Cyp1a2

Summary

Gene Symbol: Cyp1a2
Description: cytochrome P450, family 1, subfamily a, polypeptide 2
Alias: CYPD45, P-450d, RATCYPD45, cytochrome P450 1A2, CYPIA2, Cytochrome P450 subfamily I (aromatic compound-inducible) member A2 (Q42 form d), P-448, P450-D, cholesterol 25-hydroxylase, cytochrome P-448, cytochrome P-450d, cytochrome P450, 1a2, cytochrome P450, subfamily I (aromatic compound-inducible), member A2 (Q42, form d), cytochrome P450-D
Species: rat
Products:     Cyp1a2

Top Publications

  1. Plewka A, Zielińska Psuja B, Kowalówka Zawieja J, Nowaczyk Dura G, Plewka D, Wiaderkiewicz A, et al. Influence of acetaminophen and trichloroethylene on liver cytochrome P450-dependent monooxygenase system. Acta Biochim Pol. 2000;47:1129-36 pubmed
    ..APAP) and/or trichloroethylene (TRI) on the liver cytochrome P450-dependent monooxygenase system, CYP2E1 and CYP1A2 (two important P450 isoforms), and liver glutathione (GSH) content in rats...
  2. Dragin N, Dalton T, Miller M, Shertzer H, Nebert D. For dioxin-induced birth defects, mouse or human CYP1A2 in maternal liver protects whereas mouse CYP1A1 and CYP1B1 are inconsequential. J Biol Chem. 2006;281:18591-600 pubmed
    ..The Cyp1a1, Cyp1a2, and Cyp1b1 genes are up-regulated by the aryl hydrocarbon receptor...
  3. Shertzer H, Clay C, Genter M, Schneider S, Nebert D, Dalton T. Cyp1a2 protects against reactive oxygen production in mouse liver microsomes. Free Radic Biol Med. 2004;36:605-17 pubmed
    H(2)O(2) production was evaluated in liver microsomes prepared from Cyp1a1/1a2(+/+) wild-type and Cyp1a1(-/-) and Cyp1a2(-/-) knockout mice pretreated with 5 microg dioxin (TCDD)/kg body wt or vehicle alone...
  4. Darwish W, Ikenaka Y, Nakayama S, Ishizuka M. The effect of copper on the mRNA expression profile of xenobiotic-metabolizing enzymes in cultured rat H4-II-E cells. Biol Trace Elem Res. 2014;158:243-8 pubmed publisher
    ..mRNA expressions of phase I enzymes such as cytochrome P450 1A1 and 1A2 (CYP1A1 and CYP1A2) were slightly induced after exposure to low concentrations of Cu(2+); however, CYP1A1 and CYP1A2 mRNA expressions ..
  5. Liang H, Li H, McKinnon R, Duffy J, Potter S, Puga A, et al. Cyp1a2(-/-) null mutant mice develop normally but show deficient drug metabolism. Proc Natl Acad Sci U S A. 1996;93:1671-6 pubmed
    b>Cytochrome P450 1A2 (CYP1A2) is a predominantly hepatic enzyme known to be important in the metabolism of numerous foreign chemicals of pharmacologic, toxicologic, and carcinogenic significance...
  6. Jeong S, Nguyen P, Desta Z. Comprehensive in vitro analysis of voriconazole inhibition of eight cytochrome P450 (CYP) enzymes: major effect on CYPs 2B6, 2C9, 2C19, and 3A. Antimicrob Agents Chemother. 2009;53:541-51 pubmed publisher
    ..of CYP2B6, CYP2C9, CYP2C19, and CYP3A (half-maximal [50%] inhibitory concentrations, <6 microM); its effect on CYP1A2, CYP2A6, CYP2C8, and CYP2D6 was marginal (<25% inhibition at 100 microM voriconazole)...
