Ctsb

Summary

Gene Symbol: Ctsb
Description: cathepsin B
Alias: cathepsin B, RSG-2, cathepsin B1
Species: rat
Products:     Ctsb

Top Publications

  1. Riese R, Wolf P, Bromme D, Natkin L, Villadangos J, Ploegh H, et al. Essential role for cathepsin S in MHC class II-associated invariant chain processing and peptide loading. Immunity. 1996;4:357-66 pubmed
    ..Consequently, the formation of SDS-stable complexes was markedly reduced. Purified cathepsin S, but not cathepsin B, H, or D, specifically digested li from alpha beta li trimers, generating alpha beta-CLIP complexes capable of ..
  2. Rajashree S, Puvanakrishnan R. Alterations in certain lysosomal glycohydrolases and cathepsins in rats on dexamethasone administration. Mol Cell Biochem. 1996;154:165-70 pubmed
    ..beta-glucuronidase, beta-N-acetyl glucosaminidase, beta-galactosidase, alpha-galactosidase, alpha-mannosidase, cathepsin B and cathepsin D are observed in heart and kidney, but the enzyme levels are shown to increase in serum...
  3. Cataldo A, Paskevich P, Kominami E, Nixon R. Lysosomal hydrolases of different classes are abnormally distributed in brains of patients with Alzheimer disease. Proc Natl Acad Sci U S A. 1991;88:10998-1002 pubmed
    ..The actions of membrane-degrading acid hydrolases could also explain how the intramembrane portion of APP containing the C terminus of beta-amyloid becomes accessible to proteases. ..
  4. Siemieniuk E, Kolodziejczyk L, Skrzydlewska E. Oxidative Modifications of Rat Liver Cell Components During Fasciola hepatica Infection. Toxicol Mech Methods. 2008;18:519-524 pubmed
    ..A significant decrease in lysosomal as well as in the total activity of cathepsin B during fasciolosis was also observed.
  5. Li Korotky H, Swarts J, Hebda P, Doyle W. Cathepsin gene expression profile in rat acute pneumococcal otitis media. Laryngoscope. 2004;114:1032-6 pubmed
    ..Middle ear mucosa expression of a gene cluster encoding the lysosomal cysteine proteases, cathepsins B (Ctsb), L (Ctsl), and K (Ctsk), was modified after S pneumoniae challenge...
  6. Di Piazza M, Mader C, Geletneky K, Herrero Y Calle M, Weber E, Schlehofer J, et al. Cytosolic activation of cathepsins mediates parvovirus H-1-induced killing of cisplatin and TRAIL-resistant glioma cells. J Virol. 2007;81:4186-98 pubmed
    ..In vivo, parvovirus H-1 infection of rat glioma cells intracranially implanted into recipient animals triggers cathepsin B activation as well...
  7. Mahurkar S, Bhaskar S, Reddy D, Prakash S, Rao G, Singh S, et al. TCF7L2 gene polymorphisms do not predict susceptibility to diabetes in tropical calcific pancreatitis but may interact with SPINK1 and CTSB mutations in predicting diabetes. BMC Med Genet. 2008;9:80 pubmed publisher
    ..We also investigated the interaction between the TCF7L2 variants and N34S SPINK1 and L26V CTSB mutations, since they are strong predictors of risk for TCP...
  8. Lee H, Kim C. Cathepsin B is activated as an executive protease in fetal rat alveolar type II cells exposed to hyperoxia. Exp Mol Med. 2011;43:223-9 pubmed
    ..The authors investigated whether lysosomal protease, cathepsin B (CB), is activated in fetal alveolar type II cells in the transitional period from the canalicular to saccular ..
  9. Chandran K, Sullivan N, Felbor U, Whelan S, Cunningham J. Endosomal proteolysis of the Ebola virus glycoprotein is necessary for infection. Science. 2005;308:1643-5 pubmed publisher
    ..Using selective protease inhibitors and protease-deficient cell lines, we identified an essential role for cathepsin B (CatB) and an accessory role for cathepsin L (CatL) in EboV GP-dependent entry...

