Cyp17a1

Summary

Gene Symbol: Cyp17a1
Description: cytochrome P450, family 17, subfamily a, polypeptide 1
Alias: Cyp17, steroid 17-alpha-hydroxylase/17,20 lyase, 17-alpha-hydroxyprogesterone aldolase, CYPXVII, Cytochrome P450, subfamily XVII, P450-C17, P45017alpha, P450c17, cytochrome P450 17A1, cytochrome P450, subfamily 17, cytochrome P450-C17, cytochrome P450c17
Species: rat
Products:     Cyp17a1

Top Publications

  1. Givens C, Zhang P, Bair S, Mellon S. Transcriptional regulation of rat cytochrome P450c17 expression in mouse Leydig MA-10 and adrenal Y-1 cells: identification of a single protein that mediates both basal and cAMP-induced activities. DNA Cell Biol. 1994;13:1087-98 pubmed
    b>Cytochrome P450c17, 17 alpha-hydroxylase/17,20 lyase, is a key enzyme in the steroidogenic pathway leading to the production of corticosteroids and androgens from the adrenal gland and sex steroids from the gonads...
  2. Kibaly C, Patte Mensah C, Mensah Nyagan A. Molecular and neurochemical evidence for the biosynthesis of dehydroepiandrosterone in the adult rat spinal cord. J Neurochem. 2005;93:1220-30 pubmed
    ..the last decade has been marked by diverse unsuccessful investigations aiming to demonstrate the activity of cytochrome P450c17 (P450c17), the key DHEA-synthesizing enzyme, in adult rodent CNS...
  3. Duell E, Holly E, Kelsey K, Bracci P. Genetic variation in CYP17A1 and pancreatic cancer in a population-based case-control study in the San Francisco Bay Area, California. Int J Cancer. 2010;126:790-5 pubmed publisher
    ..b>CYP17A1 encodes cytochrome P450c17alpha, an enzyme with 17alpha-hydroxylase and 17,20-lyase activities in estradiol ..
  4. Manca P, Mulliri G, Burrai G, Pirino S, Mameli O. Immunohistochemical localisation and molecular expression of the steroidogenic enzyme cytochrome P450 17?-hydroxylase?/C(17,20)-lyase in the vestibular nuclei of adult male rats. J Neuroendocrinol. 2011;23:444-9 pubmed publisher
    ..Given that neurosteroids can modulate neuronal activities in the medial vestibular nucleus, DHEA synthesised in the VCN may play an important role in the control of specific activities at this level. ..
  5. Attard G, Reid A, Yap T, Raynaud F, Dowsett M, Settatree S, et al. Phase I clinical trial of a selective inhibitor of CYP17, abiraterone acetate, confirms that castration-resistant prostate cancer commonly remains hormone driven. J Clin Oncol. 2008;26:4563-71 pubmed publisher
    ..To evaluate this, a trial of abiraterone acetate-a potent, selective, small-molecule inhibitor of cytochrome P (CYP) 17, a key enzyme in androgen synthesis-was pursued...
  6. Nelson V, Qin K, Rosenfield R, Wood J, Penning T, Legro R, et al. The biochemical basis for increased testosterone production in theca cells propagated from patients with polycystic ovary syndrome. J Clin Endocrinol Metab. 2001;86:5925-33 pubmed
  7. McVey M, Cooke G, Curran I, Chan H, Kubow S, Lok E, et al. An investigation of the effects of methylmercury in rats fed different dietary fats and proteins: testicular steroidogenic enzymes and serum testosterone levels. Food Chem Toxicol. 2008;46:270-9 pubmed
    ..In conclusion, these studies show that different lipid diets can alter the toxic effects of MeHg on male rat steroidogenesis in terms of serum testosterone and steroidogenic enzyme activities. ..
