cystic fibrosis transmembrane conductance regulator

Summary

Gene Symbol: cystic fibrosis transmembrane conductance regulator
Description: cystic fibrosis transmembrane conductance regulator
Alias: RGD1561193, cystic fibrosis transmembrane conductance regulator, ATP-binding cassette sub-family C member 7, ATP-binding cassette transporter sub-family C member 7, cAMP-dependent chloride channel, channel conductance-controlling ATPase, cystic fibrosis transmembrane conductance regulator homolog
Species: rat

Top Publications

  1. Tu J, Le G, Ballard H. Involvement of the cystic fibrosis transmembrane conductance regulator in the acidosis-induced efflux of ATP from rat skeletal muscle. J Physiol. 2010;588:4563-78 pubmed publisher
    ..efflux from the perfused muscle was abolished by CFTR(inh)-172, a specific inhibitor of the cystic fibrosis transmembrane conductance regulator (CFTR), or glibenclamide, an inhibitor of both K(ATP) channels and CFTR, but it was not ..
  2. Akiba Y, Jung M, Ouk S, Kaunitz J. A novel small molecule CFTR inhibitor attenuates HCO3- secretion and duodenal ulcer formation in rats. Am J Physiol Gastrointest Liver Physiol. 2005;289:G753-9 pubmed
    ..CFTR inhibition reduces acid-induced DBS but also prevents duodenal ulcer formation, supporting our hypothesis that intracellular HCO(3)(-) may be an important protective mechanism for duodenal epithelial cells. ..
  3. Mizumori M, Choi Y, Guth P, Engel E, Kaunitz J, Akiba Y. CFTR inhibition augments NHE3 activity during luminal high CO2 exposure in rat duodenal mucosa. Am J Physiol Gastrointest Liver Physiol. 2008;294:G1318-27 pubmed publisher
    ..NHE3, by secreting H(+) into the luminal microclimate, facilitates net transmucosal HCO(3)(-) absorption with a mechanism similar to proximal tubular HCO(3)(-) absorption. ..
  4. Snouwaert J, Brigman K, Latour A, Malouf N, Boucher R, Smithies O, et al. An animal model for cystic fibrosis made by gene targeting. Science. 1992;257:1083-8 pubmed
    ..gene encoding a cyclic adenosine monophosphate-dependent chloride ion channel known as the cystic fibrosis transmembrane conductance regulator (CFTR)...
  5. Collaco A, Marathe J, Kohnke H, Kravstov D, Ameen N. Syntaxin 3 is necessary for cAMP- and cGMP-regulated exocytosis of CFTR: implications for enterotoxigenic diarrhea. Am J Physiol Cell Physiol. 2010;299:C1450-60 pubmed publisher
    ..cholerae and Escherichia coli cannot elicit fluid secretion in the absence of functional cystic fibrosis transmembrane conductance regulator (CFTR) chloride channels...
  6. Boom A, Lybaert P, Pollet J, Jacobs P, Jijakli H, Golstein P, et al. Expression and localization of cystic fibrosis transmembrane conductance regulator in the rat endocrine pancreas. Endocrine. 2007;32:197-205 pubmed
    ..diabetes (CFRD), knowledge on the possible expression and cell distribution of the cystic fibrosis transmembrane conductance regulator (CFTR) protein within the endocrine pancreas is required...
  7. Bonvin E, Le Rouzic P, Bernaudin J, Cottart C, Vandebrouck C, Crié A, et al. Congenital tracheal malformation in cystic fibrosis transmembrane conductance regulator-deficient mice. J Physiol. 2008;586:3231-43 pubmed publisher
    ..These results raise important questions concerning the mechanisms governing tracheal development within the context of CFTR protein dysfunction and the implication of such abnormalities in the pathogenesis of airway disease in CF. ..