More Information

Publications82

  1. Vidotti D, Casarini D, Cristovam P, Leite C, Schor N, Boim M. High glucose concentration stimulates intracellular renin activity and angiotensin II generation in rat mesangial cells. Am J Physiol Renal Physiol. 2004;286:F1039-45 pubmed
    ..However, after shorter periods of 24 h of HG stimulation the mRNA levels of the enzymes prorenin and cathepsin B, besides that for ACE, were significantly increased...
  2. Gartland A, Mason Savas A, Yang M, MacKay C, Birnbaum M, Odgren P. Septoclast deficiency accompanies postnatal growth plate chondrodysplasia in the toothless (tl) osteopetrotic, colony-stimulating factor-1 (CSF-1)-deficient rat and is partially responsive to CSF-1 injections. Am J Pathol. 2009;175:2668-75 pubmed publisher
    The septoclast is a specialized, cathepsin B-rich, perivascular cell type that accompanies invading capillaries on the metaphyseal side of the growth plate during endochondral bone growth...
  3. Windelborn J, Lipton P. Lysosomal release of cathepsins causes ischemic damage in the rat hippocampal slice and depends on NMDA-mediated calcium influx, arachidonic acid metabolism, and free radical production. J Neurochem. 2008;106:56-69 pubmed publisher
    ..The current studies show that these events lead to the release of the protein hydrolase, cathepsin B, from lysosomes 2 h following 5-min oxygen-glucose deprivation in the rat hippocampal slice...
  4. Hyvönen M, Merentie M, Uimari A, Keinanen T, Janne J, Alhonen L. Mechanisms of polyamine catabolism-induced acute pancreatitis. Biochem Soc Trans. 2007;35:326-30 pubmed
    ..b>Cathepsin B, a lysosomal hydrolase mediating trypsinogen activation, was activated just 2 h after induction of SSAT...
  5. Wu Q, Xu M, Yuan Y, Li F, Yang Z, Liu Y, et al. Cathepsin B deficiency attenuates cardiac remodeling in response to pressure overload via TNF-α/ASK1/JNK pathway. Am J Physiol Heart Circ Physiol. 2015;308:H1143-54 pubmed publisher
    b>Cathepsin B (CTSB), a member of the lysosomal cathepsin family that is expressed in both murine and human hearts, was previously shown to participate in apoptosis, autophagy, and the progression of certain types of cancers...
  6. Takio K, Towatari T, Katunuma N, Teller D, Titani K. Homology of amino acid sequences of rat liver cathepsins B and H with that of papain. Proc Natl Acad Sci U S A. 1983;80:3666-70 pubmed
    ..The 252-residue sequence of cathepsin B and the 220-residue sequence of cathepsin H were determined largely by automated Edman degradation of their ..
  7. Jia Z, Hasnain S, Hirama T, Lee X, Mort J, To R, et al. Crystal structures of recombinant rat cathepsin B and a cathepsin B-inhibitor complex. Implications for structure-based inhibitor design. J Biol Chem. 1995;270:5527-33 pubmed
    The lysosomal cysteine proteinase cathepsin B (EC 3.4.22.1) plays an important role in protein catabolism and has also been implicated in various disease states...
  8. Nagai A, Murakawa Y, Terashima M, Shimode K, Umegae N, Takeuchi H, et al. Cystatin C and cathepsin B in CSF from patients with inflammatory neurologic diseases. Neurology. 2000;55:1828-32 pubmed
    ..Cystatin C, a major cysteine protease inhibitor in CSF, is tightly bound to cathepsin B and H...
  9. Hassanein M, Korant B, Lu G, Mason R. Expression of cathepsin P mRNA, protein and activity in the rat choriocarcinoma cell line, Rcho-1, during giant cell transformation. Placenta. 2007;28:912-9 pubmed
    ..Cathepsin P protein co-localizes with cathepsin B, indicating that the enzyme probably functions in the endosomal-lysosomal compartment...
