Cyp3a62

Summary

Gene Symbol: Cyp3a62
Description: cytochrome P450, family 3, subfamily a, polypeptide 62
Alias: CYP3, Cyp3a, cytochrome P450, family 3, subfamily a, polypeptide 62, cytochrome P450, subfamily 3A, polypeptide 62, cytochrome P450, subfamily IIA (niphedipine oxidase), cytochrome P450, subfamily IIIA (niphedipine oxidase)
Species: rat

Top Publications

  1. Zhu X, Jiao J, Zhang C, Lou J, Liu C. Limited sampling strategy in rats to predict the inhibited activities of hepatic CYP3A. Lab Anim. 2009;43:284-90 pubmed publisher
    ..of a limited sampling strategy (LSS) to predict the systemic clearance of midazolam (MDZ), which is a hepatic CYP3A activity phenotyping probe...
  2. Faouzi S, Medzihradszky K, Hefner C, Maher J, Correia M. Characterization of the physiological turnover of native and inactivated cytochromes P450 3A in cultured rat hepatocytes: a role for the cytosolic AAA ATPase p97?. Biochemistry. 2007;46:7793-803 pubmed
    ..Pulse-chase with immunoprecipitation analyses revealed a basal 52% 35S-CYP3A loss over 6 h, which was stabilized by both proteasomal inhibitors...
  3. Zangar R, Kocarek T, Shen S, Bollinger N, Dahn M, Lee D. Suppression of cytochrome P450 3A protein levels by proteasome inhibitors. J Pharmacol Exp Ther. 2003;305:872-9 pubmed
    We have previously reported that CYP3A cross-links with polyubiquitinated proteins in microsomes from nicardipine-treated rats in a process that is distinct from classical polyubiquitination...
  4. Lee A, Conney A, Zhu B. Human cytochrome P450 3A7 has a distinct high catalytic activity for the 16alpha-hydroxylation of estrone but not 17beta-estradiol. Cancer Res. 2003;63:6532-6 pubmed
  5. Xiong S, Li J, Zhang W, Wang X, Zhang Z. Induction of CYP3A by morroniside in rats. J Pharmacol Sci. 2015;127:414-8 pubmed publisher
    ..et Zucc. The current study was designed to investigate the ex vivo and in vivo effects of morroniside on CYP3A activity in rats after treatment with morroniside for 7 days (at 10, 30, 90 mg/kg, i.g.)...
  6. Yadav S, Dhawan A, Seth P, Singh R, Parmar D. Cytochrome P4503A: evidence for mRNA expression and catalytic activity in rat brain. Mol Cell Biochem. 2006;287:91-9 pubmed
    Studies initiated to investigate the presence of cytochrome P4503A (CYP3A) isoenzymes in brain revealed constitutive mRNA and protein expression of CYP3A1 in rat brain...
  7. Mureithi D, Darwish W, Ikenaka Y, Kanja L, Ishizuka M. Cytochrome P450 3A mRNA expression along goat and rat gastrointestinal tracts. Jpn J Vet Res. 2012;60:205-10 pubmed
    ..In rats, the highest CYP3A62 mRNA expression was found in the duodenum followed by the liver...
  8. Salmin S, Giroux M, Vachon P, Beaudry F. In vitro metabolism of specific CYP2D and CYP3A opioid substrates using rat liver S9 fractions and mass spectrometry reveal a severe metabolic impairment with increasing age. Biomed Chromatogr. 2017;31: pubmed publisher
    ..metabolites using an isotopic dilution strategy and study the rate of formation of morphine (CYP2D), norcodeine (CYP3A), oxymorphone (CYP2D) and noroxycodone (CYP3A)...
  9. Chen Q, Wu Y, Cheng N, Li Y, Wang Y. [Dual effects of extract of Schisandra chinensis Baill on rat hepatic CYP3A]. Yao Xue Xue Bao. 2010;45:1194-8 pubmed
    ..of Schisandra chinensis Baill (WWZ), kadsurin, schisandrin A, schisandrin B and schisandrol B on rat hepatic CYP3A. Rats received a daily gavage of aqueous extract of WWZ for different times...

