Gene Symbol: Cysltr2
Description: cysteinyl leukotriene receptor 2
Alias: Cyslt2, RSBPT32, cysteinyl leukotriene receptor 2, cysteinyl leukotriene CysLT2 receptor
Species: rat
Products:     Cysltr2

Top Publications

  1. Park J, Chang H, Park C, Lee J, Lee Y, Choi J, et al. Association analysis of cysteinyl-leukotriene receptor 2 (CYSLTR2) polymorphisms with aspirin intolerance in asthmatics. Pharmacogenet Genomics. 2005;15:483-92 pubmed
    The cysteinyl leukotriene receptor 2 (CYSLTR2) gene on chromosome 13q14.12-q21.1 encodes a receptor for CYSLTs, potent biological mediators in the pathogenesis of asthma, particularly that associated with aspirin intolerance (AIA)...
  2. Qi L, Fang S, Shi W, Huang X, Zhang X, Lu Y, et al. CysLT2 receptor-mediated AQP4 up-regulation is involved in ischemic-like injury through activation of ERK and p38 MAPK in rat astrocytes. Life Sci. 2011;88:50-6 pubmed publisher
    We previously reported that cysteinyl leukotriene receptor 2 (CysLT(2)) mediates ischemic astrocyte injury, and leukotriene D(4)-activated CysLT(2) receptor up-regulates the water channel aquaporin 4 (AQP4)...
  3. Ogasawara H, Ishii S, Yokomizo T, Kakinuma T, Komine M, Tamaki K, et al. Characterization of mouse cysteinyl leukotriene receptors mCysLT1 and mCysLT2: differential pharmacological properties and tissue distribution. J Biol Chem. 2002;277:18763-8 pubmed
  4. Beller T, Maekawa A, Friend D, Austen K, Kanaoka Y. Targeted gene disruption reveals the role of the cysteinyl leukotriene 2 receptor in increased vascular permeability and in bleomycin-induced pulmonary fibrosis in mice. J Biol Chem. 2004;279:46129-34 pubmed
    ..Thus, in response to a particular pathobiologic event the CysLT(2) receptor can mediate an increase in vascular permeability in some tissues or promote chronic pulmonary inflammation with fibrosis. ..
  5. Huang X, Zhang W, Li C, Shi W, Fang S, Lu Y, et al. Activation of CysLT receptors induces astrocyte proliferation and death after oxygen-glucose deprivation. Glia. 2008;56:27-37 pubmed
    ..CysLT(1) receptor antagonist montelukast attenuated astrocyte proliferation, the CysLT(2) receptor antagonist BAY cysLT2 reversed astrocyte death, and the dual CysLT receptor antagonist BAY u9773 exhibited both effects...
  6. Shimbori C, Shiota N, Okunishi H. Involvement of leukotrienes in the pathogenesis of silica-induced pulmonary fibrosis in mice. Exp Lung Res. 2010;36:292-301 pubmed publisher
    ..These findings suggest that an increase in LT production in the lung and modulation of homeostatic balance among LT receptors may contribute to the progression of pulmonary fibrosis. ..
  7. Xu L, Zhang L, Liu L, Fang S, Lu Y, Wei E, et al. Involvement of cysteinyl leukotriene receptors in angiogenesis in rat thoracic aortic rings. Pharmazie. 2010;65:750-4 pubmed
    ..CysLTs) are potent inflammatory mediators that induce inflammation through the activation of CysLT1 and CysLT2 receptors...
  8. Perez Novo C, Claeys C, Van Cauwenberge P, Bachert C. Expression of eicosanoid receptors subtypes and eosinophilic inflammation: implication on chronic rhinosinusitis. Respir Res. 2006;7:75 pubmed
    ..mRNA expression of CysLT1, CysLT2, BLT1, BLT2, E-prostanoid receptors (EP1, EP2, EP3, EP4) and sol-IL-5Ralpha was determined by real-time PCR...
  9. Kaditis A, Ioannou M, Chaidas K, Alexopoulos E, Apostolidou M, Apostolidis T, et al. Cysteinyl leukotriene receptors are expressed by tonsillar T cells of children with obstructive sleep apnea. Chest. 2008;134:324-331 pubmed publisher
    ..Up-regulation of LT1-R and LT2-R could potentially promote tonsillar enlargement in children with obstructive sleep apnea. ..

More Information


  1. Hui Y, Yang G, Galczenski H, Figueroa D, Austin C, Copeland N, et al. The murine cysteinyl leukotriene 2 (CysLT2) receptor. cDNA and genomic cloning, alternative splicing, and in vitro characterization. J Biol Chem. 2001;276:47489-95 pubmed
    ..The identification of mCysLT(2)R will be useful for establishing CysLT(2)R-deficient mice and determining novel leukotriene functions. ..
  2. Fukai H, Ogasawara Y, Migita O, Koga M, Ichikawa K, Shibasaki M, et al. Association between a polymorphism in cysteinyl leukotriene receptor 2 on chromosome 13q14 and atopic asthma. Pharmacogenetics. 2004;14:683-90 pubmed
    b>Cysteinyl leukotriene receptor 2 (CYSLTR2) is one of the receptors for the cysteinyl leukotrienes (CYSLTs), which cause bronchoconstrictions, vascular hyperpermeability and mucus hypersecretion in asthmatic patients...
  3. Pillai S, Cousens D, Barnes A, Buckley P, Chiano M, Hosking L, et al. A coding polymorphism in the CYSLT2 receptor with reduced affinity to LTD4 is associated with asthma. Pharmacogenetics. 2004;14:627-33 pubmed
    ..mediators in the pathophysiology of asthma for which two receptors have been characterized, CYSLTR1 and CYSLTR2. The leukotriene modifying agents currently used to control bronchoconstriction and inflammation in asthmatic ..
  4. Zhao C, Zhao B, Zhang X, Huang X, Shi W, Liu H, et al. Cysteinyl leukotriene receptor 2 is spatiotemporally involved in neuron injury, astrocytosis and microgliosis after focal cerebral ischemia in rats. Neuroscience. 2011;189:1-11 pubmed publisher
    ..mediators, are released from ischemic brain, and may regulate ischemic injury through activating CysLT1 and CysLT2 receptors...