  8. Jesus T, Bernardino R, Martins A, Sá R, Sousa M, Alves M, et al. Aquaporin-4 as a molecular partner of cystic fibrosis transmembrane conductance regulator in rat Sertoli cells. Biochem Biophys Res Commun. 2014;446:1017-21 pubmed publisher
    ..The cystic fibrosis transmembrane conductance regulator (CFTR) plays an essential role to male fertility and it was recently suggested that it may ..
  9. Jesus T, Bernardino R, Martins A, Sá R, Sousa M, Alves M, et al. Aquaporin-9 is expressed in rat Sertoli cells and interacts with the cystic fibrosis transmembrane conductance regulator. IUBMB Life. 2014;66:639-44 pubmed publisher
    Men with mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene are usually subfertile/infertile...

More Information

Publications62

  1. El Harith E, Dork T, Stuhrmann M, Abu Srair H, Al Shahri A, Keller K, et al. Novel and characteristic CFTR mutations in Saudi Arab children with severe cystic fibrosis. J Med Genet. 1997;34:996-9 pubmed
    More than 600 different CFTR (cystic fibrosis transmembrane conductance regulator) gene mutations have been identified so far that are considered to cause the fatal genetic disorder cystic fibrosis (CF)...
  2. Tang L, Fatehi M, Linsdell P. Mechanism of direct bicarbonate transport by the CFTR anion channel. J Cyst Fibros. 2009;8:115-21 pubmed publisher
  3. Uramoto H, Okada T, Okada Y. Protective role of cardiac CFTR activation upon early reperfusion against myocardial infarction. Cell Physiol Biochem. 2012;30:1023-38 pubmed publisher
    The cardiac isoform of the cystic fibrosis transmembrane conductance regulator (CFTR) was shown to be activated by ?-adrenergic or purinergic stimulation and involved in cell volume regulation after osmotic swelling...
  4. Xie C, Sun X, Chen J, Ng C, Lau K, Cai Z, et al. Down-regulated CFTR During Aging Contributes to Benign Prostatic Hyperplasia. J Cell Physiol. 2015;230:1906-15 pubmed publisher
    ..The present study investigated the possible involvement of the cystic fibrosis transmembrane conductance regulator (CFTR), which has been previously shown to negatively regulate nuclear factor-κB (NF-κ..
  5. Bagorda A, Guerra L, Di Sole F, Hemle Kolb C, Cardone R, Fanelli T, et al. Reciprocal protein kinase A regulatory interactions between cystic fibrosis transmembrane conductance regulator and Na+/H+ exchanger isoform 3 in a renal polarized epithelial cell model. J Biol Chem. 2002;277:21480-8 pubmed
    Although Cystic fibrosis transmembrane conductance regulator (CFTR) has been shown to regulate the activity of NHE3, the potential reciprocal interaction of NHE3 to modulate the protein kinase A (PKA)-dependent regulation of CFTR in ..
  6. Wang X, Kim J, McWilliams R, Cutting G. Increased prevalence of chronic rhinosinusitis in carriers of a cystic fibrosis mutation. Arch Otolaryngol Head Neck Surg. 2005;131:237-40 pubmed
    ..Carriers of a single CF mutation have a higher prevalence of CRS than the general population. ..
  7. Shcheynikov N, Kim K, Kim K, Dorwart M, Ko S, Goto H, et al. Dynamic control of cystic fibrosis transmembrane conductance regulator Cl(-)/HCO3(-) selectivity by external Cl(-). J Biol Chem. 2004;279:21857-65 pubmed
    HCO(3)(-) secretion is a vital activity in cystic fibrosis transmembrane conductance regulator (CFTR)-expressing epithelia. However, the role of CFTR in this activity is not well understood...
  8. Cormet Boyaka E, Hong J, Berdiev B, Fortenberry J, Rennolds J, Clancy J, et al. A truncated CFTR protein rescues endogenous DeltaF508-CFTR and corrects chloride transport in mice. FASEB J. 2009;23:3743-51 pubmed publisher
    ..These findings identify complementary protein fragments as a viable in vivo approach for correcting disease-causing misfolding of plasma membrane proteins. ..