  10. Rendakov N, Topchieva L, Vinogradova I, Nemova N. Alteration of cathepsins and actin genes expression in rat brain during ageing. Dokl Biol Sci. 2011;436:50-2 pubmed publisher
  11. Donohue T, Curry McCoy T, Nanji A, Kharbanda K, Osna N, Radio S, et al. Lysosomal leakage and lack of adaptation of hepatoprotective enzyme contribute to enhanced susceptibility to ethanol-induced liver injury in female rats. Alcohol Clin Exp Res. 2007;31:1944-52 pubmed
    ..A 2-fold elevation of cathepsin B in hepatic cytosol fractions, indicating lysosomal leakage, was detected in ethanol-fed female rats but no such ..
  12. Ishii Y, Hashizume Y, Watanabe T, Waguri S, Sato N, Yamamoto M, et al. Cysteine proteinases in bronchoalveolar epithelial cells and lavage fluid of rat lung. J Histochem Cytochem. 1991;39:461-8 pubmed
    ..Immunoblotting revealed that protein bands corresponding to the pro-form and mature form of cathepsin B and the mature form of cathepsin H were present in the culture medium...
  13. Hughes S, Glover T, Zhu X, Kuick R, Thoraval D, Orringer M, et al. A novel amplicon at 8p22-23 results in overexpression of cathepsin B in esophageal adenocarcinoma. Proc Natl Acad Sci U S A. 1998;95:12410-5 pubmed
    b>Cathepsin B (CTSB) is overexpressed in tumors of the lung, prostate, colon, breast, and stomach. However, evidence of primary genomic alterations in the CTSB gene during tumor initiation or progression has been lacking...
  14. Agudo M, Pérez Marín M, Sobrado Calvo P, Lönngren U, Salinas Navarro M, Cánovas I, et al. Immediate upregulation of proteins belonging to different branches of the apoptotic cascade in the retina after optic nerve transection and optic nerve crush. Invest Ophthalmol Vis Sci. 2009;50:424-31 pubmed publisher
  15. Barrett A, Davies M, Grubb A. The place of human gamma-trace (cystatin C) amongst the cysteine proteinase inhibitors. Biochem Biophys Res Commun. 1984;120:631-6 pubmed
    ..It proves to be the tightest -binding protein inhibitor of cathepsin B so far discovered...
  16. Schaefer L, Han X, Gretz N, Schaefer R. Alterations of cathepsins B, H and L in proximal tubules from polycystic kidneys of the Han:SPRD rat. Kidney Int. 1996;50:424-31 pubmed
  17. Tagawa K, Kunishita T, Maruyama K, Yoshikawa K, Kominami E, Tsuchiya T, et al. Alzheimer's disease amyloid beta-clipping enzyme (APP secretase): identification, purification, and characterization of the enzyme. Biochem Biophys Res Commun. 1991;177:377-87 pubmed
    ..Using these substrates, we found an intracellular proteinase that has APP secretase activity. This proteinase has been identified as cathepsin B.
  18. Li S, Du L, Zhang L, Hu Y, Xia W, Wu J, et al. Cathepsin B contributes to autophagy-related 7 (Atg7)-induced nod-like receptor 3 (NLRP3)-dependent proinflammatory response and aggravates lipotoxicity in rat insulinoma cell line. J Biol Chem. 2013;288:30094-104 pubmed publisher
    ..Atg7-induced cathepsin B (CTSB) overexpression resulted in an unexpected significant increase in proinflammatory chemokine and cytokine ..
  19. Bolwell G. Significance of a common epitope of plant and animal endomembranes. J Cell Sci. 1986;82:187-201 pubmed
    ..The common antigenic site could possibly be concerned in recognition or some fusion event during membrane trafficking within the cell. ..
  20. Wu X, Zhang L, Gurley E, Studer E, Shang J, Wang T, et al. Prevention of free fatty acid-induced hepatic lipotoxicity by 18beta-glycyrrhetinic acid through lysosomal and mitochondrial pathways. Hepatology. 2008;47:1905-15 pubmed publisher
    ..GA was found to stabilize lysosomal membranes, inhibit cathepsin B expression and enzyme activity, inhibit mitochondrial cytochrome c release, and reduce FFA-induced oxidative ..
  21. Nishimura Y, Tsuji H, Kato K, Sato H, Amano J, Himeno M. Biochemical properties and intracellular processing of lysosomal cathepsins B and H. Biol Pharm Bull. 1995;18:829-36 pubmed
    ..In contrast, in the case of cathepsin B, the appearance of a radiolabel in the single-chain form or in the two-chain form was observed almost ..
