Cyp2e1

Summary

Gene Symbol: Cyp2e1
Description: cytochrome P450, family 2, subfamily e, polypeptide 1
Alias: Cyp2e, cytochrome P450 2E1, 4-nitrophenol 2-hydroxylase, CYPIIE1, P450-J, P450RLM6, cytochrome P450 subfamily 2e1 (ethanol-inducible), cytochrome P450, subfamily 2E, polypeptide 1, cytochrome P450-J, cytochrome P450RLM6
Species: rat
Products:     Cyp2e1

Top Publications

  1. Cederbaum A. CYP2E1--biochemical and toxicological aspects and role in alcohol-induced liver injury. Mt Sinai J Med. 2006;73:657-72 pubmed
    ..One central pathway appears to be the induction of the CYP2E1 form of cytochrome P450 enzymes by ethanol...
  2. Wang Z, Hall S, Maya J, Li L, Asghar A, Gorski J. Diabetes mellitus increases the in vivo activity of cytochrome P450 2E1 in humans. Br J Clin Pharmacol. 2003;55:77-85 pubmed
    b>Cytochrome P450 2E1 (CYP2E1) is thought to activate a number of protoxins, and has been implicated in the development of liver disease...
  3. Raza H, Prabu S, Robin M, Avadhani N. Elevated mitochondrial cytochrome P450 2E1 and glutathione S-transferase A4-4 in streptozotocin-induced diabetic rats: tissue-specific variations and roles in oxidative stress. Diabetes. 2004;53:185-94 pubmed
    ..We show a five- to eightfold increase of cytochrome P450 2E1 (CYP2E1) and glutathione S-transferase (GST) A4-4 levels in mitochondria from STZ-treated rat tissues ..
  4. Mochizuki M, Shimizu S, Urasoko Y, Umeshita K, Kamata T, Kitazawa T, et al. Carbon tetrachloride-induced hepatotoxicity in pregnant and lactating rats. J Toxicol Sci. 2009;34:175-81 pubmed
    ..CCl3) by CYP2E1. In the present study, the hepatotoxicity induced by a single oral dose (2,000 mg/kg) of CCl4 was compared between ..
  5. Naiman K, Frei E, Stiborova M. Identification of rat cytochromes P450 metabolizing N-(2-methoxyphenyl)hydroxylamine, a human metabolite of the environmental pollutants and carcinogens o-anisidine and o-nitroanisole. Neuro Endocrinol Lett. 2010;31 Suppl 2:36-45 pubmed
    ..we attribute most of N-(2-methoxyphenyl)hydroxylamine metabolism to o-anisidine in rat liver to CYP2C, followed by CYP2E1, 2D and 2A...
  6. Arif E, Vibhuti A, Alam P, Deepak D, Singh B, Athar M, et al. Association of CYP2E1 and NAT2 gene polymorphisms with chronic obstructive pulmonary disease. Clin Chim Acta. 2007;382:37-42 pubmed
    ..We conducted a case-control study to investigate total 9 polymorphisms of CYP2E1, CYP2D6 and NAT2 genes by PCR-RFLP...
  7. Jiang Y, He X, Ortiz de Montellano P. Radical intermediates in the catalytic oxidation of hydrocarbons by bacterial and human cytochrome P450 enzymes. Biochemistry. 2006;45:533-42 pubmed
    ..The oxidation of alpha-thujone by human CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP2E1, and CYP3A4 occurs with up to 80% C-4 methyl inversion, in agreement with a dominant radical hydroxylation ..
  8. Posadas I, Santos P, Blanco A, Muñoz Fernández M, Ceña V. Acetaminophen induces apoptosis in rat cortical neurons. PLoS ONE. 2010;5:e15360 pubmed publisher
    ..AAP also increases both neuronal cytochrome P450 isoform CYP2E1 enzymatic activity and protein levels as determined by Western blot, leading to neuronal death through ..
