Gene Symbol: Cxcl10
Description: C-X-C motif chemokine ligand 10
Alias: IP-10, Scyb10, C-X-C motif chemokine 10, 10 kDa interferon gamma-induced protein, chemokine (C-X-C motif) ligand 10, gamma-IP10, interferon-inducible cytokine IP-10, interferon-inducible protein 10, protein Mob-1, small inducible cytokine B subfamily (Cys-X-Cys) member 10, small inducible cytokine B subfamily (Cys-X-Cys), member 10, small-inducible cytokine B10
Species: rat
Products:     Cxcl10

Top Publications

  1. Wang X, Yue T, Ohlstein E, Sung C, Feuerstein G. Interferon-inducible protein-10 involves vascular smooth muscle cell migration, proliferation, and inflammatory response. J Biol Chem. 1996;271:24286-93 pubmed
  2. Nance S, Cross R, Fitzpatrick E. Chemokine production during hypersensitivity pneumonitis. Eur J Immunol. 2004;34:677-685 pubmed publisher
    ..These results suggest that IFN-gamma mediates the recruitment of CXCR3+/CD4+ T cells into the lung via production of the chemokines IP-10, Mig, and I-TAC, resulting in granuloma formation. ..
  3. Wallace K, Marshall M, Ramos S, Lannigan J, Field J, Strieter R, et al. NKT cells mediate pulmonary inflammation and dysfunction in murine sickle cell disease through production of IFN-gamma and CXCR3 chemokines. Blood. 2009;114:667-76 pubmed publisher
    ..NY1DD mice have increased pulmonary levels of IFN-gamma, IFN-gamma-inducible chemokines (CXCL9, CXCL10), and elevated numbers of lymphocytes expressing the chemokine receptor CXCR3...
  4. Agostini C, Cassatella M, Zambello R, Trentin L, Gasperini S, Perin A, et al. Involvement of the IP-10 chemokine in sarcoid granulomatous reactions. J Immunol. 1998;161:6413-20 pubmed
    ..Taken together, these data suggest the potential role of IP-10 in regulating the migration and activation of T cells toward sites of sarcoid inflammatory process and the consequent granuloma formation. ..
  5. Lasagni L, Francalanci M, Annunziato F, Lazzeri E, Giannini S, Cosmi L, et al. An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4. J Exp Med. 2003;197:1537-49 pubmed
    The chemokines CXCL9/Mig, CXCL10/IP-10, and CXCL11/I-TAC regulate lymphocyte chemotaxis, mediate vascular pericyte proliferation, and act as angiostatic agents, thus inhibiting tumor growth...
  6. Nishioka Y, Manabe K, Kishi J, Wang W, Inayama M, Azuma M, et al. CXCL9 and 11 in patients with pulmonary sarcoidosis: a role of alveolar macrophages. Clin Exp Immunol. 2007;149:317-26 pubmed
    Interferon-inducible protein-10 (IP-10)/CXCL10, which is a ligand for CXC chemokine receptor 3 (CXCR3), is known to be involved in the pathogenesis of pulmonary sarcoidosis...
  7. Hildebrandt G, Corrion L, Olkiewicz K, Lu B, Lowler K, Duffner U, et al. Blockade of CXCR3 receptor:ligand interactions reduces leukocyte recruitment to the lung and the severity of experimental idiopathic pneumonia syndrome. J Immunol. 2004;173:2050-9 pubmed
    ..activated Th1/Tc1 T cell subsets and the expression of its ligands CXCL9 (monokine induced by IFN-gamma (Mig)) and CXCL10 (IFN-gamma-inducible protein 10 (IP-10)) can be induced in a variety of cell types by IFN-gamma alone or in ..
  8. Wang Y, Gehringer R, Mousa S, Hackel D, Brack A, Rittner H. CXCL10 controls inflammatory pain via opioid peptide-containing macrophages in electroacupuncture. PLoS ONE. 2014;9:e94696 pubmed publisher
    ..the cytokine profile towards an anti-inflammatory pattern but augmented interferon (IFN)-gamma and the chemokine CXCL10 (IP-10: interferon gamma-inducible protein) protein and mRNA expression with concomitant increased numbers of ..
  9. Lai W, Wu J, Zou X, Xie J, Zhang L, Zhao X, et al. Secretome analyses of A?(1-42) stimulated hippocampal astrocytes reveal that CXCL10 is involved in astrocyte migration. J Proteome Res. 2013;12:832-43 pubmed publisher
    ..Particularly, we validated the role played by CXCL10 in promoting astrocyte aggregation around amyloid plagues through in vitro cell migration analysis...

