Gene Symbol: Dagla
Description: diacylglycerol lipase, alpha
Alias: Nsddr, sn1-specific diacylglycerol lipase alpha, DGL-alpha, neural stem cell-derived dendrite regulator
Gao Y, Vasilyev D, Goncalves M, Howell F, Hobbs C, Reisenberg M, et al
. Loss of retrograde endocannabinoid signaling and reduced adult neurogenesis in diacylglycerol lipase knock-out mice. J Neurosci. 2010;30:2017-24 pubmed publisher
..These findings provide the first evidence that DAGLalpha is the major biosynthetic enzyme for 2-AG in the nervous system and reveal an essential role for this enzyme in regulating retrograde synaptic plasticity and adult neurogenesis. ..
Tanimura A, Yamazaki M, Hashimotodani Y, Uchigashima M, Kawata S, Abe M, et al
. The endocannabinoid 2-arachidonoylglycerol produced by diacylglycerol lipase alpha mediates retrograde suppression of synaptic transmission. Neuron. 2010;65:320-7 pubmed publisher
..We conclude that 2-AG produced by DGLalpha, but not by DGLbeta, mediates retrograde suppression at central synapses. ..
Bisogno T, Howell F, Williams G, Minassi A, Cascio M, Ligresti A, et al
. Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain. J Cell Biol. 2003;163:463-8 pubmed
..This switch provides a possible explanation for a fundamental change in endocannabinoid function during brain development. Identification of these enzymes may offer new therapeutic opportunities for a wide range of disorders. ..
Liu L, Heneghan J, Michael G, Stanish L, Egertová M, Rittenhouse A. L- and N-current but not M-current inhibition by M1 muscarinic receptors requires DAG lipase activity. J Cell Physiol. 2008;216:91-100 pubmed publisher
..These results extend our previous findings that the signaling pathway mediating L- and N-current inhibition diverges from the pathway initiating M-current inhibition. ..
Suarez J, Ortiz O, Puente N, Bermudez Silva F, Blanco E, Fernández Llebrez P, et al
. Distribution of diacylglycerol lipase alpha, an endocannabinoid synthesizing enzyme, in the rat forebrain. Neuroscience. 2011;192:112-31 pubmed publisher
Jung K, Sepers M, Henstridge C, Lassalle O, Neuhofer D, Martin H, et al
. Uncoupling of the endocannabinoid signalling complex in a mouse model of fragile X syndrome. Nat Commun. 2012;3:1080 pubmed publisher
..The results identify the endocannabinoid signalosome as a molecular substrate for fragile X syndrome, which might be targeted by therapy...
Suarez J, Rivera P, Llorente R, Romero Zerbo S, Bermudez Silva F, de Fonseca F, et al
. Early maternal deprivation induces changes on the expression of 2-AG biosynthesis and degradation enzymes in neonatal rat hippocampus. Brain Res. 2010;1349:162-73 pubmed publisher
..These data support a clear association between neurodevelopmental stress and dysregulation of the endocannabinoid system. This association may be relevant for schizophrenia and other neurodevelopmental psychiatric disorders. ..
Keimpema E, Barabas K, Morozov Y, Tortoriello G, Torii M, Cameron G, et al
. Differential subcellular recruitment of monoacylglycerol lipase generates spatial specificity of 2-arachidonoyl glycerol signaling during axonal pathfinding. J Neurosci. 2010;30:13992-4007 pubmed publisher
Zhang L, Wang M, Bisogno T, Di Marzo V, Alger B. Endocannabinoids generated by Ca2+ or by metabotropic glutamate receptors appear to arise from different pools of diacylglycerol lipase. PLoS ONE. 2011;6:e16305 pubmed publisher