More Information

Publications27

  1. Iwanaga K, Arimune K, Miyazaki M, Shibano M, Taniguchi M, Baba K, et al. Effects of furanocoumarins in Kampo extract-based medicines on rat intestinal absorption of CYP3A and P-glycoprotein substrate drugs in vivo. Arch Pharm Res. 2012;35:1055-64 pubmed publisher
    ..Midazolam, a CYP3A substrate drug, or talinolol, a P-gp substrate drug, was orally administered to rats with each of these Kampo ..
  2. Lu H, Waxman D. Antitumor activity of methoxymorpholinyl doxorubicin: potentiation by cytochrome P450 3A metabolism. Mol Pharmacol. 2005;67:212-9 pubmed
    ..study, a panel of human liver microsomes activated MMDX with potentiation ratios directly correlated to the CYP3A-dependent testosterone 6beta-hydroxylase activity of each liver sample...
  3. Reid J, Kuffel M, Ruben S, Morales J, Rinehart K, Squillace D, et al. Rat and human liver cytochrome P-450 isoform metabolism of ecteinascidin 743 does not predict gender-dependent toxicity in humans. Clin Cancer Res. 2002;8:2952-62 pubmed
    ..Rat and human microsomal metabolism of ET743 was reduced in the presence of chemical CYP3A inhibitors or antirat CYP3A2 antiserum and to a much lesser extent by CYP2E, CYP2C, and CYP2A inhibitors...
  4. Minamiyama Y, Takemura S, Toyokuni S, Imaoka S, Funae Y, Hirohashi K, et al. CYP3A induction aggravates endotoxemic liver injury via reactive oxygen species in male rats. Free Radic Biol Med. 2004;37:703-12 pubmed
    ..Furthermore, either troleandomycin or ketoconazole, specific CYP3A inhibitors, significantly inhibited LPS-induced liver injury in control and PB-treated male rats...
  5. Sheng L, Tan W, Hu J, Chen H, Li Y. [Effect of CYP3A and P-glycoprotein on the absorption of buagafuran in rat intestinal lumen]. Yao Xue Xue Bao. 2010;45:43-8 pubmed
    The rat single-pass intestinal perfusion model was applied to study the effect of CYP3A and P-glycoprotein on the absorption of buagafuran in lumen of rats...
  6. Remmers E, Griffiths M, Longman R, Gulko P, Kawahito Y, Chen S, et al. An integrated rat genetic map: analysis of linkage conservation with the mouse and human maps. Transplant Proc. 1999;31:1549-54 pubmed
  7. Zhu Z, Hotchkiss S, Boobis A, Edwards R. Expression of P450 enzymes in rat whole skin and cultured epidermal keratinocytes. Biochem Biophys Res Commun. 2002;297:65-70 pubmed
    ..This suggests that primary keratinocytes grown in culture for 10-14 days may provide a useful experimental model to study P450-catalysed metabolism of xenobiotics in skin. ..
  8. Sanada H, Sekimoto M, Kamoshita A, Degawa M. Changes in expression of hepatic cytochrome P450 subfamily enzymes during development of adjuvant-induced arthritis in rats. J Toxicol Sci. 2011;36:181-90 pubmed
    ..All of the present findings demonstrate that hepatic CYP3A and CYP2B subfamily enzymes are decreased during the development of MT adjuvant-induced arthritis and further ..
  9. Kim Y, Rajagopalan P. 3D hepatic cultures simultaneously maintain primary hepatocyte and liver sinusoidal endothelial cell phenotypes. PLoS ONE. 2010;5:e15456 pubmed publisher
    ..Only rLSEC-PEM-Hepatocyte cultures exhibited increasing CYP1A1/2 and CYP3A activity. Well-defined bile canaliculi were observed only in the rLSEC-PEM-Hepatocyte cultures...
  10. Bailey I, Gibson G, Plant K, Graham M, Plant N. A PXR-mediated negative feedback loop attenuates the expression of CYP3A in response to the PXR agonist pregnenalone-16?-carbonitrile. PLoS ONE. 2011;6:e16703 pubmed publisher