  7. Wickliffe J, Abdel Rahman S, Lee C, Kormos Hallberg C, Sood G, Rondelli C, et al. CYP1A2*1F and GSTM1 alleles are associated with susceptibility to porphyria cutanea tarda. Mol Med. 2011;17:241-7 pubmed publisher
    ..are involved in the development of PCT, and genetic variants in the cytochrome P450 (CYP ) genes, CYP1A1 and CYP1A2, have been implicated...
  8. Ward B, Morocho A, Kandil A, Galinsky R, Flockhart D, Desta Z. Characterization of human cytochrome P450 enzymes catalyzing domperidone N-dealkylation and hydroxylation in vitro. Br J Clin Pharmacol. 2004;58:277-87 pubmed
    ..b>CYP1A2, 2B6, 2C8 and 2D6 also hydroxylated domperidone CYP3A-catalyzed N-dealkylation and aromatic hydroxylation are the ..
  9. Zhou M, Maitra S, Wang P. The potential role of transcription factor aryl hydrocarbon receptor in downregulation of hepatic cytochrome P-450 during sepsis. Int J Mol Med. 2008;21:423-8 pubmed
    ..However, the mechanism responsible for the decreased CYP1A2 remains unknown...

More Information

Publications62

  1. Pineau T, Fernandez Salguero P, Lee S, McPhail T, Ward J, Gonzalez F. Neonatal lethality associated with respiratory distress in mice lacking cytochrome P450 1A2. Proc Natl Acad Sci U S A. 1995;92:5134-8 pubmed
    b>Cytochrome P450 1A2 (CYP1A2) is a constitutively expressed hepatic enzyme that is highly conserved among mammals...
  2. Haniu M, Ryan D, Levin W, Shively J. The primary structure of cytochrome P-450d purified from rat liver microsomes: prediction of helical regions and domain analysis. Arch Biochem Biophys. 1986;244:323-37 pubmed
  3. Wang R, Sun Y, Yin Q, Xie H, Li W, Wang C, et al. The effects of metronidazole on Cytochrome P450 Activity and Expression in rats after acute exposure to high altitude of 4300m. Biomed Pharmacother. 2017;85:296-302 pubmed publisher
    ..The enzymatic activity of CYP1A2 and 3A1 as well as the total protein, total CYP450, cytochrome b5 and the protein expression of CYP450 isoforms ..
  4. Ronquillo Sánchez M, Camacho Carranza R, Fernandez Mejia C, Hernández Ojeda S, Elinos Baez M, Espinosa Aguirre J. Modulation of the rat hepatic cytochrome P4501A subfamily using biotin supplementation. Biomed Res Int. 2013;2013:627907 pubmed publisher
    ..All of the rats were sacrificed by cervical dislocation after 1, 3, 5, or 7 days of treatment. CYP1A1 and CYP1A2 mRNAs were modified by biotin while enzyme activity and protein concentration were not affected...
  5. Shimada T, Mernaugh R, Guengerich F. Interactions of mammalian cytochrome P450, NADPH-cytochrome P450 reductase, and cytochrome b(5) enzymes. Arch Biochem Biophys. 2005;435:207-16 pubmed
  6. Harkitis P, Daskalopoulos E, Malliou F, Lang M, Marselos M, Fotopoulos A, et al. Dopamine D2-Receptor Antagonists Down-Regulate CYP1A1/2 and CYP1B1 in the Rat Liver. PLoS ONE. 2015;10:e0128708 pubmed publisher
    ..The present study investigated the role of dopamine D2-receptor-linked pathways in the regulation of CYP1A1, CYP1A2 and CYP1B1 that belong to a battery of genes controlled by the Aryl Hydrocarbon Receptor (AhR) and play a crucial ..
  7. Kim Y, Rajagopalan P. 3D hepatic cultures simultaneously maintain primary hepatocyte and liver sinusoidal endothelial cell phenotypes. PLoS ONE. 2010;5:e15456 pubmed publisher
  8. Tang J, Zhou X, Ji H, Zhu D, Wu L. Effects of ephedra water decoction and cough tablets containing ephedra and liquorice on CYP1A2 and the pharmacokinetics of theophylline in rats. Phytother Res. 2012;26:470-4 pubmed publisher
    ..So in the present study the potential effects of EWD and MXCT on CYP1A2 activity and the pharmacokinetics of theophylline in rats were evaluated...