  8. Huang H, Chiang M, Lin C, Pu H. Lipopolysaccharide directly stimulates aldosterone production via toll-like receptor 2 and toll-like receptor 4 related PI(3)K/Akt pathway in rat adrenal zona glomerulosa cells. J Cell Biochem. 2010;111:872-80 pubmed publisher
    ..In conclusion, LPS-induced aldosterone production and SR-B1 proteins expression are through the TLR2 and TLR4 related PI(3)K/Akt pathways in adrenal ZG cells...
  9. Missaghian E, Kempna P, Dick B, Hirsch A, Alikhani Koupaei R, Jégou B, et al. Role of DNA methylation in the tissue-specific expression of the CYP17A1 gene for steroidogenesis in rodents. J Endocrinol. 2009;202:99-109 pubmed publisher
    ..In contrast to humans, adrenals of rodents do not express the CYP17A1 gene and have therefore no P450c17 enzyme for cortisol production, but produce corticosterone...

More Information

Publications62

  1. Kumar V, Balomajumder C, Roy P. Disruption of LH-induced testosterone biosynthesis in testicular Leydig cells by triclosan: probable mechanism of action. Toxicology. 2008;250:124-31 pubmed publisher
    ..The study further confirmed the anti-androgenic activity of TCS in Leydig cells with highest effective concentration at 1 microM. ..
  2. Ogishima T, Mitani F, Suematsu M. Cytochrome P-450(17alpha) in beta-cells of rat pancreas and its local steroidogenesis. J Steroid Biochem Mol Biol. 2008;111:80-6 pubmed publisher
    ..The product was supposed to be further metabolized to the reduced derivatives such as testosterone, 5alpha-androstanedione, and dihydrotestosterone, which would act as local steroids in the islets of Langerhans. ..
  3. McVey M, Cooke G, Curran I, Chan H, Kubow S, Lok E, et al. Effects of dietary fats and proteins on rat testicular steroidogenic enzymes and serum testosterone levels. Food Chem Toxicol. 2008;46:259-69 pubmed
  4. Ambrosone C, Moysich K, Furberg H, Freudenheim J, Bowman E, Ahmed S, et al. CYP17 genetic polymorphism, breast cancer, and breast cancer risk factors. Breast Cancer Res. 2003;5:R45-51 pubmed
    Findings from previous studies regarding the association between the CYP17 genotype and breast cancer are inconsistent...
  5. Pelletier G, Li S, Luu The V, Tremblay Y, Belanger A, Labrie F. Immunoelectron microscopic localization of three key steroidogenic enzymes (cytochrome P450(scc), 3 beta-hydroxysteroid dehydrogenase and cytochrome P450(c17)) in rat adrenal cortex and gonads. J Endocrinol. 2001;171:373-83 pubmed
  6. Munetsuna E, Hattori M, Yamazaki T. Stimulation of estradiol biosynthesis by tributyltin in rat hippocampal slices. Endocr Res. 2014;39:168-72 pubmed publisher
    ..1??M tributyltin, and this was accompanied by transcriptional activation of P450(17?) and P450arom. Tributyltin stimulated de novo hippocampal estradiol synthesis by modifying the transcription of specific steroidogenic enzymes. ..
  7. DeVore N, Scott E. Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001. Nature. 2012;482:116-9 pubmed publisher
    b>Cytochrome P450 17A1 (also known as CYP17A1 and cytochrome P450c17) catalyses the biosynthesis of androgens in humans...
  8. Fevold H, Lorence M, McCarthy J, Trant J, Kagimoto M, Waterman M, et al. Rat P450(17 alpha) from testis: characterization of a full-length cDNA encoding a unique steroid hydroxylase capable of catalyzing both delta 4- and delta 5-steroid-17,20-lyase reactions. Mol Endocrinol. 1989;3:968-75 pubmed
    ..0 kilobases) in rat testis RNA and Southern analysis indicates the presence of a single CYP17 gene in the rat genome...
  9. Grasfeder L, Gaillard S, Hammes S, Ilkayeva O, Newgard C, Hochberg R, et al. Fasting-induced hepatic production of DHEA is regulated by PGC-1alpha, ERRalpha, and HNF4alpha. Mol Endocrinol. 2009;23:1171-82 pubmed publisher
    ..the liver, we have made the surprising observation that this coactivator can induce the expression of CYP11A1 and CYP17A1, key rate-limiting enzymes involved in the initial steps of steroidogenesis...
