosteric activator of the NMDA-type glutamate receptor in the brain, and to be associated with the onset of schizophrenia...
  6. Sacchi S, Bernasconi M, Martineau M, Mothet J, Ruzzene M, Pilone M, et al. pLG72 modulates intracellular D-serine levels through its interaction with D-amino acid oxidase: effect on schizophrenia susceptibility. J Biol Chem. 2008;283:22244-56 pubmed publisher
  7. Hasegawa H, Matsukawa T, Shinohara Y, Konno R, Hashimoto T. Role of renal D-amino-acid oxidase in pharmacokinetics of D-leucine. Am J Physiol Endocrinol Metab. 2004;287:E160-5 pubmed
    d-Amino acids are now recognized to be widely present in mammals. Renal d-amino-acid oxidase (DAO) is associated with conversion of d-amino acids to the corresponding alpha-keto acids, but its contribution in vivo is poorly understood ..
  8. Fukudome I, Kobayashi M, Dabanaka K, Maeda H, Okamoto K, Okabayashi T, et al. Diamine oxidase as a marker of intestinal mucosal injury and the effect of soluble dietary fiber on gastrointestinal tract toxicity after intravenous 5-fluorouracil treatment in rats. Med Mol Morphol. 2014;47:100-7 pubmed publisher
    The level of plasma diamine oxidase (DAO) activity is associated with the maturation and integrity of small intestinal mucosa...