  9. Avella M, Loriol C, Boulukos K, Borgese F, Ehrenfeld J. SLC26A9 stimulates CFTR expression and function in human bronchial cell lines. J Cell Physiol. 2011;226:212-23 pubmed publisher
    ..We propose as an alternative hypothesis (not exclusive) to the known SLC26A9-STAS domain/CFTR interaction, that SLC26A9 favors the biogenesis and/or stabilization of CFTR, leading to stimulated currents. ..
  10. Matsubara A, Miyashita T, Inamoto R, Hoshikawa H, Mori N. Cystic fibrosis transmembrane conductance regulator in the endolymphatic sac of the rat. Auris Nasus Larynx. 2014;41:409-12 pubmed publisher
    ..In this study, we confirmed the expression of cystic fibrosis transmembrane conductance regulator (CFTR) in the endolymphatic sac by reverse transcriptase polymerase chain reaction (RT-PCR) ..
  11. Pan P, Guo Y, Gu J. Expression of cystic fibrosis transmembrane conductance regulator in ganglion cells of the hearts. Neurosci Lett. 2008;441:35-8 pubmed publisher
    b>Cystic fibrosis transmembrane conductance regulator (CFTR) as an important chloride-selective channel is known to distribute on the apical membrane of chloride-secreting epithelial cells...
  12. Kim J, Han W, Namkung W, Lee J, Kim K, Shin H, et al. Inhibitory regulation of cystic fibrosis transmembrane conductance regulator anion-transporting activities by Shank2. J Biol Chem. 2004;279:10389-96 pubmed
    ..In the present study, we report on the biochemical and functional association between cystic fibrosis transmembrane conductance regulator (CFTR) and a PDZ domain-containing protein Shank2...
  13. Trezise A, Szpirer C, Buchwald M. Localization of the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) in the rat to chromosome 4 and implications for the evolution of mammalian chromosomes. Genomics. 1992;14:869-74 pubmed
    We have isolated a partial cDNA encoding the cystic fibrosis transmembrane conductance regulator (CFTR) in the rat. This cDNA hybridizes to a 6...
  14. Gasparini P, Borgo G, Mastella G, Bonizzato A, Dognini M, Pignatti P. Nine cystic fibrosis patients homozygous for the CFTR nonsense mutation R1162X have mild or moderate lung disease. J Med Genet. 1992;29:558-62 pubmed
    ..These results suggest that this form of truncated CFTR protein, still containing the regulatory region, the first ATP binding domain, and both transmembrane domains, could be partially working in the lung tissues. ..
  15. Gan K, Veeze H, van den Ouweland A, Halley D, Scheffer H, van der Hout A, et al. A cystic fibrosis mutation associated with mild lung disease. N Engl J Med. 1995;333:95-9 pubmed
    ..delta F508 is the most common mutation and A455E the second most common mutation of the cystic fibrosis transmembrane conductance regulator gene on chromosome 7...
  16. Pietrement C, Da Silva N, Silberstein C, James M, Marsolais M, Van Hoek A, et al. Role of NHERF1, cystic fibrosis transmembrane conductance regulator, and cAMP in the regulation of aquaporin 9. J Biol Chem. 2008;283:2986-96 pubmed
    ..Here we show that NHERF1, cystic fibrosis transmembrane conductance regulator (CFTR), and AQP9 co-localize in the apical membrane of principal cells of the epididymis ..
  17. Raman V, Clary R, Siegrist K, Zehnbauer B, Chatila T. Increased prevalence of mutations in the cystic fibrosis transmembrane conductance regulator in children with chronic rhinosinusitis. Pediatrics. 2002;109:E13 pubmed
    ..These results suggest a role for CFTR mutations in predisposition to chronic rhinosinusitis. ..