  9. Cheng K, Park S, Krutzsch H, Grantham P, Gelboin H, Friedman F. Amino-terminal sequence and structure of monoclonal antibody immunopurified cytochromes P-450. Biochemistry. 1986;25:2397-402 pubmed
    ..This report shows the varying degree of structural relatedness among the isozymes examined and demonstrates the suitability and advantage of immunopurified cytochromes P-450 for sequencing and structural studies. ..
  10. Johnson T, Tanner M, Tucker G. Developmental changes in the expression of enterocytic and hepatic cytochromes P4501A in rat. Xenobiotica. 2002;32:595-604 pubmed
    ..4. Hepatic CYP1A (mostly CYP1A2) increased sharply just before weaning...
  11. Konstandi M, Lang M, Kostakis D, Johnson E, Marselos M. Predominant role of peripheral catecholamines in the stress-induced modulation of CYP1A2 inducibility by benzo(alpha)pyrene. Basic Clin Pharmacol Toxicol. 2008;102:35-44 pubmed
    ..For this purpose, total cytochrome P450 content, the CYP1A2 mRNA levels, 7-methoxyresorufin-O-dealkylase (MROD), 7-pentoxyresorufin-O-dealkylase (PROD) and p-nitrophenol ..
  12. Moorthy B, Muthiah K, Fazili I, Kondraganti S, Wang L, Couroucli X, et al. 3-Methylcholanthrene elicits DNA adduct formation in the CYP1A1 promoter region and attenuates reporter gene expression in rat H4IIE cells. Biochem Biophys Res Commun. 2007;354:1071-7 pubmed
    ..Here, we tested the hypothesis that CYP1A2 catalyzes formation of MC-DNA adducts that are preferentially formed in the promoter region of CYP1A1, resulting ..
  13. Kitamura R, Matsuoka K, Nagayama S, Otagiri M. Time-dependent induction of rat hepatic CYP1A1 and CYP1A2 expression after single-dose administration of the anti-angiogenic agent TSU-68. Drug Metab Pharmacokinet. 2008;23:421-7 pubmed
    ..In this study, we identified CYP1A1 and CYP1A2 as the TSU-68-induced P450 and temporally characterized the rapid induction of these isoforms...
  14. Lee W, Zhou X, Or P, Kwan Y, Yeung J. Tanshinone I increases CYP1A2 protein expression and enzyme activity in primary rat hepatocytes. Phytomedicine. 2012;19:169-76 pubmed publisher
    ..investigated the effects of Danshen and its active ingredients on the protein expression and enzymatic activity of CYP1A2 in primary rat hepatocytes...
  15. Chung H, Kang H, Bae E, Lee I, Kim S, Lee M. Effects of E. Coli lipopolysaccharide on the pharmacokinetics of ipriflavone and its metabolites, M1 and M5, after intravenous and oral administration of ipriflavone to rats: decreased metabolism of ipriflavone due to decreased expression of hepatic . J Pharm Sci. 2008;97:5024-36 pubmed publisher
    ..In the present study, the expression of CYP1A2 and 2C11 decreased in the liver, but increased in the intestine in rats pretreated with E...
  16. Lautraite S, Musonda A, Doehmer J, Edwards G, Chipman J. Flavonoids inhibit genetic toxicity produced by carcinogens in cells expressing CYP1A2 and CYP1A1. Mutagenesis. 2002;17:45-53 pubmed
    ..Neither IQ nor BaP produced DNA damage in the absence of expressed CYP1A2 or CYP1A1, respectively...
