Gene Symbol: Cyp1a1
Description: cytochrome P450, family 1, subfamily a, polypeptide 1
Alias: AHH, AHRR, CP11, CYP1, Cyp45c, Cypc45c, P-450MC, P1-450, P450-C, P450DX, cytochrome P450 1A1, CYPIA1, P450MT2, P450form6, aryl hydrocarbon hydroxylase, cytochrome P1-450, cytochrome P450 subfamily I (aromatic compound-inducible) member A1 (C6 form c) (C6 form c), cytochrome P450, 1a1, cytochrome P450, subfamily I (aromatic compound-inducible), member A1 (C6, form c) (C6, form c), cytochrome P450-C, cytochrome P450MT2, dioxin-inducible, flavoprotein-linked monooxygenase, microsomal monooxygenase, xenobiotic monooxygenase
Species: rat
Products:     Cyp1a1

Top Publications

  1. Lee W, Lee S. Differential regulation of cytochrome P450 isozyme mRNAs and proteins by femur fracture trauma. Arch Pharm Res. 2003;26:1079-86 pubmed
    ..FFx increased the mRNA level of CYP1A1; an increase that was not prevented by GdCl3...
  2. Yabusaki Y, Shimizu M, Murakami H, Nakamura K, Oeda K, Ohkawa H. Nucleotide sequence of a full-length cDNA coding for 3-methylcholanthrene-induced rat liver cytochrome P-450MC. Nucleic Acids Res. 1984;12:2929-38 pubmed
    ..The predicted molecular weight of the apoprotein was 59,300 daltons. Therefore, we concluded that the amino acid sequence determined here is for cytochrome P-450MC, probably corresponding to cytochrome P-450c. ..
  3. Nicholson T, Dibb S, Renton K. Nitric oxide mediates an LPS-induced depression of cytochrome P450 (CYP1A) activity in astrocytes. Brain Res. 2004;1029:148-54 pubmed
    ..Taken together, these observations suggest that NO plays a pivotal role in the inflammation mediated loss in CYP1A activity in the brain. ..
  4. Moorthy B, Muthiah K, Fazili I, Kondraganti S, Wang L, Couroucli X, et al. 3-Methylcholanthrene elicits DNA adduct formation in the CYP1A1 promoter region and attenuates reporter gene expression in rat H4IIE cells. Biochem Biophys Res Commun. 2007;354:1071-7 pubmed
    ..that CYP1A2 catalyzes formation of MC-DNA adducts that are preferentially formed in the promoter region of CYP1A1, resulting in modulation of CYP1A1 gene expression...
  5. Floreani M, Gabbia D, Barbierato M, De Martin S, Palatini P. Differential inducing effect of benzo[a]pyrene on gene expression and enzyme activity of cytochromes P450 1A1 and 1A2 in Sprague-Dawley and Wistar rats. Drug Metab Pharmacokinet. 2012;27:640-52 pubmed a specific CYP1A2 substrate in both uninduced and BaP-treated rats, whereas ethoxyresorufin is a specific CYP1A1 substrate only in BaP-treated rats...
  6. Xue X, Xiao Y, Zhu H, Wang H, Liu Y, Xie T, et al. Induction of P450 1A by 3-methylcholanthrene protects mice from aristolochic acid-I-induced acute renal injury. Nephrol Dial Transplant. 2008;23:3074-81 pubmed publisher
    ..This study was designed to investigate whether P450 1A plays a role in AAI-induced renal injury in C57BL/6 mice...
  7. Huang D, Ohnishi T, Jiang H, Furukawa A, Ichikawa Y. Inhibition by retinoids of benzo(A)pyrene metabolism catalyzed by 3-methylcholanthrene-induced rat cytochrome P-450 1A1. Metabolism. 1999;48:689-92 pubmed
  8. Zhao L, Huang M, Chen J, Ee P, Chan E, Duan W, et al. Induction of propranolol metabolism by Ginkgo biloba extract EGb 761 in rats. Curr Drug Metab. 2006;7:577-87 pubmed
    ..b>CYP1A1, 1A2, 2B1/2, and 3A1 activities and gene expression in the rat liver were significantly increased in a dose-..