  9. Gong P, Cederbaum A. Nrf2 is increased by CYP2E1 in rodent liver and HepG2 cells and protects against oxidative stress caused by CYP2E1. Hepatology. 2006;43:144-53 pubmed
    Induction of CYP2E1 by ethanol is one pathway through which ethanol generates oxidative stress. Nrf2 is a transcription factor that regulates important antioxidant and phase II detoxification genes...

More Information

Publications62

  1. Lin J, Zhao J, Li T, Zhou J, Hu J, Hong Z. Hepatoprotection in a rat model of acute liver damage through inhibition of CY2E1 activity by total alkaloids extracted from Rubus alceifolius Poir. Int J Toxicol. 2011;30:237-43 pubmed publisher
    ..Carbon tetrachloride treatment alone caused a decrease in total cytochrome P450 content, an increase in CYP2E1 and CYP3A1 messenger RNA (mRNA) levels, and an increase in CYP2E1 and a decrease in CYP3A1 enzymatic activity...
  2. Shimada T, Mernaugh R, Guengerich F. Interactions of mammalian cytochrome P450, NADPH-cytochrome P450 reductase, and cytochrome b(5) enzymes. Arch Biochem Biophys. 2005;435:207-16 pubmed
  3. Neve E, Hidestrand M, Ingelman Sundberg M. Identification of sequences responsible for intracellular targeting and membrane binding of rat CYP2E1 in yeast. Biochemistry. 2003;42:14566-75 pubmed
    The role of the hydrophobic NH(2)-terminal domain of rat CYP2E1 for intracellular targeting and membrane binding was investigated in Saccharomyces cerevisiae as a model system...
  4. Hassan H, Guo H, Yousef B, Guerram M, Hamdi A, Zhang L, et al. Role of Inflammatory and Oxidative Stress, Cytochrome P450 2E1, and Bile Acid Disturbance in Rat Liver Injury Induced by Isoniazid and Lipopolysaccharide Cotreatment. Antimicrob Agents Chemother. 2016;60:5285-93 pubmed publisher
    ..Moreover, the principal impact of cytochrome P450 2E1 (CYP2E1) on INH toxicity could be anticipated, as its protein expression showed enormous increases in INH-..
  5. Emery M, Fisher J, Chien J, Kharasch E, Dellinger E, Kowdley K, et al. CYP2E1 activity before and after weight loss in morbidly obese subjects with nonalcoholic fatty liver disease. Hepatology. 2003;38:428-35 pubmed
    Previous studies suggest that hepatic cytochrome P450 2E1 (CYP2E1) activity is increased in individuals with chronic alcoholism, nonalcoholic steatohepatitis (NASH), and morbid obesity, and may contribute to liver disease...
  6. Cho H, Koh W, Ryu Y, Ki C, Nam M, Kim J, et al. Genetic polymorphisms of NAT2 and CYP2E1 associated with antituberculosis drug-induced hepatotoxicity in Korean patients with pulmonary tuberculosis. Tuberculosis (Edinb). 2007;87:551-6 pubmed
    ..INH is metabolized by hepatic N-acetyltransferase (NAT) and cytochrome P450 2E1 (CYP2E1) to form hepatotoxins...
  7. Vokhmintseva L. [Effect of adrenaline on the cytochrome P4502E1 content in microsomes and lysosomal fractions induced by isoniazid in rats]. Eksp Klin Farmakol. 2008;71:40-2 pubmed
    ..Epinephrine administration under these conditions increased the cytochrome P-4502E1 level in lysosomes due to autophagy. ..
  8. Tanaka Y, Fujii W, Hori H, Kitagawa Y, Ozaki K. Changes in coumarin kinetics and subcellular localization of CYP2E1 contribute to bile duct damage and reduce hepatocellular damage after repeated administration of coumarin in rats. Toxicol Lett. 2017;280:99-105 pubmed publisher
    ..In the control group, cytochrome P450 2E1 (CYP2E1) showed a diffuse subcellular distribution but accumulated within the hepatocyte endoplasmic ..