  17. Ma J, Wang J, Cheng J, Xiao W, Fan K, Gu J, et al. Impacts of Blast-Induced Traumatic Brain Injury on Expressions of Hepatic Cytochrome P450 1A2, 2B1, 2D1, and 3A2 in Rats. Cell Mol Neurobiol. 2017;37:111-120 pubmed publisher
    ..Therefore, in this study, we investigated the expressions of hepatic CYP1A2, CYP2B1, CYP2D1, and CYP3A2 in rats suffering bTBI...
  18. Wang Y, Wu S, Chen Z, Zhang H, Zhao W. Inhibitory effects of cytochrome P450 enzymes CYP1A2, CYP2A6, CYP2E1 and CYP3A4 by extracts and alkaloids of Gelsemium elegans roots. J Ethnopharmacol. 2015;166:66-73 pubmed publisher
    ..elegans (GE) roots on four major cytochrome P450 (CYP450) isoforms (CYP1A2, CYP2A6, CYP2E1 and CYP3A4) in vitro...
  19. Kot M, Daniel W. The relative contribution of human cytochrome P450 isoforms to the four caffeine oxidation pathways: an in vitro comparative study with cDNA-expressed P450s including CYP2C isoforms. Biochem Pharmacol. 2008;76:543-51 pubmed publisher
    ..The obtained results show that (1) apart from the 3-N-demethylation of caffeine - a CYP1A2 marker reaction and the main oxidation pathway of caffeine in man - 1-N-demethylation is also specifically ..
  20. Higuchi S, Wu R, Zhou M, Ravikumar T, Wang P. Downregulation of hepatic cytochrome P-450 isoforms and PPAR-gamma: their role in hepatic injury and proinflammatory responses in a double-hit model of hemorrhage and sepsis. J Surg Res. 2007;137:46-52 pubmed
    ..Although the protein expression of a cytochrome (CYP) P-450 isoform CYP1A2 is reduced in the late stage of sepsis, the effect of hemorrhage on CYP isoforms and the anti-inflammatory nuclear ..
  21. Lee S, Lee S. Suppression of hepatic cytochrome p450-mediated drug metabolism during the late stage of sepsis in rats. Shock. 2005;23:144-9 pubmed
    ..The CYP1A1 activity and its protein level decreased 24 h after CLP. The CYP1A2 activity decreased 2 h and 24 h after CLP...
  22. Liu R, Qin M, Hang P, Liu Y, Zhang Z, Liu G. Effects of Panax notoginseng saponins on the activities of CYP1A2, CYP2C9, CYP2D6 and CYP3A4 in rats in vivo. Phytother Res. 2012;26:1113-8 pubmed publisher
    ..The activities of CYP1A2, 2?C9, 2D6 and 3A4 were measured using specific probe drugs...
  23. Stiborova M, Mares J, Levová K, Pavlickova J, Bárta F, Hodek P, et al. Role of cytochromes P450 in metabolism of carcinogenic aristolochic acid I: evidence of their contribution to aristolochic acid I detoxication and activation in rat liver. Neuro Endocrinol Lett. 2011;32 Suppl 1:121-30 pubmed
  24. Tsyrlov I, Goldfarb I, Gelboin H. Enzyme-kinetic and immunochemical characteristics of mouse cDNA-expressed, microsomal, and purified CYP1A1 and CYP1A2. Arch Biochem Biophys. 1993;307:259-66 pubmed
    ..were estimated in microsomes of Hep G2 cells infected with a recombinant vaccinia virus bearing mouse CYP1A1 or CYP1A2 cDNAs...
  25. Botelho L, Ryan D, Yuan P, Kutny R, Shively J, Levin W. Amino-terminal and carboxy-terminal sequence of hepatic microsomal cytochrome P-450d, a unique hemoprotein from rats treated with isosafrole. Biochemistry. 1982;21:1152-5 pubmed
  26. Butler M, Iwasaki M, Guengerich F, Kadlubar F. Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines. Proc Natl Acad Sci U S A. 1989;86:7696-700 pubmed
  27. Kotsovolou O, Ingelman Sundberg M, Lang M, Marselos M, Overstreet D, Papadopoulou Daifoti Z, et al. Hepatic drug metabolizing profile of Flinders Sensitive Line rat model of depression. Prog Neuropsychopharmacol Biol Psychiatry. 2010;34:1075-84 pubmed publisher
    ..Interestingly, the wide spread environmental pollutant benzo(alpha)pyrene (B(alpha)P) induced CYP1A1, CYP1A2, CYP2B1/2 and ALDH3c at a lesser extend in FSL than in SD rats, whereas the antidepressant mirtazapine (MIRT) up-..
