Cxcr4

Summary

Gene Symbol: Cxcr4
Description: C-X-C motif chemokine receptor 4
Alias: C-X-C chemokine receptor type 4, CXC chemokine receptor, CXC-R4, CXCR-4, LESTR, SDF-1 receptor, chemokine (C-X-C motif) receptor 4, chemokine receptor (LCR1), fusin, leukocyte-derived seven transmembrane domain receptor, stromal cell-derived factor 1 receptor
Species: rat
Products:     Cxcr4

Top Publications

  1. Segret A, Rucker Martin C, Pavoine C, Flavigny J, Deroubaix E, Chatel M, et al. Structural localization and expression of CXCL12 and CXCR4 in rat heart and isolated cardiac myocytes. J Histochem Cytochem. 2007;55:141-50 pubmed
    CXCL12 (SDF-1), which binds CXCR4, is involved in several physiological and pathophysiological processes. In heart, this axis seems to play a key role in cardiogenesis and is involved in the neovascularization of ischemic tissues...
  2. Thoma G, Streiff M, Kovarik J, Glickman F, Wagner T, Beerli C, et al. Orally bioavailable isothioureas block function of the chemokine receptor CXCR4 in vitro and in vivo. J Med Chem. 2008;51:7915-20 pubmed publisher
    The interaction of the chemokine receptor CXCR4 with its ligand CXCL12 is involved in many biological processes such as hematopoesis, migration of immune cells, as well as in cancer metastasis...
  3. Lin A, Lei M, Xie X, Xu H. [Expression and meaning of pro-angiogenic factors in retinopathy of diabetic rats]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2009;34:1243-50 pubmed
    ..The expression of VEGF, SDF-1alpha, and CXCR-4 on the retina in retinopathy of diabetic rats increases gradually with the prolongation of the disease. It is an important factor for diabetic retinopathy. ..
  4. Xu C, Liu J, Chen L, Liang S, Fujii N, Tamamura H, et al. HIV-1 gp120 enhances outward potassium current via CXCR4 and cAMP-dependent protein kinase A signaling in cultured rat microglia. Glia. 2011;59:997-1007 pubmed publisher
    ..The gp120-associated enhancement of outward K(+) current was blocked by either a CXCR4 receptor antagonist T140 or a specific protein kinase A (PKA) inhibitor H89, suggesting the involvement of ..
  5. Pujol F, Kitabgi P, Boudin H. The chemokine SDF-1 differentially regulates axonal elongation and branching in hippocampal neurons. J Cell Sci. 2005;118:1071-80 pubmed
    ..role of SDF-1 in the development of central neurons, we studied the cellular distribution of the SDF-1 receptor CXCR4 by immunocytochemistry of developing hippocampal neurons and tested the effect of SDF-1 in process patterning at ..
  6. Zhang D, Fan G, Zhou X, Zhao T, Pasha Z, Xu M, et al. Over-expression of CXCR4 on mesenchymal stem cells augments myoangiogenesis in the infarcted myocardium. J Mol Cell Cardiol. 2008;44:281-92 pubmed publisher
    ..To overcome this limitation, we genetically engineered male rat MSCs overexpressing CXCR4 in order to maximize the effect of stromal cell-derived factor-1alpha (SDF-1alpha) for cell migration and ..
  7. Smith J, Johanesen P, Wendt M, Binion D, Dwinell M. CXCL12 activation of CXCR4 regulates mucosal host defense through stimulation of epithelial cell migration and promotion of intestinal barrier integrity. Am J Physiol Gastrointest Liver Physiol. 2005;288:G316-26 pubmed
    ..The aim of this study was to define the role for the chemokine CXCL12 and its sole cognate receptor CXCR4 in regulating intestinal epithelial cell migration and to determine its impact on barrier integrity...
  8. Banisadr G, Fontanges P, Haour F, Kitabgi P, Rostene W, Mélik Parsadaniantz S. Neuroanatomical distribution of CXCR4 in adult rat brain and its localization in cholinergic and dopaminergic neurons. Eur J Neurosci. 2002;16:1661-71 pubmed
    ..b>CXCR4, a G protein-coupled receptor for the chemokine stromal cell-derived factor-1 (SDF-1/CXCL12) was reported to have ..
  9. Yu X, Chen D, Zhang Y, Wu X, Huang Z, Zhou H, et al. Overexpression of CXCR4 in mesenchymal stem cells promotes migration, neuroprotection and angiogenesis in a rat model of stroke. J Neurol Sci. 2012;316:141-9 pubmed publisher
    Stromal cell-derived factor-1 (SDF-1) and its cognate receptor, chemokine (C-X-C motif) receptor 4 (CXCR4), are involved in the migration of stem cells...

More Information

Publications94

  1. Cheng M, Zhou J, Wu M, Boriboun C, Thorne T, Liu T, et al. CXCR4-mediated bone marrow progenitor cell maintenance and mobilization are modulated by c-kit activity. Circ Res. 2010;107:1083-93 pubmed publisher
    ..progenitor cells (PCs) is largely governed by interactions between stromal cell-derived factor (SDF)-1 and CXC chemokine receptor (CXCR)4...