  9. Raza H, Ahmed I, Lakhani M, Sharma A, Pallot D, Montague W. Effect of bitter melon (Momordica charantia) fruit juice on the hepatic cytochrome P450-dependent monooxygenases and glutathione S-transferases in streptozotocin-induced diabetic rats. Biochem Pharmacol. 1996;52:1639-42 pubmed
    ..The expression of CYP1A1, 2B1, 2E1, 3A4, and 4A2 in diabetes, while a decrease in GST mu was observed...

More Information


  1. Shepel L, Lan H, Haag J, Brasic G, Gheen M, Simon J, et al. Genetic identification of multiple loci that control breast cancer susceptibility in the rat. Genetics. 1998;149:289-99 pubmed
    ..The isolation of the Mcs genes may help elucidate novel mechanisms of carcinogenesis, provide information important for human breast cancer risk estimation, and also provide unique drug discovery targets for breast cancer prevention. ..
  2. Pannozzo M, Holland P, Scullion G, Talbot R, Mullins J, Horsburgh K. Controlled hypertension induces cerebrovascular and gene alterations in Cyp1a1-Ren2 transgenic rats. J Am Soc Hypertens. 2013;7:411-9 pubmed publisher
    ..durations (4 or 6 months) of controlled hypertension in an inducible transgenic rat model of hypertension (Cyp1a1-Ren2) as compared with normotensive litter mate controls...
  3. Leite J, Bufalo N, Santos R, Romaldini J, Ward L. Herpesvirus type 7 infection may play an important role in individuals with a genetic profile of susceptibility to Graves' disease. Eur J Endocrinol. 2010;162:315-21 pubmed publisher
    ..120-5.527; P<0.001) and cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1) variants (OR=1.649; 95% CI=1.012-2.686; P=0.0445) as significant risk factors for the disease...
  4. Hussain T, Al Attas O, Al Daghri N, Mohammed A, De Rosas E, Ibrahim S, et al. Induction of CYP1A1, CYP1A2, CYP1B1, increased oxidative stress and inflammation in the lung and liver tissues of rats exposed to incense smoke. Mol Cell Biochem. 2014;391:127-36 pubmed publisher
    ..Incense smoke exposure significantly induced the expression of CYP1A1, CYP1A2, and CYP1B1 mRNAs in both lung and liver tissues...
  5. Sterling K, Cutroneo K. Differentiation-dependent induction of CYP1A1 in cultured rat small intestinal epithelial cells, colonocytes, and human colon carcinoma cells: basement membrane-mediated apoptosis. J Cell Biochem. 2002;86:440-50 pubmed
    ..2,3,7,8-tetrachlorodibenzo-p-dioxin treatment caused a 14-fold induction of transfected, rat CYP1A1-promoter-luciferase activity in rat small intestinal epithelial cells cultured on Matrigel...
  6. Wang G, Hou J, Ma L, Xie J, Yin J, Xu D, et al. Risk factor for clear cell renal cell carcinoma in Chinese population: a case-control study. Cancer Epidemiol. 2012;36:177-82 pubmed publisher
    ..Genetic polymorphisms of cytochrome P450 mono-oxygenase (CYP1A1: 6235T>C, 4889A>G, and 4887C>A), glutathione S-transferase (GSTP1: 342A>G), and N-acetyltransferase (..
  7. Ansari M, Maayah Z, Bakheet S, El Kadi A, Korashy H. The role of aryl hydrocarbon receptor signaling pathway in cardiotoxicity of acute lead intoxication in vivo and in vitro rat model. Toxicology. 2013;306:40-9 pubmed publisher
    ..the molecular mechanisms and the role of aryl hydrocarbon receptor (AhR) and regulated gene, cytochrome P4501A1 (CYP1A1), in Pb(2+)-mediated cardiotoxicity...
  8. Pan J, Xiang Q, Renwick A, Price R, Ball S, Kao J, et al. Use of a quantitative real-time reverse transcription-polymerase chain reaction method to study the induction of CYP1A, CYP2B and CYP4A forms in precision-cut rat liver slices. Xenobiotica. 2002;32:739-47 pubmed
    ..2. Taqman primers and probe sets were developed for rat CYP1A1, CYP1A2, CYP2B1 and CYP4A1 forms. 3...