  22. Linke M, Herzog V, Brix K. Trafficking of lysosomal cathepsin B-green fluorescent protein to the surface of thyroid epithelial cells involves the endosomal/lysosomal compartment. J Cell Sci. 2002;115:4877-89 pubmed
    b>Cathepsin B, a lysosomal cysteine proteinase, is involved in limited proteolysis of thyroglobulin with thyroxine liberation at the apical surface of thyroid epithelial cells...
  23. Wassélius J, Wallin H, Abrahamson M, Ehinger B. Cathepsin B in the rat eye. Graefes Arch Clin Exp Ophthalmol. 2003;241:934-42 pubmed
    b>Cathepsin B is a mammalian cysteine protease. The enzyme has been suggested to participate in the patophysiological processes of keratoconus as well as in the corneal response to infectious agents...
  24. Maes K, Testelmans D, Powers S, Decramer M, Gayan Ramirez G. Leupeptin inhibits ventilator-induced diaphragm dysfunction in rats. Am J Respir Crit Care Med. 2007;175:1134-8 pubmed
    ..Atrophy of type IIx/b fibers was present after CMV, but not after treatment with leupeptin. Cathepsin B and calpain activities were significantly higher after CMV compared with the other groups; this was abolished ..
  25. Zhang H, Feng Q, Li H, Chen S, Wang X, Peng J, et al. [Effects of Qushi Huayu Decoction on cathepsin B and tumor necrosis factor-alpha expression in rats with non-alcoholic steatohepatitis]. Zhong Xi Yi Jie He Xue Bao. 2008;6:928-33 pubmed publisher
    ..b>Cathepsin B (Ctsb), phospho-inhibitor kappa B (P-IkappaB), TNF-alpha protein expressions in liver tissue were assayed with ..
  26. Gruenheid S, Pinner E, Desjardins M, Gros P. Natural resistance to infection with intracellular pathogens: the Nramp1 protein is recruited to the membrane of the phagosome. J Exp Med. 1997;185:717-30 pubmed
  27. Hall A, Hakansson K, Mason R, Grubb A, Abrahamson M. Structural basis for the biological specificity of cystatin C. Identification of leucine 9 in the N-terminal binding region as a selectivity-conferring residue in the inhibition of mammalian cysteine peptidases. J Biol Chem. 1995;270:5115-21 pubmed
    ..for the major part of cystatin C affinity for cathepsin L and are also of considerable importance for cathepsin B and H affinity...
  28. Johnson E, Doyle J, Wetzel J, McClung R, Katunuma N, Chappell J, et al. Genetic and pharmacologic alteration of cathepsin expression influences reovirus pathogenesis. J Virol. 2009;83:9630-40 pubmed publisher
    ..Mammalian reoviruses utilize cathepsins B (Ctsb), L (Ctsl), and S (Ctss) for disassembly of the virus outer capsid and activation of the membrane penetration ..
  29. Nagai A, Terashima M, Harada T, Shimode K, Takeuchi H, Murakawa Y, et al. Cathepsin B and H activities and cystatin C concentrations in cerebrospinal fluid from patients with leptomeningeal metastasis. Clin Chim Acta. 2003;329:53-60 pubmed
    ..A high enzyme activity/cystatin C concentration ratio in the CSF could be useful when diagnosing LM in combination with other parameters. ..
  30. Clark A, Grist J, Al Kashi A, Perretti M, Malcangio M. Spinal cathepsin S and fractalkine contribute to chronic pain in the collagen-induced arthritis model. Arthritis Rheum. 2012;64:2038-47 pubmed publisher
    ..The inhibition of microglial targets by centrally penetrant CatS inhibitors and CX(3) CR1 receptor antagonists represents a potential therapeutic avenue for the treatment of pain in RA. ..
  31. Ellis R, O Steen W, Hayes R, Nick H, Wang K, Anderson D. Cellular localization and enzymatic activity of cathepsin B after spinal cord injury in the rat. Exp Neurol. 2005;193:19-28 pubmed
    ..b>Cathepsin B (Cath B), a potent lysosomal protease, has also been implicated in the pathology of CNS diseases including ..
