Genomes and Genes
Gene Symbol: Cysltr2
Description: cysteinyl leukotriene receptor 2
Alias: Cyslt2, RSBPT32, cysteinyl leukotriene receptor 2, cysteinyl leukotriene CysLT2 receptor
- Hui Y, Yang G, Galczenski H, Figueroa D, Austin C, Copeland N, et al. The murine cysteinyl leukotriene 2 (CysLT2) receptor. cDNA and genomic cloning, alternative splicing, and in vitro characterization. J Biol Chem. 2001;276:47489-95 pubmed..The identification of mCysLT(2)R will be useful for establishing CysLT(2)R-deficient mice and determining novel leukotriene functions. ..
- Fukai H, Ogasawara Y, Migita O, Koga M, Ichikawa K, Shibasaki M, et al. Association between a polymorphism in cysteinyl leukotriene receptor 2 on chromosome 13q14 and atopic asthma. Pharmacogenetics. 2004;14:683-90 pubmedb>Cysteinyl leukotriene receptor 2 (CYSLTR2) is one of the receptors for the cysteinyl leukotrienes (CYSLTs), which cause bronchoconstrictions, vascular hyperpermeability and mucus hypersecretion in asthmatic patients...
- Pillai S, Cousens D, Barnes A, Buckley P, Chiano M, Hosking L, et al. A coding polymorphism in the CYSLT2 receptor with reduced affinity to LTD4 is associated with asthma. Pharmacogenetics. 2004;14:627-33 pubmed..mediators in the pathophysiology of asthma for which two receptors have been characterized, CYSLTR1 and CYSLTR2. The leukotriene modifying agents currently used to control bronchoconstriction and inflammation in asthmatic ..
- Zhao C, Zhao B, Zhang X, Huang X, Shi W, Liu H, et al. Cysteinyl leukotriene receptor 2 is spatiotemporally involved in neuron injury, astrocytosis and microgliosis after focal cerebral ischemia in rats. Neuroscience. 2011;189:1-11 pubmed publisher..mediators, are released from ischemic brain, and may regulate ischemic injury through activating CysLT1 and CysLT2 receptors...