Gene Symbol: Dag1
Description: dystroglycan 1
Alias: dystroglycan, alpha-dystroglycan, beta-dystroglycan, dystroglycan 1 (dystrophin-associated glycoprotein 1)
Species: rat
Products:     Dag1

Top Publications

  1. Tian M, Jacobson C, Gee S, Campbell K, Carbonetto S, Jucker M. Dystroglycan in the cerebellum is a laminin alpha 2-chain binding protein at the glial-vascular interface and is expressed in Purkinje cells. Eur J Neurosci. 1996;8:2739-47 pubmed
    b>Dystroglycan is a core component of the dystrophin receptor complex in skeletal muscle which links the extracellular matrix to the muscle cytoskeleton...
  2. Kanagawa M, Saito F, Kunz S, Yoshida Moriguchi T, Barresi R, Kobayashi Y, et al. Molecular recognition by LARGE is essential for expression of functional dystroglycan. Cell. 2004;117:953-64 pubmed
    Reduced ligand binding activity of alpha-dystroglycan is associated with muscle and central nervous system pathogenesis in a growing number of muscular dystrophies...
  3. Noel G, Tham D, Moukhles H. Interdependence of laminin-mediated clustering of lipid rafts and the dystrophin complex in astrocytes. J Biol Chem. 2009;284:19694-704 pubmed publisher
    ..A growing body of evidence points to a role for dystroglycan and its interaction with perivascular laminin in the targeting of the dystrophin complex and the water-..
  4. Cerecedo D, Cisneros B, Suárez Sánchez R, Hernández González E, Galván I. beta-Dystroglycan modulates the interplay between actin and microtubules in human-adhered platelets. Br J Haematol. 2008;141:517-28 pubmed publisher
    ..Interestingly, beta-dystroglycan was found to act as an interplay protein between actin and microtubules and an additional communication between ..
  5. Hayashi Y, Ogawa M, Tagawa K, Noguchi S, Ishihara T, Nonaka I, et al. Selective deficiency of alpha-dystroglycan in Fukuyama-type congenital muscular dystrophy. Neurology. 2001;57:115-21 pubmed
    ..The authors found a selective deficiency of highly glycosylated alpha-dystroglycan, but not beta-dystroglycan, on the surface membrane of skeletal and cardiac muscle fibers in patients with FCMD...
  6. Saito F, Saito Arai Y, Nakamura A, Shimizu T, Matsumura K. Processing and secretion of the N-terminal domain of alpha-dystroglycan in cell culture media. FEBS Lett. 2008;582:439-44 pubmed publisher
    Alpha-dystroglycan (alpha-DG) plays a crucial role in maintaining the stability of muscle cell membrane...
  7. Cullen M, Walsh J, Nicholson L. Immunogold localization of the 43-kDa dystroglycan at the plasma membrane in control and dystrophic human muscle. Acta Neuropathol. 1994;87:349-54 pubmed
    ..This is significant because the potential success of dystrophin gene therapy could depend not only on restoring dystrophin but also on restoring the lost DAGs. ..
  8. Galbiati F, Engelman J, Volonte D, Zhang X, Minetti C, Li M, et al. Caveolin-3 null mice show a loss of caveolae, changes in the microdomain distribution of the dystrophin-glycoprotein complex, and t-tubule abnormalities. J Biol Chem. 2001;276:21425-33 pubmed
    ..These results have clear mechanistic implications for understanding the pathogenesis of LGMD-1C at a molecular level. ..
  9. Matsumura K, Chiba A, Yamada H, Fukuta Ohi H, Fujita S, Endo T, et al. A role of dystroglycan in schwannoma cell adhesion to laminin. J Biol Chem. 1997;272:13904-10 pubmed
    b>Dystroglycan is encoded by a single gene and cleaved into two proteins alpha- and beta-dystroglycan by posttranslational processing...

More Information


  1. Hoshino S, Ohkoshi N, Ishii A, Shoji S. The expression of dystrophin, alpha-sarcoglycan, and beta-dystroglycan during skeletal muscle regeneration: immunohistochemical and western blot studies. Acta Histochem. 2002;104:139-47 pubmed
    We evaluated re-expression of dystrophin, alpha-sarcoglycan and beta-dystroglycan in regenerating skeletal muscles of rats after cardiotoxin-induced myonecrosis in order to understand the dynamic behaviour of these proteins during the ..