  9. Couroucli X, Liang Y, Jiang W, Wang L, Barrios R, Yang P, et al. Prenatal administration of the cytochrome P4501A inducer, ?-naphthoflavone (BNF), attenuates hyperoxic lung injury in newborn mice: implications for bronchopulmonary dysplasia (BPD) in premature infants. Toxicol Appl Pharmacol. 2011;256:83-94 pubmed publisher
    ..These mice displayed marked induction of ethoxyresorufin O-deethylase (EROD) (CYP1A1) and methoxyresorufin O-demethylase (MROD) (CYP1A2) activities, and levels of the corresponding apoproteins and ..
  10. Richter Hintz D, Their R, Steinwachs S, Kronenberg S, Fritsche E, Sachs B, et al. Allelic variants of drug metabolizing enzymes as risk factors in psoriasis. J Invest Dermatol. 2003;120:765-70 pubmed
    ..Significantly more carriers of the variant alleles of CYP1A1 (alleles *2A and *2C) were found in healthy controls than in patients, suggesting a protective role for these ..
  11. Laine J, Auriola S, Pasanen M, Juvonen R. Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes. Xenobiotica. 2009;39:11-21 pubmed two concentrations: 50 microM therapeutic and 1 mM toxic by using nine human recombinant CYP enzymes: CYP1A1, CYP1A2, CYP2A6, CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP2E1, and CYP3A4; and with different microsomes from ..
  12. Park S, Andreotti G, Sakoda L, Gao Y, Rashid A, Chen J, et al. Variants in hormone-related genes and the risk of biliary tract cancers and stones: a population-based study in China. Carcinogenesis. 2009;30:606-14 pubmed publisher
    ..The CYP1A1 IVS1 + 606 (rs2606345) T allele was associated with gallbladder [odds ratio (OR) = 2...
  13. Bailey L, Roodi N, Verrier C, Yee C, Dupont W, Parl F. Breast cancer and CYPIA1, GSTM1, and GSTT1 polymorphisms: evidence of a lack of association in Caucasians and African Americans. Cancer Res. 1998;58:65-70 pubmed
    ..based differences in carcinogen metabolism have been related to polymorphisms of the cytochrome P450IA1 gene (CYPIA1) and the null genotypes of glutathione S-transferase classes mu and theta (GSTM1 and GSTT1)...
  14. Cheng S, Yu C, Yang P. Genetic polymorphisms of cytochrome p450 and matrix metalloproteinase in chronic obstructive pulmonary disease. Biochem Genet. 2009;47:591-601 pubmed publisher
    ..4 (95% CI 1.1-5.9). No differences were observed in the frequency of polymorphic genotypes in CYP1A1, 1A2, MMP-1 and -3...
  15. Shertzer H, Genter M, Talaska G, Curran C, Nebert D, Dalton T. 7H-dibenzo[c,g]carbazole metabolism by the mouse and human CYP1 family of enzymes. Carcinogenesis. 2007;28:1371-8 pubmed
    ..Using knockout mice for Cyp1a1, Cyp1a2 and Cyp1b1, we showed that the major CYP1 enzymes that metabolize DBC are CYP1A1 in beta-naphthoflavone (..
  16. Navratilova V, Paloncýová M, Berka K, Mise S, Haga Y, Matsumura C, et al. Molecular insights into the role of a distal F240A mutation that alters CYP1A1 activity towards persistent organic pollutants. Biochim Biophys Acta Gen Subj. 2017;1861:2852-2860 pubmed publisher
    ..This calls for rational design of enzymes capable of catalyzing their biotransformation. Cytochrome P450 1A1 isoforms catalyze the biotransformation of some POPs, and constitute good starting points for the design of ..
  17. Taura K, Yamada H, Hagino Y, Ishii Y, Mori M, Oguri K. Interaction between cytochrome P450 and other drug-metabolizing enzymes: evidence for an association of CYP1A1 with microsomal epoxide hydrolase and UDP-glucuronosyltransferase. Biochem Biophys Res Commun. 2000;273:1048-52 pubmed
    ..between cytochrome P450 (P450) and other drug-metabolizing enzymes were studied by affinity chromatography using CYP1A1-, glycine-, and bovine serum albumin (BSA)-conjugated Sepharose 4B columns...
