Cyp19a1

Summary

Gene Symbol: Cyp19a1
Description: cytochrome P450, family 19, subfamily a, polypeptide 1
Alias: Aromatase, Cyp19, Cyp19a, p450arom, aromatase, CYPXIX, Cytochrome P450, 19, aromatase, P-450AROM, cytochrome P-450AROM, cytochrome P450 19A1, cytochrome P450 19A1-like, cytochrome P450 family 19 subfamily a, cytochrome P450, subfamily 19, estrogen synthase, estrogen synthetase
Species: rat
Products:     Cyp19a1

Top Publications

  1. Hojo Y, Hattori T, Enami T, Furukawa A, Suzuki K, Ishii H, et al. Adult male rat hippocampus synthesizes estradiol from pregnenolone by cytochromes P45017alpha and P450 aromatase localized in neurons. Proc Natl Acad Sci U S A. 2004;101:865-70 pubmed
    ..rat hippocampal formation, significant localization was demonstrated for both cytochromes P45017alpha and P450 aromatase, in pyramidal neurons in the CA1-CA3 regions, as well as in the granule cells in the dentate gyrus, by means of ..
  2. Shayu D, Rao A. Expression of functional aromatase in the epididymis: role of androgens and LH in modulation of expression and activity. Mol Cell Endocrinol. 2006;249:40-50 pubmed
    The primary source of 17beta-estradiol (E2) in the male is the testis, which expresses the enzyme complex aromatase that is involved in E2 biosynthesis...
  3. Ceccarelli I, Rossi A, Maddalena M, Weber E, Aloisi A. Effects of morphine on testosterone levels in rat C6 glioma cells: modulation by anastrozole. J Cell Physiol. 2009;221:1-4 pubmed publisher
    ..we cultured them in media with or without the addition of testosterone propionate and anastrozole, a blocker of aromatase, the enzyme needed to transform testosterone into estradiol...
  4. Pietranera L, Bellini M, Arevalo M, Goya R, Brocca M, Garcia Segura L, et al. Increased aromatase expression in the hippocampus of spontaneously hypertensive rats: effects of estradiol administration. Neuroscience. 2011;174:151-9 pubmed publisher
    ..potential role of local estrogen biosynthesis in the hippocampus of SHR and WKY, by measuring the expression of aromatase, the key enzyme responsible for estrogen biosynthesis and involved in neuroprotection...
  5. Yague J, Lavaque E, Carretero J, Azcoitia I, Garcia Segura L. Aromatase, the enzyme responsible for estrogen biosynthesis, is expressed by human and rat glioblastomas. Neurosci Lett. 2004;368:279-84 pubmed
    The biosynthesis of estradiol and related estrogens is catalyzed by the enzyme aromatase. Among other tissues, aromatase is expressed in the brain, where it is involved in the regulation of neuroendocrine events and reproduction...
  6. Sakurada Y, Shirota M, Inoue K, Uchida N, Shirota K. New approach to in situ quantification of ovarian gene expression in rat using a laser microdissection technique: relationship between follicle types and regulation of inhibin-alpha and cytochrome P450aromatase genes in the rat ovary. Histochem Cell Biol. 2006;126:735-41 pubmed
    ..this study aimed at comparing the amounts of mRNAs encoding the inhibin-alpha subunit and cytochrome P450 aromatase (P450(arom)) in granulosa cells between preantral and antral follicles in immature rat ovaries...
  7. Zhao C, Fujinaga R, Yanai A, Kokubu K, Takeshita Y, Watanabe Y, et al. Sex-steroidal regulation of aromatase mRNA expression in adult male rat brain: a quantitative non-radioactive in situ hybridization study. Cell Tissue Res. 2008;332:381-91 pubmed publisher
    Neuronal aromatase, the enzyme that catalyzes the conversion of androgens to estrogens, is involved in brain sexual differentiation, the regulation of reproductive behavior, and gonadotropin secretion...