  9. Hong Z, Li T, Zhao J. [Effect of total alkaloids of Rubus alceaefolius poiron on gene expressions of CYP2E1 and CYP3A1 in rats with acute liver injury]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2009;29:711-5 pubmed
    ..the effects of total alkaloids of Rubus alceaefolius Poiron (RAP) on gene expressions of drug-metabolic enzymes, CYP2E1 and CYP3A1 in liver...
  10. Aleynik M, Lieber C. Dilinoleoylphosphatidylcholine decreases ethanol-induced cytochrome P4502E1. Biochem Biophys Res Commun. 2001;288:1047-51 pubmed
    Cytochrome P4502E1 (CYP2E1) induction by ethanol contributes to alcoholic liver disease and we found that a mixture of polyunsaturated phosphatidylcholines (PPC), which protects against alcohol-induced liver injury, also decreases CYP2E1...
  11. Wu D, Cederbaum A. Opposite action of S-adenosyl methionine and its metabolites on CYP2E1-mediated toxicity in pyrazole-induced rat hepatocytes and HepG2 E47 cells. Am J Physiol Gastrointest Liver Physiol. 2006;290:G674-84 pubmed
    ..The ability of SAMe to protect against cytochrome P-450 2E1 (CYP2E1)-dependent toxicity was studied in hepatocytes from pyrazole-treated rats and HepG2 E47 cells, both of which ..
  12. Robin M, Anandatheerthavarada H, Biswas G, Sepuri N, Gordon D, Pain D, et al. Bimodal targeting of microsomal CYP2E1 to mitochondria through activation of an N-terminal chimeric signal by cAMP-mediated phosphorylation. J Biol Chem. 2002;277:40583-93 pubmed
    b>Cytochrome P450 2E1 (CYP2E1) plays an important role in alcohol-induced toxicity and oxidative stress. Recently, we showed that this predominantly microsomal protein is also localized in rat hepatic mitochondria...
  13. Ností Palacios R, Gómez Garduño J, Molina Ortiz D, Calzada León R, Dorado González V, Vences Mejía A. Aspartame Administration and Insulin Treatment Altered Brain Levels of CYP2E1 and CYP3A2 in Streptozotocin-Induced Diabetic Rats. Int J Toxicol. 2014;33:325-331 pubmed
    ..Brain and liver tissue samples were used to analyze the activity of CYP2E1 and CYP3A2 and protein levels...
  14. De Roos A, Rothman N, Inskip P, Linet M, Shapiro W, Selker R, et al. Genetic polymorphisms in GSTM1, -P1, -T1, and CYP2E1 and the risk of adult brain tumors. Cancer Epidemiol Biomarkers Prev. 2003;12:14-22 pubmed
    GST and CYP2E1 genes are involved in metabolism of several compounds (e.g., solvents) that may play a role in brain cancer etiology. We evaluated associations between polymorphisms in these genes and adult brain tumor incidence...
  15. Gong P, Cederbaum A, Nieto N. Increased expression of cytochrome P450 2E1 induces heme oxygenase-1 through ERK MAPK pathway. J Biol Chem. 2003;278:29693-700 pubmed
    ..b>Cytochrome P450 2E1 (CYP2E1) generates reactive oxygen species and promotes lipid peroxidation...
  16. Hartman J, Martin H, Caro A, Pearce A, Miller G. Subcellular localization of rat CYP2E1 impacts metabolic efficiency toward common substrates. Toxicology. 2015;338:47-58 pubmed publisher
    b>Cytochrome P450 2E1 (CYP2E1) detoxifies or bioactivates many low molecular-weight compounds...
  17. Xu M, Tang H, Rong Q, Zhang Y, Li Y, Zhao L, et al. The Effects of Formaldehyde on Cytochrome P450 Isoform Activity in Rats. Biomed Res Int. 2017;2017:6525474 pubmed publisher
    ..The effects of acute FA poisoning on the activities of CYP450 isoforms CYP1A2, CYP2C11, CYP2E1, and CYP3A2 were assessed by determining changes in the pharmacokinetic parameters of the probe drugs phenacetin, ..