  32. Staack A, Tolic D, Kristiansen G, Schnorr D, Loening S, Jung K. Expression of cathepsins B, H, and L and their inhibitors as markers of transitional cell carcinoma of the bladder. Urology. 2004;63:1089-94 pubmed
    It has been shown that the expression of the lysosomal proteolytic enzymes cathepsin B, H, and L (CB, CH, and CL, respectively) correlate with tumor progression in various neoplasms...
  33. Elsaid K, Jay G, Chichester C. Reduced expression and proteolytic susceptibility of lubricin/superficial zone protein may explain early elevation in the coefficient of friction in the joints of rats with antigen-induced arthritis. Arthritis Rheum. 2007;56:108-16 pubmed
    ..Levels of messenger RNA (mRNA) for lubricin, cathepsin B, and interleukin-1beta (IL-1beta) in synovial tissue from control and affected joints were determined by ..
  34. San Segundo B, Chan S, Steiner D. Identification of cDNA clones encoding a precursor of rat liver cathepsin B. Proc Natl Acad Sci U S A. 1985;82:2320-4 pubmed
    Recent studies have suggested that many lysosomal enzymes, including cathepsin B (EC 3.4.22.1), may be synthesized as larger precursors and proteolytically processed to their mature forms...
  35. Mathur P, Grima J, Mo M, Zhu L, Aravindan G, Calcagno K, et al. Differential expression of multiple cathepsin mRNAs in the rat testis during maturation and following lonidamine induced tissue restructuring. Biochem Mol Biol Int. 1997;42:217-33 pubmed
    ..Sertoli, Leydig, and germ cells for reverse-transcription and polymerase chain reaction (RT-PCR), the mRNAs of cathepsin B, C, D, H, L, and S were shown to be expressed by Sertoli and Leydig cells, whereas germ cells isolated from ..
  36. Anagli J, Abounit K, Stemmer P, Han Y, Allred L, Weinsheimer S, et al. Effects of cathepsins B and L inhibition on postischemic protein alterations in the brain. Biochem Biophys Res Commun. 2008;366:86-91 pubmed
    ..b>Cathepsin B activity increased predominantly in the subcortical region of the ischemic hemisphere where the levels of ..
  37. Song R, Singh A, Leehey D. Decreased glomerular proteinase activity in the streptozotocin diabetic rat. Am J Nephrol. 1999;19:441-6 pubmed
    ..Glomeruli from diabetic rats 1 month after STZ injection demonstrated significant decreases in collagenase and cathepsin B activities compared to control glomeruli...
  38. Shechter P, Shi J, Rabkin R. Renal tubular cell protein breakdown in uninephrectomized and ammonium chloride-loaded rats. J Am Soc Nephrol. 1994;5:1201-7 pubmed
    ..depressed in renal tubules isolated from the acidotic rats and was accompanied by a decrease in proximal tubule cathepsin B and combined B and L activities. These changes are comparable to earlier observations with the diabetic kidney...
  39. Moreau T, Esnard F, Gutman N, Degand P, Gauthier F. Cysteine-proteinase-inhibiting function of T kininogen and of its proteolytic fragments. Eur J Biochem. 1988;173:185-90 pubmed
  40. Chaitanya G, Babu P. Activation of calpain, cathepsin-b and caspase-3 during transient focal cerebral ischemia in rat model. Neurochem Res. 2008;33:2178-86 pubmed publisher
    ..The differences in the regional distribution and elevation of these proteases at different reperfusion time periods indicates that differential mode of cell death occur in the brain during cerebral ischemia in rat model. ..
  41. Ma J, Tanaka K, Yamada G, Ikenaka K. Induced expression of cathepsins and cystatin C in a murine model of demyelination. Neurochem Res. 2007;32:311-20 pubmed
    ..We propose that in MS, remyelination may be impaired by increasing activity of cathepsins inadequately controlled by cystatin C. ..