  10. Dalla Valle L, Toffolo V, Vianello S, Belvedere P, Colombo L. Expression of cytochrome P450c17 and other steroid-converting enzymes in the rat kidney throughout the life-span. J Steroid Biochem Mol Biol. 2004;91:49-58 pubmed
    ..DHEA was mainly converted to androst-5-ene-3beta,17beta-diol, with smaller amounts of the above androgens. Cytochrome P450c17 mRNA and protein were demonstrated by Northern blotting and Western blotting analyses, respectively...
  11. Miller W. Androgen synthesis in adrenarche. Rev Endocr Metab Disord. 2009;10:3-17 pubmed publisher
    ..Qualitative regulation, which determines the type of steroid produced in a cell, is principally at the level of P450c17 (CYP17)...
  12. Munetsuna E, Hojo Y, Hattori M, Ishii H, Kawato S, Ishida A, et al. Retinoic acid stimulates 17beta-estradiol and testosterone synthesis in rat hippocampal slice cultures. Endocrinology. 2009;150:4260-9 pubmed publisher
    ..The stimulation of estradiol and testosterone synthesis by 9-cis-retinoic acid might be caused by activation of P450(17alpha) transcription via retinoid X receptor signaling. ..
  13. Taketoh J, Mutoh J, Takeda T, Ogishima T, Takeda S, Ishii Y, et al. Suppression of fetal testicular cytochrome P450 17 by maternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin: a mechanism involving an initial effect on gonadotropin synthesis in the pituitary. Life Sci. 2007;80:1259-67 pubmed
    The effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the fetal expression of testicular cytochrome P450 17 (CYP17), one of the enzymes necessary for sex steroid synthesis, was studied in Wistar rats...
  14. Wang H, Wen Y, Polan M, Boostanfar R, Feinman M, Behr B. Exogenous granulocyte-macrophage colony-stimulating factor promotes follicular development in the newborn rat in vivo. Hum Reprod. 2005;20:2749-56 pubmed
    ..Ovaries were collected for histologic examination and immunostaining determination of CYP17, a theca cell marker...
  15. Carr T, Ciurlionis R, Milicic I, Whitney K, Liguori M, Warder S, et al. Role of cytochrome P450c17? in dibromoacetic acid-induced testicular toxicity in rats. Arch Toxicol. 2011;85:513-23 pubmed publisher
    ..and regulated the expression of a small number of genes, including a mild but consistent downregulation of cytochrome P450c17? (CYP17) mRNA, an enzyme expressed by Leydig cells and essential for the production of testicular androgens...
  16. Fisseha S, Towns R, Harada M, Peegel H, Menon K. Inhibitory effect of valproic acid on ovarian androgen biosynthesis in rat theca-interstitial cells. Endocrine. 2010;37:187-93 pubmed publisher
    ..of T-I cells with hCG resulted in a significant increase in the mRNA expression of steroidogenic enzymes CYP17A1 and 17?-hydroxysteroid dehydrogenase...
  17. Svechnikov K, Spatafora C, Svechnikova I, Tringali C, Soder O. Effects of resveratrol analogs on steroidogenesis and mitochondrial function in rat Leydig cells in vitro. J Appl Toxicol. 2009;29:673-80 pubmed publisher
    ..in Leydig cells through suppression of the expression of steroidogenic acute regulatory protein and cytochrome P450c17. 3,5-Diacetyl resveratrol was observed to modulate mitochondrial function in Leydig cells, suppressing ..
  18. Compagnone N, Bulfone A, Rubenstein J, Mellon S. Steroidogenic enzyme P450c17 is expressed in the embryonic central nervous system. Endocrinology. 1995;136:5212-23 pubmed
    ..However, cytochrome P450c17, which has 17-hydroxylase and 17,20-lyase activity and is thought to be required for the synthesis of ..