More Information


  1. Agostini C, Calabrese F, Poletti V, Marcer G, Facco M, Miorin M, et al. CXCR3/CXCL10 interactions in the development of hypersensitivity pneumonitis. Respir Res. 2005;6:20 pubmed
    ..flow cytometry, immunohistochemistry, confocal microscopy analysis and chemotaxis assays we evaluated whether CXCL10 and its receptor CXCR3 regulate the trafficking of CD8(+) T cells in HP lung...
  2. Schulthess F, Paroni F, Sauter N, Shu L, Ribaux P, Haataja L, et al. CXCL10 impairs beta cell function and viability in diabetes through TLR4 signaling. Cell Metab. 2009;9:125-39 pubmed publisher
    ..Islets isolated from patients with T2DM secreted CXCL10 and contained 33.5-fold more CXCL10 mRNA than islets from control patients...
  3. Crawford M, Burdick M, Glomski I, Boyer A, Barr J, Mehrad B, et al. Interferon-inducible CXC chemokines directly contribute to host defense against inhalational anthrax in a murine model of infection. PLoS Pathog. 2010;6:e1001199 pubmed publisher
    ..Here, we show that the murine interferon-inducible CXC chemokines CXCL9, CXCL10, and CXCL11 each exert direct antimicrobial effects in vitro against Bacillus anthracis Sterne strain spores and ..
  4. Emmer A, Gerlach K, Staege M, Kornhuber M. Cerebral gene expression of superantigen encephalitis in the lewis rat induced by staphylococcal enterotoxin a. Scand J Immunol. 2008;67:464-72 pubmed publisher
    ..Elevated chemokines comprised RANTES (CCL5), osteopontin, MCP-1 (CCL2) and CXCL10. Further, genes with increased expression were assigned to the extracellular matrix, microglia/macrophage cell ..
  5. Lang S, Li L, Wang X, Sun J, Xue X, Xiao Y, et al. CXCL10/IP-10 Neutralization Can Ameliorate Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome in Rats. PLoS ONE. 2017;12:e0169100 pubmed publisher
    The role of C-X-C motif chemokine 10 (CXCL10), a pro-inflammatory factor, in the development of acute respiratory distress syndrome (ARDS) remains unclear...
  6. Nelson T, Gruol D. The chemokine CXCL10 modulates excitatory activity and intracellular calcium signaling in cultured hippocampal neurons. J Neuroimmunol. 2004;156:74-87 pubmed
    In this study, we provide evidence for direct modulatory effects of the chemokine, CXCL10, on the physiology of hippocampal neurons maintained in primary culture...
  7. Tang P, Yakimov A, Teesdale M, Coady M, Dardik A, Elefteriades J, et al. Transmural inflammation by interferon-gamma-producing T cells correlates with outward vascular remodeling and intimal expansion of ascending thoracic aortic aneurysms. FASEB J. 2005;19:1528-30 pubmed
    ..Th1, but not Th2, immune responses have a positive correlation with both outward vascular remodeling and intimal expansion of ascending thoracic aortic aneurysms. ..
  8. Cai X, Castleman W. Increased IFN-gamma protein in bronchoalveolar lavage fluid of anti-IP-10 antibody-treated F344 rats following Sendai viral infection. J Interferon Cytokine Res. 2002;22:1175-9 pubmed
    ..This interesting phenomenon suggests that expression of IFN-gamma protein can be modulated by treatment with anti-IP-10 antibody at the posttranscriptional or translational level in this model. ..
  9. Roe M, Bloxham D, Cowburn A, O Donnell D. Changes in helper lymphocyte chemokine receptor expression and elevation of IP-10 during acute respiratory syncytial virus infection in infants. Pediatr Allergy Immunol. 2011;22:229-34 pubmed publisher
    ..Free DNA is detectable in plasma. This may allow significant alterations in the generation of T-cell memory. ..
  10. Zeng X, Moore T, Newstead M, Deng J, Kunkel S, Luster A, et al. Interferon-inducible protein 10, but not monokine induced by gamma interferon, promotes protective type 1 immunity in murine Klebsiella pneumoniae pneumonia. Infect Immun. 2005;73:8226-36 pubmed
    CXC chemokines that lack the ELR motif, including interferon-inducible protein 10 [IP-10 (CXCL10)] and monokine induced by gamma interferon (IFN-gamma) [MIG (CXCL9)], have been shown to mediate the generation of type 1 immune responses...
