Gene Symbol: cyclophilin B
Description: peptidylprolyl isomerase B
Alias: CypB, Scylp, peptidyl-prolyl cis-trans isomerase B, CYP-S1, PPIase B, S-cyclophilin, S-cyclophylin, cyclophilin B, rotamase B
Watashi K, Ishii N, Hijikata M, Inoue D, Murata T, Miyanari Y, et al
. Cyclophilin B is a functional regulator of hepatitis C virus RNA polymerase. Mol Cell. 2005;19:111-22 pubmed
..Here, we demonstrate that a cellular peptidyl-prolyl cis-trans isomerase (PPIase), cyclophilin B (CyPB), is critical for the efficient replication of the hepatitis C virus (HCV) genome...
Kim J, Choi T, Ding Y, Kim Y, Ha K, Lee K, et al
. Overexpressed cyclophilin B suppresses apoptosis associated with ROS and Ca2+ homeostasis after ER stress. J Cell Sci. 2008;121:3636-48 pubmed publisher
..In this study, we demonstrated that ER stress activates the expression of the ER-localized cyclophilin B (CypB) gene through a novel ER stress response element...
Barnes A, Carter E, Cabral W, Weis M, Chang W, Makareeva E, et al
. Lack of cyclophilin B in osteogenesis imperfecta with normal collagen folding. N Engl J Med. 2010;362:521-8 pubmed publisher
..a homozygous start-codon mutation in the peptidyl-prolyl isomerase B gene (PPIB), which results in a lack of cyclophilin B (CyPB), the third component of the complex...
Iwai N, Inagami T. Molecular cloning of a complementary DNA to rat cyclophilin-like protein mRNA. Kidney Int. 1990;37:1460-5 pubmed
..By virtue of its possible involvement in sodium homeostasis and its homology to cyclophilin, this molecule might have significant implications in the mechanism of cyclosporine-induced renal insufficiency and hypertension. ..
Hasel K, Glass J, Godbout M, Sutcliffe J. An endoplasmic reticulum-specific cyclophilin. Mol Cell Biol. 1991;11:3484-91 pubmed
..These results suggest that cyclosporin A mediates its effect on cells through more than one cyclophilin and that cyclosporin A-induced misfolding of T-cell membrane proteins normally mediated by CPH2 plays a role in immunosuppression. ..
Wang H, Zhang Y, Wang T, You H, Jia J. N-methyl-4-isoleucine cyclosporine attenuates CCl -induced liver fibrosis in rats by interacting with cyclophilin B and D. J Gastroenterol Hepatol. 2011;26:558-67 pubmed publisher
..expression of matrix metalloproteinase-13, tissue inhibitor of metalloproteinase-1, ?-smooth muscle actin and cyclophilin B and D in liver tissue were determined. Cyclophilin B and D were also studied in an hepatic stellate cell line...
Arber S, Krause K, Caroni P. s-cyclophilin is retained intracellularly via a unique COOH-terminal sequence and colocalizes with the calcium storage protein calreticulin. J Cell Biol. 1992;116:113-25 pubmed
..Because of its conserved structure, widespread distribution, and abundance s-cyclophilin may be a useful marker to study the biogenesis and distribution of ER subcompartments. ..
Oh Y, Kim E, Kim Y, Jin J, Jin B, Jahng G, et al
. Neuroprotective effects of overexpressed cyclophilin B against A?-induced neurotoxicity in PC12 cells. Free Radic Biol Med. 2011;51:905-20 pubmed publisher
..Our previous work suggested that cyclophilin B (CypB) protects against endoplasmic reticulum (ER) stress...
Jansen G, Maattanen P, Denisov A, Scarffe L, Schade B, Balghi H, et al
. An interaction map of endoplasmic reticulum chaperones and foldases. Mol Cell Proteomics. 2012;11:710-23 pubmed publisher
..We have examined in detail a novel ERp72-cyclophilin B complex that enhances the rate of folding of immunoglobulin G...