  2. Bhandari D, Robia S, Marchese A. The E3 ubiquitin ligase atrophin interacting protein 4 binds directly to the chemokine receptor CXCR4 via a novel WW domain-mediated interaction. Mol Biol Cell. 2009;20:1324-39 pubmed publisher
    ..ligase atrophin interacting protein 4 (AIP4) mediates ubiquitination and down-regulation of the chemokine receptor CXCR4. AIP4 belongs to the Nedd4-like homologous to E6-AP carboxy terminus domain family of E3 ubiquitin ligases, which ..
  3. Yu L, Hales C. Effect of chemokine receptor CXCR4 on hypoxia-induced pulmonary hypertension and vascular remodeling in rats. Respir Res. 2011;12:21 pubmed publisher
    b>CXCR4 is the receptor for chemokine CXCL12 and reportedly plays an important role in systemic vascular repair and remodeling, but the role of CXCR4 in development of pulmonary hypertension and vascular remodeling has not been fully ..
  4. Kolodziej A, Schulz S, Guyon A, Wu D, Pfeiffer M, Odemis V, et al. Tonic activation of CXC chemokine receptor 4 in immature granule cells supports neurogenesis in the adult dentate gyrus. J Neurosci. 2008;28:4488-500 pubmed publisher
    Stromal-cell-derived factor-1 (SDF-1) and its receptor CXC chemokine receptor 4 (CXCR4) play a well-established role during embryonic development of dentate gyrus granule cells...
  5. Wang Y, Deng Y, Zhou G. SDF-1alpha/CXCR4-mediated migration of systemically transplanted bone marrow stromal cells towards ischemic brain lesion in a rat model. Brain Res. 2008;1195:104-12 pubmed publisher
    ..Interaction between stromal cell-derived factor-1alpha (SDF-1alpha) and its cognate receptor CXCR4 is crucial for homing and migration of multiple stem cell types...
  6. Shepherd A, Loo L, Gupte R, Mickle A, Mohapatra D. Distinct modifications in Kv2.1 channel via chemokine receptor CXCR4 regulate neuronal survival-death dynamics. J Neurosci. 2012;32:17725-39 pubmed publisher
    ..a proinflammatory microenvironment within the brain, via signaling through C-X-C-type chemokine receptor 4 (CXCR4), although the underlying cellular/molecular mechanisms are unclear...
  7. Song C, Li G. CXCR4 and matrix metalloproteinase-2 are involved in mesenchymal stromal cell homing and engraftment to tumors. Cytotherapy. 2011;13:549-61 pubmed publisher
    ..Chemokine (C-X-C motif) Receptor 4 (CXCR4) upregulation was also found in BMSC after 24 h exposure to tumor CM...
  8. Saini V, Marchese A, Majetschak M. CXC chemokine receptor 4 is a cell surface receptor for extracellular ubiquitin. J Biol Chem. 2010;285:15566-76 pubmed publisher
    ..However, its mechanism of action is unknown. Here we show that extracellular ubiquitin is a natural CXC chemokine receptor 4 (CXCR4 and CD184) agonist...
  9. Kaul M, Ma Q, Medders K, Desai M, Lipton S. HIV-1 coreceptors CCR5 and CXCR4 both mediate neuronal cell death but CCR5 paradoxically can also contribute to protection. Cell Death Differ. 2007;14:296-305 pubmed
    The chemokine receptors CCR5 and CXCR4 serve, in addition to CD4, as coreceptors for human immunodeficiency virus-1 (HIV-1), and infection with HIV-1 can cause dementia...
  10. Pereira L, Wong M, Mossman A, Sourris K, Janes M, Knezevic K, et al. Pdgfr? and Flk1 are direct target genes of Mixl1 in differentiating embryonic stem cells. Stem Cell Res. 2012;8:165-79 pubmed publisher
    ..These data support the hypothesis that Mixl1 directly regulates Pdgfr? and Flk1 gene expression and strengthens the position of Mixl1 as a key regulator of mesendoderm development during mammalian gastrulation. ..
  11. Li S, Deng L, Gong L, Bian H, Dai Y, Wang Y. Upregulation of CXCR4 favoring neural-like cells migration via AKT activation. Neurosci Res. 2010;67:293-9 pubmed publisher
    Stromal cell-derived factor-1alpha (SDF-1alpha) and its chemokine receptor 4 (CXCR4) play an important role in regulating bone marrow stromal stem cells (BMSCs) migration, proliferation and differentiation...
  12. Cheng S, Quinn J, Graeber C, Filardo E. Down-modulation of the G-protein-coupled estrogen receptor, GPER, from the cell surface occurs via a trans-Golgi-proteasome pathway. J Biol Chem. 2011;286:22441-55 pubmed publisher
    ..Our results provide an explanation as to why GPER is not readily detected on the cell surface in some cell types and further suggest that TGN serves as the checkpoint for degradation of endocytosed GPER. ..