  11. Steinmetz O, Sadaghiani S, Panzer U, Krebs C, Meyer Schwesinger C, Streichert T, et al. Antihypertensive therapy induces compartment-specific chemokine expression and a Th1 immune response in the clipped kidney of Goldblatt hypertensive rats. Am J Physiol Renal Physiol. 2007;292:F876-87 pubmed
    ..These findings suggest that the Th1 chemokines IP10 and Mig as well as their receptor CXCR3 are potential targets for therapeutic interventions in ischemic nephropathy. ..
  12. Taub D, Longo D, Murphy W. Human interferon-inducible protein-10 induces mononuclear cell infiltration in mice and promotes the migration of human T lymphocytes into the peripheral tissues and human peripheral blood lymphocytes-SCID mice. Blood. 1996;87:1423-31 pubmed
    ..These results show that rhIP-10 is capable of inducing human T-cell migration in vivo and may play an important role in monocyte and lymphocyte recruitment into inflammatory sites. ..
  13. Yang J, Zoeller R. Differential display identifies neuroendocrine-specific protein-A (NSP-A) and interferon-inducible protein 10 (IP-10) as ethanol-responsive genes in the fetal rat brain. Brain Res Dev Brain Res. 2002;138:117-33 pubmed
    ..A critical analysis of the approaches used in the present study may be important for future studies in this field. ..
  14. Liu H, Ning H, Men H, Hou R, Fu M, Zhang H, et al. Regulation of CCL5 expression in smooth muscle cells following arterial injury. PLoS ONE. 2012;7:e30873 pubmed publisher
    ..Methods targeting MK2 expression could be used to selectively regulate CCL5 but not IP-10 expression in SMCs. ..
  15. Altara R, Manca M, Hessel M, Gu Y, van Vark L, Akkerhuis K, et al. CXCL10 Is a Circulating Inflammatory Marker in Patients with Advanced Heart Failure: a Pilot Study. J Cardiovasc Transl Res. 2016;9:302-14 pubmed publisher
    ..We observed that circulating CXCR3 receptor chemokines CXCL9 and CXCL10 in a rat model of heart failure were increased 1 week after myocardial infarction...
  16. Weigelt C, Rose B, Poschen U, Ziegler D, Friese G, Kempf K, et al. Immune mediators in patients with acute diabetic foot syndrome. Diabetes Care. 2009;32:1491-6 pubmed publisher
    ..Further studies should investigate whether an activation of the immune system precedes the development of foot ulcer and whether anti-inflammatory therapies might be effective. ..
  17. Kawamura A, Miura S, Fujino M, Nishikawa H, Matsuo Y, Tanigawa H, et al. CXCR3 chemokine receptor-plasma IP10 interaction in patients with coronary artery disease. Circ J. 2003;67:851-4 pubmed
    ..The CXCR3 - plasma IP10 chemokine receptor - chemokine interaction on monocytes may affect the development of coronary restenosis, but not de novo stenosis, in patients with CAD. ..
  18. Cho Y, Gong T, Kanicki A, Altschuler R, Lomax M. Noise overstimulation induces immediate early genes in the rat cochlea. Brain Res Mol Brain Res. 2004;130:134-48 pubmed
    ..NUR77/TR3 was a nuclear protein before noise, but following noise translocated to the cytoplasm. These studies provide new insights into the molecular response to noise overstimulation in the mammalian cochlea. ..
  19. Rabquer B, Tsou P, Hou Y, Thirunavukkarasu E, Haines G, Impens A, et al. Dysregulated expression of MIG/CXCL9, IP-10/CXCL10 and CXCL16 and their receptors in systemic sclerosis. Arthritis Res Ther. 2011;13:R18 pubmed publisher
    ..ELR) motif, such as monokine induced by interferon-? (IFN-?) (MIG/CXCL9) and IFN-inducible protein 10 (IP-10/CXCL10), inhibit angiogenesis by binding CXCR3...
  20. Hassanshahi G, Patel S, Jafarzadeh A, Dickson A. Expression of CXC chemokine IP-10/Mob-1 by primary hepatocytes following heat shock. Saudi Med J. 2007;28:514-8 pubmed
    ..This study also provides a useful model to study the regulation of expression of this chemokines in vitro. ..