  28. Laine J, Auriola S, Pasanen M, Juvonen R. Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes. Xenobiotica. 2009;39:11-21 pubmed
    ..at two concentrations: 50 microM therapeutic and 1 mM toxic by using nine human recombinant CYP enzymes: CYP1A1, CYP1A2, CYP2A6, CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP2E1, and CYP3A4; and with different microsomes from experimental ..
  29. Sogawa K, Gotoh O, Kawajiri K, Harada T, Fujii Kuriyama Y. Complete nucleotide sequence of a methylcholanthrene-inducible cytochrome P-450 (P-450d) gene in the rat. J Biol Chem. 1985;260:5026-32 pubmed
    ..Middle repetitive sequence reported as ID or identifier sequence were found in and in the vicinity of the cytochrome P-450d gene. ..
  30. Korhonen T, Turpeinen M, Tolonen A, Laine K, Pelkonen O. Identification of the human cytochrome P450 enzymes involved in the in vitro biotransformation of lynestrenol and norethindrone. J Steroid Biochem Mol Biol. 2008;110:56-66 pubmed publisher
    ..In conclusion, CYP2C9, CYP2C19 and CYP3A4 are the primary cytochromes in the bioactivation of lynestrenol in vitro, while CYP3A4 catalyses the further metabolism of norethindrone. ..
  31. Wu R, Cui X, Dong W, Zhou M, Simms H, Wang P. Suppression of hepatocyte CYP1A2 expression by Kupffer cells via AhR pathway: the central role of proinflammatory cytokines. Int J Mol Med. 2006;18:339-46 pubmed
    ..Although we have recently shown that CYP1A2, one of the major isoforms of CYP in rats, is downregulated in sepsis, the underlying mechanism and possible ..
  32. Xu M, Tang H, Rong Q, Zhang Y, Li Y, Zhao L, et al. The Effects of Formaldehyde on Cytochrome P450 Isoform Activity in Rats. Biomed Res Int. 2017;2017:6525474 pubmed publisher
    ..The effects of acute FA poisoning on the activities of CYP450 isoforms CYP1A2, CYP2C11, CYP2E1, and CYP3A2 were assessed by determining changes in the pharmacokinetic parameters of the probe ..
  33. Diliberto J, Burgin D, Birnbaum L. Role of CYP1A2 in hepatic sequestration of dioxin: studies using CYP1A2 knock-out mice. Biochem Biophys Res Commun. 1997;236:431-3 pubmed
    ..Transgenic mice lacking a cytochrome P450 1A2 gene were used to study the influence of the CYP1A2 gene on the hepatic sequestration and distribution of ..
  34. Singhal R, Badger T, Ronis M. Estrogenic status modulates the effect of soy on hepatic responses to 7,12-dimethylbenz(a)anthracene (DMBA). Toxicol Appl Pharmacol. 2009;234:89-97 pubmed publisher
    ..AhR-activated genes (CYP1A1, CYP1A2, and NQO1) were down-regulated by SPI+E2+DMBA compared to SPI+DMBA...
  35. Sinclair P, Gorman N, Dalton T, Walton H, Bement W, Sinclair J, et al. Uroporphyria produced in mice by iron and 5-aminolaevulinic acid does not occur in Cyp1a2(-/-) null mutant mice. Biochem J. 1998;330 ( Pt 1):149-53 pubmed
    In the present study we have investigated the putative requirement for the cytochrome P-450 isoform CYP1A2 in murine uroporphyria, by comparing Cyp1a2(-/-) knockout mice with Cyp1a2(+/+) wild-type mice...