  13. Lipfert J, Odemis V, Wagner D, Boltze J, Engele J. CXCR4 and CXCR7 form a functional receptor unit for SDF-1/CXCL12 in primary rodent microglia. Neuropathol Appl Neurobiol. 2013;39:667-80 pubmed publisher
    Microglial cells have been originally identified as a target for the CXC chemokine, SDF-1, by their expression of CXCR4. More recently, it has been recognized that SDF-1 additionally binds to CXCR7, which depending on the cell type acts ..
  14. Bagri A, Gurney T, He X, Zou Y, Littman D, Tessier Lavigne M, et al. The chemokine SDF1 regulates migration of dentate granule cells. Development. 2002;129:4249-60 pubmed
    ..migration, we found that SDF1, a chemokine that regulates cerebellar and leukocyte migration, and its receptor CXCR4 are expressed in patterns that suggest a role in dentate granule cell migration...
  15. Liu J, Yang X, Shi W. Overexpression of CXCR4 in tracheal epithelial cells promotes their proliferation and migration to a stromal cell-derived factor-1 gradient. Exp Biol Med (Maywood). 2013;238:144-50 pubmed publisher
    ..Several reports have shown that stromal cell-derived factor-1 (SDF-1) and chemokine receptor CXCR4 play an important role in cell proliferation and migration of multiple cell types...
  16. Siddiqi F, Chen L, Advani S, Thai K, Batchu S, Alghamdi T, et al. CXCR4 promotes renal tubular cell survival in male diabetic rats: implications for ligand inactivation in the human kidney. Endocrinology. 2015;156:1121-32 pubmed publisher
    Binding of the receptor CXCR4 to its ligand stromal cell-derived factor 1 (SDF-1) promotes cell survival and is under the influence of a number of regulatory processes including enzymatic ligand inactivation by endopeptidases such as ..
  17. Larocca T, Schwarzkopf M, Altman P, Zhang S, Gupta A, Gomes I, et al. ?2-Adrenergic receptor signaling in the cardiac myocyte is modulated by interactions with CXCR4. J Cardiovasc Pharmacol. 2010;56:548-59 pubmed publisher
    ..role for one such chemokine pair, stromal cell-derived factor-1? and its G-protein coupled receptor, CXCR4. Stromal cell-derived factor-1/CXCR4 are expressed on cardiac myocytes and have direct consequences on cardiac ..
  18. Jost T, Borga C, Radaelli E, Romagnani A, Perruzza L, Omodho L, et al. Role of CXCR4-mediated bone marrow colonization in CNS infiltration by T cell acute lymphoblastic leukemia. J Leukoc Biol. 2016;99:1077-87 pubmed publisher
    ..Inhibition of CXC chemokine receptor 4 significantly ameliorates T cell acute lymphoblastic leukemia in murine models of the disease; however, ..
  19. Vera P, Iczkowski K, Wang X, Meyer Siegler K. Cyclophosphamide-induced cystitis increases bladder CXCR4 expression and CXCR4-macrophage migration inhibitory factor association. PLoS ONE. 2008;3:e3898 pubmed publisher
    ..MIF) is a pro-inflammatory cytokine involved in cystitis and a non-cognate ligand of the chemokine receptor CXCR4 in vitro. We studied whether CXCR4-MIF associations occur in rat bladder and the effect of experimental cystitis...
  20. Mei H, Zhou M, Zhang X, Huang X, Wang Y, Wang P, et al. Effects of miR-338 on morphine tolerance by targeting CXCR4 in a rat model of bone cancer pain. Biosci Rep. 2017;37: pubmed publisher
    ..study aimed to investigate the effects of miR-338 on morphine tolerance through the targeting of CXC chemokine receptor-4 (CXCR4) in a rat model of bone cancer pain (BCP)...
  21. Reiss K, Mentlein R, Sievers J, Hartmann D. Stromal cell-derived factor 1 is secreted by meningeal cells and acts as chemotactic factor on neuronal stem cells of the cerebellar external granular layer. Neuroscience. 2002;115:295-305 pubmed
    ..Correspondingly, the SDF-1 receptor (termed CXCR4) can be demonstrated on stem cells of the external granular layer, but is absent on postmitotic cells commencing ..
  22. Su B, Pan S, He X, Li P, Liang Y. Sprouting of nervous fibers and upregulation of C-X-C chemokine receptor type 4 expression in hippocampal formation of rats with enhanced spatial learning and memory. Anat Rec (Hoboken). 2012;295:121-6 pubmed publisher
    ..The C-X-C chemokine receptor type 4 (CXCR4) is the main receptor for stromal cell-derived factor-1 (SDF-1), which is a chemokine that can regulate axonal ..