  21. Horiguchi K, Fujiwara K, Tsukada T, Yoshida S, Higuchi M, Tateno K, et al. CXCL10/CXCR3 signaling mediates inhibitory action by interferon-gamma on CRF-stimulated adrenocorticotropic hormone (ACTH) release. Cell Tissue Res. 2016;364:395-404 pubmed publisher
    ..Using rat anterior pituitary, we previously demonstrated that the CXC chemokine ligand 10 (CXCL10), known as interferon-γ (IFN-γ) inducible protein 10 kDa, is expressed in dendritic cell-like S100β ..
  22. Nash B, Thomson C, Linington C, Arthur A, McClure J, McBride M, et al. Functional duality of astrocytes in myelination. J Neurosci. 2011;31:13028-38 pubmed publisher
    ..A combination of microarray gene expression analysis and quantitative real-time PCR identified CXCL10 as a potential candidate for the reduction in myelination in cultures on TnC-astrocytes...
  23. Shiozawa F, Kasama T, Yajima N, Odai T, Isozaki T, Matsunawa M, et al. Enhanced expression of interferon-inducible protein 10 associated with Th1 profiles of chemokine receptor in autoimmune pulmonary inflammation of MRL/lpr mice. Arthritis Res Ther. 2004;6:R78-R86 pubmed
    ..Our results suggest that IP-10 expression in the lung is involved, through CXCR3, in the pathogenesis of pulmonary inflammation associated with migration of Th1 cells. ..
  24. Laragione T, Gulko P. Liver X receptor regulates rheumatoid arthritis fibroblast-like synoviocyte invasiveness, matrix metalloproteinase 2 activation, interleukin-6 and CXCL10. Mol Med. 2012;18:1009-17 pubmed publisher
    ..1 (MMP-1), MMP-2, MMP-3, interleukin-6 (IL-6), tumor necrosis factor-? and C-X-C motif chemokine ligand 10 (CXCL10)...
  25. Costa C, Rufino R, Traves S, Lapa E Silva J, Barnes P, Donnelly L. CXCR3 and CCR5 chemokines in induced sputum from patients with COPD. Chest. 2008;133:26-33 pubmed
    ..The aims of this study were to determine the concentrations of CXCR3 chemokines CXCL9, CXCL10, CXCL11, and the CCR5 chemokine CCL5 in induced sputum from patients with COPD, smokers, and nonsmokers, and to ..
  26. Bu H, Shu B, Gao F, Liu C, Guan X, Ke C, et al. Spinal IFN-?-induced protein-10 (CXCL10) mediates metastatic breast cancer-induced bone pain by activation of microglia in rat models. Breast Cancer Res Treat. 2014;143:255-63 pubmed publisher
    ..Then we measured the expression of CXCL10 in the spinal cord of metastatic bone cancer rats, investigated the role of CXCL10 in the development of CIBP, and ..
  27. Feng J, Zhang Z, Li W, Shen X, Song W, Yang C, et al. Missense mutations in the MEFV gene are associated with fibromyalgia syndrome and correlate with elevated IL-1beta plasma levels. PLoS ONE. 2009;4:e8480 pubmed publisher
  28. Bajova H, Nelson T, Gruol D. Chronic CXCL10 alters the level of activated ERK1/2 and transcriptional factors CREB and NF-kappaB in hippocampal neuronal cell culture. J Neuroimmunol. 2008;195:36-46 pubmed publisher
    ..In the current study, Western blot analyses show that in rat hippocampal neuronal/glial cell cultures chronic CXCL10 increases the level of protein for ERK1/2 as well as for the transcriptional factors CREB and NF-kappaB...
  29. Han G, Suzuki K, Koike H, Suzuki K, Yoneyama H, Narumi S, et al. IFN-inducible protein-10 plays a pivotal role in maintaining slit-diaphragm function by regulating podocyte cell-cycle balance. J Am Soc Nephrol. 2006;17:442-53 pubmed
    IFN-inducible protein-10 (IP-10/CXCL10) is a potent chemoattractant for activated T lymphocytes and was reported recently to have several additional biologic activities...
  30. Cho J, Nelson T, Bajova H, Gruol D. Chronic CXCL10 alters neuronal properties in rat hippocampal culture. J Neuroimmunol. 2009;207:92-100 pubmed publisher
    The chemokine CXCL10 is expressed in the central nervous system (CNS) during neuroinflammatory conditions. Neurons express CXCR3, the receptor for CXCL10, and neuronal function has been shown to be altered by acute exposure to CXCL10...