  18. Couroucli X, Wei Y, Jiang W, Muthiah K, Evey L, Barrios R, et al. Modulation of pulmonary cytochrome P4501A1 expression by hyperoxia and inhaled nitric oxide in the newborn rat: implications for lung injury. Pediatr Res. 2006;59:401-6 pubmed iNO, hyperoxia (>95%), or iNO (20 or 40 ppm) + hyperoxia for up to 168 h, and lung injury parameters and CYP1A1 expression were studied...
  19. Shinkyo R, Sakaki T, Ohta M, Inouye K. Metabolic pathways of dioxin by CYP1A1: species difference between rat and human CYP1A subfamily in the metabolism of dioxins. Arch Biochem Biophys. 2003;409:180-7 pubmed
    ..and reaction specificity, considerable species differences between rats and humans were observed in both CYP1A1- and CYP1A2-dependent metabolism of dioxins...
  20. Guo L, Li Q, Xia Q, Dial S, Chan P, Fu P. Analysis of gene expression changes of drug metabolizing enzymes in the livers of F344 rats following oral treatment with kava extract. Food Chem Toxicol. 2009;47:433-42 pubmed publisher
    ..While gene expression of Cyp1a1, 1a2, 2c6, 3a1, and 3a3 increased; Cyp 2c23 and 2c40 decreased, all in a dose-dependent manner...
  21. Liu P, Liu Z, Shao M, Chen B. [Genetic polymorphisms of cytochrome P450 1A1 and susceptibility of early-onset Parkinson's disease]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2001;18:283-5 pubmed
    To assess the possible association between the Msp I polymorphisms of cytochrome P450 1A1(CYP1A1) and the susceptibility of early-onset Parkinson's disease among Hans in the northern part of China...
  22. Anandatheerthavarada H, Amuthan G, Biswas G, Robin M, Murali R, Waterman M, et al. Evolutionarily divergent electron donor proteins interact with P450MT2 through the same helical domain but different contact points. EMBO J. 2001;20:2394-403 pubmed
    We have investigated the sites of N-terminally truncated cytochrome P4501A1 targeted to mitochondria (P450MT2) which interact with adrenodoxin (Adx), cytochrome P450 reductase (CPR) and bacterial flavodoxin (Fln)...
  23. Singh S, Singh K, Patel S, Patel D, Singh C, Nath C, et al. Nicotine and caffeine-mediated modulation in the expression of toxicant responsive genes and vesicular monoamine transporter-2 in 1-methyl 4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease phenotype in mouse. Brain Res. 2008;1207:193-206 pubmed publisher
    ..e., CYP1A1, CYP2E1, GST-ya, GST-yc, GSTA4-4 and VMAT-2 in the striatum of control and MPTP-induced PD phenotype in mouse...
  24. Tuerxun M, Hamulati W, Bai L, Peng X, Dolikun M. [Study of cytochrome P450 1A1 gene 3'-UTR 6235T-C polymorphism and susceptibility to breast cancer with Uighur medicine]. Zhonghua Yi Xue Za Zhi. 2011;91:86-91 pubmed
    To explore the association between polymorphism of cytochrome P450 1A1 Gene 3'-UTR (3'-untranslated region) 6235T-C and breast cancer with abnormal Hilit in Chinese Han population of Xinjiang...
  25. Shekharyadav C, Bajpai M, Kumar V, Ahmed R, Gupta P, Banerjee B. Polymorphism in CYP1A1, GSTMI, GSTT1 genes and organochlorine pesticides in the etiology of hypospadias. Hum Exp Toxicol. 2011;30:1464-74 pubmed publisher
    ..Cytochrome P4501A1 (CYP1A1) and glutathione S-transferases (GSTM1 and GSTT1) of xenobiotic metabolizing enzyme family are involved in the ..
  26. Beristain Castillo E, Martínez Vázquez M, Camacho Carranza R, Espinosa Aguirre J. CYP1A1 and Cnr nitroreductase bioactivated niclosamide in vitro. Mutagenesis. 2013;28:645-51 pubmed publisher
    ..BaP) or cyclohexanol, which are known to induce different cytochrome P450 subfamilies, such as CYP2B, CYP1A1, CYP1A2 and CYP2E1...