  18. Wang B, Bai M, Bai Y, Li Q. Liver injury following renal ischemia reperfusion in rats. Transplant Proc. 2010;42:3422-6 pubmed publisher
    ..included serum alanine aminotransferase (sALT) aspartate aminotransferase (sAST), cytochrome P-450 enzymes (CYP3A, CYP2E1), hepatic glutathione S-transferase (GST), glutathione (GSH), malondialdehyde (MDA), superoxide dismutase (SOD), ..
  19. Yang H, Lin H, Chao J, Chien Y, Peng H, Chen J. Effects of soy protein on alcoholic liver disease in rats undergoing ethanol withdrawal. J Nutr Biochem. 2012;23:679-84 pubmed publisher
    ..Expression of the hepatic cytochrome P450 2E1 (CYP2E1) protein in the EP group was significantly lower than that in the EC group, and the hepatic ..
  20. Yao H, Lin P, Chang Y, Chen C, Chiang M, Chang L, et al. Effect of taurine supplementation on cytochrome P450 2E1 and oxidative stress in the liver and kidneys of rats with streptozotocin-induced diabetes. Food Chem Toxicol. 2009;47:1703-9 pubmed publisher
    To investigate whether diabetes-induced alterations of CYP2E1 and oxidative stress can be modulated by dietary taurine supplementation, male Wistar rats were divided into non-diabetic, diabetic, and diabetic taurine-supplemented groups (..
  21. Ahmad I, Shukla S, Singh D, Chauhan A, Kumar V, Singh B, et al. CYP2E1-mediated oxidative stress regulates HO-1 and GST expression in maneb- and paraquat-treated rat polymorphonuclear leukocytes. Mol Cell Biochem. 2014;393:209-22 pubmed publisher
    Cytochrome P4502E1 (CYP2E1), glutathione-S-transferase A4-4 (GSTA4-4), and inducible nitric oxide synthase (iNOS) are implicated in maneb- and paraquat-induced toxicity leading to various pathological conditions...
  22. Pianalto K, Hartman J, Boysen G, Miller G. Differences in butadiene adduct formation between rats and mice not due to selective inhibition of CYP2E1 by butadiene metabolites. Toxicol Lett. 2013;223:221-7 pubmed publisher
    b>CYP2E1 metabolizes 1,3-butadiene (BD) into genotoxic and possibly carcinogenic 1,2-epoxy-3-butene (EB), 1,2:3,4-diepoxybutane (DEB), and 1,2-epoxy-3,4-butanediol (EB-diol)...
  23. Leclercq I, Field J, Enriquez A, Farrell G, Robertson G. Constitutive and inducible expression of hepatic CYP2E1 in leptin-deficient ob/ob mice. Biochem Biophys Res Commun. 2000;268:337-44 pubmed
    In this study we have analyzed the inducible as well as constitutive hepatic expression of Cyp2e1 in a genetic model of obesity and non-insulin dependent (type II) diabetes, the leptin-deficient ob/ob mouse...
  24. Zhang S, Cawley G, Eyer C, Backes W. Altered ethylbenzene-mediated hepatic CYP2E1 expression in growth hormone-deficient dwarf rats. Toxicol Appl Pharmacol. 2002;179:74-82 pubmed
    Ethylbenzene (EB) effectively induces several hepatic P450 enzymes including CYP2E1 and CYP2B. Hypophysectomy diminishes the magnitude of EB-mediated induction of CYP2B...
  25. Plewka A, Zielińska Psuja B, Kowalówka Zawieja J, Nowaczyk Dura G, Plewka D, Wiaderkiewicz A, et al. Influence of acetaminophen and trichloroethylene on liver cytochrome P450-dependent monooxygenase system. Acta Biochim Pol. 2000;47:1129-36 pubmed
    ..acetaminophen (APAP) and/or trichloroethylene (TRI) on the liver cytochrome P450-dependent monooxygenase system, CYP2E1 and CYP1A2 (two important P450 isoforms), and liver glutathione (GSH) content in rats...
