Ctsa

Summary

Gene Symbol: Ctsa
Description: cathepsin A
Alias: Ppgb, lysosomal protective protein, protective protein for beta-galactosidase
Species: rat
Products:     Ctsa

Top Publications

  1. Shimmoto M, Fukuhara Y, Itoh K, Oshima A, Sakuraba H, Suzuki Y. Protective protein gene mutations in galactosialidosis. J Clin Invest. 1993;91:2393-8 pubmed
    ..Pulse-chase analysis detected a small amount of the mature form, as well as the precursor, in the cells transfected with the Y249N cDNA. Only precursor proteins were detected, mature proteins not appearing for the other mutant cDNAs. ..
  2. Cuervo A, Mann L, Bonten E, D AZZO A, Dice J. Cathepsin A regulates chaperone-mediated autophagy through cleavage of the lysosomal receptor. EMBO J. 2003;22:47-59 pubmed
    ..In addition to the well-studied role of PPCA in targeting and protecting two lysosomal glycosidases, we have defined a role for the proteolytic activity of this multifunctional protein. ..
  3. Linz D, Hohl M, Dhein S, Ruf S, Reil J, Kabiri M, et al. Cathepsin A mediates susceptibility to atrial tachyarrhythmia and impairment of atrial emptying function in Zucker diabetic fatty rats. Cardiovasc Res. 2016;110:371-80 pubmed publisher
    ..CatA-inhibition reduces LA bradykinin-degrading activity in ZDF and suppresses the development of atrial structural changes and AF-promotion, implicating CatA as an important mediator for AF-substrate in T2D. ..