  31. Kishi J, Nishioka Y, Kuwahara T, Kakiuchi S, Azuma M, Aono Y, et al. Blockade of Th1 chemokine receptors ameliorates pulmonary granulomatosis in mice. Eur Respir J. 2011;38:415-24 pubmed publisher
    ..The cDNA microarray assay demonstrated that the gene expression of CXCL9 and CXCL10, ligands for CXCR3, and of CCL4, a ligand for CCR5, was strongly upregulated during granulomatosis...
  32. Lindell D, Lane T, Lukacs N. CXCL10/CXCR3-mediated responses promote immunity to respiratory syncytial virus infection by augmenting dendritic cell and CD8(+) T cell efficacy. Eur J Immunol. 2008;38:2168-79 pubmed publisher
    ..The present studies investigated the role of the chemokine CXCL10 and its specific receptor, CXCR3, in the host response to pulmonary respiratory syncytial virus (RSV) infection...
  33. Matsumoto Y, Tsukada Y, Miyakoshi A, Sakuma H, Kohyama K. C protein-induced myocarditis and subsequent dilated cardiomyopathy: rescue from death and prevention of dilated cardiomyopathy by chemokine receptor DNA therapy. J Immunol. 2004;173:3535-41 pubmed
    ..The present study has demonstrated for the first time that gene therapy targeting the chemokine receptor could be a powerful tool for the control of experimental autoimmune myocarditis and DCM. ..
  34. Bonville C, Bennett N, Percopo C, Branigan P, Del Vecchio A, Rosenberg H, et al. Diminished inflammatory responses to natural pneumovirus infection among older mice. Virology. 2007;368:182-90 pubmed
  35. Rhode A, Pauza M, Barral A, Rodrigo E, Oldstone M, Von Herrath M, et al. Islet-specific expression of CXCL10 causes spontaneous islet infiltration and accelerates diabetes development. J Immunol. 2005;175:3516-24 pubmed
    During inflammation, chemokines are conductors of lymphocyte trafficking. The chemokine CXCL10 is expressed early after virus infection...
  36. Gremy O, Benderitter M, Linard C. Acute and persisting Th2-like immune response after fractionated colorectal gamma-irradiation. World J Gastroenterol. 2008;14:7075-85 pubmed
    ..Colorectal irradiation induces Th2 polarization, defective IL-10/STAT3 pathway activation and SOCS3 overexpression. These changes, in turn, maintain a immunological imbalance that persists in the long term. ..
  37. Loos T, Mortier A, Gouwy M, Ronsse I, Put W, Lenaerts J, et al. Citrullination of CXCL10 and CXCL11 by peptidylarginine deiminase: a naturally occurring posttranslational modification of chemokines and new dimension of immunoregulation. Blood. 2008;112:2648-56 pubmed publisher
    ..of chemokines, that is, the deimination of arginine at position 5 into citrulline of CXC chemokine ligand 10 (CXCL10) by rabbit PAD and human PAD2...
  38. Zhu J, Xu Z, Miao Y, Liu X, Zhang H. Changes of inducible protein-10 and regulated upon activation, normal T cell expressed and secreted protein in acute rejection of pancreas transplantation in rats. World J Gastroenterol. 2006;12:4156-60 pubmed
    ..Our study suggests a possible role of IP-10 and RANTES in acute rejection and early monitoring of chemokines may be helpful in predicting the outcome of pancreas transplantation. ..
  39. Kobayashi K, Inohara N, Hernandez L, Galan J, Nunez G, Janeway C, et al. RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems. Nature. 2002;416:194-9 pubmed
    ..Rip2 is therefore a signal transducer and integrator of signals for both the innate and adaptive immune systems. ..
  40. Wang X, Li X, Schmidt D, Foley J, Barone F, Ames R, et al. Identification and molecular characterization of rat CXCR3: receptor expression and interferon-inducible protein-10 binding are increased in focal stroke. Mol Pharmacol. 2000;57:1190-8 pubmed
    ..In addition, the cloning of rat CXCR3 provides an important tool for the investigation of the pathophysiological role of CXCR3 in other rodent disease models. ..
  41. Xia J, Liu G, Chen Z, Mao C, Zhou D, Wu H, et al. Hypoxia/ischemia promotes CXCL10 expression in cardiac microvascular endothelial cells by NFkB activation. Cytokine. 2016;81:63-70 pubmed publisher
    b>CXCL10, the chemokine with potent chemotactic activity on immune cells and other non-immune cells expressing its receptor CXCR3, has been demonstrated to involve in myocardial infarction, which was resulted from hypoxia/ischemia...