  26. Moncion A, Truong N, Garrone A, Beaune P, Barouki R, de Waziers I. Identification of a 16-nucleotide sequence that mediates post-transcriptional regulation of rat CYP2E1 by insulin. J Biol Chem. 2002;277:45904-10 pubmed
    Insulin directly down-regulates the gene expression of the rat CYP2E1 by altering its mRNA stability (De Waziers, I., Garlatti, M., Bouguet, J., Beaune, P. H., and Barouki, R. (1995) Mol. Pharmacol. 47, 474-479)...
  27. Stoilov I, Krueger W, Mankowski D, Guernsey L, Kaur A, Glynn J, et al. The cytochromes P450 (CYP) response to allergic inflammation of the lung. Arch Biochem Biophys. 2006;456:30-8 pubmed
    ..During the acute inflammatory phase the mRNA levels of Cyp2e1, Cyp2f2, Cyp2j6, Cyp4b1, Cyp8a1 and Cypor were decreased while the mRNA levels of Cyp4f18, Cyp5a1 and Cyp7b1 were ..
  28. Piao Y, Li J, Shi Y. Relationship between genetic polymorphism of cytochrome P450IIE1 and fatty liver. World J Gastroenterol. 2003;9:2612-5 pubmed
    To study the correlation between genetic polymorphism of cytochrome P450IIE1 (CYPIIE1) and fatty liver...
  29. Kim H, Kim D, Cho H. Protective effects of Platycodi radix on alcohol-induced fatty liver. Biosci Biotechnol Biochem. 2007;71:1550-2 pubmed
    ..Furthermore, PR treatment normalized hepatic liver fatty acid binding protein (L-FABP) expression and cytochrome P450 2E1 (CYP2E1) activity in alcohol-treated rats...
  30. Robin M, Sauvage I, Grandperret T, Descatoire V, Pessayre D, Fromenty B. Ethanol increases mitochondrial cytochrome P450 2E1 in mouse liver and rat hepatocytes. FEBS Lett. 2005;579:6895-902 pubmed
    Enhanced hepatic levels of cytochrome P450 2E1 (CYP2E1) may play a key role in the pathogenesis of some liver diseases because CYP2E1 represents a significant source of reactive oxygen species...
  31. Doody E, Groebner J, Walker J, Frizol B, Tuma D, Fernandez D, et al. Ethanol metabolism by alcohol dehydrogenase or cytochrome P450 2E1 differentially impairs hepatic protein trafficking and growth hormone signaling. Am J Physiol Gastrointest Liver Physiol. 2017;313:G558-G569 pubmed publisher
    The liver metabolizes alcohol using alcohol dehydrogenase (ADH) and cytochrome P450 2E1 (CYP2E1)...
  32. Imaoka S, Terano Y, Funae Y. Changes in the amount of cytochrome P450s in rat hepatic microsomes with starvation. Arch Biochem Biophys. 1990;278:168-78 pubmed
    ..The spectral properties, catalytic activity, peptide map, and NH2-terminal sequence of P450 4b agreed with those of P450 K-5. P450 3b was a new cytochrome P450, judged by these criteria. ..
  33. Armoni M, Harel C, Ramdas M, Karnieli E. CYP2E1 impairs GLUT4 gene expression and function: NRF2 as a possible mediator. Horm Metab Res. 2014;46:477-83 pubmed publisher
    ..Cytochrome P450 isoform 2E1 (CYP2E1) induces oxidative stress, leading to impaired insulin action...
  34. Qi X, Miao L, Cai Y, Gong L, Ren J. ROS generated by CYP450, especially CYP2E1, mediate mitochondrial dysfunction induced by tetrandrine in rat hepatocytes. Acta Pharmacol Sin. 2013;34:1229-36 pubmed publisher
  35. Tindberg N, Bengtsson I, Hu Y. A novel lipopolysaccharide-modulated Jun binding repressor in intron 2 of CYP2E1. J Neurochem. 2004;89:1336-46 pubmed
    b>Cytochrome P450 2E1 (CYP2E1) exhibits a pronounced oxidase activity that may mediate apoptotic injury in glial cells as well as hepatocytes. Strict regulation of CYP2E1 and it's activity is therefore thought to be crucial...