  19. Moustafa G, Ibrahim Z, Hashimoto Y, Alkelch A, Sakamoto K, Ishizuka M, et al. Testicular toxicity of profenofos in matured male rats. Arch Toxicol. 2007;81:875-81 pubmed
    ..microarray analysis and real-time RT-PCR, which revealed that genes related to steroidogenesis including cytochrome P450 17A1 (CYP17A1), steroidogenic acute regulatory protein (StAR) and CYP11A1 were significantly increased...
  20. Svechnikov K, Supornsilchai V, Strand M, Wahlgren A, Seidlova Wuttke D, Wuttke W, et al. Influence of long-term dietary administration of procymidone, a fungicide with anti-androgenic effects, or the phytoestrogen genistein to rats on the pituitary-gonadal axis and Leydig cell steroidogenesis. J Endocrinol. 2005;187:117-24 pubmed
    ..acute regulatory protein (StAR), cytochrome P450 side-chain cleavage (P450 scc) and cytochrome P450 17alpha (P450c17)...
  21. Kibaly C, Meyer L, Patte Mensah C, Mensah Nyagan A. Biochemical and functional evidence for the control of pain mechanisms by dehydroepiandrosterone endogenously synthesized in the spinal cord. FASEB J. 2008;22:93-104 pubmed
    ..Real-time polymerase chain reaction (PCR) after reverse transcription revealed cytochrome P450c17 (DHEA-synthesizing enzyme) gene repression in neuropathic rat SC...
  22. Shi Z, Zhang H, Liu Y, Xu M, Dai J. Alterations in gene expression and testosterone synthesis in the testes of male rats exposed to perfluorododecanoic acid. Toxicol Sci. 2007;98:206-15 pubmed
    ..Our results demonstrate that PFDoA affects the reproduction function of male rats via alterations in steroidogenesis genes, testosterone levels, and testes ultrastructure. ..
  23. Blystone C, Lambright C, Howdeshell K, Furr J, Sternberg R, Butterworth B, et al. Sensitivity of fetal rat testicular steroidogenesis to maternal prochloraz exposure and the underlying mechanism of inhibition. Toxicol Sci. 2007;97:512-9 pubmed
    ..These results suggest that PCZ inhibits the conversion of progesterone to testosterone through the inhibition of CYP17. To test this hypothesis, PCZ effects on CYP17 gene expression and in vitro CYP17 hydroxylase activity were ..
  24. Jablonska O, Shi Z, Valdez K, Ting A, Petroff B. Temporal and anatomical sensitivities to the aryl hydrocarbon receptor agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin leading to premature acyclicity with age in rats. Int J Androl. 2010;33:405-12 pubmed publisher
    ..Real-time PCR was used to determine differences in Cyp1a1, Cyp19a1, Cyp17a1, LH receptor (LHR), FoxA2 and FoxJ1 genes expression between control and remaining groups...
  25. Han D, Kang S, Park O, Cho J, Won C, Park H, et al. Polychlorinated biphenyls have inhibitory effect on testicular steroidogenesis by downregulation of P450(17alpha) and P450(scc). Toxicol Ind Health. 2010;26:287-96 pubmed publisher
    ..These results suggest that PCB126 may affect testicular steroidogenesis by downregulating P450(17alpha), P450(scc) and have inhibitory effect on the testicular functions. ..
  26. Idkowiak J, Randell T, Dhir V, Patel P, Shackleton C, Taylor N, et al. A missense mutation in the human cytochrome b5 gene causes 46,XY disorder of sex development due to true isolated 17,20 lyase deficiency. J Clin Endocrinol Metab. 2012;97:E465-75 pubmed publisher
    ..activity but severely reduced 17,20 lyase activity of the bifunctional enzyme cytochrome P450 (CYP) enzyme 17A1 (CYP17A1), resulting in sex steroid deficiency but normal glucocorticoid and mineralocorticoid reserve...