  18. Ngiam N, Chong S, Shek L, Goh D, Ong K, Chng S, et al. Cystic fibrosis transmembrane conductance regulator (CFTR) gene mutations in Asians with chronic pulmonary disease: a pilot study. J Cyst Fibros. 2006;5:159-64 pubmed
    Little is known about the relationship between cystic fibrosis transmembrane conductance regulator (CFTR) gene mutations in Asian patients and severe asthma or idiopathic bronchiectasis...
  19. Ishibashi K, Yamazaki J, Okamura K, Teng Y, Kitamura K, Abe K. Roles of CLCA and CFTR in electrolyte re-absorption from rat saliva. J Dent Res. 2006;85:1101-5 pubmed
    ..To address the question as to whether rCLCA and cystic fibrosis transmembrane conductance regulator (CFTR) are involved in Cl- re-absorption, we evaluated the electrolyte content of saliva ..
  20. Kolesar P, Minarik G, Baldovic M, Ficek A, Kovacs L, Kádasi L. Mutation analysis of the CFTR gene in Slovak cystic fibrosis patients by DHPLC and subsequent sequencing: identification of four novel mutations. Gen Physiol Biophys. 2008;27:299-305 pubmed
    ..Four mutations (G437D, H954P, H1375N, and 3120+33G>T) are novel, not yet found in any other CF patient all over the word. ..
  21. de Andrade Pinto A, Barbosa C, Ornellas D, Novaira H, de Souza Menezes J, Ortiga Carvalho T, et al. Thyroid hormones stimulate renal expression of CFTR. Cell Physiol Biochem. 2007;20:83-90 pubmed
    ..05). Analysis of the promoter region of CFTR transfected to IRPTC showed that T(3) (10(-7) M) stimulates the CFTR promoter (38%, n=4, p<0.05). ..
  22. Daudin M, Bieth E, Bujan L, Massat G, Pontonnier F, Mieusset R. Congenital bilateral absence of the vas deferens: clinical characteristics, biological parameters, cystic fibrosis transmembrane conductance regulator gene mutations, and implications for genetic counseling. Fertil Steril. 2000;74:1164-74 pubmed
    ..History, clinical and seminal characteristics, and cystic fibrosis transmembrane conductance regulator (CFTR) gene mutations including IVS-8 polyT analysis...
  23. Ramjeesingh M, Li C, Kogan I, Wang Y, Huan L, Bear C. A monomer is the minimum functional unit required for channel and ATPase activity of the cystic fibrosis transmembrane conductance regulator. Biochemistry. 2001;40:10700-6 pubmed
    The cystic fibrosis transmembrane conductance regulator (CFTR) normally functions as a phosphorylation-regulated chloride channel on the apical surface of epithelial cells, and lack of this function is the primary cause for the fatal ..
  24. Yang L, Reece J, Gabriel S, Shears S. Apical localization of ITPK1 enhances its ability to be a modifier gene product in a murine tracheal cell model of cystic fibrosis. J Cell Sci. 2006;119:1320-8 pubmed
    ..Compartmentalization of Ins(3,4,5,6)P4 synthesis adjacent to its site of action will enhance its regulatory capacity. ..
  25. Denamur E, Chehab F. Analysis of the mouse and rat CFTR promoter regions. Hum Mol Genet. 1994;3:1089-94 pubmed
    To gain insights into the regulation of the mouse and rat cystic fibrosis transmembrane conductance regulator (CFTR) genes, we cloned and sequenced their respective upstream promoter regions...
  26. Andrieux J, Audrezet M, Frachon I, Leroyer C, Roge C, Scotet V, et al. Quantification of CFTR splice variants in adults with disseminated bronchiectasis, using the TaqMan fluorogenic detection system. Clin Genet. 2002;62:60-7 pubmed
    Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene are associated with different related disorders such as congenital bilateral absence of the vas deferens, chronic idiopathic pancreatitis, or disseminated ..