  23. Konoplev S, Lin P, Yin C, Lin E, Nogueras Gonzalez G, Kantarjian H, et al. CXC chemokine receptor 4 expression, CXC chemokine receptor 4 activation, and wild-type nucleophosmin are independently associated with unfavorable prognosis in patients with acute myeloid leukemia. Clin Lymphoma Myeloma Leuk. 2013;13:686-92 pubmed publisher
    b>CXC chemokine receptor 4 (CXCR4) is activated by phosphorylation and essential for migration of hematopoietic precursors to bone marrow. CXCR4 overexpression predicts unfavorable prognosis in patients with acute myeloid leukemia (AML)...
  24. Trimble A, Gochuico B, Markello T, Fischer R, Gahl W, Lee J, et al. Circulating fibrocytes as biomarker of prognosis in Hermansky-Pudlak syndrome. Am J Respir Crit Care Med. 2014;190:1395-401 pubmed publisher
    ..The blood concentration of fibrocytes expressing the chemokine receptor CXCR4 correlated significantly with the plasma concentration of the CXCR4 ligand, CXCL12...
  25. Scheurer S, Rybak J, Rösli C, Neri D, Elia G. Modulation of gene expression by hypoxia in human umbilical cord vein endothelial cells: A transcriptomic and proteomic study. Proteomics. 2004;4:1737-60 pubmed
    ..g., CXCR4, claudin 3, CD24, tetranectin, Del-1, procollagen lysyl hydroxylase 1 and 2) which are transcriptionally ..
  26. McDermott D, Liu Q, Ulrick J, Kwatemaa N, Anaya O Brien S, Penzak S, et al. The CXCR4 antagonist plerixafor corrects panleukopenia in patients with WHIM syndrome. Blood. 2011;118:4957-62 pubmed publisher
    ..Because WHIM syndrome is caused by mutations in the chemokine receptor CXCR4 that result in increased agonist-dependent signaling, we hypothesized that the CXCR4 antagonist plerixafor (..
  27. Molyneaux K, Zinszner H, Kunwar P, Schaible K, Stebler J, Sunshine M, et al. The chemokine SDF1/CXCL12 and its receptor CXCR4 regulate mouse germ cell migration and survival. Development. 2003;130:4279-86 pubmed
    ..has shown that the interaction between stromal cell-derived factor 1 (SDF1) and its G-protein-coupled receptor CXCR4, already known to control many types of normal and pathological cell migrations, is also required for the normal ..
  28. Lieberam I, Agalliu D, Nagasawa T, Ericson J, Jessell T. A Cxcl12-CXCR4 chemokine signaling pathway defines the initial trajectory of mammalian motor axons. Neuron. 2005;47:667-79 pubmed
    ..We show here that the chemokine receptor Cxcr4 is expressed on the axons of vMNs as they follow their ventral trajectory, whereas its ligand, Cxcl12, is ..
  29. Pleskoff O, Sol N, Labrosse B, Alizon M. Human immunodeficiency virus strains differ in their ability to infect CD4+ cells expressing the rat homolog of CXCR-4 (fusin). J Virol. 1997;71:3259-62 pubmed
    ..B strain of human immunodeficiency virus type 1 (HIV-1(LAI)) could infect CD4+ cells expressing human CXCR-4 (fusin) or its rat homolog with similar efficacy...
  30. Nagasawa T, Nakajima T, Tachibana K, Iizasa H, Bleul C, Yoshie O, et al. Molecular cloning and characterization of a murine pre-B-cell growth-stimulating factor/stromal cell-derived factor 1 receptor, a murine homolog of the human immunodeficiency virus 1 entry coreceptor fusin. Proc Natl Acad Sci U S A. 1996;93:14726-9 pubmed
    ..The deduced amino acid sequence has 90% identity with that of a HUMSTSR/fusin, a human immunodeficiency virus 1 (HIV-1) entry coreceptor...
  31. Farkas D, Kraskauskas D, Drake J, Alhussaini A, Kraskauskiene V, Bogaard H, et al. CXCR4 inhibition ameliorates severe obliterative pulmonary hypertension and accumulation of C-kit? cells in rats. PLoS ONE. 2014;9:e89810 pubmed publisher
    ..The goal of our study was to evaluate whether inhibition of CXC chemokine receptor 4 will prevent the accumulation of c-kit? cells and severe pulmonary arterial hypertension...
  32. Shepherd A, Loo L, Mohapatra D. Chemokine co-receptor CCR5/CXCR4-dependent modulation of Kv2.1 channel confers acute neuroprotection to HIV-1 glycoprotein gp120 exposure. PLoS ONE. 2013;8:e76698 pubmed publisher
    ..1. Such modifications in Kv2.1 are dependent on the activation of the chemokine co-receptors CCR5 and CXCR4, and subsequent activation of the protein phosphatase calcineurin...