  2. Sciandra F, Bozzi M, Morlacchi S, Galtieri A, Giardina B, Brancaccio A. Mutagenesis at the alpha-beta interface impairs the cleavage of the dystroglycan precursor. FEBS J. 2009;276:4933-45 pubmed publisher
    The interaction between a-dystroglycan (alpha-DG) and beta-dystroglycan (beta-DG), the two constituent subunits of the adhesion complex dystroglycan, is crucial in maintaining the integrity of the dystrophin-glycoprotein complex...
  3. Zhan Y, Tremblay M, Melian N, Carbonetto S. Evidence that dystroglycan is associated with dynamin and regulates endocytosis. J Biol Chem. 2005;280:18015-24 pubmed
    Disruption of the dystroglycan gene in humans and mice leads to muscular dystrophies and nervous system defects including malformation of the brain and defective synaptic transmission...
  4. Huizing M, Rakocevic G, Sparks S, Mamali I, Shatunov A, Goldfarb L, et al. Hypoglycosylation of alpha-dystroglycan in patients with hereditary IBM due to GNE mutations. Mol Genet Metab. 2004;81:196-202 pubmed
    ..Hypoglycosylation of alpha-dystroglycan, a central protein of the skeletal muscle dystrophin-glycoprotein complex, results in disturbed interactions ..
  5. Aragón J, Romo Yáñez J, Martínez Herrera A, Ceja V, Rendon A, Montañez C. Characterization of Dp71?(78-79), a novel dystrophin mutant that stimulates PC12 cell differentiation. J Neurochem. 2011;119:697-707 pubmed publisher
    ..Protein expression analysis showed a down-regulation of Dp71a and an up-regulation of Dp71ab and/or Up71, ?-dystroglycan and neuron-specific enolase in undifferentiated and in neural growth factor differentiated PC12-C11 cells...
  6. Colognato H, Galvin J, Wang Z, Relucio J, Nguyen T, Harrison D, et al. Identification of dystroglycan as a second laminin receptor in oligodendrocytes, with a role in myelination. Development. 2007;134:1723-36 pubmed
    ..However, it is a non-integrin ECM receptor, dystroglycan, that provides the key linkage between the dystrophin-glycoprotein complex (DGC) and laminin in skeletal muscle ..
  7. Durbeej M, Henry M, Ferletta M, Campbell K, Ekblom P. Distribution of dystroglycan in normal adult mouse tissues. J Histochem Cytochem. 1998;46:449-57 pubmed
    b>Dystroglycan is a cell surface protein which, in muscle, links the extracellular matrix protein laminin-2 to the intracellular cytoskeleton. Dystroglycan also binds laminin-1 and the binding occurs via the E3 fragment of laminin-1...
  8. Ursitti J, Lee P, Resneck W, McNally M, Bowman A, O Neill A, et al. Cloning and characterization of cytokeratins 8 and 19 in adult rat striated muscle. Interaction with the dystrophin glycoprotein complex. J Biol Chem. 2004;279:41830-8 pubmed
    ..Together these results indicate that at least two cytokeratins are expressed in adult striated muscle, where they may contribute to the organization of both the myoplasm and sarcolemma. ..
  9. Qiu G, Xu J, Zhuo F, Sun S, Liu H, Yang M, et al. Loss of AQP4 polarized localization with loss of β-dystroglycan immunoreactivity may induce brain edema following intracerebral hemorrhage. Neurosci Lett. 2015;588:42-8 pubmed publisher
    ..The brain-selective deletion of the dystroglycan (DG) gene causes a disorganization of AQP4 on the astroglial endfeet...
  10. Rice K, Preston D, Neff D, Norton M, Blough E. Age-related dystrophin-glycoprotein complex structure and function in the rat extensor digitorum longus and soleus muscle. J Gerontol A Biol Sci Med Sci. 2006;61:1119-29 pubmed
    ..The amount of dystrophin, beta-dystroglycan, and alpha-sarcoglycan increased with aging in the EDL and decreased with aging in the soleus...
  11. Galvin J, Eyermann C, Colognato H. Dystroglycan modulates the ability of insulin-like growth factor-1 to promote oligodendrocyte differentiation. J Neurosci Res. 2010;88:3295-307 pubmed publisher
    The adhesion receptor dystroglycan positively regulates terminal differentiation of oligodendrocytes, but the mechanism by which this occurs remains unclear...