  27. Mulberg A, Wiedner E, Bao X, Marshall J, Jefferson D, Altschuler S. Cystic fibrosis transmembrane conductance regulator protein expression in brain. Neuroreport. 1994;5:1684-8 pubmed
    The cystic fibrosis transmembrane conductance regulator protein (CFTR) has been identified in bovine brain clathrin-coated vesicles, rat brain and a human neuroblastoma cell line using affinity-purified polyclonal peptide antibodies ..
  28. Edlund A, Esguerra J, Wendt A, Flodstrom Tullberg M, Eliasson L. CFTR and Anoctamin 1 (ANO1) contribute to cAMP amplified exocytosis and insulin secretion in human and murine pancreatic beta-cells. BMC Med. 2014;12:87 pubmed publisher
    Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene lead to the disease cystic fibrosis (CF)...
  29. Zeng J, Zeng X, Li F, Ma M, Yuan F, Liu J, et al. Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) prevents apoptosis induced by hydrogen peroxide in basilar artery smooth muscle cells. Apoptosis. 2014;19:1317-29 pubmed publisher
    b>Cystic fibrosis transmembrane conductance regulator (CFTR) acts as a cAMP-dependent chloride channel, has been studied in various types of cells...
  30. Swiatecka Urban A, Talebian L, Kanno E, Moreau Marquis S, Coutermarsh B, Hansen K, et al. Myosin Vb is required for trafficking of the cystic fibrosis transmembrane conductance regulator in Rab11a-specific apical recycling endosomes in polarized human airway epithelial cells. J Biol Chem. 2007;282:23725-36 pubmed
    b>Cystic fibrosis transmembrane conductance regulator (CFTR)-mediated Cl(-) secretion across fluid-transporting epithelia is regulated, in part, by modulating the number of CFTR Cl(-) channels in the plasma membrane by adjusting CFTR ..
  31. Kalin N, Dork T, Tummler B. A cystic fibrosis allele encoding missense mutations in both nucleotide binding folds of the cystic fibrosis transmembrane conductance regulator. Hum Mutat. 1992;1:204-10 pubmed
    ..German cystic fibrosis (CF) chromosomes were screened for molecular lesions in exon 20 of the cystic fibrosis transmembrane conductance regulator (CFTR) gene by chemical cleavage of mismatch...
  32. Kim R, Greenberg D, Ehrmantraut M, Guide S, Ding L, Shea Y, et al. Pulmonary nontuberculous mycobacterial disease: prospective study of a distinct preexisting syndrome. Am J Respir Crit Care Med. 2008;178:1066-74 pubmed publisher
    ..To prospectively determine the morphotype, immunophenotype, and cystic fibrosis transmembrane conductance regulator genotype in a large cohort with PNTM...
  33. Lahousse S, Stopa E, Mulberg A, de la Monte S. Reduced expression of the cystic fibrosis transmembrane conductance regulator gene in the hypothalamus of patients with Alzheimer's disease. J Alzheimers Dis. 2003;5:455-62 pubmed
    The cystic fibrosis transmembrane conductance regulator (CFTR) gene encodes an approximately 150-165 kD glycoprotein that is mutated in individuals with cystic fibrosis...
  34. Novaira H, Ornellas D, Ortiga Carvalho T, Zhang X, Souza Menezes J, Guggino S, et al. Atrial natriuretic peptide modulates cystic fibrosis transmembrane conductance regulator chloride channel expression in rat proximal colon and human intestinal epithelial cells. J Endocrinol. 2006;189:155-65 pubmed
    The cystic fibrosis transmembrane conductance regulator (CFTR) is one of the most intensively investigated Cl- channels. Different mutations in the CFTR gene cause the disease cystic fibrosis (CF)...
  35. Minagawa N, Nagata J, Shibao K, Masyuk A, Gomes D, Rodrigues M, et al. Cyclic AMP regulates bicarbonate secretion in cholangiocytes through release of ATP into bile. Gastroenterology. 2007;133:1592-602 pubmed
    ..The effect of forskolin on luminal pH was reduced by a cystic fibrosis transmembrane conductance regulator (CFTR) inhibitor and by siRNA for the type III InsP3R...