  33. Lin S, Gou G, Hsia C, Ho C, Huang K, Wu Y, et al. Simulated Microgravity Disrupts Cytoskeleton Organization and Increases Apoptosis of Rat Neural Crest Stem Cells Via Upregulating CXCR4 Expression and RhoA-ROCK1-p38 MAPK-p53 Signaling. Stem Cells Dev. 2016;25:1172-93 pubmed publisher
    ..In addition, rNCSCs showed increased C-X-C chemokine receptor 4 (CXCR4) expression, RhoA GTPase activation, Rho-associated kinase 1 (ROCK1) and p38 mitogen-activated protein kinase (..
  34. Lee I, Evans A, Yang C, Works M, Kumar V, De Miguel Z, et al. Toxoplasma gondii is dependent on glutamine and alters migratory profile of infected host bone marrow derived immune cells through SNAT2 and CXCR4 pathways. PLoS ONE. 2014;9:e109803 pubmed publisher
    ..Blocking both SNAT2 and C-X-C chemokine receptor 4 (CXCR4; the unique receptor for SDF-1) blocks hypermotility and the enhanced migration in T. gondii-infected DCs...
  35. Bach H, Wong Y, Tripathi A, Nevins A, Gamelli R, Volkman B, et al. Chemokine (C-X-C motif) receptor 4 and atypical chemokine receptor 3 regulate vascular ??-adrenergic receptor function. Mol Med. 2014;20:435-47 pubmed publisher
    ..Thus, it was the aim of the present study to determine how pharmacological modulation of CXCR4 and ACKR3 regulate cardiovascular function...
  36. Liang J, Huang W, Yu X, Ashraf A, Wary K, Xu M, et al. Suicide gene reveals the myocardial neovascularization role of mesenchymal stem cells overexpressing CXCR4 (MSC(CXCR4)). PLoS ONE. 2012;7:e46158 pubmed publisher
    Our previous studies indicated that MSC(CXCR4) improved cardiac function after myocardial infarction (MI)...
  37. Arscott W, LaBauve A, May V, Wesley U. Suppression of neuroblastoma growth by dipeptidyl peptidase IV: relevance of chemokine regulation and caspase activation. Oncogene. 2009;28:479-91 pubmed publisher
    ..marker MAP2 and decreased expression of chemokines, including stromal-derived factor 1 (SDF1) and its receptor CXCR4. Furthermore, DPPIV promoted apoptosis, and inhibited SDF1-mediated in vitro cell migration and angiogenic ..
  38. Abe D, Kubota T, Morozumi T, Shimizu T, Nakasone N, Itagaki M, et al. Altered gene expression in leukocyte transendothelial migration and cell communication pathways in periodontitis-affected gingival tissues. J Periodontal Res. 2011;46:345-53 pubmed publisher
  39. Alfinito F, Ruggiero G, Sica M, Udhayachandran A, Rubino V, Della Pepa R, et al. Eculizumab treatment modifies the immune profile of PNH patients. Immunobiology. 2012;217:698-703 pubmed publisher
    ..an altered cytokine profile of invariant-NKT cells (NKTi) and the increasing of C-X-C chemokine receptor type 4 (CXCR4) receptor in PNH patients before the Eculizumab therapy...
  40. Ara T, Itoi M, Kawabata K, Egawa T, Tokoyoda K, Sugiyama T, et al. A role of CXC chemokine ligand 12/stromal cell-derived factor-1/pre-B cell growth stimulating factor and its receptor CXCR4 in fetal and adult T cell development in vivo. J Immunol. 2003;170:4649-55 pubmed
    ..ligand (CXCL) 12/stromal cell-derived factor-1/pre-B cell growth stimulating factor and its physiologic receptor CXCR4 in T cell development are controversial...
  41. Vasyutina E, Stebler J, Brand Saberi B, Schulz S, Raz E, Birchmeier C. CXCR4 and Gab1 cooperate to control the development of migrating muscle progenitor cells. Genes Dev. 2005;19:2187-98 pubmed
    ..We show here that migrating muscle progenitors express the chemokine receptor CXCR4. The corresponding ligand, SDF1, is expressed in limb and branchial arch mesenchyme; i.e...
  42. Luo Y, Lathia J, Mughal M, Mattson M. SDF1alpha/CXCR4 signaling, via ERKs and the transcription factor Egr1, induces expression of a 67-kDa form of glutamic acid decarboxylase in embryonic hippocampal neurons. J Biol Chem. 2008;283:24789-800 pubmed publisher
    Stromal cell-derived factor alpha (SDF1alpha) and its cognate receptor CXCR4 play an important role in neuronal development in the hippocampus, but the genes directly regulated by SDF1alpha/CXCR4 signaling are unknown...
  43. Peng H, Huang Y, Rose J, Erichsen D, Herek S, Fujii N, et al. Stromal cell-derived factor 1-mediated CXCR4 signaling in rat and human cortical neural progenitor cells. J Neurosci Res. 2004;76:35-50 pubmed
    Stromal cell-derived factor 1 (SDF-1) and the chemokine receptor CXCR4 are highly expressed in the nervous system...