  27. Mack S, Garrett W, Guthrie H. Absence of correlation between in situ expression of cytochrome P450 17alpha hydroxylase/lyase and 3beta-hydroxysteroid dehydrogenase/(Delta5-4) isomerase messenger ribonucleic acids and steroidogenesis during pubertal development in the rat testis. J Steroid Biochem Mol Biol. 2000;73:19-28 pubmed
    ..Possible explanations of the depletion of transcripts during pubertal development include: specific inhibition of transcription, increased mRNA instability, or high translational activity. ..
  28. Buczko E, Koh Y, Miyagawa Y, Dufau M. The rat 17 alpha-hydroxylase-17,20-desmolase (CYP17) active site: computerized homology modeling and site directed mutagenesis. J Steroid Biochem Mol Biol. 1995;52:209-18 pubmed
    A homology model of the rat 17 alpha-hydroxylase-17,20 desmolase (CYP17) steroid binding domain was derived from the alpha/beta F supersecondary structural element of the 3 alpha/20 beta hydroxysteroid dehydrogenase (HSD) of Streptomyces ..
  29. Grignard E, Gueguen Y, Grison S, Lobaccaro J, Gourmelon P, Souidi M. Contamination with depleted or enriched uranium differently affects steroidogenesis metabolism in rat. Int J Toxicol. 2008;27:323-8 pubmed publisher
    ..001), cyp11a1 (cytochrome P45011a1; 2.2-fold, p < .001), cyp17a1 (cytochrome P45017a1; 2.5-fold, p = .014), cyp19a1 (cytochrome P45019a1; 2.3-fold, p = ...
  30. Zhang P, Nason T, Han X, Hall P. Gene for 17 alpha-hydroxylase/C (17-20) lyase P-450: complete nucleotide sequence of the porcine gene and 5' upstream sequence of the rat gene. Biochim Biophys Acta. 1992;1131:345-8 pubmed
    ..the isolation and characterization of a full-length clone for the porcine 17 alpha-hydroxylase/C(17-20) lyase (CYP17) gene. The complete exon and partial intron sequences are presented including approx...
  31. Hojo Y, Hattori T, Enami T, Furukawa A, Suzuki K, Ishii H, et al. Adult male rat hippocampus synthesizes estradiol from pregnenolone by cytochromes P45017alpha and P450 aromatase localized in neurons. Proc Natl Acad Sci U S A. 2004;101:865-70 pubmed
    ..endogenous cholesterol has been doubted because of the inability to detect dehydroepiandrosterone synthase, P45017alpha. In adult male rat hippocampal formation, significant localization was demonstrated for both cytochromes ..
  32. Imaoka S, Kamataki T, Funae Y. Purification and characterization of six cytochromes P-450 from hepatic microsomes of immature female rats. J Biochem. 1987;102:843-51 pubmed
    ..Based on these results, we concluded that P-450IF-1 corresponded to one of the phenobarbital-inducible forms in male rat liver. P-450IF-2 was a female-specific form and its concentration was low.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  33. O Shaughnessy P, Morris I, Baker P. Leydig cell re-generation and expression of cell signaling molecules in the germ cell-free testis. Reproduction. 2008;135:851-8 pubmed publisher
    ..of Leydig cell-specific mRNA transcripts coding for steroidogenic enzymes cytochrome P450 11a1 (Cyp11a1), cytochrome P450 17a1 (Cyp17a1), 3beta-hydroxysteroid dehydrogenase type 1 (Hsd3b1), 17beta-hydroxysteroid dehydrogenase type 3 (..
  34. Bair S, Mellon S. Deletion of the mouse P450c17 gene causes early embryonic lethality. Mol Cell Biol. 2004;24:5383-90 pubmed
    ..The synthesis of DHEA and sex steroids, but not mouse glucocorticoids and mineralocorticoids, requires P450c17, which catalyzes both 17 alpha-hydroxylase and 17,20-lyase activities...
  35. Orisaka M, Jiang J, Orisaka S, Kotsuji F, Tsang B. Growth differentiation factor 9 promotes rat preantral follicle growth by up-regulating follicular androgen biosynthesis. Endocrinology. 2009;150:2740-8 pubmed publisher
    ..GDF-9 antisense suppressed androgen production and CYP17A1 mRNA expression in cultured follicles, a response attenuated by exogenous GDF-9...
