Gene Symbol: Cybrd1
Description: cytochrome b reductase 1
Alias: Dcytb, cytochrome b reductase 1, duodenal cytochrome b
Loke S, Siddiqi N, Alhomida A, Kim H, Ong W. Expression and localization of duodenal cytochrome b in the rat hippocampus after kainate-induced excitotoxicity. Neuroscience. 2013;245:179-90 pubmed publisher
..The present study was carried out to investigate the expression of a ferric reductase, duodenal cytochrome b (DCYTB), in the rat hippocampus after KA injury...
McKie A, Barrow D, Latunde Dada G, Rolfs A, Sager G, Mudaly E, et al
. An iron-regulated ferric reductase associated with the absorption of dietary iron. Science. 2001;291:1755-9 pubmed
..We have isolated a complementary DNA, Dcytb (for duodenal cytochrome b), which encoded a putative plasma membrane di-heme protein in mouse duodenal mucosa...
Vargas J, Herpers B, McKie A, Gledhill S, McDonnell J, van den Heuvel M, et al
. Stromal cell-derived receptor 2 and cytochrome b561 are functional ferric reductases. Biochim Biophys Acta. 2003;1651:116-23 pubmed
..Given that a fourth member, duodenal cytochrome b (Dcytb), has previously been shown to be a ferric reductase, it is likely that all remaining members of ..
Turi J, Wang X, McKie A, Nozik Grayck E, Mamo L, Crissman K, et al
. Duodenal cytochrome b: a novel ferrireductase in airway epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2006;291:L272-80 pubmed
..Because cellular iron uptake requires membrane ferrireductase activity that in the gut can be provided by duodenal cytochrome b (Dcytb), we sought Dcytb in the lung to test the hypothesis that it contributes to epithelial iron ..
Thomas C, Gaffney Stomberg E, Sun B, O Brien K, Kerstetter J, Insogna K. Increasing dietary protein acutely augments intestinal iron transporter expression and significantly increases iron absorption in rats. FASEB J. 2013;27:2476-83 pubmed publisher
..2-fold, duodenal cytochrome b (Dcytb) 1.8-fold, and transferrin receptor (TfR) 1.8-fold...
Marciano R, Santamarina A, de Santana A, Silva M, Amancio O, do Nascimento C, et al
. Effects of prebiotic supplementation on the expression of proteins regulating iron absorption in anaemic growing rats. Br J Nutr. 2015;113:901-8 pubmed publisher
..of the divalent metal transporter 1 protein in the caecum by 162 % (P= 0Â·04), and the expression of duodenal cytochrome b reductase in the colon by 136 % (P= 0Â·02)...
Lane D, Merlot A, Huang M, Bae D, Jansson P, Sahni S, et al
. Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease. Biochim Biophys Acta. 2015;1853:1130-44 pubmed publisher
..g., Friedreich's ataxia. Increased knowledge of the molecules and their mechanisms of action in iron processing pathways (e.g., ISC biogenesis) will shape the investigation of iron metabolism in human health and disease. ..