  8. Sohl C, Guengerich F. Kinetic analysis of the three-step steroid aromatase reaction of human cytochrome P450 19A1. J Biol Chem. 2010;285:17734-43 pubmed publisher
    b>Cytochrome P450 19A1 (P450 19A1), the aromatase, catalyzes the conversion of androgens to estrogens through a sequential three-step reaction, generating 19-hydroxy and 19-aldehyde intermediates en route to the product estrogen...
  9. Colciago A, Celotti F, Pravettoni A, Mornati O, Martini L, Negri Cesi P. Dimorphic expression of testosterone metabolizing enzymes in the hypothalamic area of developing rats. Brain Res Dev Brain Res. 2005;155:107-16 pubmed
    Androgen transformation into estrogens through the aromatase enzyme, occurring in the rat hypothalamus during fetal life, leads to male-specific sexual differentiation of brain...

More Information

Publications62

  1. Antonio Rubio N, Guerrero Estévez S, Lira Romero E, Moreno Mendoza N. Expression of 3?-HSD1 and P450 Aromatase enzymes during mouse gonad differentiation. J Mol Histol. 2011;42:535-43 pubmed publisher
    ..To know this, we analyzed the mRNA expression pattern of 3?-Hsd1 and P450arom as well as protein expression pattern of 3?-HSD1 and Testosterone in normal undifferentiated and differentiated ..
  2. Fisher C, Graves K, Parlow A, Simpson E. Characterization of mice deficient in aromatase (ArKO) because of targeted disruption of the cyp19 gene. Proc Natl Acad Sci U S A. 1998;95:6965-70 pubmed
    The formation of estrogens from C19 steroids is catalyzed by aromatase cytochrome P450 (P450arom), the product of the cyp19 gene...
  3. Pezzi V, Sirianni R, Chimento A, Maggiolini M, Bourguiba S, Delalande C, et al. Differential expression of steroidogenic factor-1/adrenal 4 binding protein and liver receptor homolog-1 (LRH-1)/fetoprotein transcription factor in the rat testis: LRH-1 as a potential regulator of testicular aromatase expression. Endocrinology. 2004;145:2186-96 pubmed
    b>Aromatase converts testicular androgens to estrogens, which are essential for male fertility...
  4. Grignard E, Gueguen Y, Grison S, Dublineau I, Gourmelon P, Souidi M. Testicular steroidogenesis is not altered by 137 cesium Chernobyl fallout, following in utero or post-natal chronic exposure. C R Biol. 2010;333:416-23 pubmed publisher
    ..Expression of several genes involved in testicular steroidogenesis was affected (cyp19a1, fxr, sf-1), without modification of protein expression or activity...
  5. Miller W. Androgen synthesis in adrenarche. Rev Endocr Metab Disord. 2009;10:3-17 pubmed publisher
  6. Israel J, Cabelguen J, Le Masson G, Oliet S, Ciofi P. Neonatal testosterone suppresses a neuroendocrine pulse generator required for reproduction. Nat Commun. 2014;5:3285 pubmed publisher
    ..This steroid effect is aromatase and caspase dependent, and is mediated via oestrogen receptor-?...
  7. Burul Bozkurt N, Pekiner C, Kelicen P. Diabetes alters aromatase enzyme levels in sciatic nerve and hippocampus tissues of rats. Cell Mol Neurobiol. 2010;30:445-51 pubmed publisher
    ..Estrogens prevent neuronal loss in experimental models of neurodegeneration and accelerate nerve regeneration. Aromatase catalyzes the conversion of androgens to estrogens and expressed in a variety of tissues including neurons...
  8. Schaeffer V, Meyer L, Patte Mensah C, Eckert A, Mensah Nyagan A. Sciatic nerve injury induces apoptosis of dorsal root ganglion satellite glial cells and selectively modifies neurosteroidogenesis in sensory neurons. Glia. 2010;58:169-80 pubmed publisher
    ..Consistently, immunohistochemical investigations localized aromatase (estradiol-synthesizing enzyme) in DRG neurons but not in SGC...