  36. Zhou W, Liu J, Liao L, Han S, Liu J. Effect of bisphenol A on steroid hormone production in rat ovarian theca-interstitial and granulosa cells. Mol Cell Endocrinol. 2008;283:12-8 pubmed publisher
    ..In T-I cells, BPA increased testosterone synthesis and mRNA expression of 17-alpha hydroxylase (P450c17), cholesterol side chain cleavage enzyme (P450scc) and steroidogenic acute regulatory protein (StAR) at ..
  37. Keeney D, Jenkins C, Waterman M. Developmentally regulated expression of adrenal 17 alpha-hydroxylase cytochrome P450 in the mouse embryo. Endocrinology. 1995;136:4872-9 pubmed
    ..in adult mice and rats, and this is explained, in part, by the absence of 17 alpha-hydroxylase cytochrome P450 (P450c17) in adrenal glands of these rodents...
  38. Mellon S, Vaisse C. cAMP regulates P450scc gene expression by a cycloheximide-insensitive mechanism in cultured mouse Leydig MA-10 cells. Proc Natl Acad Sci U S A. 1989;86:7775-9 pubmed
    ..We cloned rat P450c17 cDNA and showed it detected no P450c17 mRNA in control or cAMP-stimulated MA-10 cells by RNA transfer blots or ..
  39. Yanase T, Simpson E, Waterman M. 17 alpha-hydroxylase/17,20-lyase deficiency: from clinical investigation to molecular definition. Endocr Rev. 1991;12:91-108 pubmed
  40. Kumar V, Kural M, Pereira B, Roy P. Spearmint induced hypothalamic oxidative stress and testicular anti-androgenicity in male rats - altered levels of gene expression, enzymes and hormones. Food Chem Toxicol. 2008;46:3563-70 pubmed publisher
    ..analysis demonstrated the decreased expression of some of the steroidogenic enzymes, cytochrome P450scc, cytochrome P450C17, 3beta-Hydroxysteroid dehydrogenase (3beta-HSD), 17beta-Hydroxysteroid dehydrogenase (17beta-HSD) and other ..
  41. Manca P, Caria M, Blasi J, Martín Satué M, Mameli O. Cytochrome P450 17?-hydroxylase/C(17,20)-lyase immunoreactivity and molecular expression in the cerebellar nuclei of adult male rats. J Chem Neuroanat. 2012;45:18-25 pubmed publisher
    ..Taken together, these data demonstrate the occurrence of P450C(17) in the deep cerebellar nuclei, and enable the chemical characterization of the cells that express the cytochrome. ..
  42. Li Y, Liang X, Wei L, Xiong Y, Yang X, Shi H, et al. Study of RNA interference inhibiting rat ovarian androgen biosynthesis by depressing 17alpha-hydroxylase/17, 20-lyase activity in vivo. Reprod Biol Endocrinol. 2009;7:73 pubmed publisher
    17alpha-hydroxylase/17, 20-lyase encoded by CYP17 is the key enzyme in androgen biosynthesis pathway...
  43. Namiki M, Kitamura M, Buczko E, Dufau M. Rat testis P-450(17)alpha cDNA: the deduced amino acid sequence, expression and secondary structural configuration. Biochem Biophys Res Commun. 1988;157:705-12 pubmed
    ..Hydropathic analysis indicates that the remainder of the C terminus is associated with the membrane through four hydrophobic clefts, including the putative steroid binding site. ..
  44. Ryu J, Lee E, Kim T, Lee Y, Lee J, Lee B, et al. Time-response effects of testicular gene expression profiles in Sprague-Dawley male rats treated with di(n-butyl) phthalate. J Toxicol Environ Health A. 2008;71:1542-9 pubmed publisher
    ..High doses of DBP significantly increased the Cyp17 mRNA level after 28 d of exposure...
