cysteine string protein


Gene Symbol: cysteine string protein
Description: DnaJ heat shock protein family (Hsp40) member C5
Alias: Csp, dnaJ homolog subfamily C member 5, DnaJ (Hsp40) homolog, subfamily C, member 5, cysteine string protein
Species: rat
Products:     cysteine string protein

Top Publications

  1. Evans G, Morgan A. Phosphorylation-dependent interaction of the synaptic vesicle proteins cysteine string protein and synaptotagmin I. Biochem J. 2002;364:343-7 pubmed
    ..strategy from purified rat brain membrane or cytosolic proteins using recombinant hexahistidine-tagged (His(6)-)CSP. Western blotting of the CSP-binding proteins identified synaptotagmin I to be a putative binding partner...
  2. Chandra S, Gallardo G, Fernandez Chacon R, Schlüter O, Sudhof T. Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration. Cell. 2005;123:383-96 pubmed
  3. Evans G, Morgan A. Phosphorylation of cysteine string protein in the brain: developmental, regional and synaptic specificity. Eur J Neurosci. 2005;21:2671-80 pubmed publisher
    Protein phosphorylation modulates regulated exocytosis in most cells, including neurons. Cysteine string protein (CSP) has been implicated in this process because its phosphorylation on Ser10 alters its interactions with syntaxin and ..
  4. Sakisaka T, Meerlo T, Matteson J, Plutner H, Balch W. Rab-alphaGDI activity is regulated by a Hsp90 chaperone complex. EMBO J. 2002;21:6125-35 pubmed
    ..novel alphaGDI complex from synaptic membranes that contains three chaperone components: Hsp90, Hsc70 and cysteine string protein (CSP)...
  5. Swayne L, Blattler C, Kay J, Braun J. Oligomerization characteristics of cysteine string protein. Biochem Biophys Res Commun. 2003;300:921-6 pubmed
    b>CSP function is vital to synaptic transmission, however; the precise nature of its role remains controversial. Conflicting reports support either a role for CSP: (i) in exocytosis or (ii) in the regulation of transmembrane calcium fluxes...
  6. Tobaben S, Varoqueaux F, Brose N, Stahl B, Meyer G. A brain-specific isoform of small glutamine-rich tetratricopeptide repeat-containing protein binds to Hsc70 and the cysteine string protein. J Biol Chem. 2003;278:38376-83 pubmed
    ..Both isoforms of SGT possess similar binding properties toward Hsc70 and cysteine string protein, a synaptic vesicle-associated J-domain-containing protein...
  7. Chiang N, Hsiao Y, Yang H, Lin Y, Lu J, Wang C. Phosphomimetic mutation of cysteine string protein-? increases the rate of regulated exocytosis by modulating fusion pore dynamics in PC12 cells. PLoS ONE. 2014;9:e99180 pubmed publisher
    b>Cysteine string protein-? (CSP?) is a chaperone to ensure protein folding. Loss of CSP? function associates with many neurological diseases. However, its function in modulating regulated exocytosis remains elusive...
  8. Mastrogiacomo A, Gundersen C. The nucleotide and deduced amino acid sequence of a rat cysteine string protein. Brain Res Mol Brain Res. 1995;28:12-8 pubmed mammals, we isolated and sequenced the cDNA and conducted an initial characterization of a rat cysteine string protein. Nucleotide sequencing reveals that this rat protein is highly homologous to the insect and fish cysteine ..
  9. Carnini A, Scott L, Ahrendt E, Proft J, Winkfein R, Kim S, et al. Cell line specific modulation of extracellular a?42 by Hsp40. PLoS ONE. 2012;7:e37755 pubmed publisher
    ..Therefore, increasing Hsp40 therapeutically with the intention of interfering with the pathogenic cascade leading to neurodegeneration in AD should be pursued with caution. ..