  9. Hobler C, Andrade A, Grande S, Gericke C, Talsness C, Appel K, et al. Sex-dependent aromatase activity in rat offspring after pre- and postnatal exposure to triphenyltin chloride. Toxicology. 2010;276:198-205 pubmed publisher
    ..and mammals and a number of in vivo and in vitro studies have argued that OTCs may act through inhibition of the aromatase enzyme. In vivo studies supporting the aromatase inhibition hypothesis in mammals are lacking...
  10. Gray S, Mannan M, O Shaughnessy P. Development of cytochrome P450 aromatase mRNA levels and enzyme activity in ovaries of normal and hypogonadal (hpg) mice. J Mol Endocrinol. 1995;14:295-301 pubmed
    The cytochrome P450 aromatase (P450arom) enzyme is required for bioconversion of androgen to oestrogen...
  11. Kobayashi H, Yoshida S, Sun Y, Shirasawa N, Naito A. Changes of gastric aromatase and portal venous 17?-estradiol during the postnatal development and estrus cycle in female rats. Endocrine. 2014;46:605-14 pubmed publisher
    ..Wistar female rats aged from 15 to 40 days and 10 weeks were used in the study. The expression of aromatase and estrogen receptor (ER) ? mRNAs and proteins was analyzed in the stomach, ovary, and liver by RT-PCR, ..
  12. Zhong Y, Dhawan J, Kovoor J, Sullivan J, Zhang W, Choi D, et al. Aromatase and neuroinflammation in rat focal brain ischemia. J Steroid Biochem Mol Biol. 2017;174:225-233 pubmed publisher
    Accumulating evidence suggests that expression of aromatase, the enzyme responsible for the conversion of androgens to estrogens, is transiently upregulated in rat stroke models...
  13. Vanderschueren D, Van Herck E, De Coster R, Bouillon R. Aromatization of androgens is important for skeletal maintenance of aged male rats. Calcif Tissue Int. 1996;59:179-83 pubmed
    A nonsteroidal aromatase inhibitor vorozole (VOR) was administered to aged (12 months old) male Wistar rats and its effect was compared with the effect of androgen deficiency...
  14. Gonzalez A, Martinez Campa C, Mediavilla M, Alonso Gonzalez C, Sanchez Barcelo E, Cos S. Inhibitory effects of pharmacological doses of melatonin on aromatase activity and expression in rat glioma cells. Br J Cancer. 2007;97:755-60 pubmed
    ..the growth of C6 glioma cells and reduces the local biosynthesis of oestrogens, through the inhibition of aromatase, the enzyme that catalyses the conversion of androgens into oestrogens...
  15. Ren Y, Sun L, Shao X, Chen J, Xiong B, Nong L. [Expressions of eNOS and cytochrome P450 in the testis of sexually mature SD rats and their significance]. Zhonghua Nan Ke Xue. 2009;15:911-4 pubmed
    To explore the expressions of endothelial nitric oxide synthase (eNOS) and cytochrome P450 (aromatase) in the testis of sexually mature male SD rats and their significance...
  16. Jablonska O, Shi Z, Valdez K, Ting A, Petroff B. Temporal and anatomical sensitivities to the aryl hydrocarbon receptor agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin leading to premature acyclicity with age in rats. Int J Androl. 2010;33:405-12 pubmed publisher
    ..b>Aromatase, 17alpha-hydroxylase and LHR gene expressions were largely unchanged (or occasionally elevated) by TCDD...
  17. O Grady S, Caprau D, Ke X, Contreras Y, Haley S, Ermini F, et al. Intrauterine growth restriction alters hippocampal expression and chromatin structure of Cyp19a1 variants. Syst Biol Reprod Med. 2010;56:292-302 pubmed publisher
    ..intrauterine growth restriction (IUGR), on serum testosterone and hippocampal expression of Cyp19a1 variants and aromatase in rats...