  12. Wappler E, Adorjan I, Gal A, Galgóczy P, Bindics K, Nagy Z. Dynamics of dystroglycan complex proteins and laminin changes due to angiogenesis in rat cerebral hypoperfusion. Microvasc Res. 2011;81:153-9 pubmed publisher
    ..and on the adjacent cortex in order to investigate extracellular martix proteins, such as the markers of dystroglycan complex (?-dystroglycan, ?-dystrobrevin and utrophin) and a marker of basal lamina (laminin)...
  13. Koh T, Escobedo J. Cytoskeletal disruption and small heat shock protein translocation immediately after lengthening contractions. Am J Physiol Cell Physiol. 2004;286:C713-22 pubmed
  14. Marquez F, Cisneros B, Garcia F, Ceja V, Velazquez F, Depardon F, et al. Differential expression and subcellular distribution of dystrophin Dp71 isoforms during differentiation process. Neuroscience. 2003;118:957-66 pubmed
    ..Dp71f co-localizes with beta-dystroglycan and synaptophysin while Dp71d co-localizes with beta-dystroglycan in the nucleus...
  15. Reissner C, Stahn J, Breuer D, Klose M, Pohlentz G, Mormann M, et al. Dystroglycan binding to α-neurexin competes with neurexophilin-1 and neuroligin in the brain. J Biol Chem. 2014;289:27585-603 pubmed publisher
    ..partners of α-Nrxn are identified that depend on alternative splicing, including neuroligins (Nlgn) and dystroglycan (αDAG)...
  16. Sherman D, Fabrizi C, Gillespie C, Brophy P. Specific disruption of a schwann cell dystrophin-related protein complex in a demyelinating neuropathy. Neuron. 2001;30:677-87 pubmed
    b>Dystroglycan-dystrophin complexes are believed to have structural and signaling functions by linking extracellular matrix proteins to the cytoskeleton and cortical signaling molecules...
  17. Hagiwara Y, Sasaoka T, Araishi K, Imamura M, Yorifuji H, Nonaka I, et al. Caveolin-3 deficiency causes muscle degeneration in mice. Hum Mol Genet. 2000;9:3047-54 pubmed
    ..No apparent muscle degeneration was observed in heterozygous mutant mice, indicating that pathological changes caused by caveolin-3 gene disruption were inherited through the recessive form of genetic transmission. ..
  18. Ishiyama A, Mowry S, Lopez I, Ishiyama G. Immunohistochemical distribution of basement membrane proteins in the human inner ear from older subjects. Hear Res. 2009;254:1-14 pubmed publisher
    ..Fluorescent immunostaining using antibodies directed at collagen IV alpha 2, nidogen-1, laminin-beta2, alpha-dystroglycan, and tenascin-C was applied to cryosections from human cochlea, cristae ampullares, utricular and saccular ..
  19. Kojima K, Davidovits A, Poczewski H, Langer B, Uchida S, Nagy Bojarski K, et al. Podocyte flattening and disorder of glomerular basement membrane are associated with splitting of dystroglycan-matrix interaction. J Am Soc Nephrol. 2004;15:2079-89 pubmed
    The transmembrane component of the dystroglycan complex, a heterodimer of alpha- and beta-dystroglycan, was recently localized at the basal cell membrane domain of podocytes, and it was speculated that it serves as a device of the ..
  20. Fortunato M, Ball C, Hollinger K, Patel N, Modi J, Rajasekaran V, et al. Development of rabbit monoclonal antibodies for detection of alpha-dystroglycan in normal and dystrophic tissue. PLoS ONE. 2014;9:e97567 pubmed publisher
    Alpha-dystroglycan requires a rare O-mannose glycan modification to form its binding epitope for extracellular matrix proteins such as laminin...
  21. Chockalingam P, Cholera R, Oak S, Zheng Y, Jarrett H, Thomason D. Dystrophin-glycoprotein complex and Ras and Rho GTPase signaling are altered in muscle atrophy. Am J Physiol Cell Physiol. 2002;283:C500-11 pubmed
    ..The amount of some of the DGC proteins, including dystrophin, beta-dystroglycan, and alpha-sarcoglycan, is reduced significantly in rat skeletal muscle atrophy induced by tenotomy...