  42. Cai X, Castleman W. Early high expression of IP-10 in F344 rats resistant to Sendai virus-induced airway injury. Am J Physiol Lung Cell Mol Physiol. 2003;285:L1263-9 pubmed
    ..IP-10 early high expression might contribute to the resistance to virus-induced airway disease in F344 rats by promoting Th1 responses and increasing antiviral activity. ..
  43. Feferman T, Maiti P, Berrih Aknin S, Bismuth J, Bidault J, Fuchs S, et al. Overexpression of IFN-induced protein 10 and its receptor CXCR3 in myasthenia gravis. J Immunol. 2005;174:5324-31 pubmed
    ..The chemokine IFN-gamma-inducible protein 10 (IP-10; CXCL10), a CXC chemokine, and its receptor, CXCR3, were found to be overexpressed in lymph node cells of EAMG rats...
  44. Katoh S, Fukushima K, Matsumoto N, Ehara N, Matsumoto K, Yamauchi A, et al. Accumulation of CXCR3-expressing eosinophils and increased concentration of its ligands (IP10 and Mig) in bronchoalveolar lavage fluid of patients with chronic eosinophilic pneumonia. Int Arch Allergy Immunol. 2005;137:229-35 pubmed
    ..Our findings suggest that IP10 and Mig contribute to the accumulation of CXCR3-expressing eosinophils in the lungs of patients with CEP, and modulate the eosinophilic inflammation of the lung. ..
  45. Panzer U, Steinmetz O, Reinking R, Meyer T, Fehr S, Schneider A, et al. Compartment-specific expression and function of the chemokine IP-10/CXCL10 in a model of renal endothelial microvascular injury. J Am Soc Nephrol. 2006;17:454-64 pubmed
    ..Among the analyzed chemokine mRNA, IP-10/CXCL10 (119-fold), acting via CXCR3 on activated T cells, and MCP-1/CCL2 (65-fold), acting via CCR2 on monocytes, were by ..
  46. Medoff B, Sauty A, Tager A, Maclean J, Smith R, Mathew A, et al. IFN-gamma-inducible protein 10 (CXCL10) contributes to airway hyperreactivity and airway inflammation in a mouse model of asthma. J Immunol. 2002;168:5278-86 pubmed
    ..IFN-gamma-inducible protein 10 (IP-10; CXCL10) is an IFN-gamma-inducible chemokine that preferentially attracts activated Th1 lymphocytes...
  47. Antonelli A, Fallahi P, Ferrari S, Pupilli C, D Annunzio G, Lorini R, et al. Serum Th1 (CXCL10) and Th2 (CCL2) chemokine levels in children with newly diagnosed Type 1 diabetes: a longitudinal study. Diabet Med. 2008;25:1349-53 pubmed publisher
    ..The aim of this study was to investigate whether circulating chemokines involved in T-helper 1 (CXCL10) and T-helper 2 (CCL2) autoimmunity are increased in children with Type 1 diabetes at onset and follow-up...
  48. Liu Z, Xu W, Zhang X, Cui D, Liu B. Expression of the CXC chemokine receptor 3 and its ligands in ischemia-reperfusion injury of liver in rats. Transplant Proc. 2008;40:1300-2 pubmed publisher
    ..The mRNA expressions of CXCR3 and its ligand IP-10 were up-regulated in liver I/R tissue in the early time, which suggested that they play an important role in liver injury induced by I/R. ..
  49. Martin A, Alexander Brett J, Canasto Chibuque C, Garin A, Bromberg J, Fremont D, et al. The chemokine binding protein M3 prevents diabetes induced by multiple low doses of streptozotocin. J Immunol. 2007;178:4623-31 pubmed
    ..Ten days after treatment, the expression of several chemokines, including CXCL9, CCL1, CXCL10, and CCL21, was dramatically up-regulated...
  50. Feferman T, Aricha R, Mizrachi K, Geron E, Alon R, Souroujon M, et al. Suppression of experimental autoimmune myasthenia gravis by inhibiting the signaling between IFN-gamma inducible protein 10 (IP-10) and its receptor CXCR3. J Neuroimmunol. 2009;209:87-95 pubmed publisher
    ..Treatment by either of these reagents led to suppression of EAMG suggesting that inhibition of CXCR3/IP-10 signaling can be considered as a potential treatment modality for MG. ..