  44. Tripathi A, Davis J, Staren D, Volkman B, Majetschak M. CXC chemokine receptor 4 signaling upon co-activation with stromal cell-derived factor-1? and ubiquitin. Cytokine. 2014;65:121-5 pubmed publisher
    Recently, we reported that extracellular ubiquitin functions as another agonist of CXC chemokine receptor (CXCR)4...
  45. McIntyre J, Titlow W, McClintock T. Axon growth and guidance genes identify nascent, immature, and mature olfactory sensory neurons. J Neurosci Res. 2010;88:3243-56 pubmed publisher
    ..gene expression in olfactory sensory neurons (OSNs), in situ hybridization and immunohistochemistry revealed that Cxcr4 and Dbn1, two axon initiation genes, marked the developmental transition from basal progenitor cells to immature ..
  46. Dubeykovskaya Z, Dubeykovskiy A, Solal Cohen J, Wang T. Secreted trefoil factor 2 activates the CXCR4 receptor in epithelial and lymphocytic cancer cell lines. J Biol Chem. 2009;284:3650-62 pubmed publisher
    ..Here we demonstrate the ability of TFF2 peptide to activate signaling via the CXCR4 chemokine receptor in cancer cell lines. We found that both mouse and human TFF2 proteins (at approximately 0...
  47. Roccaro A, Sacco A, Jimenez C, Maiso P, Moschetta M, Mishima Y, et al. C1013G/CXCR4 acts as a driver mutation of tumor progression and modulator of drug resistance in lymphoplasmacytic lymphoma. Blood. 2014;123:4120-31 pubmed publisher
    The C-X-C chemokine receptor type 4 (CXCR4) plays a crucial role in modulating cell trafficking in hematopoietic stem cells and clonal B cells...
  48. Dai X, Tan Y, Cai S, Xiong X, Wang L, Ye Q, et al. The role of CXCR7 on the adhesion, proliferation and angiogenesis of endothelial progenitor cells. J Cell Mol Med. 2011;15:1299-309 pubmed publisher
    ..b>CXC chemokine receptor 4 (CXCR4) has been considered as the unique receptor of SDF-1 and as the only mediator of SDF-1-induced ..
  49. Wong M, Xin W, Duman R. Rat LCR1: cloning and cellular distribution of a putative chemokine receptor in brain. Mol Psychiatry. 1996;1:133-40 pubmed
    ..The finding that LCR1 is expressed in the adult indicates that this receptor influences neuronal function at times after maturation of the brain. ..
  50. Shahzad U, Li G, Zhang Y, Li R, Rao V, Yau T. Transmyocardial Revascularization Enhances Bone Marrow Stem Cell Engraftment in Infarcted Hearts Through SCF-C-kit and SDF-1-CXCR4 Signaling Axes. Stem Cell Rev. 2015;11:332-46 pubmed publisher
    We investigated the roles of stem cell factor (SCF)-c-kit and stromal derived factor-1 (SDF-1)-CXCR4 signaling axes in transmyocardial revascularization (TMR)-enhanced engraftment of transplanted bone marrow stem cells (BMSCs) in ..
  51. Mao L, Huang M, Chen S, Li Y, Xia Y, He Q, et al. Endogenous endothelial progenitor cells participate in neovascularization via CXCR4/SDF-1 axis and improve outcome after stroke. CNS Neurosci Ther. 2014;20:460-8 pubmed publisher
    ..After inhibiting recruitment of EPCs with AMD3100, a CXCR4 antagonist, endogenous EPCs, capillary density, cerebral blood flow (CBF) in IBZ, and neurobehavioral functions ..
  52. Kasyanov A, Tamamura H, Fujii N, Xiong H. HIV-1 gp120 enhances giant depolarizing potentials via chemokine receptor CXCR4 in neonatal rat hippocampus. Eur J Neurosci. 2006;23:1120-8 pubmed
    ..gp120-induced enhancement of GDPs was blocked by T140, a highly specific antagonist for the chemokine receptor, CXCR4, indicating the involvement of CXCR4 in the gp120-induced increase of GDPs...
  53. Wei F, Leung K, Li G, Qin J, Chow S, Huang S, et al. Low intensity pulsed ultrasound enhanced mesenchymal stem cell recruitment through stromal derived factor-1 signaling in fracture healing. PLoS ONE. 2014;9:e106722 pubmed publisher
    ..stem cells (MSCs) and the pivotal role of stromal cell-derived factor-1/C-X-C chemokine receptor type 4 (SDF-1/CXCR4) pathway in response to LIPUS stimulation, which are essential factors in bone fracture healing...
  54. Huang W, Zheng W, Ouyang H, Yi H, Liu S, Zeng W, et al. Mechanical allodynia induced by nucleoside reverse transcriptase inhibitor is suppressed by p55TNFSR mediated by herpes simplex virus vector through the SDF1?/CXCR4 system in rats. Anesth Analg. 2014;118:671-80 pubmed publisher
    ..tumor necrosis factor-? (TNF-?), stromal cell-derived factor 1-? (SDF1-?), and C-X-C chemokine receptor type 4 (CXCR4), the detailed mechanisms by which NRTIs contribute to the development of neuropathic pain are not known...