  22. Belkin A, Smalheiser N. Localization of cranin (dystroglycan) at sites of cell-matrix and cell-cell contact: recruitment to focal adhesions is dependent upon extracellular ligands. Cell Adhes Commun. 1996;4:281-96 pubmed
    We report that cranin (dystroglycan) can become recruited to focal adhesions of cultured rat REF 52 fibroblasts and human aortic smooth muscle cells...
  23. Bao X, Kobayashi M, Hatakeyama S, Angata K, Gullberg D, Nakayama J, et al. Tumor suppressor function of laminin-binding alpha-dystroglycan requires a distinct beta3-N-acetylglucosaminyltransferase. Proc Natl Acad Sci U S A. 2009;106:12109-14 pubmed publisher
    Alpha-dystroglycan (alpha-DG) represents a highly glycosylated cell surface molecule that is expressed in the epithelial cell-basement membrane (BM) interface and plays an essential role in epithelium development and tissue organization...
  24. Lara Chacón B, de León M, Leocadio D, Gomez P, Fuentes Mera L, Martínez Vieyra I, et al. Characterization of an Importin alpha/beta-recognized nuclear localization signal in beta-dystroglycan. J Cell Biochem. 2010;110:706-17 pubmed publisher
    Beta-dystroglycan (beta-DG) is a widely expressed transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton, and thereby contributing to plasma membrane integrity and signal transduction...
  25. Bedossa P, Ferlicot S, Paradis V, Dargere D, Bonvoust F, Vidaud M. Dystroglycan expression in hepatic stellate cells: role in liver fibrosis. Lab Invest. 2002;82:1053-61 pubmed
    b>Dystroglycan is a membrane component of the dystrophin-glycoprotein transmembrane complex. Its expression is required for the spatial organization of laminin on the cell surface and for basement membrane assembly...
  26. Cerna J, Cerecedo D, Ortega A, Garcia Sierra F, Centeno F, Garrido E, et al. Dystrophin Dp71f associates with the beta1-integrin adhesion complex to modulate PC12 cell adhesion. J Mol Biol. 2006;362:954-65 pubmed
    ..Our data indicate that Dp71f is a structural component of the beta1-integrin adhesion complex of PC12 cells that modulates PC12 cell adhesion by conferring proper complex assembly and/or maintenance. ..
  27. Mehes E, Czirok A, Hegedus B, Szabó B, Vicsek T, Satz J, et al. Dystroglycan is involved in laminin-1-stimulated motility of Müller glial cells: combined velocity and directionality analysis. Glia. 2005;49:492-500 pubmed
    We investigate the role of dystroglycan, a major laminin-1 receptor and central member of the dystrophin-glycoprotein complex, in the laminin-1 induced motility of cultured Muller glial cells...
  28. Wright K, Lyon K, Leung H, Leahy D, Ma L, Ginty D. Dystroglycan organizes axon guidance cue localization and axonal pathfinding. Neuron. 2012;76:931-44 pubmed publisher
    ..for novel determinants of axon guidance, we identified B3gnt1 and ISPD as required for the glycosylation of dystroglycan in vivo...
  29. Durbeej M, Talts J, Henry M, Yurchenco P, Campbell K, Ekblom P. Dystroglycan binding to laminin alpha1LG4 module influences epithelial morphogenesis of salivary gland and lung in vitro. Differentiation. 2001;69:121-34 pubmed
    b>Dystroglycan is a receptor for the basement membrane components laminin-1, -2, perlecan, and agrin. Genetic studies have revealed a role for dystroglycan in basement membrane formation of the early embryo...
  30. Vega Moreno J, Tirado Cortés A, Alvarez R, Irles C, Mas Oliva J, Ortega A. Cholesterol depletion uncouples ?-dystroglycans from discrete sarcolemmal domains, reducing the mechanical activity of skeletal muscle. Cell Physiol Biochem. 2012;29:905-18 pubmed publisher
    b>Dystroglycan (?-DG) is a transmembrane glycoprotein that links the intracellular cytoskeleton to the extracellular matrix and is crucial for the molecular pathway of lateral force transmission in muscle...
  31. Bozzi M, Bianchi M, Sciandra F, Paci M, Giardina B, Brancaccio A, et al. Structural characterization by NMR of the natively unfolded extracellular domain of beta-dystroglycan: toward the identification of the binding epitope for alpha-dystroglycan. Biochemistry. 2003;42:13717-24 pubmed
    b>Dystroglycan (DG) is an adhesion molecule playing a crucial role for tissue stability during both early embriogenesis and adulthood and is composed by two tightly interacting subunits: alpha-DG, membrane-associated and highly glycosylated,..