  27. Harkitis P, Daskalopoulos E, Malliou F, Lang M, Marselos M, Fotopoulos A, et al. Dopamine D2-Receptor Antagonists Down-Regulate CYP1A1/2 and CYP1B1 in the Rat Liver. PLoS ONE. 2015;10:e0128708 pubmed publisher
    ..The present study investigated the role of dopamine D2-receptor-linked pathways in the regulation of CYP1A1, CYP1A2 and CYP1B1 that belong to a battery of genes controlled by the Aryl Hydrocarbon Receptor (AhR) and play a ..
  28. Cantlay A, Lamb D, Gillooly M, Norrman J, Morrison D, Smith C, et al. Association between the CYP1A1 gene polymorphism and susceptibility to emphysema and lung cancer. Clin Mol Pathol. 1995;48:M210-4 pubmed
    Aim-To investigate cytochrome P4501A1 (CYP1A1) polymorphism and susceptibility to emphysema and lung cancer...
  29. Cheng K, Park S, Krutzsch H, Grantham P, Gelboin H, Friedman F. Amino-terminal sequence and structure of monoclonal antibody immunopurified cytochromes P-450. Biochemistry. 1986;25:2397-402 pubmed
    ..This report shows the varying degree of structural relatedness among the isozymes examined and demonstrates the suitability and advantage of immunopurified cytochromes P-450 for sequencing and structural studies. ..
  30. Zhao H, Barger M, Ma J, Castranova V, Ma J. Cooperation of the inducible nitric oxide synthase and cytochrome P450 1A1 in mediating lung inflammation and mutagenicity induced by diesel exhaust particles. Environ Health Perspect. 2006;114:1253-8 pubmed
    ..DEPE) -mediated inflammatory responses and evaluated the interaction of inducible NO synthase (iNOS) and cytochrome P450 1A1 (CYP1A1)...
  31. Pałasz A, Wiaderkiewicz A, Wiaderkiewicz R, Czekaj P, Czajkowska B, Lebda Wyborny T, et al. Age-related changes in the mRNA levels of CYP1A1, CYP2B1/2 and CYP3A1 isoforms in rat small intestine. Genes Nutr. 2012;7:197-207 pubmed publisher
    ..RNA was isolated from intestinal mucosa, and then standard RT-PCR was used for the analysis of CYP1A1, CYP2B1/2 and CYP3A1 mRNA expression...
  32. Sidorova Y, Grishanova A. Inhibitory effect of alpha-tocopherol on benzo(a)pyrene-induced CYPA1 activity in rat liver. Bull Exp Biol Med. 2005;140:517-20 pubmed
    ..of cytochromes P450 of subfamily 1A, CYPA1 and CYP1A2) and alpha-tocopherol decreased benzo(a)pyrene-induced CYP1A1 activity in rat liver...
  33. Yen J, Tsai W, Chen C, Lin C, Ou T, Hu C, et al. Cytochrome P450 1A1 and manganese superoxide dismutase genes polymorphisms in ankylosing spondylitis. Immunol Lett. 2003;88:113-6 pubmed
    To investigate the associations of cytochrome p450 1A1 (CYP1A1) and manganese superoxide dismutase (MnSOD) genes polymorphisms with the susceptibility to AS in Taiwan...
  34. Yan Y, Wang H, Feng Y. Alterations of placental cytochrome P450 1A1 and P-glycoprotein in tobacco-induced intrauterine growth retardation in rats. Acta Pharmacol Sin. 2005;26:1387-94 pubmed
    To investigate the alterations of placental P-glycoprotein (P-gp) and cytochrome P450 1A1 (CYP1A1) at different gestational days (GD), and to explore the possible significance of placental P-gp and CYP1A1 in tobacco smoke-induced ..
  35. Gui S, Zhang Z, Zheng L, Cui Y, Liu X, Li N, et al. Molecular mechanism of kidney injury of mice caused by exposure to titanium dioxide nanoparticles. J Hazard Mater. 2011;195:365-70 pubmed publisher
    ..interleukin-18, interleukin-1?, cross-reaction protein, transforming growth factor-?, interferon-? and CYP1A1, while heat shock protein 70 expression was inhibited...