  42. Sebzda T, Hanczyc P, Saleh Y, Akinpelumi B, Siewinski M, Rudnicki J. Effect of vitamin E and human placenta cysteine peptidase inhibitor on expression of cathepsins B and L in implanted hepatoma Morris 5123 tumor model in Wistar rats. World J Gastroenterol. 2005;11:587-92 pubmed
    ..0001). The data indicate formation of metastasis significantly reduced in treated rats, which might provide a therapeutic basis for anti-cancer therapy. ..
  43. Ohashi A, Murata E, Yamamoto K, Majima E, Sano E, Le Q, et al. New functions of lactoferrin and beta-casein in mammalian milk as cysteine protease inhibitors. Biochem Biophys Res Commun. 2003;306:98-103 pubmed
    ..Lactoferrin and beta-casein in milk might play a role in antiseptic and antiinfectious functions due to cysteine protease inhibition of bacteria and viruses. ..
  44. Dahlmann B, Kuehn L, Heinrich P, Kirschke H, Wiederanders B. ATP-activated, high-molecular-mass proteinase-I from rat skeletal muscle is a cysteine proteinase-alpha 1-macroglobulin complex. Biochim Biophys Acta. 1989;991:253-62 pubmed
    ..that this high-molecular-mass proteinase is a complex of alpha 1-macroglobulin and the cysteine proteinases cathepsin B, H and L. A similar 'proteinase' has been isolated from rat serum...
  45. Cygler M, Sivaraman J, Grochulski P, Coulombe R, Storer A, Mort J. Structure of rat procathepsin B: model for inhibition of cysteine protease activity by the proregion. Structure. 1996;4:405-16 pubmed
    ..The 62-residue proregion does not form a globular structure on its own, but folds along the surface of mature cathepsin B. The N-terminal part of the proregion packs against a surface loop, with Trp24p (p indicating the proregion) ..
  46. Masini M, Bugliani M, Lupi R, Del Guerra S, Boggi U, Filipponi F, et al. Autophagy in human type 2 diabetes pancreatic beta cells. Diabetologia. 2009;52:1083-6 pubmed publisher
    ..Unchanged gene expression of beclin-1 and ATG1 (also known as ULK1), and reduced transcription of LAMP2 and cathepsin B and D was observed in type 2 diabetic islets...
  47. Hilliard L, Russo L, Comper W. Hypertension-mediated albuminuria is associated with reduced lysosomal activity in the kidney and the heart. Am J Nephrol. 2009;29:454-64 pubmed publisher
    ..expression were determined by real-time reverse transcription-polymerase chain reaction, and renal and cardiac cathepsin B and L activities were measured as an indicator of lysosomal proteolytic activity...
  48. Chaitanya G, Babu P. Multiple apoptogenic proteins are involved in the nuclear translocation of Apoptosis Inducing Factor during transient focal cerebral ischemia in rat. Brain Res. 2008;1246:178-90 pubmed publisher
    ..These results indicate that multiple proteases were involved in the nuclear translocation of AIF during the pathology of cerebral ischemia. ..
  49. Zhang Z, Li Z. Cathepsin B and phospo-JNK in relation to ongoing apoptosis after transient focal cerebral ischemia in the rat. Neurochem Res. 2012;37:948-57 pubmed publisher
    b>Cathepsin B, one of major lysosomal cathepsins, and JNK, a downstream component of Rho kinase (ROCK), are two families of proteases, which play an important role in ischemic cell apoptosis...
  50. Foekens J, Kos J, Peters H, Krasovec M, Look M, Cimerman N, et al. Prognostic significance of cathepsins B and L in primary human breast cancer. J Clin Oncol. 1998;16:1013-21 pubmed
    Evaluation of the clinical significance of cytosolic tumor levels of the lysosomal cysteine proteases cathepsin B (catB) and cathepsin L (catL) in patients with primary breast cancer...
  51. Popovic T, Puizdar V, Ritonja A, Brzin J. Simultaneous isolation of human kidney cathepsins B, H, L and C and their characterisation. J Chromatogr B Biomed Appl. 1996;681:251-62 pubmed
    ..In this step, pure cathepsin L was obtained, while two isoforms of cathepsin B had to be finally purified on Sephacryl S-200 columns...