  32. Miyagawa S, Sawa Y, Taketani S, Kawaguchi N, Nakamura T, Matsuura N, et al. Myocardial regeneration therapy for heart failure: hepatocyte growth factor enhances the effect of cellular cardiomyoplasty. Circulation. 2002;105:2556-61 pubmed
    ..In an immunohistochemical study, strong staining for beta(1)-integrin, alpha-, and beta-dystroglycan were found principally in the basement membrane of myocytes in the T-H group 8 weeks after transplantation, ..
  33. Eyermann C, Czaplinski K, Colognato H. Dystroglycan promotes filopodial formation and process branching in differentiating oligodendroglia. J Neurochem. 2012;120:928-47 pubmed publisher
    ..In the current study, we report that the ECM receptor dystroglycan is necessary for Lm enhancement of filopodial formation, process outgrowth, and process branching in ..
  34. Peng H, Shah W, Holland P, Carbonetto S. Integrins and dystroglycan regulate astrocyte wound healing: the integrin beta1 subunit is necessary for process extension and orienting the microtubular network. Dev Neurobiol. 2008;68:559-74 pubmed publisher
    ..We have previously shown that the major functional ECM receptors on astrocytes are dystroglycan (DG) plus integrins alpha1beta1, alpha5beta1, alpha6beta1, and alphavbeta3...
  35. Budinger G, Urich D, DeBiase P, Chiarella S, Burgess Z, Baker C, et al. Stretch-induced activation of AMP kinase in the lung requires dystroglycan. Am J Respir Cell Mol Biol. 2008;39:666-72 pubmed publisher
    ..b>Dystroglycan is a ubiquitously expressed matrix receptor that is required for normal basement membrane formation during ..
  36. Collins B, Gorelick G, Schneider A. Dystroglycan is present in rat thyroid and rat thyroid cells and responds to thyrotropin. Endocrinology. 2001;142:3152-62 pubmed
    b>Dystroglycan is a high affinity laminin-binding glycoprotein originally described as a member of the dystrophin-associated glycoprotein complex in muscle...
  37. Boor I, Nagtegaal M, Kamphorst W, van der Valk P, Pronk J, van Horssen J, et al. MLC1 is associated with the dystrophin-glycoprotein complex at astrocytic endfeet. Acta Neuropathol. 2007;114:403-10 pubmed
    ..We demonstrated a direct protein interaction between MLC1 and Kir4.1. From these results we conclude that MLC1 is associated with the DGC at astrocytic endfeet...
  38. Masaki T, Matsumura K, Hirata A, Yamada H, Hase A, Arai K, et al. Expression of dystroglycan and the laminin-alpha 2 chain in the rat peripheral nerve during development. Exp Neurol. 2002;174:109-17 pubmed
    In Schwann cells, the transmembrane glycoprotein beta-dystroglycan comprises the dystroglycan complex, together with the extracellular glycoprotein alpha-dystroglycan, which binds laminin-2 (alpha 2/beta 1/gamma 1), a major component of ..
  39. Masaki T, Matsumura K, Saito F, Yamada H, Higuchi S, Kamakura K, et al. Association of dystroglycan and laminin-2 coexpression with myelinogenesis in peripheral nerves. Med Electron Microsc. 2003;36:221-39 pubmed
    To provide clues to the biological functions of dystroglycan-laminin-2 complex in peripheral nerves, we investigated the expressions of beta-dystroglycan and laminin-alpha(2) chain in rat sciatic nerve during axonal degeneration and ..
  40. Grewal P, Holzfeind P, Bittner R, Hewitt J. Mutant glycosyltransferase and altered glycosylation of alpha-dystroglycan in the myodystrophy mouse. Nat Genet. 2001;28:151-4 pubmed
    ..On immunoblots, a monoclonal antibody to alpha-dystroglycan (a component of the dystrophin-associated glycoprotein complex) shows reduced binding in myd, which we ..
  41. Sharma P, Tran T, Stelmack G, McNeill K, Gosens R, Mutawe M, et al. Expression of the dystrophin-glycoprotein complex is a marker for human airway smooth muscle phenotype maturation. Am J Physiol Lung Cell Mol Physiol. 2008;294:L57-68 pubmed
    ..Western blotting confirmed that beta-dystroglycan, beta-, delta-, and epsilon-sarcoglycan, and dystrophin abundance increased six- to eightfold in association ..