  36. Palamanda J, Kumari P, Murgolo N, Benbow L, Lin X, Nomeir A. Evaluation of CYP1A1 and CYP2B1/2 m-RNA induction in rat liver slices using the NanoString technology: a novel tool for drug discovery lead optimization. Drug Metab Lett. 2009;3:171-5 pubmed
    ..In particular, CYP1A1 and CYP2B1/2 have been associated with the induction of liver tumors in oncogenicity studies during safety ..
  37. Pandey S, Choudhuri G, Mittal B. Association of CYP1A1 Msp1 polymorphism with tobacco-related risk of gallbladder cancer in a north Indian population. Eur J Cancer Prev. 2008;17:77-81 pubmed publisher
    Polymorphisms in the gene encoding the metabolic enzyme cytochrome P450 1A1 (CYP1A1) might contribute to the variability in individual susceptibility to gallbladder cancer (GBC)...
  38. Shin A, Kang D, Choi J, Lee K, Park S, Noh D, et al. Cytochrome P450 1A1 (CYP1A1) polymorphisms and breast cancer risk in Korean women. Exp Mol Med. 2007;39:361-6 pubmed
    b>Cytochrome P450 1A1 (CYP1A1) is involved in the 2-hydroxylation of estrogen, the hormone that plays a critical role in the etiology of breast carcinoma...
  39. Pons N, Pipino S, De Matteis F. Interaction of polyhalogenated compounds of appropriate configuration with mammalian or bacterial CYP enzymes. Increased bilirubin and uroporphyrinogen oxidation in vitro. Biochem Pharmacol. 2003;66:405-14 pubmed
    ..b>CYP1A1 required planar polyhalogenated biphenyls for these oxidative reactions, while CYP1A2 was capable of oxidation in ..
  40. Ronquillo Sánchez M, Camacho Carranza R, Fernandez Mejia C, Hernández Ojeda S, Elinos Baez M, Espinosa Aguirre J. Modulation of the rat hepatic cytochrome P4501A subfamily using biotin supplementation. Biomed Res Int. 2013;2013:627907 pubmed publisher
    ..All of the rats were sacrificed by cervical dislocation after 1, 3, 5, or 7 days of treatment. CYP1A1 and CYP1A2 mRNAs were modified by biotin while enzyme activity and protein concentration were not affected...
  41. Iba M, Fung J, Chung L, Zhao J, Winnik B, Buckley B, et al. Differential inducibility of rat pulmonary CYP1A1 by cigarette smoke and wood smoke. Mutat Res. 2006;606:1-11 pubmed
    Mainstream cigarette smoke (CS) and wood smoke (WS) were compared in terms of their pulmonary CYP1A1 inducibility...
  42. Grando J, Kuasne H, Losi Guembarovski R, Sant Ana Rodrigues I, Matsuda H, Fuganti P, et al. Association between polymorphisms in the biometabolism genes CYP1A1, GSTM1, GSTT1 and GSTP1 in bladder cancer. Clin Exp Med. 2009;9:21-8 pubmed publisher
    ..We investigated the relationship between polymorphisms in the CYP1A1, GSTM1, GSTT1, and GSTP1 genes in a case-control study with 100 bladder cancer patients and 100 controls matched ..
  43. De Zwart L, Scholten M, Monbaliu J, Annaert P, Van Houdt J, van den Wyngaert I, et al. The ontogeny of drug metabolizing enzymes and transporters in the rat. Reprod Toxicol. 2008;26:220-30 pubmed publisher
    ..concentrations of total protein and albumin, enzyme activity and mRNA expression of cytochrome P450 isoenzymes (CYP1A1/2, CYP2B1/2, CYP2E1, CYP3A1/2, and CYP4A1), carboxylesterase and thyroxin glucuronidation (T4-GT) activity in ..
  44. Nakamura K, Fujiki T, Tamura H. Age, gender and region-specific differences in drug metabolising enzymes in rat ocular tissues. Exp Eye Res. 2005;81:710-5 pubmed
    ..In 5-week-old animals, the CYP genes, CYP2B2 and CYP3A1, were abundantly expressed in the lens, with higher CYP1A1 expression detectable in the extra-lenticular tissues, of both genders...