  45. Pogrmic Majkic K, Fa S, Dakic V, Kaisarevic S, Kovacevic R. Upregulation of peripubertal rat Leydig cell steroidogenesis following 24 h in vitro and in vivo exposure to atrazine. Toxicol Sci. 2010;118:52-60 pubmed publisher
    ..protein, cytochrome P450 (CYP)17A1, and 17?-hydroxysteroid dehydrogenase (HSD), as well as the activity of CYP17A1 and 17?HSD...
  46. Pignatelli D, Xiao F, Gouveia A, Ferreira J, Vinson G. Adrenarche in the rat. J Endocrinol. 2006;191:301-8 pubmed
    ..One factor thought to contribute to the adrenarche in man is increased adrenal 17-hydroxylase (CYP17) activity...
  47. Kimoto T, Ishii H, Higo S, Hojo Y, Kawato S. Semicomprehensive analysis of the postnatal age-related changes in the mRNA expression of sex steroidogenic enzymes and sex steroid receptors in the male rat hippocampus. Endocrinology. 2010;151:5795-806 pubmed publisher
    ..Srd5a1 > Star > Ar ? Hsd17b4 ? Hsd17b1 ? Hsd17b7 ? Esr1 ? Srd5a2 > Hsd17b3 > Esr2 > Cyp11a1 > Cyp17a1 > Cyp19a1 ? Hsd17b2 > 3?-hydroxysteroid dehydrogenase I...
  48. Hou L, Xu J, Gao Y, Rashid A, Zheng S, Sakoda L, et al. CYP17 MspA1 polymorphism and risk of biliary tract cancers and gallstones: a population-based study in Shanghai, China. Int J Cancer. 2006;118:2847-53 pubmed
    ..In view of reports linking the CYP17 MspA1 polymorphism to high circulating levels of estrogens and a predisposition to other hormonally related ..
  49. Song L, Tang X, Kong Y, Ma H, Zou S. The expression of serum steroid sex hormones and steroidogenic enzymes following intraperitoneal administration of dehydroepiandrosterone (DHEA) in male rats. Steroids. 2010;75:213-8 pubmed publisher
    ..In total, the results of the present study indicate that DHEA at high pharmacological doses may affect steroid through an effect on steroidogenic enzymes. ..
  50. Lahousse S, Wallace D, Liu D, Gaido K, Johnson K. Testicular gene expression profiling following prepubertal rat mono-(2-ethylhexyl) phthalate exposure suggests a common initial genetic response at fetal and prepubertal ages. Toxicol Sci. 2006;93:369-81 pubmed
    ..a unique, dose-dependent expression pattern was observed for the transcription factor Nr0b1, steroidogenic genes (Cyp17a1 and StAR), and a cholesterol metabolism gene (Dhcr7)...
  51. Nishihara M, Winters C, Buzko E, Waterman M, Dufau M. Hormonal regulation of rat Leydig cell cytochrome P-45017 alpha mRNA levels and characterization of a partial length rat P-45017 alpha cDNA. Biochem Biophys Res Commun. 1988;154:151-8 pubmed
  52. Xiong D, Shen H, Zhao L, Xiao P, Yang T, Guo Y, et al. Robust and comprehensive analysis of 20 osteoporosis candidate genes by very high-density single-nucleotide polymorphism screen among 405 white nuclear families identified significant association and gene-gene interaction. J Bone Miner Res. 2006;21:1678-95 pubmed
    ..We detected four genes (DBP, LRP5, CYP17, and RANK) that showed highly suggestive associations (10,000-permutation derived empirical global p < or = 0...
  53. Kim Y, Kang M, Choi J, Lee B, Kim G, Ohn J, et al. A review of the literature on common CYP17A1 mutations in adults with 17-hydroxylase/17,20-lyase deficiency, a case series of such mutations among Koreans and functional characteristics of a novel mutation. Metabolism. 2014;63:42-9 pubmed publisher
    ..Wild-type and mutant CYP17A1 cDNAs were inserted into the pcDNA3.1/V5-His-P450c17 vector, and transiently expressed in COS-7 cells...