Gene Symbol: Cyp4a3
Description: cytochrome P450, family 4, subfamily a, polypeptide 3
Alias: CYPIVA3, Cyp4a14, cytochrome P450 4A14, CYPIVA14, P450-LA-omega 3, cytochrome P450 4A3, cytochrome P450, family 4, subfamily a, polypeptide 14, cytochrome P450-LA-omega 3, long-chain fatty acid omega-monooxygenase
Species: rat
Products:     Cyp4a3

Top Publications

  1. Kawashima H, Kusunose E, Kubota I, Maekawa M, Kusunose M. Purification and NH2-terminal amino acid sequences of human and rat kidney fatty acid omega-hydroxylases. Biochim Biophys Acta. 1992;1123:156-62 pubmed
    ..To our knowledge, this is the first time that a P-450 specific for fatty acid omega-hydroxylase activity has been isolated to homogeneity from human tissues. ..
  2. Hoch U, Ortiz de Montellano P. Covalently linked heme in cytochrome p4504a fatty acid hydroxylases. J Biol Chem. 2001;276:11339-46 pubmed
    ..The extent of heme covalent binding in the proteins as isolated varies and is substoichiometric. In CYP4A3, the heme is attached to the protein via an ester link to glutamic acid residue 318, which is on the I-helix, and ..
  3. LeBrun L, Hoch U, Ortiz de Montellano P. Autocatalytic mechanism and consequences of covalent heme attachment in the cytochrome P4504A family. J Biol Chem. 2002;277:12755-61 pubmed
    ..Mutation of the glutamic acid to an alanine in CYP4A1, CYP4A3, and CYP4A11 suppresses covalent heme binding...
  4. Wang M, Wang J, Chang H, Zand B, Jiang M, Nasjletti A, et al. Regulation of renal CYP4A expression and 20-HETE synthesis by nitric oxide in pregnant rats. Am J Physiol Renal Physiol. 2003;285:F295-302 pubmed
    ..However, it is not known whether NO interacts with and affects the activity of CYP4A1 and CYP4A3, the major renal CYP4A isoforms in female rats...
  5. Hercule H, Wang M, Oyekan A. Contribution of cytochrome P450 4A isoforms to renal functional response to inhibition of nitric oxide production in the rat. J Physiol. 2003;551:971-9 pubmed
    ..the reduction in RBF and the consequent increase in RVR by L-NAME with a potency order of CYP4A2 = CYP4A1 > CYP4A3. ASODN to CYP4A1 and -4A2 but not -4A3 attenuated L-NAME-induced reduction in GFR, but ASODN to all three CYP4A ..
  6. Kimura S, Hanioka N, Matsunaga E, Gonzalez F. The rat clofibrate-inducible CYP4A gene subfamily. I. Complete intron and exon sequence of the CYP4A1 and CYP4A2 genes, unique exon organization, and identification of a conserved 19-bp upstream element. DNA. 1989;8:503-16 pubmed
    ..The CYP4A2 gene also contained two 378-bp direct repeats upstream from the start site; these repeats are derived from portions of the long interspersed middle repetitive element present in high copy numbers in the rat genome. ..
  7. Imaoka S, Shimojo N, Funae Y. Induction of renal cytochrome P-450 in hepatic microsomes of diabetic rats. Biochem Biophys Res Commun. 1988;152:680-7 pubmed
    ..The NH2-terminal sequence of P450 DM-2 was identical to that of P450 K-5, the major renal cytochrome P-450. Both forms gave very similar electrophoretic patterns of proteolytic digests. P450 DM-2 and P450 K-5 are closely related forms. ..
  8. Imaoka S, Nagashima K, Funae Y. Characterization of three cytochrome P450s purified from renal microsomes of untreated male rats and comparison with human renal cytochrome P450. Arch Biochem Biophys. 1990;276:473-80 pubmed
    ..Anti-P450 K-5 antibody cross-reacted with P450 HK as well as P450 K-5 and only one band was stained on immunostained Western blotting for partially purified P450 HK. The molecular weight of P450 HK was 52,000 on Western blotting. ..
  9. Kimura S, Hardwick J, Kozak C, Gonzalez F. The rat clofibrate-inducible CYP4A subfamily. II. cDNA sequence of IVA3, mapping of the Cyp4a locus to mouse chromosome 4, and coordinate and tissue-specific regulation of the CYP4A genes. DNA. 1989;8:517-25 pubmed
    ..In contrast to the coordinate induction in liver, only the CYP4A3 gene was induced in the rat hepatoma cell line McA-RH7777...

More Information


  1. Kroetz D, Huse L, Thuresson A, Grillo M. Developmentally regulated expression of the CYP4A genes in the spontaneously hypertensive rat kidney. Mol Pharmacol. 1997;52:362-72 pubmed
    ..Distinct age-dependent patterns of expression were observed for the individual CYP4A genes, with only CYP4A3 mRNA measurable in the kidneys of 1-week-old rats...
  2. Nguyen X, Wang M, Reddy K, Falck J, Schwartzman M. Kinetic profile of the rat CYP4A isoforms: arachidonic acid metabolism and isoform-specific inhibitors. Am J Physiol. 1999;276:R1691-700 pubmed
    ..min-1 for CYP4A1 was followed by 72 and 22 nM-1. min-1 for CYP4A2 and CYP4A3, respectively...
  3. Wang J, Maier K, Roman R, de la Cruz L, Zhu J, Henderson L, et al. Expression of cytochrome P450-4A isoforms in the rat cremaster muscle microcirculation. Microcirculation. 2004;11:89-96 pubmed
  4. Park F, Sweeney W, Jia G, Akbulut T, Mueller B, Falck J, et al. Chronic blockade of 20-HETE synthesis reduces polycystic kidney disease in an orthologous rat model of ARPKD. Am J Physiol Renal Physiol. 2009;296:F575-82 pubmed publisher
    ..RT-PCR analysis indicated that the expression of CYP4A1, CYP4A2, CYP4A3, and CYP4A8 mRNA was increased two- to fourfold in cystic PCK compared with noncystic Sprague-Dawley rat kidneys...
  5. Zhang X, Li S, Zhou Y, Su W, Ruan X, Wang B, et al. Ablation of cytochrome P450 omega-hydroxylase 4A14 gene attenuates hepatic steatosis and fibrosis. Proc Natl Acad Sci U S A. 2017;114:3181-3185 pubmed publisher
    ..Cytochrome P450 omega-hydroxylase 4A14 (CYP4A14) is a homolog of human CYP4A hydroxylase that catalyzes omega-hydroxylation of medium-chain fatty acids and ..