  36. Lieber C, Cao Q, DeCarli L, Leo M, Mak K, Ponomarenko A, et al. Role of medium-chain triglycerides in the alcohol-mediated cytochrome P450 2E1 induction of mitochondria. Alcohol Clin Exp Res. 2007;31:1660-8 pubmed
    Chronic alcohol consumption is known to induce cytochrome P450 2E1 (CYP2E1) leading to lipid peroxidation, mitochondrial dysfunction and hepatotoxicity...
  37. Alcorn J, Elbarbry F, Allouh M, McNamara P. Evaluation of the assumptions of an ontogeny model of rat hepatic cytochrome P450 activity. Drug Metab Dispos. 2007;35:2225-31 pubmed
    ..We used two developmentally dissimilar enzymes, CYP2E1 and CYP1A2, and male rats (n = 4) at age groups representing critical developmental stages...
  38. Anzenbacherova E, Anzenbacher P, Zidek Z, Buchar E, Kmoníčková E, Potmesil P, et al. In vivo study of the effect of antiviral acyclic nucleotide phosphonate (R)-9-[2-(phosphonomethoxy)propyl]adenine (PMPA, tenofovir) and its prodrug tenofovir disoproxil fumarate on rat microsomal cytochrome P450. Physiol Res. 2008;57:761-7 pubmed
    ..This effect was confirmed by a parallel study of the activities of selected CYP forms, CYP2E1 (p-nitrophenol hydroxylation) and CYP1A2 (7-ethoxyresorufin deethylation)...
  39. Elbarbry F, McNamara P, Alcorn J. Ontogeny of hepatic CYP1A2 and CYP2E1 expression in rat. J Biochem Mol Toxicol. 2007;21:41-50 pubmed
    We report a comprehensive examination of rat hepatic CYP1A2 and CYP2E1 ontogeny...
  40. Shukla U, Tumma N, Gratsch T, Dombkowski A, Novak R. Insights into insulin-mediated regulation of CYP2E1: miR-132/-212 targeting of CYP2E1 and role of phosphatidylinositol 3-kinase, Akt (protein kinase B), mammalian target of rapamycin signaling in regulating miR-132/-212 and miR-122/-181a expression i. Drug Metab Dispos. 2013;41:1769-77 pubmed publisher
    ..selected for characterization of their response to insulin signaling based on in silico predictions of targeting CYP2E1 mRNA and previous reports implicating their role in hepatic metabolism and disease...
  41. Wauthier V, Schenten V, Verbeeck R, Calderon P. Ageing is associated with increased expression but decreased activity of CYP2E1 in male Wistar rats. Life Sci. 2006;79:1913-20 pubmed
    The effect of ageing on CYP2E1 activity and its protein and mRNA contents was investigated in both adult (9 months) and senescent (24 months) male Wistar rats...
  42. Helmig S, Döhrel J, Schneider J. Decreased Cyp2E1 mRNA expression in human leucocytes in patients with fibrotic and inflammatory lung diseases. Int J Mol Med. 2010;26:143-9 pubmed
    b>Cytochrome P450 2E1 (CYP2E1), a phase I enzyme, is involved in the activation of a broad spectrum of pro-carcinogens. The importance of this enzyme for pharmacology is derived from its unique substrate spectrum...
  43. Shayakhmetova G, Bondarenko L, Voronina A, Anisimova S, Matvienko A, Kovalenko V. Induction of CYP2E1 in testes of isoniazid-treated rats as possible cause of testicular disorders. Toxicol Lett. 2015;234:59-66 pubmed publisher
    ..the study was to identify in vivo influence of isoniazid on induction of testicular cytochrome Р-450 2Е1 (CYP2E1) mRNA expression and enzymatic activity, testes DNA fragmentation, serum total testosterone level, and ..
  44. Lee S, Chung L, Huang H, Chuang T, Liou Y, Wu L. NAT2 and CYP2E1 polymorphisms and susceptibility to first-line anti-tuberculosis drug-induced hepatitis. Int J Tuberc Lung Dis. 2010;14:622-6 pubmed
    ..To evaluate whether the polymorphisms of the cytochrome P450 2EI (CYP2E1) and N-acetyltransferase 2 (NAT2) gene are associated with ATDH...