  42. Leone L, De Stefano M, Del Signore A, Petrucci T, Paggi P. Axotomy of sympathetic neurons activates the metalloproteinase-2 enzymatic pathway. J Neuropathol Exp Neurol. 2005;64:1007-17 pubmed
    ..disassembly consequent on superior cervical ganglion (SCG) neuron axotomy was preceded by the loss of the dystroglycan beta subunit (beta-DG) localized at the postsynaptic specializations...
  43. Rambukkana A, Yamada H, Zanazzi G, Mathus T, Salzer J, Yurchenco P, et al. Role of alpha-dystroglycan as a Schwann cell receptor for Mycobacterium leprae. Science. 1998;282:2076-9 pubmed
    alpha-Dystroglycan (alpha-DG) is a component of the dystroglycan complex, which is involved in early development and morphogenesis and in the pathogenesis of muscular dystrophies...
  44. Jimi T, Wakayama Y, Takeda A, Kobayashi T, Kumagai T, Suzuki Y, et al. Altered distribution of beta-dystroglycan in sarcolemma of human dystrophic muscles: an immunohistochemical study. Muscle Nerve. 1995;18:910-3 pubmed
  45. Bozzi M, Veglia G, Paci M, Sciandra F, Giardina B, Brancaccio A. A synthetic peptide corresponding to the 550-585 region of alpha-dystroglycan binds beta-dystroglycan as revealed by NMR spectroscopy. FEBS Lett. 2001;499:210-4 pubmed
    We have probed the binding of a synthetic peptide corresponding to the region 550-585 of the alpha subunit of dystroglycan with a recombinant protein fragment corresponding to the N-terminal extracellular region of beta-dystroglycan (654-..
  46. Imperiali M, Thoma C, Pavoni E, Brancaccio A, Callewaert N, Oxenius A. O Mannosylation of alpha-dystroglycan is essential for lymphocytic choriomeningitis virus receptor function. J Virol. 2005;79:14297-308 pubmed
    Alpha-dystroglycan (alpha-DG) was identified as a common receptor for lymphocytic choriomeningitis virus (LCMV) and several other arenaviruses including the human pathogenic Lassa fever virus...
  47. Sciandra F, Schneider M, Giardina B, Baumgartner S, Petrucci T, Brancaccio A. Identification of the beta-dystroglycan binding epitope within the C-terminal region of alpha-dystroglycan. Eur J Biochem. 2001;268:4590-7 pubmed
    b>Dystroglycan is a receptor for extracellular matrix proteins that plays a crucial role during embryogenesis in addition to adult tissue stabilization...
  48. Nakaya Y, Sukowati E, Sheng G. Epiblast integrity requires CLASP and Dystroglycan-mediated microtubule anchoring to the basal cortex. J Cell Biol. 2013;202:637-51 pubmed publisher
    ..to the basal cortex via CLIP-associated protein (CLASP), a microtubule plus-end tracking protein, and Dystroglycan, a transmembrane protein that bridges the cytoskeleton and basement membrane (BM)...
  49. Williams M, Bloch R. Differential distribution of dystrophin and beta-spectrin at the sarcolemma of fast twitch skeletal muscle fibers. J Muscle Res Cell Motil. 1999;20:383-93 pubmed
    ..The dystrophin-associated proteins, syntrophin and beta-dystroglycan, are also concentrated at costameres but, like dystrophin, are present in intercostameric regions as well...
  50. Sotgia F, Lee H, Bedford M, Petrucci T, Sudol M, Lisanti M. Tyrosine phosphorylation of beta-dystroglycan at its WW domain binding motif, PPxY, recruits SH2 domain containing proteins. Biochemistry. 2001;40:14585-92 pubmed
    beta-Dystroglycan is a ubiquitously expressed integral membrane protein that undergoes tyrosine phosphorylation in an adhesion-dependent manner...
  51. Jimenez Mallebrera C, Torelli S, Feng L, Kim J, Godfrey C, Clement E, et al. A comparative study of alpha-dystroglycan glycosylation in dystroglycanopathies suggests that the hypoglycosylation of alpha-dystroglycan does not consistently correlate with clinical severity. Brain Pathol. 2009;19:596-611 pubmed publisher
    Hypoglycosylation of alpha-dystroglycan underpins a subgroup of muscular dystrophies ranging from congenital onset of weakness, severe brain malformations and death in the perinatal period to mild weakness in adulthood without brain ..
