Genomes and Genes
Gene Symbol: Cyp7b1
Description: cytochrome P450 family 7 subfamily B member 1
Alias: 25-hydroxycholesterol 7-alpha-hydroxylase, HCT-1, cytochrome P450 7B1, cytochrome P450, family 7, subfamily b, polypeptide 1, cytochrome P450, subfamily 7B, polypeptide 1, hippocampal transcript 1 protein, oxysterol 7-alpha-hydroxylase
- Laes J, Ravoet M, Quan X, Van Vooren P, Szpirer J, Szpirer C. Improved radiation hybrid map of rat chromosome 2: colocalization of the genes encoding corticotropin-releasing hormone and IL6-receptor with quantitative trait loci regulating the inflammatory response. Cytogenet Cell Genet. 2001;92:130-3 pubmed..Our data show that they reside within regions that were genetically defined as QTLs controlling the inflammatory response. These genes are thus both functional and positional candidates. ..
- Ren S, Marques D, Redford K, Hylemon P, Gil G, Vlahcevic Z, et al. Regulation of oxysterol 7alpha-hydroxylase (CYP7B1) in the rat. Metabolism. 2003;52:636-42 pubmed..of cholesterol by 27-hydroxylase (CYP27), followed by 7alpha-hydroxylation by oxysterol 7alpha-hydroxylase (CYP7B1)...
- Yau J, Noble J, Graham M, Seckl J. Central administration of a cytochrome P450-7B product 7 alpha-hydroxypregnenolone improves spatial memory retention in cognitively impaired aged rats. J Neurosci. 2006;26:11034-40 pubmed
- Shi Q, Lin Y, Zhou X, Lin Y, Yan S. [Interaction among peroxisome proliferators-activated receptor alpha, cytochrome P450 oxysterol 7?-hydroxylase and estrogen receptor and its association with intrahepatic cholestasis in pregnant rats]. Zhonghua Fu Chan Ke Za Zhi. 2010;45:440-4 pubmed..of peroxisome proliferators-activated receptor alpha (PPAR?), cytochrome P450 oxysterol 7?-hydroxylase (CYP7B1) and estrogen receptor (ER) and intrahepatic cholestasis in pregnant rats...