  18. Liu Z, Rudd M, Hernandez Gonzalez I, Gonzalez Robayna I, Fan H, Zeleznik A, et al. FSH and FOXO1 regulate genes in the sterol/steroid and lipid biosynthetic pathways in granulosa cells. Mol Endocrinol. 2009;23:649-61 pubmed publisher
    ..steroidogenic biosynthetic pathways (Hmgcs1, Hmgcr, Mvk, Sqle, Lss, Cyp51, Tm7sf2, Dhcr24 and Star, Cyp11a1, and Cyp19), including two key transcriptional regulators Srebf1 and Srebf2 of cholesterol biosynthesis and steroidogenesis (..
  19. Nakamura E, Otsuka F, Inagaki K, Miyoshi T, Yamanaka R, Tsukamoto N, et al. A novel antagonistic effect of the bone morphogenetic protein system on prolactin actions in regulating steroidogenesis by granulosa cells. Endocrinology. 2010;151:5506-18 pubmed publisher
    ..In accordance with the data for steroids, FSH-induced aromatase expression was suppressed by PRL, whereas FSH-induced steroidogenic acute regulatory protein, P450scc (P450 side-..
  20. Colciago A, Casati L, Mornati O, Vergoni A, Santagostino A, Celotti F, et al. Chronic treatment with polychlorinated biphenyls (PCB) during pregnancy and lactation in the rat Part 2: Effects on reproductive parameters, on sex behavior, on memory retention and on hypothalamic expression of aromatase and 5alpha-reductases in the. Toxicol Appl Pharmacol. 2009;239:46-54 pubmed publisher
    The gender-specific expression pattern of aromatase and 5alpha-reductases (5alpha-R) during brain development provides neurons the right amount of estradiol and DHT to induce a dimorphic organization of the structure...
  21. Burul Bozkurt N, Pekiner C, Kelicen P. Diabetes alters aromatase enzyme levels in gonadal tissues of rats. Naunyn Schmiedebergs Arch Pharmacol. 2010;382:33-41 pubmed publisher
    ..Estrogens have important roles in reproductive processes in both genders. Aromatase catalyzes the conversion of androgens to estrogens and is expressed in a variety of tissues...
  22. Lu X, Yu T, Ma M, Jin C, Liu Q, Wu S, et al. [Effect on the testis development and StAR, CYP19a1 and CYP11a1 expression of prepubertal male rats after sub-acute exposure to DEHP]. Wei Sheng Yan Jiu. 2010;39:263-7 pubmed
    ..The effect of DEHP on gene expression of StAR, CYP19a1 and CYP11a1 was compared to each other in different DEHP group...
  23. Kelicen Ugur P, Lule S, Cincioglu M, Pekiner C, Gursoy Ozdemir Y. Megestrol acetate inhibits the expression of cytoplasmic aromatase through nuclear C/EBP? in reperfusion injury-induced ischemic rat hippocampus. Eur J Pharmacol. 2011;654:217-25 pubmed publisher
    ..Neurodegeneration can be prevented by local aromatase expression, and estrogen synthesis can be neuroprotective in ischemia/reperfusion...
  24. Napoli N, Rastelli A, Ma C, Yarramaneni J, Vattikutti S, Moskowitz G, et al. Genetic polymorphism at Val80 (rs700518) of the CYP19A1 gene is associated with aromatase inhibitor associated bone loss in women with ER + breast cancer. Bone. 2013;55:309-14 pubmed publisher
    Polymorphisms in the CYP19A1 (aromatase) gene have been reported to influence disease-free survival and the incidence of musculoskeletal complaints in patients taking aromatase inhibitors (AIs) for estrogen receptor positive (ER+) breast ..
  25. MacKenzie S, Dewar D, Stewart W, Fraser R, Connell J, Davies E. The transcription of steroidogenic genes in the human cerebellum and hippocampus: a comparative survey of normal and Alzheimer's tissue. J Endocrinol. 2008;196:123-30 pubmed publisher
    ..There is no evidence of a link between AD and altered steroid biosynthesis within human hippocampus and cerebellum. ..
  26. Levallet J, Mittre H, Delarue B, Carreau S. Alternative splicing events in the coding region of the cytochrome P450 aromatase gene in male rat germ cells. J Mol Endocrinol. 1998;20:305-12 pubmed
    ..At least two unusual isoforms (Ex10-S and INT) of P450 aromatase (P450arom) mRNA were expressed...