  45. Monk S, Denison M, Rice R. Reversible stepwise negative regulation of CYP1A1 in cultured rat epidermal cells. Arch Biochem Biophys. 2003;419:158-69 pubmed
    When serially passaged, rat epidermal keratinocytes lose the inducibility of CYP1A1 gene expression in response to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure...
  46. Cui Z, Li P, Liu J, Liu S. [Induction of CYP1A1 expression of H4IIE cell after treated with the water organic pollutants from the Yangtze River and Jialing River]. Wei Sheng Yan Jiu. 2008;37:540-2 pubmed
    To take Cuntan (Yangtze River) and Daxigou (Jialing River) as the representative, in order to study the cytochrome P450 1A1 (CYP1A1) gene expression in H4IIE cell treated with the organic pollutants in Chongqing source water between 2004 ..
  47. Nagy S, Denison M. Specificity of nuclear protein binding to a CYP1A1 negative regulatory element. Biochem Biophys Res Commun. 2002;296:799-805 pubmed
    Primary cultures of rat epidermal keratinocytes lose the ability to respond to chemicals with the induction of CYP1A1 gene expression after approximately 15 passages...
  48. Tsatsakis A, Zafiropoulos A, Tzatzarakis M, Tzanakakis G, Kafatos A. Relation of PON1 and CYP1A1 genetic polymorphisms to clinical findings in a cross-sectional study of a Greek rural population professionally exposed to pesticides. Toxicol Lett. 2009;186:66-72 pubmed publisher
    Allelic variants of CYP1A1 and PON1 have been extensively studied as susceptibility factors in toxic response, although little is known about the role of these variants as risk factors for the plethora of diseases appearing in the human ..
  49. Singh M, Stringfellow H, Taylor S, Ashton K, Ahmad M, Abdo K, et al. Elevated expression of CYP1A1 and gamma-SYNUCLEIN in human ectopic (ovarian) endometriosis compared with eutopic endometrium. Mol Hum Reprod. 2008;14:655-63 pubmed publisher
    ..dioxins) might be involved. Dioxins, via the arylhydrocarbon receptor (AhR), induce estrogen-metabolizing enzymes CYP1A1 and CYP1B1. Elevated expression of gamma-SYNUCLEIN (gamma-SYN) has been associated with hormone-related conditions...
  50. Tamasi V, Fülöp A, Hegyi K, Monostory K, Falus A. Upregulation of CYP2e1 and CYP3a activities in histamine-deficient histidine decarboxylase gene targeted mice. Cell Biol Int. 2003;27:1011-5 pubmed
    ..The results indicate a significant elevation of CYP2E1 and CYP3A activities, however, no change in CYP1A and CYP2B activities was seen in HDC targeted mice compared to wild type controls with identical genetic backgrounds. ..
  51. Henkens T, Vinken M, Vanhaecke T, Rogiers V. Modulation of CYP1A1 and CYP2B1 expression upon cell cycle progression in cultures of primary rat hepatocytes. Toxicol In Vitro. 2007;21:1253-7 pubmed
    ..blot analysis revealed that in hepatocytes cultured under proliferative conditions, the protein expression of CYP1A1 and CYP2B1 was substantially decreased, as well as the CYP2B-mediated PROD activity...
  52. Hines R, Levy J, Conrad R, Iversen P, Shen M, Renli A, et al. Gene structure and nucleotide sequence for rat cytochrome P-450c. Arch Biochem Biophys. 1985;237:465-76 pubmed
    ..Cross-hybridization studies with human DNA suggest a high degree of conservation between rat cytochrome P-450c and its human homolog although gross structural differences do exist between the two genes. ..
  53. Konstandi M, Johnson E, Marselos M, Kostakis D, Fotopoulos A, Lang M. Stress-mediated modulation of B(alpha)P-induced hepatic CYP1A1: role of catecholamines. Chem Biol Interact. 2004;147:65-77 pubmed
    The present study investigated the involvement of catecholamines in stress-mediated alterations in CYP1A1 induction by benzo(alpha)pyrene (B(alpha)P) in Wistar rats...