  36. Shepel L, Lan H, Haag J, Brasic G, Gheen M, Simon J, et al. Genetic identification of multiple loci that control breast cancer susceptibility in the rat. Genetics. 1998;149:289-99 pubmed
    ..The isolation of the Mcs genes may help elucidate novel mechanisms of carcinogenesis, provide information important for human breast cancer risk estimation, and also provide unique drug discovery targets for breast cancer prevention. ..
  37. Kondraganti S, Jiang W, Moorthy B. Differential regulation of expression of hepatic and pulmonary cytochrome P4501A enzymes by 3-methylcholanthrene in mice lacking the CYP1A2 gene. J Pharmacol Exp Ther. 2002;303:945-51 pubmed
    ..In this study, we tested the hypothesis that CYP1A2, a liver-specific P450 isozyme, plays an important role in the mechanisms governing persistent CYP1A1 induction by ..
  38. Gulyaeva L, Mikhailova O, PustyInyak V, Kim I, Gerasimov A, Krasilnikov S, et al. Comparative analysis of SNP in estrogen-metabolizing enzymes for ovarian, endometrial, and breast cancers in Novosibirsk, Russia. Adv Exp Med Biol. 2008;617:359-66 pubmed publisher
    We estimated the frequency of CYP1A1, CYP1A2, CYP1B1, CYP19, and SULT1A1 allelic variants in a female population of the Novosibirsk district and their association with the elevated risk of breast (BC), ovarian (OC), and endometrial (EC) ..
  39. Borodin Y, Maiborodin I, Safina A, Strunkin D. The possibility of cytochrome P450 1A1/1A2 induction in cells of distant lymph nodes of rats after enteral treatment with benzo[a]pyrene. Bull Exp Biol Med. 2005;140:564-7 pubmed
    ..The results indicate that exo- and endogenous toxic substances are oxidized not only in the liver, but also in lymph nodes. ..
  40. Hussain T, Al Attas O, Al Daghri N, Mohammed A, De Rosas E, Ibrahim S, et al. Induction of CYP1A1, CYP1A2, CYP1B1, increased oxidative stress and inflammation in the lung and liver tissues of rats exposed to incense smoke. Mol Cell Biochem. 2014;391:127-36 pubmed publisher
    ..Incense smoke exposure significantly induced the expression of CYP1A1, CYP1A2, and CYP1B1 mRNAs in both lung and liver tissues...
  41. Abu Bakar A, Moore M, Lang M. Evidence for induced microsomal bilirubin degradation by cytochrome P450 2A5. Biochem Pharmacol. 2005;70:1527-35 pubmed
    ..By contrast, the total cytochrome P450 (CYP) content and the expression of Cyp1a2 were down-regulated by the treatment...
  42. Walker A, Dickmann L, Isoherranen N. Pregnancy decreases rat CYP1A2 activity and expression. Drug Metab Dispos. 2011;39:4-7 pubmed publisher
    Pregnancy results in increased CYP3A- and CYP2D6-mediated clearance but decreases the clearance of CYP1A2 probe drugs...
  43. Westerink W, Stevenson J, Schoonen W. Pharmacologic profiling of human and rat cytochrome P450 1A1 and 1A2 induction and competition. Arch Toxicol. 2008;82:909-21 pubmed publisher
    ..Competition was human and rat specific for 12 and 10 compounds, respectively. CYP1A2 competition was observed for 37 compounds of which 14 and 3 compounds showed human and rat specific inhibition, ..
  44. Michaud J, Nolin T, Naud J, Dani M, Lafrance J, Leblond F, et al. Effect of hemodialysis on hepatic cytochrome P450 functional expression. J Pharmacol Sci. 2008;108:157-63 pubmed
    ..e., obtained immediately post-hemodialysis) had no effect. CYP1A2, 2C11, and 3A2 mRNA expression, as well as CYP3A activity, were similarly impacted by uremic serum and were ..