  52. Bozzi M, Inzitari R, Sbardell D, Monaco S, Pavoni E, Gioia M, et al. Enzymatic processing of beta-dystroglycan recombinant ectodomain by MMP-9: identification of the main cleavage site. IUBMB Life. 2009;61:1143-52 pubmed publisher
    b>Dystroglycan (DG) is a membrane receptor belonging to the complex of glycoproteins associated to dystrophin. DG is formed by two subunits, alpha-DG, a highly glycosylated extracellular matrix protein, and beta-DG, a transmembrane protein...
  53. Liu H, Qiu G, Zhuo F, Yu W, Sun S, Li F, et al. Lost Polarization of Aquaporin4 and Dystroglycan in the Core Lesion after Traumatic Brain Injury Suggests Functional Divergence in Evolution. Biomed Res Int. 2015;2015:471631 pubmed publisher
    To understand how aquaporin4 (AQP4) and dystroglycan (DG) polarized distribution change and their roles in brain edema formation after traumatic brain injury (TBI)...
  54. Matsumura K, Zhong D, Saito F, Arai K, Adachi K, Kawai H, et al. Proteolysis of beta-dystroglycan in muscular diseases. Neuromuscul Disord. 2005;15:336-41 pubmed
    Alpha-dystroglycan is a cell surface peripheral membrane protein which binds to the extracellular matrix (ECM), while beta-dystroglycan is a type I integral membrane protein which anchors alpha-dystroglycan to the cell membrane via the N-..
  55. Biral D, Senter L, Salviati G. Increased expression of dystrophin, beta-dystroglycan and adhalin in denervated rat muscles. J Muscle Res Cell Motil. 1996;17:523-32 pubmed
    To evaluate a potential regulatory role of the nerve, the distribution and expression of dystrophin, of beta-dystroglycan (43DAG) and adhalin (50DAG), two of the dystrophin-associated proteins and utrophin (dystrophin related protein or ..
  56. Concolino P, Capoluongo E, Santonocito C, Vento G, Tana M, Romagnoli C, et al. Genetic analysis of the dystroglycan gene in bronchopulmonary dysplasia affected premature newborns. Clin Chim Acta. 2007;378:164-7 pubmed
    b>Dystroglycan (DG) is an extracellular matrix receptor that serves as an adhesion molecule and is essential for the stability of the plasma membrane...
  57. Sotgia F, Lee J, Das K, Bedford M, Petrucci T, Macioce P, et al. Caveolin-3 directly interacts with the C-terminal tail of beta -dystroglycan. Identification of a central WW-like domain within caveolin family members. J Biol Chem. 2000;275:38048-58 pubmed
    ..Here, we demonstrate that caveolin-3 directly interacts with beta-dystroglycan, an integral membrane component of the dystrophin complex...
  58. Saito F, Moore S, Barresi R, Henry M, Messing A, Ross Barta S, et al. Unique role of dystroglycan in peripheral nerve myelination, nodal structure, and sodium channel stabilization. Neuron. 2003;38:747-58 pubmed
    b>Dystroglycan is a central component of the dystrophin-glycoprotein complex implicated in the pathogenesis of several neuromuscular diseases...
  59. Satz J, Barresi R, Durbeej M, Willer T, Turner A, Moore S, et al. Brain and eye malformations resembling Walker-Warburg syndrome are recapitulated in mice by dystroglycan deletion in the epiblast. J Neurosci. 2008;28:10567-75 pubmed publisher
    ..two of the causative genes, form an active enzyme complex in the posttranslational biosynthetic pathway of dystroglycan. Deletion of either Pomt1 or the dystroglycan gene causes early embryonic lethality in mice...
  60. Mulvey C, Harno E, Keenan A, Ohlendieck K. Expression of the skeletal muscle dystrophin-dystroglycan complex and syntrophin-nitric oxide synthase complex is severely affected in the type 2 diabetic Goto-Kakizaki rat. Eur J Cell Biol. 2005;84:867-83 pubmed
    ..In addition, this analysis revealed an unexpected drastic reduction in the surface membrane marker beta-dystroglycan, a dystrophin-associated glycoprotein...