  27. Keskin H, Sirin Y, Keles H, Turgut O, Ide T, Avsar A. The aromatase inhibitor letrozole reduces adhesion formation after intraperitoneal surgery in a rat uterine horn model. Eur J Obstet Gynecol Reprod Biol. 2013;167:199-204 pubmed publisher
    ..To investigate, in an experimental animal study, the effects of letrozole and tamoxifen in the reduction of adhesion formation following abdominopelvic surgery...
  28. Carretero J, Burks D, Vazquez G, Rubio M, Hernandez E, Bodego P, et al. Expression of aromatase P450 is increased in spontaneous prolactinomas of aged rats. Pituitary. 2002;5:5-10 pubmed
    We have recently reported the presence of aromatase P450 in the rat hypophysis. This enzyme is responsible for the aromatization of testosterone to estradiol...
  29. McDonald C, Millena A, Reddy S, Finlay S, Vizcarra J, Khan S, et al. Follicle-stimulating hormone-induced aromatase in immature rat Sertoli cells requires an active phosphatidylinositol 3-kinase pathway and is inhibited via the mitogen-activated protein kinase signaling pathway. Mol Endocrinol. 2006;20:608-18 pubmed
    ..from immature (10-d-old) rats, and examines which intracellular signals may be involved in their effects on aromatase activity and estradiol production in immature rat Sertoli cells...
  30. Takahashi K, Tamura Y, Watanabe Y, Langstrom B, Bergstrom M. Alteration in [11C]vorozole binding to aromatase in neuronal cells of rat brain induced by anabolic androgenic steroids and flutamide. Neuroreport. 2008;19:431-5 pubmed publisher
    In a previous study, we demonstrated that androgenic-anabolic steroids increased aromatase expression in the bed nucleus of stria terminalis and preoptic area in rat brain, as evaluated using autoradiography with [11C]vorozole, a ..
  31. Kwintkiewicz J, Cai Z, Stocco C. Follicle-stimulating hormone-induced activation of Gata4 contributes in the up-regulation of Cyp19 expression in rat granulosa cells. Mol Endocrinol. 2007;21:933-47 pubmed
    ..This study evaluated the effects of GATA4 on the regulation of the Cyp19 gene in primary rat granulosa cells under basal conditions and in response to stimulation by FSH...
  32. Ghosh D, Griswold J, Erman M, Pangborn W. Structural basis for androgen specificity and oestrogen synthesis in human aromatase. Nature. 2009;457:219-23 pubmed publisher
    b>Aromatase cytochrome P450 is the only enzyme in vertebrates known to catalyse the biosynthesis of all oestrogens from androgens. Aromatase inhibitors therefore constitute a frontline therapy for oestrogen-dependent breast cancer...
  33. Stocco C, Kwintkiewicz J, Cai Z. Identification of regulatory elements in the Cyp19 proximal promoter in rat luteal cells. J Mol Endocrinol. 2007;39:211-21 pubmed
    The cytochrome P450 aromatase (Cyp19) gene encodes an enzyme of crucial importance in the synthesis of estradiol. Estradiol is luteotropic in the rat...
  34. Andric N, Ascoli M. Mutations of the lutropin/choriogonadotropin receptor that do not activate the phosphoinositide cascade allow hCG to induce aromatase expression in immature rat granulosa cells. Mol Cell Endocrinol. 2008;285:62-72 pubmed publisher
    ..elicits a transient increase in Akt phosphorylation, and a sustained increase in ERK1/2 phosphorylation but aromatase expression is not enhanced...
  35. Zurvarra F, Salvetti N, Mason J, Velazquez M, Alfaro N, Ortega H. Disruption in the expression and immunolocalisation of steroid receptors and steroidogenic enzymes in letrozole-induced polycystic ovaries in rat. Reprod Fertil Dev. 2009;21:827-39 pubmed publisher
    ..beta (ERalpha, ERbeta), androgen receptor (AR) and progesterone receptor (PR)) and steroidogenic enzymes (P450 aromatase (P450arom), 3beta-hydroxysteroid dehydrogenase (3beta-HSD) and steroidogenic acute regulatory protein (StAR)) in ..
