Gene Symbol: Cyp26a1
Description: cytochrome P450, family 26, subfamily a, polypeptide 1
Alias: Cyp26, cytochrome P450, family 26, subfamily a, polypeptide 1, cytochrome P450, 26, retinoic acid, retinoic acid hydrolase, retinoic acid hydroxylase
Species: rat
Products:     Cyp26a1

Top Publications

  1. Xia H, Ma J, Sun J, Yang Y, Peng J. Retinoic acid metabolizing enzyme CYP26A1 is implicated in rat embryo implantation. Hum Reprod. 2010;25:2985-98 pubmed publisher
    The retinoic acid metabolizing enzyme Cyp26a1 plays a pivotal role in vertebrate embryo development...
  2. Sakai Y, Luo T, McCaffery P, Hamada H, DRAGER U. CYP26A1 and CYP26C1 cooperate in degrading retinoic acid within the equatorial retina during later eye development. Dev Biol. 2004;276:143-57 pubmed
    ..dorsal and ventral retina are separated by a horizontal RA-poor stripe that contains the RA-inactivating enzyme CYP26A1. To explore the developmental role of this arrangement, we studied formation of the retina and its projections in ..
  3. Fujii H, Sato T, Kaneko S, Gotoh O, Fujii Kuriyama Y, Osawa K, et al. Metabolic inactivation of retinoic acid by a novel P450 differentially expressed in developing mouse embryos. EMBO J. 1997;16:4163-73 pubmed
    ..These results suggest that P450RA regulates the intracellular level of RA and may be involved in setting up the uneven distribution of active RA in mammalian embryos. ..
  4. White J, Beckett Jones B, Guo Y, Dilworth F, Bonasoro J, Jones G, et al. cDNA cloning of human retinoic acid-metabolizing enzyme (hP450RAI) identifies a novel family of cytochromes P450. J Biol Chem. 1997;272:18538-41 pubmed
    ..retinoic acid-metabolizing cytochrome P450 (hP450RAI), which belongs to a novel class of cytochromes (CYP26)...
  5. Wang Y, Zolfaghari R, Ross A. Cloning of rat cytochrome P450RAI (CYP26) cDNA and regulation of its gene expression by all-trans-retinoic acid in vivo. Arch Biochem Biophys. 2002;401:235-43 pubmed
    A novel retinoic acid (RA)-inducible cytochrome P450 (P450 RAI or CYP26), previously cloned from human, zebra fish, and mouse, functions in the metabolism of all-trans-RA to polar metabolites including 4-hydroxy-RA and 4-oxo-RA...
  6. Foti R, Isoherranen N, Zelter A, Dickmann L, Buttrick B, Diaz P, et al. Identification of Tazarotenic Acid as the First Xenobiotic Substrate of Human Retinoic Acid Hydroxylase CYP26A1 and CYP26B1. J Pharmacol Exp Ther. 2016;357:281-92 pubmed publisher
    ..The objectives of this study were to use homology models of CYP26A1 and CYP26B1 to characterize substrate binding characteristics, to compare structural aspects of their active ..
  7. Emoto Y, Wada H, Okamoto H, Kudo A, Imai Y. Retinoic acid-metabolizing enzyme Cyp26a1 is essential for determining territories of hindbrain and spinal cord in zebrafish. Dev Biol. 2005;278:415-27 pubmed
    ..Here we characterize a mutant of the zebrafish named giraffe (gir) in which the gene for the RA-degrading enzyme Cyp26a1 is mutated...
  8. Napoli J. Physiological insights into all-trans-retinoic acid biosynthesis. Biochim Biophys Acta. 2012;1821:152-67 pubmed publisher
    ..This article is part of a Special Issue entitled: Retinoid and Lipid Metabolism. ..
  9. Niederreither K, Abu Abed S, Schuhbaur B, Petkovich M, Chambon P, Dolle P. Genetic evidence that oxidative derivatives of retinoic acid are not involved in retinoid signaling during mouse development. Nat Genet. 2002;31:84-8 pubmed
    ..The Cyp26a1 (cytochrome p450, 26) protein metabolizes retinoic acid into more polar hydroxylated and oxidized derivatives...