More Information


  1. Noskova L, Stránecký V, Hartmannova H, Přistoupilová A, Baresova V, Ivanek R, et al. Mutations in DNAJC5, encoding cysteine-string protein alpha, cause autosomal-dominant adult-onset neuronal ceroid lipofuscinosis. Am J Hum Genet. 2011;89:241-52 pubmed publisher
    ..346_348delCTC and c.344T>G, in DNAJC5 encoding cysteine-string protein alpha (CSP?). These mutations-causing a deletion, p.Leu116del, and an amino acid exchange, p...
  2. Greaves J, Salaun C, Fukata Y, Fukata M, Chamberlain L. Palmitoylation and membrane interactions of the neuroprotective chaperone cysteine-string protein. J Biol Chem. 2008;283:25014-26 pubmed publisher
    Cysteine-string protein (CSP) is an extensively palmitoylated DnaJ-family chaperone, which exerts an important neuroprotective function...
  3. Miller L, Swayne L, Chen L, Feng Z, Wacker J, Muchowski P, et al. Cysteine string protein (CSP) inhibition of N-type calcium channels is blocked by mutant huntingtin. J Biol Chem. 2003;278:53072-81 pubmed
    b>Cysteine string protein (CSP), a 34-kDa molecular chaperone, is expressed on synaptic vesicles in neurons and on secretory vesicles in endocrine, neuroendocrine, and exocrine cells...
  4. Beck K, Kay J, Braun J. Rdj2, a J protein family member, interacts with cellular prion PrP(C). Biochem Biophys Res Commun. 2006;346:866-71 pubmed
    ..These findings suggest that the J protein family serves as a 'folding catalyst' for PrP(C) and implicates Rdj2 as a factor in the protection against prion diseases. ..
  5. Fukuda M. Distinct developmental expression of synaptotagmin I and IX in the mouse brain. Neuroreport. 2006;17:179-82 pubmed
    ..These findings suggest that synaptotagmin IX regulates the transport of certain vesicles in the brain other than synaptic vesicles. ..
  6. Yamada M, Yamazaki S, Takahashi K, Nara K, Ozawa H, Yamada S, et al. Induction of cysteine string protein after chronic antidepressant treatment in rat frontal cortex. Neurosci Lett. 2001;301:183-6 pubmed
    ..With this ADRG microarray, we found that the expression of a spot, ADRG55, which representing cysteine string protein (CSP), was significantly increased in rat brain after chronic treatment with a selective serotonin ..
  7. Braun J, Scheller R. Cysteine string protein, a DnaJ family member, is present on diverse secretory vesicles. Neuropharmacology. 1995;34:1361-9 pubmed
    ..CSP (cysteine string protein) is a 34 kDa protein which copurifies with cholinergic synaptic vesicles from the marine ray Torpedo ..
  8. Bai L, Swayne L, Braun J. The CSPalpha/G protein complex in PC12 cells. Biochem Biophys Res Commun. 2007;352:123-9 pubmed
    ..These results indicate that CSPalpha activity is subject to regulation by factors that alter Hsc70 distribution and translocation within the cell. ..
  9. Miller L, Swayne L, Kay J, Feng Z, Jarvis S, Zamponi G, et al. Molecular determinants of cysteine string protein modulation of N-type calcium channels. J Cell Sci. 2003;116:2967-74 pubmed
    ..We have previously reported an interaction of CSP with both heterotrimeric GTP-binding proteins (G proteins) and N-type calcium channels that results in a tonic G ..
  10. Weng N, Baumler M, Thomas D, Falkowski M, Swayne L, Braun J, et al. Functional role of J domain of cysteine string protein in Ca2+-dependent secretion from acinar cells. Am J Physiol Gastrointest Liver Physiol. 2009;296:G1030-9 pubmed publisher
    ..b>Cysteine string protein (CSP-alpha) is a zymogen granule (ZG) membrane protein characterized by an NH(2)-terminal "J domain&..
  11. Eybalin M, Renard N, Aure F, Safieddine S. Cysteine-string protein in inner hair cells of the organ of Corti: synaptic expression and upregulation at the onset of hearing. Eur J Neurosci. 2002;15:1409-20 pubmed
    ..This also suggests that this role may be common to ribbon synapses and conventional central nervous system synapses...
  12. Shimomura H, Imai A, Nashida T. Characterization of cysteine string protein in rat parotid acinar cells. Arch Biochem Biophys. 2013;538:1-5 pubmed publisher
    ..i) a heavily palmitoylated cysteine string (comprised of 14 cysteine residues, responsible for the localization of CSP to secretory vesicle membranes), (ii) an N-terminal J-domain (DnaJ domain of Hsc70, 70kDa heat-shock cognate ..