cyclophilin B


Gene Symbol: cyclophilin B
Description: peptidylprolyl isomerase B
Alias: CypB, Scylp, peptidyl-prolyl cis-trans isomerase B, CYP-S1, PPIase B, S-cyclophilin, S-cyclophylin, cyclophilin B, rotamase B
Species: rat
Products:     cyclophilin B

Top Publications

  1. Watashi K, Ishii N, Hijikata M, Inoue D, Murata T, Miyanari Y, et al. Cyclophilin B is a functional regulator of hepatitis C virus RNA polymerase. Mol Cell. 2005;19:111-22 pubmed
    ..Here, we demonstrate that a cellular peptidyl-prolyl cis-trans isomerase (PPIase), cyclophilin B (CyPB), is critical for the efficient replication of the hepatitis C virus (HCV) genome...
  2. Kim J, Choi T, Ding Y, Kim Y, Ha K, Lee K, et al. Overexpressed cyclophilin B suppresses apoptosis associated with ROS and Ca2+ homeostasis after ER stress. J Cell Sci. 2008;121:3636-48 pubmed publisher
    ..In this study, we demonstrated that ER stress activates the expression of the ER-localized cyclophilin B (CypB) gene through a novel ER stress response element...
  3. Barnes A, Carter E, Cabral W, Weis M, Chang W, Makareeva E, et al. Lack of cyclophilin B in osteogenesis imperfecta with normal collagen folding. N Engl J Med. 2010;362:521-8 pubmed publisher
    ..a homozygous start-codon mutation in the peptidyl-prolyl isomerase B gene (PPIB), which results in a lack of cyclophilin B (CyPB), the third component of the complex...
  4. Iwai N, Inagami T. Molecular cloning of a complementary DNA to rat cyclophilin-like protein mRNA. Kidney Int. 1990;37:1460-5 pubmed
    ..By virtue of its possible involvement in sodium homeostasis and its homology to cyclophilin, this molecule might have significant implications in the mechanism of cyclosporine-induced renal insufficiency and hypertension. ..
  5. Hasel K, Glass J, Godbout M, Sutcliffe J. An endoplasmic reticulum-specific cyclophilin. Mol Cell Biol. 1991;11:3484-91 pubmed
    ..These results suggest that cyclosporin A mediates its effect on cells through more than one cyclophilin and that cyclosporin A-induced misfolding of T-cell membrane proteins normally mediated by CPH2 plays a role in immunosuppression. ..
  6. Wang H, Zhang Y, Wang T, You H, Jia J. N-methyl-4-isoleucine cyclosporine attenuates CCl -induced liver fibrosis in rats by interacting with cyclophilin B and D. J Gastroenterol Hepatol. 2011;26:558-67 pubmed publisher
    ..expression of matrix metalloproteinase-13, tissue inhibitor of metalloproteinase-1, ?-smooth muscle actin and cyclophilin B and D in liver tissue were determined. Cyclophilin B and D were also studied in an hepatic stellate cell line...
  7. Arber S, Krause K, Caroni P. s-cyclophilin is retained intracellularly via a unique COOH-terminal sequence and colocalizes with the calcium storage protein calreticulin. J Cell Biol. 1992;116:113-25 pubmed
    ..Because of its conserved structure, widespread distribution, and abundance s-cyclophilin may be a useful marker to study the biogenesis and distribution of ER subcompartments. ..
  8. Oh Y, Kim E, Kim Y, Jin J, Jin B, Jahng G, et al. Neuroprotective effects of overexpressed cyclophilin B against A?-induced neurotoxicity in PC12 cells. Free Radic Biol Med. 2011;51:905-20 pubmed publisher
    ..Our previous work suggested that cyclophilin B (CypB) protects against endoplasmic reticulum (ER) stress...
  9. Jansen G, Maattanen P, Denisov A, Scarffe L, Schade B, Balghi H, et al. An interaction map of endoplasmic reticulum chaperones and foldases. Mol Cell Proteomics. 2012;11:710-23 pubmed publisher
    ..We have examined in detail a novel ERp72-cyclophilin B complex that enhances the rate of folding of immunoglobulin G...

More Information


  1. Kainer D, Doris P. Cyclophilin B expression in renal proximal tubules of hypertensive rats. Hypertension. 2000;35:958-64 pubmed
    ..We report the molecular characterization of rat cyclophilin B (CypB) and demonstrate, through sequence analysis and an allele-specific polymerase chain reaction primer ..
  2. Rycyzyn M, Reilly S, O MALLEY K, Clevenger C. Role of cyclophilin B in prolactin signal transduction and nuclear retrotranslocation. Mol Endocrinol. 2000;14:1175-86 pubmed
    ..this retrotranslocation, a yeast two-hybrid screen was performed and revealed an interaction between PRL and cyclophilin B (CypB)...