  51. Hasegawa M, Fujimoto M, Matsushita T, Hamaguchi Y, Takehara K, Sato S. Serum chemokine and cytokine levels as indicators of disease activity in patients with systemic sclerosis. Clin Rheumatol. 2011;30:231-7 pubmed publisher
    ..with systemic sclerosis (SSc), concentrations of four chemokines (interferon ?-inducible protein-10 [IP-10, CXCL10], monokine induced by interferon ? [MIG/CXCL9], monocyte chemoattractant protein-1 [MCP-1/CCL2], interleukin 8 [IL-..
  52. Liang P, Averboukh L, Zhu W, Pardee A. Ras activation of genes: Mob-1 as a model. Proc Natl Acad Sci U S A. 1994;91:12515-9 pubmed
    ..These findings link chronic inflammatory response to constitutive ras activation and tumorigenesis. Mob-1 may serve as a secreted marker for oncogenic Ha-ras mutations. ..
  53. Gysemans C, Cardozo A, Callewaert H, Giulietti A, Hulshagen L, Bouillon R, et al. 1,25-Dihydroxyvitamin D3 modulates expression of chemokines and cytokines in pancreatic islets: implications for prevention of diabetes in nonobese diabetic mice. Endocrinology. 2005;146:1956-64 pubmed
    ..This beneficial effect of 1,25-(OH)(2)D(3) is associated with decreased chemokine and cytokine expression by the pancreatic islets. ..
  54. Chaitanya G, Kolli M, Babu P. Granzyme-b mediated cell death in the spinal cord-injured rat model. Neuropathology. 2009;29:270-9 pubmed publisher
    ..The chemokine IP-10/CXCL10 was also found to be elevated along with gra-b correlating with the infiltration of CD-8(+) cytotoxic T ..
  55. Ko F, Lun S, Wong C, Szeto C, Lam C, Leung T, et al. Decreased T-bet expression and changes in chemokine levels in adults with asthma. Clin Exp Immunol. 2007;147:526-32 pubmed
    ..controls for assay of T-bet expression, specific IgE and chemokines (interferon-gamma inducible protein-10 (IP-10/CXCL10), monokines induced by interferon-gamma (MIG/CXCL9), monocyte chemotactic protein-1 (MCP-1/CCL2), regulated upon ..
  56. Kusakabe K, Abe H, Kondo T, Kato K, Okada T, Otsuki Y. DNA microarray analysis in a mouse model for endometriosis and validation of candidate factors with human adenomyosis. J Reprod Immunol. 2010;85:149-60 pubmed publisher
    ..g. CXCL10) and metabolic factors (e.g. calbindin D-28K) were highly up-regulated in the grafts...
  57. Jha P, Sohn J, Xu Q, Nishihori H, Wang Y, Nishihori S, et al. The complement system plays a critical role in the development of experimental autoimmune anterior uveitis. Invest Ophthalmol Vis Sci. 2006;47:1030-8 pubmed
    ..The role of complement in ocular autoimmunity was explored in a experimental autoimmune anterior uveitis (EAAU) animal model...
  58. Wong C, Ho A, Tong P, Yeung C, Kong A, Lun S, et al. Aberrant activation profile of cytokines and mitogen-activated protein kinases in type 2 diabetic patients with nephropathy. Clin Exp Immunol. 2007;149:123-31 pubmed
    ..with diabetic nephropathy (DN) were significantly higher than control subjects, while IL-10, CXCL8, CXCL9, CXCL10 and adiponectin concentrations of DN were significantly higher than patients without diabetic nephropathy (NDN) ..
  59. Valbuena G, Bradford W, Walker D. Expression analysis of the T-cell-targeting chemokines CXCL9 and CXCL10 in mice and humans with endothelial infections caused by rickettsiae of the spotted fever group. Am J Pathol. 2003;163:1357-69 pubmed
    ..The expression of the CXCR3 ligands CXCL9 and CXCL10 was significantly higher than the other chemokines investigated...
  60. Bodnar R, Yates C, Rodgers M, Du X, Wells A. IP-10 induces dissociation of newly formed blood vessels. J Cell Sci. 2009;122:2064-77 pubmed publisher
    ..Treatment of endothelial cords with CXCL10 (IP-10), a CXCR3 ligand present during the resolving phase of wounds, either in vitro or in vivo caused ..
  61. Kremlev S, Roberts R, Palmer C. Minocycline modulates chemokine receptors but not interleukin-10 mRNA expression in hypoxic-ischemic neonatal rat brain. J Neurosci Res. 2007;85:2450-9 pubmed
    ..These effects confirm the antiinflammatory effect of MN in neonatal HI brain injury. ..