  36. Jesmin S, Mowa C, Sakuma I, Matsuda N, Togashi H, Yoshioka M, et al. Aromatase is abundantly expressed by neonatal rat penis but downregulated in adulthood. J Mol Endocrinol. 2004;33:343-59 pubmed
    ..whether the penis is capable of generating its own local estrogen by examining evidence of the expression of aromatase, a microsomal enzymatic complex which irreversibly converts androgens to estrogens, using immunohistochemistry, ..
  37. Munetsuna E, Hojo Y, Hattori M, Ishii H, Kawato S, Ishida A, et al. Retinoic acid stimulates 17beta-estradiol and testosterone synthesis in rat hippocampal slice cultures. Endocrinology. 2009;150:4260-9 pubmed publisher
    ..The mRNA levels for P450(17alpha), P450 aromatase and estrogen receptor-beta in the slices were increased by treatment with 9-cis-retinoic acid but not by all-..
  38. Rogler L, Pintar J. Expression of the P450 side-chain cleavage and adrenodoxin genes begins during early stages of adrenal cortex development. Mol Endocrinol. 1993;7:453-61 pubmed
    ..abstract truncated at 250 words) ..
  39. Maliqueo M, Sun M, Johansson J, Benrick A, Labrie F, Svensson H, et al. Continuous administration of a P450 aromatase inhibitor induces polycystic ovary syndrome with a metabolic and endocrine phenotype in female rats at adult age. Endocrinology. 2013;154:434-45 pubmed publisher
    ..In female rats, continuous administration of letrozole, a nonsteroidal inhibitor of P450 aromatase, at 400 ?g/d starting before puberty induces hyperandrogenemia and reproductive abnormalities similar to those ..
  40. Hapon M, Gamarra Luques C, Jahn G. Short term hypothyroidism affects ovarian function in the cycling rat. Reprod Biol Endocrinol. 2010;8:14 pubmed publisher
    ..doubled the ovarian mRNA contents of estrogen receptor-beta on proestrus and estrus evenings, cyp19A1 aromatase mRNA on estrus evening and of growth hormone receptor on proestrus evening...
  41. Silandre D, Delalande C, Durand P, Carreau S. Three promoters PII, PI.f, and PI.tr direct the expression of aromatase (cyp19) gene in male rat germ cells. J Mol Endocrinol. 2007;39:169-81 pubmed
    b>Aromatase is the key enzyme responsible for the irreversible transformation of androgens into estrogens. It is encoded by the cyp19 gene and is expressed in the mammalian testis under the control of the proximal promoter PII...
  42. Srivastava D, Woolfrey K, Liu F, Brandon N, Penzes P. Estrogen receptor ß activity modulates synaptic signaling and structure. J Neurosci. 2010;30:13454-60 pubmed publisher
    ..Moreover, we found that aromatase, an enzyme critical for estrogen production, is present at presynaptic termini, supporting a role for brain-..
  43. Tinfo N, Hotchkiss M, Buckalew A, Zorrilla L, Cooper R, Laws S. Understanding the effects of atrazine on steroidogenesis in rat granulosa and H295R adrenal cortical carcinoma cells. Reprod Toxicol. 2011;31:184-93 pubmed publisher
    ..A primary concern has been whether atrazine increases the synthesis of estrogens, perhaps by enhancing aromatase gene expression and activity...
  44. Yonezawa T, Higashi M, Yoshioka K, Mutoh K. Distribution of aromatase and sex steroid receptors in the baculum during the rat life cycle: effects of estrogen during the early development of the baculum. Biol Reprod. 2011;85:105-12 pubmed publisher
    ..of sex steroids in the development of the baculum of rats, the distributions of androgen receptors (ARs), aromatase, and estrogen receptor alpha (ESR1) were observed immunohistochemically...