  45. Hakkola J, Hu Y, Ingelman Sundberg M. Mechanisms of down-regulation of CYP2E1 expression by inflammatory cytokines in rat hepatoma cells. J Pharmacol Exp Ther. 2003;304:1048-54 pubmed
    b>CYP2E1 is one of the major cytochrome P450 forms whose expression is strongly inhibited by inflammatory cytokines in humans and rodents...
  46. Korhonen T, Turpeinen M, Tolonen A, Laine K, Pelkonen O. Identification of the human cytochrome P450 enzymes involved in the in vitro biotransformation of lynestrenol and norethindrone. J Steroid Biochem Mol Biol. 2008;110:56-66 pubmed publisher
    ..In conclusion, CYP2C9, CYP2C19 and CYP3A4 are the primary cytochromes in the bioactivation of lynestrenol in vitro, while CYP3A4 catalyses the further metabolism of norethindrone. ..
  47. Dávila Borja V, Belmont J, Espinosa J, Moreno Sanchez R, Albores A, Montero R. Induction of CYP1A1 and CYP2E1 in rat liver by histamine: binding and kinetic studies. Arch Toxicol. 2007;81:697-709 pubmed
    ..In the present work, it is shown that HA increases the activity and protein level of CYP1A1 and CYP2E1, in vivo...
  48. Caro A, Cederbaum A. Inhibition of CYP2E1 catalytic activity in vitro by S-adenosyl-L-methionine. Biochem Pharmacol. 2005;69:1081-93 pubmed
    ..SAH), 5'-Deoxy-5'-(methylthio)adenosine (MTA) and methionine with cytochrome P450 enzymes, in particular CYP2E1. SAM (but not SAH, MTA or methionine) produced a type II binding spectrum with liver microsomal cytochrome P450 ..
  49. Bi Y, Chen J, Li Y, Fu Q, Zeng T, Xie K. [The role of CYP2E1 in the protection of garlic oil's from n-hexane-induced neurotoxicity]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2011;29:825-33 pubmed
    To study the role of CYP2E1 in the protective effects and mechanism of garlic oil (GO) on the peripheral nerve injuries induced by n-hexane...
  50. Khemawoot P, Yokogawa K, Shimada T, Miyamoto K. Obesity-induced increase of CYP2E1 activity and its effect on disposition kinetics of chlorzoxazone in Zucker rats. Biochem Pharmacol. 2007;73:155-62 pubmed
    This study was designed to investigate the induction of CYP2E1 in obese Zucker rats and its effect on the disposition kinetics of chlorzoxazone (CZX)...
  51. Bansal S, Liu C, Sepuri N, Anandatheerthavarada H, Selvaraj V, Hoek J, et al. Mitochondria-targeted cytochrome P450 2E1 induces oxidative damage and augments alcohol-mediated oxidative stress. J Biol Chem. 2010;285:24609-19 pubmed publisher
    The ethanol-inducible cytochrome P450 2E1 (CYP2E1) is also induced under different pathological and physiological conditions...
  52. Nieto N, Friedman S, Cederbaum A. Cytochrome P450 2E1-derived reactive oxygen species mediate paracrine stimulation of collagen I protein synthesis by hepatic stellate cells. J Biol Chem. 2002;277:9853-64 pubmed
    ..a model was developed using co-cultures of HepG2 cells, which do (E47 cells) or do not (C34 cells) express cytochrome P450 2E1 (CYP2E1) with stellate cells...
  53. Bai J, Cederbaum A. Overexpression of CYP2E1 in mitochondria sensitizes HepG2 cells to the toxicity caused by depletion of glutathione. J Biol Chem. 2006;281:5128-36 pubmed
    Induction of CYP2E1 by ethanol is one mechanism by which ethanol causes oxidative stress and alcohol liver disease. Although CYP2E1 is predominantly found in the endoplasmic reticulum, it is also located in rat hepatic mitochondria...