  62. Lun S, Wong C, Ko F, Ip W, Hui D, Lam C. Aberrant expression of CC and CXC chemokines and their receptors in patients with asthma. J Clin Immunol. 2006;26:145-52 pubmed
    ..05). In conclusion, plasma RANTES may be a surrogate marker for asthma and the diminished Th1 related CXC chemokine production may contribute to Th2 predominance in asthma. ..
  63. Widney D, Hu Y, Foreman Wykert A, Bui K, Nguyen T, Lu B, et al. CXCR3 and its ligands participate in the host response to Bordetella bronchiseptica infection of the mouse respiratory tract but are not required for clearance of bacteria from the lung. Infect Immun. 2005;73:485-93 pubmed
    ..In this study, we evaluated the roles of the chemokines MIG (CXCL9), IP-10 (CXCL10), and I-TAC (CXCL11) and their common receptor, CXCR3...
  64. Grumelli S, Corry D, Song L, Song L, Green L, Huh J, et al. An immune basis for lung parenchymal destruction in chronic obstructive pulmonary disease and emphysema. PLoS Med. 2004;1:e8 pubmed
    ..These data suggest that Th1 lymphoctytes in the lungs of people with smoking-related damage drive progression of emphysema through CXCR3 ligands, interferon-inducible protein 10, and monokine induced by interferon. ..
  65. Ganta C, Helwig B, Blecha F, Ganta R, Cober R, Parimi S, et al. Hypothermia-enhanced splenic cytokine gene expression is independent of the sympathetic nervous system. Am J Physiol Regul Integr Comp Physiol. 2006;291:R558-65 pubmed
    ..Hypothermia upregulated the transcripts of several genes, including, chemokine ligands CCL2, CXCL2, CXCL10, and CCL20, and interleukins IL-1alpha, IL-1beta, and IL-6...
  66. Chien J, Hsueh P, Cheng W, Yu C, Yang P. Temporal changes in cytokine/chemokine profiles and pulmonary involvement in severe acute respiratory syndrome. Respirology. 2006;11:715-22 pubmed
    ..These changes in cytokine/chemokine profile are remarkably different from those observed in CAP patients. ..
  67. Niewczas M, Ficociello L, Johnson A, Walker W, Rosolowsky E, Roshan B, et al. Serum concentrations of markers of TNFalpha and Fas-mediated pathways and renal function in nonproteinuric patients with type 1 diabetes. Clin J Am Soc Nephrol. 2009;4:62-70 pubmed publisher
    ..interleukin 8 (IL8/CXCL8), monocytes chemoattractant protein-1 (MCP1), and IFNgamma inducible protein-10 (IP10/CXCL10)], the Fas pathway [soluble Fas (sFas) and Fas ligand (sFasL)], CRP, and IL6...
  68. Cui A, Anhenn O, Theegarten D, Ohshimo S, Bonella F, Sixt S, et al. Angiogenic and angiostatic chemokines in idiopathic pulmonary fibrosis and granulomatous lung disease. Respiration. 2010;80:372-8 pubmed publisher
    ..The difference in the expression of CXC chemokines and a Th1 cytokine may contribute to the different immunopathogenesis, clinical course and responsiveness to treatment of these diseases. ..
  69. Medoff B, Wain J, Seung E, Jackobek R, Means T, Ginns L, et al. CXCR3 and its ligands in a murine model of obliterative bronchiolitis: regulation and function. J Immunol. 2006;176:7087-95 pubmed
    ..The chemokine receptor CXCR3 and two of its ligands, CXCL9 and CXCL10, have been identified as important mediators of OB...
  70. Wildbaum G, Netzer N, Karin N. Plasmid DNA encoding IFN-gamma-inducible protein 10 redirects antigen-specific T cell polarization and suppresses experimental autoimmune encephalomyelitis. J Immunol. 2002;168:5885-92 pubmed
    ..This demonstrates not only the pivotal role of a chemokine in T cell polarization and function but also its potential implications for plasmid DNA gene therapy. ..
  71. Kelsen S, Aksoy M, Georgy M, Hershman R, Ji R, Li X, et al. Lymphoid follicle cells in chronic obstructive pulmonary disease overexpress the chemokine receptor CXCR3. Am J Respir Crit Care Med. 2009;179:799-805 pubmed publisher
    ..We assessed the expression of CXCR3 and its ligands (IP-10/CXCL10, Mig/CXCL9, and ITAC/CXCL11) by LF cells in never-smokers, smokers without COPD, and subjects with COPD...