  45. Yu S, Xing X, Jiao K, Sun L, Liu L, Wang M. Changes in the expression of aromatase, estrogen receptor ? and ? in mandibular condylar cartilage of rats induced by disordered occlusion. BMC Musculoskelet Disord. 2012;13:190 pubmed publisher
    ..The present study was to investigate the expression of aggrecan, collagen type II (Col II), Col X, aromatase, ER? and ER? in degenerative changes of mandibular condylar cartilage...
  46. Toyoshima K, Seta Y, Toyono T, Kataoka S. Immunohistochemical identification of cells expressing steroidogenic enzymes cytochrome P450scc and P450 aromatase in taste buds of rat circumvallate papillae. Arch Histol Cytol. 2007;70:215-24 pubmed
    ..of expression of key enzymes for steroidogenesis, cytochrome P450 side-chain-cleavage (P450scc), and P450 aromatase in the taste buds of rat circumvallate papillae, using immunoblot analyses and immunohistochemistry...
  47. Munetsuna E, Hattori M, Yamazaki T. Stimulation of estradiol biosynthesis by tributyltin in rat hippocampal slices. Endocr Res. 2014;39:168-72 pubmed publisher
    ..A concentration of 0.1??M tributyltin induced an increase in the mRNA content of P450(17?) and P450arom in hippocampal slices, as determined using real-time PCR...
  48. Xia X, Guo L, Su J, Fang X. [Effect of letrozole on endometrosis and apoptosis of ectopic endometrial cells in rats]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2013;38:54-9 pubmed publisher
    To investigate the therapeutic mechanism of letrozole, the third-generation aromatase inhibitor, on endometriotic lesions in a rat model and its effect on the apoptosis of ectopic endometrial cells...
  49. Zanatta L, Bouraïma Lelong H, Delalande C, Silva F, Carreau S. Regulation of aromatase expression by 1?,25(OH)2 vitamin D3 in rat testicular cells. Reprod Fertil Dev. 2011;23:725-35 pubmed publisher
    ..Therefore, in this study the effect and mechanisms of action of 1?,25(OH)(2) vitamin D(3) (1,25D) on aromatase gene expression in immature rat Sertoli cells were evaluated...
  50. Pinilla L, Castellano J, Romero M, Tena Sempere M, Gaytan F, Aguilar E. Delayed puberty in spontaneously hypertensive rats involves a primary ovarian failure independent of the hypothalamic KiSS-1/GPR54/GnRH system. Endocrinology. 2009;150:2889-97 pubmed publisher
    ..or FSH-receptor mRNA expression but might be linked to blunted P450scc, 3beta-hydroxy steroid dehydrogenase, and aromatase mRNA levels in ovaries from SH rats...
  51. Miyoshi T, Otsuka F, Yamashita M, Inagaki K, Nakamura E, Tsukamoto N, et al. Functional relationship between fibroblast growth factor-8 and bone morphogenetic proteins in regulating steroidogenesis by rat granulosa cells. Mol Cell Endocrinol. 2010;325:84-92 pubmed publisher
    ..upregulated FSH-induced estradiol synthesis, indicating that ERK pathway is also involved in suppressing aromatase activity in granulosa cells...
  52. Riancho J, Valero C, Naranjo A, Morales D, Sañudo C, Zarrabeitia M. Identification of an aromatase haplotype that is associated with gene expression and postmenopausal osteoporosis. J Clin Endocrinol Metab. 2007;92:660-5 pubmed
    Osteoporosis has a significant genetic component. The aromatase-dependent conversion of androgenic precursors is the main source of estrogens in postmenopausal women...
  53. Santen R, Worgul T, Lipton A, Harvey H, Boucher A, Samojlik E, et al. Aminoglutethimide as treatment of postmenopausal women with advanced breast carcinoma. Ann Intern Med. 1982;96:94-101 pubmed
    ..Aminoglutethimide, a known inhibitor of steroid synthesis, is also a potent blocker of the aromatase enzyme and, thus, of estrogen production...