Gene Symbol: Cyp7b1
Description: cytochrome P450 family 7 subfamily B member 1
Alias: 25-hydroxycholesterol 7-alpha-hydroxylase, HCT-1, cytochrome P450 7B1, cytochrome P450, family 7, subfamily b, polypeptide 1, cytochrome P450, subfamily 7B, polypeptide 1, hippocampal transcript 1 protein, oxysterol 7-alpha-hydroxylase
Species: rat
Products:     Cyp7b1

Top Publications

  1. Stapleton G, Steel M, Richardson M, Mason J, Rose K, Morris R, et al. A novel cytochrome P450 expressed primarily in brain. J Biol Chem. 1995;270:29739-45 pubmed
  2. Wicher G, Norlin M. Estrogen-mediated regulation of steroid metabolism in rat glial cells; effects on neurosteroid levels via regulation of CYP7B1-mediated catalysis. J Steroid Biochem Mol Biol. 2015;145:21-7 pubmed publisher
    ..In the current study we examined effects of estrogens on steroid metabolism catalyzed by CYP7B1 and other enzymes in primary cultures of rat astrocytes...
  3. Yi T, Wang X, Kelly L, An J, Xu Y, Sailer A, et al. Oxysterol gradient generation by lymphoid stromal cells guides activated B cell movement during humoral responses. Immunity. 2012;37:535-48 pubmed publisher
    ..7?,25-OHC is synthesized from cholesterol by the stepwise actions of two enzymes, CH25H and CYP7B1, and is metabolized to a 3-oxo derivative by HSD3B7...
  4. Li Hawkins J, Lund E, Bronson A, Russell D. Expression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterol. J Biol Chem. 2000;275:16543-9 pubmed
    ..of 7alpha-hydroxylated bile acids from oxysterols requires an oxysterol 7alpha-hydroxylase encoded by the Cyp7b1 locus...
  5. Pandak W, Hylemon P, Ren S, Marques D, Gil G, Redford K, et al. Regulation of oxysterol 7alpha-hydroxylase (CYP7B1) in primary cultures of rat hepatocytes. Hepatology. 2002;35:1400-8 pubmed
    ..CYP27) with subsequent 7alpha-hydroxylation of 27-hydroxycholesterol by oxysterol 7alpha-hydroxylase (CYP7B1)...
  6. Weihua Z, Lathe R, Warner M, Gustafsson J. An endocrine pathway in the prostate, ERbeta, AR, 5alpha-androstane-3beta,17beta-diol, and CYP7B1, regulates prostate growth. Proc Natl Acad Sci U S A. 2002;99:13589-94 pubmed
    ..We have used ERbeta(-/-) and CYP7B1(-/-) mice to investigate the role of ERbeta and one of its ligands, 5alpha-androstane-3beta,17beta-diol (..
  7. Anderson P, O Loughlin P, May B, Morris H. Quantification of mRNA for the vitamin D metabolizing enzymes CYP27B1 and CYP24 and vitamin D receptor in kidney using real-time reverse transcriptase- polymerase chain reaction. J Mol Endocrinol. 2003;31:123-32 pubmed
    ..Low levels of CYP24 mRNA were associated with high PTH levels. These findings suggest that kidney CYP24 activity, possibly regulated by factors such as PTH, acts in concert with kidney CYP27B1 to control serum 1,25D levels. ..
  8. Gälman C, Bonde Y, Matasconi M, Angelin B, Rudling M. Dramatically increased intestinal absorption of cholesterol following hypophysectomy is normalized by thyroid hormone. Gastroenterology. 2008;134:1127-36 pubmed publisher
    ..Hypopituitarism is associated with dyslipidemia, and feeding hypophysectomized rats cholesterol induces severe hypercholesterolemia. This study aimed to unravel further how hypophysectomy alters cholesterol and bile acid metabolism...
  9. Noreau A, Dion P, Szuto A, Levert A, Thibodeau P, Brais B, et al. CYP7B1 mutations in French-Canadian hereditary spastic paraplegia subjects. Can J Neurol Sci. 2012;39:91-4 pubmed

More Information


  1. Laes J, Ravoet M, Quan X, Van Vooren P, Szpirer J, Szpirer C. Improved radiation hybrid map of rat chromosome 2: colocalization of the genes encoding corticotropin-releasing hormone and IL6-receptor with quantitative trait loci regulating the inflammatory response. Cytogenet Cell Genet. 2001;92:130-3 pubmed
    ..Our data show that they reside within regions that were genetically defined as QTLs controlling the inflammatory response. These genes are thus both functional and positional candidates. ..
  2. Ren S, Marques D, Redford K, Hylemon P, Gil G, Vlahcevic Z, et al. Regulation of oxysterol 7alpha-hydroxylase (CYP7B1) in the rat. Metabolism. 2003;52:636-42 pubmed
    ..of cholesterol by 27-hydroxylase (CYP27), followed by 7alpha-hydroxylation by oxysterol 7alpha-hydroxylase (CYP7B1)...
  3. Yau J, Noble J, Graham M, Seckl J. Central administration of a cytochrome P450-7B product 7 alpha-hydroxypregnenolone improves spatial memory retention in cognitively impaired aged rats. J Neurosci. 2006;26:11034-40 pubmed
  4. Shi Q, Lin Y, Zhou X, Lin Y, Yan S. [Interaction among peroxisome proliferators-activated receptor alpha, cytochrome P450 oxysterol 7?-hydroxylase and estrogen receptor and its association with intrahepatic cholestasis in pregnant rats]. Zhonghua Fu Chan Ke Za Zhi. 2010;45:440-4 pubmed
    ..of peroxisome proliferators-activated receptor alpha (PPAR?), cytochrome P450 oxysterol 7?-hydroxylase (CYP7B1) and estrogen receptor (ER) and intrahepatic cholestasis in pregnant rats...