  36. Uramoto H, Takahashi N, Dutta A, Sabirov R, Ando Akatsuka Y, Morishima S, et al. Ischemia-induced enhancement of CFTR expression on the plasma membrane in neonatal rat ventricular myocytes. Jpn J Physiol. 2003;53:357-65 pubmed
    Pathophysiological functions of cardiac cystic fibrosis transmembrane conductance regulator (cCFTR) in ischemia are not well known...
  37. Xu W, Chen J, Chen H, Diao R, Fok K, Dong J, et al. Defective CFTR-dependent CREB activation results in impaired spermatogenesis and azoospermia. PLoS ONE. 2011;6:e19120 pubmed publisher
    ..common life-limiting recessive genetic disease among Caucasians caused by mutations of the cystic fibrosis transmembrane conductance regulator (CFTR) with over 95% male patients infertile...
  38. Dork T, Kalin N, Stuhrmann M, Schmidtke J, Tummler B. A termination mutation (2143delT) in the CFTR gene of German cystic fibrosis patients. Hum Genet. 1992;90:279-84 pubmed
    ..patients with cystic fibrosis (CF) were screened for molecular lesions in exon 13 of the cystic fibrosis transmembrane conductance regulator (CFTR) gene by single strand conformation polymorphism (SSCP) and chemical cleavage of ..
  39. Burghardt B, Elkaer M, Kwon T, Racz G, Varga G, Steward M, et al. Distribution of aquaporin water channels AQP1 and AQP5 in the ductal system of the human pancreas. Gut. 2003;52:1008-16 pubmed
    ..Both AQP1 and AQP5 were colocalised with cystic fibrosis transmembrane conductance regulator (CFTR) at the apical membrane of intercalated duct cells...
  40. Kulka M, Gilchrist M, Duszyk M, Befus A. Expression and functional characterization of CFTR in mast cells. J Leukoc Biol. 2002;71:54-64 pubmed
    ..that rat-cultured mast cells (RCMC) and peritoneal mast cells (PMC) contain mRNA for the cystic fibrosis transmembrane conductance regulator (CFTR), an important chloride channel...
  41. Kulka M, Dery R, Nahirney D, Duszyk M, Befus A. Differential regulation of cystic fibrosis transmembrane conductance regulator by interferon gamma in mast cells and epithelial cells. J Pharmacol Exp Ther. 2005;315:563-70 pubmed
    b>Cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-dependent chloride channel in epithelial cells; recently, we identified it in mast cells...
  42. Chen L, Yu B, Zhang Y, Gao X, Zhu L, Ma T, et al. Bioactivity-guided fractionation of an antidiarrheal Chinese herb Rhodiola kirilowii (Regel) Maxim reveals (-)-epicatechin-3-gallate and (-)-epigallocatechin-3-gallate as inhibitors of cystic fibrosis transmembrane conductance regulator. PLoS ONE. 2015;10:e0119122 pubmed publisher
    b>Cystic fibrosis transmembrane conductance regulator (CFTR) is the principal apical route for transepithelial fluid transport induced by enterotoxin...
  43. Collaco A, Jakab R, Hegan P, Mooseker M, Ameen N. Alpha-AP-2 directs myosin VI-dependent endocytosis of cystic fibrosis transmembrane conductance regulator chloride channels in the intestine. J Biol Chem. 2010;285:17177-87 pubmed publisher
    The actin motor myosin VI regulates endocytosis of cystic fibrosis transmembrane conductance regulator (CFTR) in the intestine, but the endocytic adaptor linking CFTR to myosin VI is unknown...
  44. Constantinescu A, Gleizes C, Alhosin M, Yala E, Zobairi F, Leclercq A, et al. Exocrine cell-derived microparticles in response to lipopolysaccharide promote endocrine dysfunction in cystic fibrosis. J Cyst Fibros. 2014;13:219-26 pubmed publisher
    ..During recurrent infections associated with CF, exocrine MPs may contribute to endocrine cell dysfunction via NF-?B pathways. Membrane CFTR dysfunction is associated with decreased insulin secretion. ..