  55. Liu X, Duan B, Cheng Z, Jia X, Mao L, Fu H, et al. SDF-1/CXCR4 axis modulates bone marrow mesenchymal stem cell apoptosis, migration and cytokine secretion. Protein Cell. 2011;2:845-54 pubmed publisher
    ..We hypothesized that stromal-derived factor-1 (SDF-1)/CXCR4 axis plays a critical role in the regulation of these processes...
  56. Arakura M, Lee S, Takahara S, Okumachi E, Iwakura T, Fukui T, et al. Altered expression of SDF-1 and CXCR4 during fracture healing in diabetes mellitus. Int Orthop. 2017;41:1211-1217 pubmed publisher
    ..and compare the gene expression patterns and localization of stromal cell-derived factor 1 (SDF-1) and CXC chemokine receptor 4 (CXCR4) during fracture healing of the femur in rats with and without DM...
  57. Cui C, Wang P, Cui N, Song S, Liang H, Ji A. Stichopus japonicus Polysaccharide, Fucoidan, or Heparin Enhanced the SDF-1α/CXCR4 Axis and Promoted NSC Migration via Activation of the PI3K/Akt/FOXO3a Signaling Pathway. Cell Mol Neurobiol. 2016;36:1311-1329 pubmed
    ..SDF-1α modulated by SJP, fucoidan, or heparin activated the CXCR4 receptor and directed cellular migration via the activation of the PI3K/Akt/FOXO3a signaling pathway...
  58. Tripathi A, Vana P, Chavan T, Brueggemann L, Byron K, Tarasova N, et al. Heteromerization of chemokine (C-X-C motif) receptor 4 with ?1A/B-adrenergic receptors controls ?1-adrenergic receptor function. Proc Natl Acad Sci U S A. 2015;112:E1659-68 pubmed publisher
    Recent evidence suggests that chemokine (C-X-C motif) receptor 4 (CXCR4) contributes to the regulation of blood pressure through interactions with ?1-adrenergic receptors (ARs) in vascular smooth muscle...
  59. Zong Z, Cheng T, Su Y, Ran X, Shen Y, Li N, et al. Recruitment of transplanted dermal multipotent stem cells to sites of injury in rats with combined radiation and wound injury by interaction of SDF-1 and CXCR4. Radiat Res. 2008;170:444-50 pubmed
    ..before transplantation, which specifically blocks binding of stromal cell-derived factor 1 (SDF-1) to its receptor CXCR4, diminished the recruitment of dermal multipotent stem cells to the irradiated bone marrow and wounded skin by 58 +..
  60. Cho B, Zeng Z, Mu H, Wang Z, Konoplev S, McQueen T, et al. Antileukemia activity of the novel peptidic CXCR4 antagonist LY2510924 as monotherapy and in combination with chemotherapy. Blood. 2015;126:222-32 pubmed publisher
    Targeting the stromal cell-derived factor 1α (SDF-1α)/C-X-C chemokine receptor type 4 (CXCR4) axis has been shown to be a promising therapeutic approach to overcome chemoresistance in acute myeloid leukemia (AML)...
  61. Cai W, Kang K, Huang W, Liang J, Feng Y, Liu G, et al. CXCR4 attenuates cardiomyocytes mitochondrial dysfunction to resist ischaemia-reperfusion injury. J Cell Mol Med. 2015;19:1825-35 pubmed publisher
    The chemokine (C-X-C motif) receptor 4 (CXCR4) is expressed on native cardiomyocytes and can modulate isolated cardiomyocyte contractility...
  62. Pan C, Chen C, Sheu M, Wu C. Salvianolic acid B inhibits SDF-1?-stimulated cell proliferation and migration of vascular smooth muscle cells by suppressing CXCR4 receptor. Vascul Pharmacol. 2012;56:98-105 pubmed publisher
    ..Salvia miltiorrhiza, widely used to treat cardiovascular diseases, and stromal cell-derived factor-1? (SDF-1?)/CXCR4 pathway has been correlated with balloon angioplasty-induced neointimal formation...
  63. Lu D, Tang C, Yeh W, Wong K, Lin C, Chen Y, et al. SDF-1alpha up-regulates interleukin-6 through CXCR4, PI3K/Akt, ERK, and NF-kappaB-dependent pathway in microglia. Eur J Pharmacol. 2009;613:146-54 pubmed publisher
    Stromal cell-derived factor-1 (SDF-1), also known as CXCL12, and its receptor CXC chemokine receptor 4 (CXCR4) express in various kinds of cells in central nervous system...
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    ..and dual-staining immunofluorescent methods to determine the localization of the CXCL12 receptor, CXCR4, in the caudate putamen and nucleus accumbens of the adult rat brain...
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    The actual relationship between neural stem cells and SDF-1alpha/CXCR4 after brain injury has not yet been elucidated, although recent studies have speculated that stromal cell-derived factor-1alpha (SDF-1alpha) and its receptor, CXCR4, ..