  52. Caserman S, Lah T. Comparison of expression of cathepsins B and L and MMP2 in endothelial cells and in capillary sprouting in collagen gel. Int J Biol Markers. 2004;19:120-9 pubmed
  53. Aoki T, Kataoka H, Ishibashi R, Nozaki K, Hashimoto N. Cathepsin B, K, and S are expressed in cerebral aneurysms and promote the progression of cerebral aneurysms. Stroke. 2008;39:2603-10 pubmed publisher
    ..CAs were induced in Sprague-Dawley rats with or without cysteine cathepsin inhibitor, NC-2300. Expression of cathepsin B, K, S, and cystatin C, an endogenous inhibitor of cysteine cathepsins, in aneurysmal walls was examined in ..
  54. Jane D, Morvay L, DaSilva L, Cavallo Medved D, Sloane B, Dufresne M. Cathepsin B localizes to plasma membrane caveolae of differentiating myoblasts and is secreted in an active form at physiological pH. Biol Chem. 2006;387:223-34 pubmed
    Our in vitro studies support a functional link between the induction of cathepsin B gene expression and the catabolic restructuring associated with myotube formation during myogenesis in vivo...
  55. Stauber W, Gauthier F, Ong S. Identification and possible regulation of muscle cell lysosomal protease activity by exogenous protease inhibitors. Acta Biol Med Ger. 1981;40:1317-22 pubmed
    ..b>Cathepsin B and dipeptidyl peptidase I were localized primarily in subsarcolemmal regions whereas cathepsin H and ..
  56. Wu S, Huang Y, Yeh C, Tsai M, Liao C, Cheng W, et al. Cathepsin H regulated by the thyroid hormone receptors associate with tumor invasion in human hepatoma cells. Oncogene. 2011;30:2057-69 pubmed publisher
    ..This study demonstrated that CTSH overexpression in a subset hepatoma may be TR dependent and suggests that this overexpression has an important role in hepatoma progression. ..
  57. Hartwig W, Kolvenbach M, Hackert T, Fortunato F, Schneider L, Buchler M, et al. Enterokinase induces severe necrosis and rapid mortality in cerulein pancreatitis: characterization of a novel noninvasive rat model of necro-hemorrhagic pancreatitis. Surgery. 2007;142:327-36 pubmed
    ..Trypsin as well as elastase and cathepsin B activity in pancreatic tissue samples were increased markedly in these animals...
  58. Xu M, Yang L, Rong J, Ni Y, Gu W, Luo Y, et al. Inhibition of cysteine cathepsin B and L activation in astrocytes contributes to neuroprotection against cerebral ischemia via blocking the tBid-mitochondrial apoptotic signaling pathway. Glia. 2014;62:855-80 pubmed publisher
    ..Here, we test the hypothesis that activation of cathepsin B and L contributes to the ischemic astrocyte injury via the tBid-mitochondrial apoptotic signaling pathways...
  59. Bao G, Wang H, Shang Y, Fan H, Gu M, Xia R, et al. Quantitative proteomic study identified cathepsin B associated with doxorubicin-induced damage in H9c2 cardiomyocytes. Biosci Trends. 2012;6:283-7 pubmed
    ..We further validated the expression of cathepsin B and its possible regulator nuclear factor kappa B (NF-?B) in H9c2 cells were increased during doxorubicin ..
  60. Fortunato F, Berger I, Gross M, Rieger P, Buechler M, Werner J. Immune-compromised state in the rat pancreas after chronic alcohol exposure: the role of peroxisome proliferator-activated receptor gamma. J Pathol. 2007;213:441-52 pubmed
    ..Furthermore, alcohol exposure increased the activities of trypsin and cathepsin B, both known to be critical in initiating acinar cell injury and pancreatitis...
  61. Hsing L, Kirk E, McMillen T, Hsiao S, Caldwell M, Houston B, et al. Roles for cathepsins S, L, and B in insulitis and diabetes in the NOD mouse. J Autoimmun. 2010;34:96-104 pubmed publisher
    ..NOD mice deficient in Ctss or Ctsb were partially protected from diabetes with incidence at 33% and 28%, respectively, versus wild-type NOD (69%; p &..