  45. Shertzer H, Genter M, Talaska G, Curran C, Nebert D, Dalton T. 7H-dibenzo[c,g]carbazole metabolism by the mouse and human CYP1 family of enzymes. Carcinogenesis. 2007;28:1371-8 pubmed
    ..Using knockout mice for Cyp1a1, Cyp1a2 and Cyp1b1, we showed that the major CYP1 enzymes that metabolize DBC are CYP1A1 in beta-naphthoflavone (BNF)-..
  46. Sansen S, Yano J, Reynald R, Schoch G, Griffin K, Stout C, et al. Adaptations for the oxidation of polycyclic aromatic hydrocarbons exhibited by the structure of human P450 1A2. J Biol Chem. 2007;282:14348-55 pubmed
    ..This report provides the first structure of a microsomal P450 from family 1 and offers a template to study further structure-function relationships of alternative substrates and other cytochrome P450 family 1 members. ..
  47. Zaccaro C, Sweitzer S, Pipino S, Gorman N, Sinclair P, Sinclair J, et al. Role of cytochrome P450 1A2 in bilirubin degradation Studies in Cyp1a2 (-/-) mutant mice. Biochem Pharmacol. 2001;61:843-9 pubmed
    ..CYP1A1 to CYP1A2 ratios were greater in rats treated with BNF...
  48. Dewa Y, Nishimura J, Muguruma M, Jin M, Kawai M, Saegusa Y, et al. Involvement of oxidative stress in hepatocellular tumor-promoting activity of oxfendazole in rats. Arch Toxicol. 2009;83:503-11 pubmed publisher
    ..real-time RT-PCR analysis revealed that OX induced not only mRNA expression of phase I enzymes Cyp1a1, Cyp1a2, but also Nrf2-regulated phase II enzymes such as Gpx2, Nqo1, Yc2, Akr7a3 and Gstm1, presumably due to an adaptive ..
  49. Pan J, Xiang Q, Renwick A, Price R, Ball S, Kao J, et al. Use of a quantitative real-time reverse transcription-polymerase chain reaction method to study the induction of CYP1A, CYP2B and CYP4A forms in precision-cut rat liver slices. Xenobiotica. 2002;32:739-47 pubmed
    ..2. Taqman primers and probe sets were developed for rat CYP1A1, CYP1A2, CYP2B1 and CYP4A1 forms. 3...
  50. Fisher C, Lickteig A, Augustine L, Ranger Moore J, Jackson J, Ferguson S, et al. Hepatic cytochrome P450 enzyme alterations in humans with progressive stages of nonalcoholic fatty liver disease. Drug Metab Dispos. 2009;37:2087-94 pubmed publisher
    ..Microsomal CYP1A2, CYP2D6, and CYP2E1 mRNA levels were decreased with NAFLD progression, whereas CYP2A6, CYP2B6, and CYP2C9 mRNA ..
  51. Fukushima S, Okuno H, Shibatani N, Nakahashi Y, Seki T, Okazaki K. Effect of biliary obstruction and internal biliary drainage on hepatic cytochrome P450 isozymes in rats. World J Gastroenterol. 2008;14:2556-60 pubmed
    ..A marked reduction in the expression of CYP1A2, 2B1/2, 2C11, 2E1, 3A1, and 3A2 mRNA was detected during biliary obstruction, while expression increased ..
  52. Yabusaki Y, Murakami H, Nakamura K, Nomura N, Shimizu M, Oeda K, et al. Characterization of complementary DNA clones coding for two forms of 3-methylcholanthrene-inducible rat liver cytochrome P-450. J Biochem. 1984;96:793-804 pubmed
    ..Two highly homologous regions were found in the amino acid sequences of these cytochrome P-450 species. ..
  53. Fagan J, Pastewka J, Chalberg S, Gozukara E, Guengerich F, Gelboin H. Noncoordinate regulation of the mRNAs encoding cytochromes P-450BNF/MC-B and P-450ISF/BNF-G. Arch Biochem Biophys. 1986;244:261-72 pubmed
    ..abstract truncated at 400 words) ..