Gene Symbol: Cyp4b1
Description: cytochrome P450, family 4, subfamily b, polypeptide 1
Alias: cytochrome P450 4B1, CYPIVB1, P450 L-2, P450-isozyme 5, cytochrome P450 L-2, cytochrome P450 isozyme 5, cytochrome P450, subfamily 4B, polypeptide 1, cytochrome P450, subfamily IVB, polypeptide 1
Imaoka S, Yoneda Y, Sugimoto T, Ikemoto S, Hiroi T, Yamamoto K, et al
. Androgen regulation of CYP4B1 responsible for mutagenic activation of bladder carcinogens in the rat bladder: detection of CYP4B1 mRNA by competitive reverse transcription-polymerase chain reaction. Cancer Lett. 2001;166:119-23 pubmed
..These carcinogenic amines are activated to genotoxic substances by cytochrome P 450 CYP4B1, which is present in bladder mucosa...
Gasser R, Philpot R. Primary structures of cytochrome P-450 isozyme 5 from rabbit and rat and regulation of species-dependent expression and induction in lung and liver: identification of cytochrome P-450 gene subfamily IVB. Mol Pharmacol. 1989;35:617-25 pubmed
Kimura S, Hanioka N, Matsunaga E, Gonzalez F. The rat clofibrate-inducible CYP4A gene subfamily. I. Complete intron and exon sequence of the CYP4A1 and CYP4A2 genes, unique exon organization, and identification of a conserved 19-bp upstream element. DNA. 1989;8:503-16 pubmed
..The CYP4A2 gene also contained two 378-bp direct repeats upstream from the start site; these repeats are derived from portions of the long interspersed middle repetitive element present in high copy numbers in the rat genome. ..
Hardwick J, Song B, Huberman E, Gonzalez F. Isolation, complementary DNA sequence, and regulation of rat hepatic lauric acid omega-hydroxylase (cytochrome P-450LA omega). Identification of a new cytochrome P-450 gene family. J Biol Chem. 1987;262:801-10 pubmed
..Southern blot analysis indicates that this family contains two or three genes. ..
Imaoka S, Funae Y. Purification and characterization of rat pulmonary cytochrome P-450. J Biochem. 1990;108:33-6 pubmed
..Also, P-450 IIB1 was detected by immunoblotting in one of the peaks on ion-exchange HPLC during the purification of P450 L-2, suggesting the presence of P-450 IIB1 in rat pulmonary microsomes. ..
Verschoyle R, Philpot R, Wolf C, Dinsdale D. CYP4B1 activates 4-ipomeanol in rat lung. Toxicol Appl Pharmacol. 1993;123:193-8 pubmed
Inhibition of pulmonary CYP4B1 activity by pretreatment of rats with p-xylene decreased the ability of lung microsomes to N-hydroxylate 2-aminofluorene and prevented the lung damage normally seen after dosing with ipomeanol...
Imaoka S, Yoneda Y, Matsuda T, Degawa M, Fukushima S, Funae Y. Mutagenic activation of urinary bladder carcinogens by CYP4B1 and the presence of CYP4B1 in bladder mucosa. Biochem Pharmacol. 1997;54:677-83 pubmed
..Mouse renal microsomes had high mutagenic activation toward DCB and low activity toward 2-NA. Purified mouse Cyp4b1 also had high mutagenic activity toward DCB...
Genter M, Yost G, Rettie A. Localization of CYP4B1 in the rat nasal cavity and analysis of CYPs as secreted proteins. J Biochem Mol Toxicol. 2006;20:139-41 pubmed
b>CYP4B1 is highly expressed in rat nasal respiratory mucosa, and to a lesser extent in olfactory mucosa...