  45. Kondo S, Fujiki K, Ko S, Yamamoto A, Nakakuki M, Ito Y, et al. Functional characteristics of L1156F-CFTR associated with alcoholic chronic pancreatitis in Japanese. Am J Physiol Gastrointest Liver Physiol. 2015;309:G260-9 pubmed publisher
    ..fibrosis is rare in Japanese, measurement of sweat Cl(-) has suggested mild dysfunction of cystic fibrosis transmembrane conductance regulator (CFTR) in some patients with chronic pancreatitis...
  46. Divac A, Nikolic A, Mitic Milikic M, Nagorni Obradovic L, Petrovic Stanojevic N, Dopudja Pantic V, et al. High frequency of the R75Q CFTR variation in patients with chronic obstructive pulmonary disease. J Cyst Fibros. 2004;3:189-91 pubmed
    ..002). In all patients carrying the R75Q chronic bronchitis was a dominant symptom of COPD, and all were homozygous for the V470 allele. These findings suggest that R75Q mutation could be characteristic CFTR variant for COPD patients. ..
  47. Highsmith W, Burch L, Zhou Z, Olsen J, Boat T, Spock A, et al. A novel mutation in the cystic fibrosis gene in patients with pulmonary disease but normal sweat chloride concentrations. N Engl J Med. 1994;331:974-80 pubmed
    ..the diagnosis of cystic fibrosis in these patients because no associated mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene has been identified...
  48. Wen G, Xu J, Liu X, Zhao Z, Jiang Y, Xie R, et al. [Effects of weile powder on bicarbonate transporters CFTR SLC26A3 and SLC26A6 in gastric ulcers of rats]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2013;33:81-4 pubmed
    ..The gastric ulcer and its peripheral tissue were sectioned. The changes of cystic fibrosis transmembrane conductance regulator (CFTR) were measured by immunofluorescence...
  49. Amaral M, Pacheco P, Beck S, Farinha C, Penque D, Nogueira P, et al. Cystic fibrosis patients with the 3272-26A>G splicing mutation have milder disease than F508del homozygotes: a large European study. J Med Genet. 2001;38:777-83 pubmed
  50. Sharma S, Hanukoglu A, Hanukoglu I. Localization of epithelial sodium channel (ENaC) and CFTR in the germinal epithelium of the testis, Sertoli cells, and spermatozoa. J Mol Histol. 2018;49:195-208 pubmed publisher
    ..Based on the nuclear localization of CFTR we suggest that, in addition to its role as an ion channel, CFTR may have an independent role in gene regulation within the nuclei. ..
  51. Li Y, Sun Z, Wu Y, Babovic Vuksanovic D, Li Y, Cunningham J, et al. Cystic fibrosis transmembrane conductance regulator gene mutation and lung cancer risk. Lung Cancer. 2010;70:14-21 pubmed publisher
    The cystic fibrosis transmembrane conductance regulator (CFTR) holds an important role in retaining lung function, but its association with lung cancer is unclear...
  52. Ousingsawat J, Kongsuphol P, Schreiber R, Kunzelmann K. CFTR and TMEM16A are separate but functionally related Cl- channels. Cell Physiol Biochem. 2011;28:715-24 pubmed publisher
    Previous reports point out to a functional relationship of the cystic fibrosis transmembrane conductance regulator (CFTR) and Ca(2+) activated Cl(-) channels (CaCC)...
  53. Walentinsson A, Helou K, Wallenius V, Hedrich H, Szpirer C, Levan G. Independent amplification of two gene clusters on chromosome 4 in rat endometrial cancer: identification and molecular characterization. Cancer Res. 2001;61:8263-73 pubmed
    ..Taken together, our findings suggest that up-regulation of Cdk6 and/or Met may contribute to the development of endometrial cancers in the BDII rat. ..