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    ..To address the role of CXCL12/CXCR4 signaling in normal micturition and inflammation-induced bladder hyperreflexia, bladder inflammation in adult ..
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    ..We demonstrated the colocalization of SDF-1 and its receptor CXCR4 with arginine vasopressin (AVP) in the magnocellular neurons of the supraoptic nucleus (SON) and the ..
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    ..Stromal-derived factor-1 (SDF-1) and its receptor chemokine receptor 4 (CXCR4) modulate the inflammatory response...
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    The G protein-coupled chemokine receptor CXCR4 serves as the primary coreceptor for entry of T-cell tropic human immunodeficiency virus...
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    The chemokine receptor CXCR4 has recently been shown to be a co-receptor involved in the entry of human immunodeficiency virus type 1 into target cells...
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    ..12 (CXCL12; stromal cell-derived factor-1 [SDF-1]/pre-B-cell growth-stimulating factor [PBSF]) and its receptor CXCR4 are essential for vascularization in the gastrointestinal tract as well as B lymphopoiesis and colonization of ..
  76. Zhou Z, Liu T, Sun X, Mu X, Zhu G, Xiao T, et al. CXCR4 antagonist AMD3100 reverses the neurogenesis promoted by enriched environment and suppresses long-term seizure activity in adult rats of temporal lobe epilepsy. Behav Brain Res. 2017;322:83-91 pubmed publisher
    ..the enhanced neurogenesis and improved cognitive functions induced by EE following seizures were mediated by SDF-1/CXCR4 pathway...
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    Emerging evidence has demonstrated the involvement of stromal cell-derived factor 1 (SDF1, also known as CXCL12)-CXCR4 signaling in a variety of pain state...
  78. Wang Y, Fu W, Zhang S, He X, Liu Z, Gao D, et al. CXCR-7 receptor promotes SDF-1?-induced migration of bone marrow mesenchymal stem cells in the transient cerebral ischemia/reperfusion rat hippocampus. Brain Res. 2014;1575:78-86 pubmed publisher
    ..The effect of CXCR-7 was stronger than that of CXCR-4. Moreover, BMSCs that migrated to hippocampus promoted the autocrine and paracrine signaling of SDF-1?. ..
  79. Li J, Guo W, Xiong M, Han H, Chen J, Mao D, et al. Effect of SDF-1/CXCR4 axis on the migration of transplanted bone mesenchymal stem cells mobilized by erythropoietin toward lesion sites following spinal cord injury. Int J Mol Med. 2015;36:1205-14 pubmed publisher
    Accumulating evidence has indicated that the stromal cell-derived factor-1 (SDF-1)/CXC chemokine receptor 4 (CXCR4) axis plays a crucial role in the recruitment of bone marrow-derived mesenchymal stem cells (BMSCs) into lesion sites in ..
  80. Li B, Bai W, Sun P, Zhou B, Hu B, Ying J. The effect of CXCL12 on endothelial progenitor cells: potential target for angiogenesis in intracerebral hemorrhage. J Interferon Cytokine Res. 2015;35:23-31 pubmed publisher
    ..vessel formation in vitro and in vivo were detected after pretreatment with the C-X-C chemokine receptor type 4 (CXCR4) inhibitor AMD3100...
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    ..HIV gp120 has been shown to bind to CD4, CXCR4, and CCR5 receptors on lymphocytes and macrophages...
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    ..as playing an essential role in renal vascular development is the stromal cell-derived factor-1? (SDF-1)/CXCR4 pathway...
  83. Liu X, Zuo D, Fan H, Tang Q, Shou Z, Cao D, et al. Over-expression of CXCR4 on mesenchymal stem cells protect against experimental colitis via immunomodulatory functions in impaired tissue. J Mol Histol. 2014;45:181-93 pubmed publisher
    ..plays an important role in chemotaxis and stem cell homing through interaction with its specific receptor CXC chemokine receptor 4 (CXCR4)...
  84. Zhang W, Zhang F, Han Y, Liu H, Wang Y, Yue B, et al. Auditory stimulation modulates CXCL12/CXCR4 expression in postnatal development of the newborn rat cochlea. Neuroreport. 2015;26:681-7 pubmed publisher
    ..Recently, inner-ear stem cell therapy has been proposed for auditory afferent rehabilitation. CXCR4 is the primary physiologic receptor for CXC chemokine ligand 12 (CXCL12) and the CXCL12-CXCR4 pathway has been ..
  85. Chen P, Cai X, Yang Y, Chen Z, Qiu J, Yu N, et al. Nuclear Respiratory Factor-1 (NRF-1) Regulates Transcription of the CXC Receptor 4 (CXCR4) in the Rat Retina. Invest Ophthalmol Vis Sci. 2017;58:4662-4669 pubmed publisher
    The CXC receptor 4 (CXCR4) is required for various physiologic and pathologic processes in the eye, including stem cell trafficking, neuronal development, immune responses, and ocular neovascularization...