    ..demonstrate that this feed-back loop is an important factor to prevent hyperexpression of PXR target genes such as CYP3A and confirm these findings in vitro...
  11. Wang X, Yeung J. Effects of Salvia miltiorrhiza extract on the liver CYP3A activity in humans and rats. Phytother Res. 2011;25:1653-9 pubmed publisher
    ..This study explored the effects of Danshen capsules commonly used in clinical practice on the liver CYP3A activity in humans and rats...
  12. Park D, Jeon J, Shin S, Joo S, Kang D, Moon S, et al. Green tea extract increases cyclophosphamide-induced teratogenesis by modulating the expression of cytochrome P-450 mRNA. Reprod Toxicol. 2009;27:79-84 pubmed publisher
    ..which metabolizes cyclophosphamide into teratogenic acrolein and cytotoxic phosphoramide mustard, while reducing CYP3A expression (a detoxifying enzyme)...
  13. Kim S, Acharya P, Engel J, Correia M. Liver cytochrome P450 3A ubiquitination in vivo by gp78/autocrine motility factor receptor and C terminus of Hsp70-interacting protein (CHIP) E3 ubiquitin ligases: physiological and pharmacological relevance. J Biol Chem. 2010;285:35866-77 pubmed publisher
    ..CYP3A4 and its mammalian liver CYP3A orthologs are endoplasmic reticulum (ER)-anchored monotopic proteins that undergo ubiquitin (Ub)-dependent ..
  14. Ronis M, Chen Y, Jo C, Simpson P, Badger T. Diets containing soy protein isolate increase hepatic CYP3A expression and inducibility in weanling male rats exposed during early development. J Nutr. 2004;134:3270-6 pubmed
    Hepatic CYP3A enzymes were studied in weanling male Sprague-Dawley rats exposed to diets from gestational d 4 in which the sole protein source was either casein (CAS) or soy protein isolate (SPI)...
  15. Matsubara T, Kim H, Miyata M, Shimada M, Nagata K, Yamazoe Y. Isolation and characterization of a new major intestinal CYP3A form, CYP3A62, in the rat. J Pharmacol Exp Ther. 2004;309:1282-90 pubmed
    Based on information of the nucleotide sequence obtained from rat genome clones, a new CYP3A (CYP3A62) cDNA was isolated from the cDNA library of a rat liver...
  16. Miyazawa M, Shindo M, Shimada T. Roles of cytochrome P450 3A enzymes in the 2-hydroxylation of 1,4-cineole, a monoterpene cyclic ether, by rat and human liver microsomes. Xenobiotica. 2001;31:713-23 pubmed
    ..activities catalysed by human liver microsomes were inhibited by ketoconazole, a potent inhibitor of CYP3A activities, and an anti-CYP3A4 antibody...
  17. Dey A, Yadav S, Dhawan A, Seth P, Parmar D. Evidence for cytochrome P450 3A expression and catalytic activity in rat blood lymphocytes. Life Sci. 2006;79:1729-35 pubmed
    ..rats were found to catalyze the N-demethylation of erythromycin, known to be mediated by cytochrome P450 3A (CYP3A) isoenzymes in rat liver. Pretreatment of rats with dexamethasone (100 mg/kgx3 days, i.p...
  18. Maté M, Ballent M, Larsen K, Lifschitz A, Lanusse C, Virkel G. Gene expression and enzyme function of two cytochrome P450 3A isoenzymes in rat and cattle precision cut liver slices. Xenobiotica. 2015;45:563-70 pubmed publisher
    ..slices after 12 h culture, whereas the gene expression profiles of transcriptional factors involved in CYP3A regulation were unaffected. A CYP3A-dependent enzyme activity (triacetyl-oleandomycin N-demethylase) increased 3...