More Information


  1. Okano J, Sakai Y, Shiota K. Retinoic acid down-regulates Tbx1 expression and induces abnormal differentiation of tongue muscles in fetal mice. Dev Dyn. 2008;237:3059-70 pubmed publisher
    ..RA-degrading enzymes (Cyp26a1 and Cyp26b1) were expressed at early stages of normal tongue development, but exogenous RA perturbed their ..
  2. Uehara M, Yashiro K, Mamiya S, Nishino J, Chambon P, Dolle P, et al. CYP26A1 and CYP26C1 cooperatively regulate anterior-posterior patterning of the developing brain and the production of migratory cranial neural crest cells in the mouse. Dev Biol. 2007;302:399-411 pubmed
    ..Although both CYP26A1 and CYP26C1, retinoic acid-degrading enzymes that are expressed at the anterior end of the gastrulating mouse ..
  3. Wu L, Ross A. Acidic retinoids synergize with vitamin A to enhance retinol uptake and STRA6, LRAT, and CYP26B1 expression in neonatal lung. J Lipid Res. 2010;51:378-87 pubmed publisher
    ..However, the pronounced and prolonged induction of CYP26B1 by Am580 may counteract lung RE accumulation after the absorption process is completed. ..
  4. White J, Ramshaw H, Taimi M, Stangle W, Zhang A, Everingham S, et al. Identification of the human cytochrome P450, P450RAI-2, which is predominantly expressed in the adult cerebellum and is responsible for all-trans-retinoic acid metabolism. Proc Natl Acad Sci U S A. 2000;97:6403-8 pubmed
    ..The high level of expression of P450RAI-2, particularly in the cerebellum and pons of human adult brain, suggests a unique role for this enzyme in the protection of specific tissues from exposure to retinoids. ..
  5. Zolfaghari R, Cifelli C, Lieu S, Chen Q, Li N, Ross A. Lipopolysaccharide opposes the induction of CYP26A1 and CYP26B1 gene expression by retinoic acid in the rat liver in vivo. Am J Physiol Gastrointest Liver Physiol. 2007;292:G1029-36 pubmed
    ..We investigated the regulation of CYP26A1 and CYP26B1 mRNA levels by RA and LPS in the rat liver, as the liver is centrally involved in retinoid metabolism ..
  6. Zhang Y, Zolfaghari R, Ross A. Multiple retinoic acid response elements cooperate to enhance the inducibility of CYP26A1 gene expression in liver. Gene. 2010;464:32-43 pubmed publisher
    b>CYP26A1, which catalyzes the oxidation of all-trans (at)-retinoic acid (RA), is induced moderately by RA in numerous tissues, but is highly responsive in liver...
  7. Sonneveld E, van den Brink C, van der Leede B, Schulkes R, Petkovich M, van der Burg B, et al. Human retinoic acid (RA) 4-hydroxylase (CYP26) is highly specific for all-trans-RA and can be induced through RA receptors in human breast and colon carcinoma cells. Cell Growth Differ. 1998;9:629-37 pubmed
    ..Northern analysis showed that this novel human CYP26 is induced within 1 h upon RA treatment in RA-sensitive T-47D breast carcinoma cells but not in RA-resistant MDA-..
  8. Liu H, Chao H, Liu Z, Xia H, Song Z, Yang Y, et al. Regulation of cyp26a1 on Th17 cells in mouse peri-implantation. J Cell Mol Med. 2014;18:455-67 pubmed publisher
    Cytochrome P450 26A1 (cyp26a1) is expressed in the mouse uterus during peri-implantation...
  9. Abu Abed S, Beckett B, Chiba H, Chithalen J, Jones G, Metzger D, et al. Mouse P450RAI (CYP26) expression and retinoic acid-inducible retinoic acid metabolism in F9 cells are regulated by retinoic acid receptor gamma and retinoid X receptor alpha. J Biol Chem. 1998;273:2409-15 pubmed
    ..previously been isolated from zebrafish and human cDNAs and found to encode a retinoic acid-inducible retinoic acid hydroxylase activity...