  62. Gao B, Stuart L, Feener E. Label-free quantitative analysis of one-dimensional PAGE LC/MS/MS proteome: application on angiotensin II-stimulated smooth muscle cells secretome. Mol Cell Proteomics. 2008;7:2399-409 pubmed publisher
    ..Ang II-stimulated changes of plasminogen activator inhibitor-1, GAS6, cathepsin B, and periostin were validated by Western blot...
  63. Sakamoto M, Miyamoto K, Wu Z, Nakanishi H. Possible involvement of cathepsin B released by microglia in methylmercury-induced cerebellar pathological changes in the adult rat. Neurosci Lett. 2008;442:292-6 pubmed publisher
    There is increasing evidence that cathepsin B (CB), a lysosomal cysteine protease, is one of the toxic molecules that are secreted by activated microglia...
  64. Punithavathi V, Prince P. Pretreatment with a combination of quercetin and alpha-tocopherol ameliorates adenosine triphosphatases and lysosomal enzymes in myocardial infarcted rats. Life Sci. 2010;86:178-84 pubmed publisher
    ..Our study demonstrated that combined pretreatment was better than single pretreatment. This study may have significant impact on myocardial infarcted patients. ..
  65. Hou Q, Ling L, Wang F, Xing S, Pei Z, Zeng J. Endostatin expression in neurons during the early stage of cerebral ischemia is associated with neuronal apoptotic cell death in adult hypertensive rat model of stroke. Brain Res. 2010;1311:182-8 pubmed publisher
    ..A single dose of Ca-074ME, a membrane-permeable cathepsin B (CB) specific inhibitor, or vehicle was given by intraperitoneal injection immediately after distal middle ..
  66. Cattaruzza F, Lyo V, Jones E, Pham D, Hawkins J, Kirkwood K, et al. Cathepsin S is activated during colitis and causes visceral hyperalgesia by a PAR2-dependent mechanism in mice. Gastroenterology. 2011;141:1864-74.e1-3 pubmed publisher
    ..Macrophage cathepsins are activated during colitis, and Cat-S activates nociceptors to induce visceral pain via protease-activated receptor-2. Cat-S mediates colitis pain and is a potential therapeutic target. ..
  67. Hayashi Y, Edwards N, Proescholdt M, Oldfield E, Merrill M. Regulation and function of aquaporin-1 in glioma cells. Neoplasia. 2007;9:777-87 pubmed
    ..Upregulation of the protease cathepsin B was also observed in 9L cells cultured under glycolytic conditions...
  68. Rowan A, Mason P, Mach L, Mort J. Rat procathepsin B. Proteolytic processing to the mature form in vitro. J Biol Chem. 1992;267:15993-9 pubmed
    ..been incubated with a variety of proteinases, and results indicate that cathepsins D and L, as well as mature cathepsin B itself, can produce a processed (single-chain) form of cathepsin B from this precursor...
  69. Durmaz R, Ozden H, Kanbak G, Aral E, Arslan O, Kartkaya K, et al. The protective effect of dexanabinol (HU-211) on nitric oxide and cysteine protease-mediated neuronal death in focal cerebral ischemia. Neurochem Res. 2008;33:1683-91 pubmed publisher
    ..In post-ischemic brain tissue, NO content and cathepsin B and L activity increased (p < 0.05)...
  70. Afonso S, Romagnano L, Babiarz B. The expression and function of cystatin C and cathepsin B and cathepsin L during mouse embryo implantation and placentation. Development. 1997;124:3415-25 pubmed
    ..Northern blots showed that trophoblast expressed cathepsin B throughout the invasive period (days 5.5-10.5)...
  71. Sage J, Leblanc Noblesse E, Nizard C, Sasaki T, Schnebert S, Perrier E, et al. Cleavage of nidogen-1 by cathepsin S impairs its binding to basement membrane partners. PLoS ONE. 2012;7:e43494 pubmed publisher
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    ..The aim was to investigate a potential relationship between the accumulated ECM protein fibronectin (FN), and cathepsin B activity in isolated glomeruli of diabetic and healthy rats...
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    ..Taken together, we summarize the recent evidence to elucidate that Htt is also a potential substrate of CMA. We propose that the manipulation of CMA could be a therapeutic strategy for HD. ..