Gene Symbol: Ctrb1
Description: chymotrypsinogen B1
Alias: Ctrb, chymotrypsinogen B, Chymotrypsin B, chymotrypsin B1
Species: rat
Products:     Ctrb1

Top Publications

  1. Iovanna J, Keim V, Michel R, Dagorn J. Pancreatic gene expression is altered during acute experimental pancreatitis in the rat. Am J Physiol. 1991;261:G485-9 pubmed
    ..Contents in amylase, trypsinogen I, chymotrypsinogen B, elastase 1, and procarboxypeptidase A mRNAs decreased by greater than 50% during the acute phase (days 0-2),..
  2. Giorgi D, Renaud W, Bernard J, Dagorn J. Regulation of proteolytic enzyme activities and mRNA concentrations in rat pancreas by food content. Biochem Biophys Res Commun. 1985;127:937-42 pubmed
    ..As compared to diet I, the pancreatic concentration of mRNAs encoding trypsinogen I and chymotrypsinogen B, measured by filter hybridization to specific cDNA probes, were found respectively 3.6 and 3...
  3. Bodi A, Kaslik G, Venekei I, Graf L. Structural determinants of the half-life and cleavage site preference in the autolytic inactivation of chymotrypsin. Eur J Biochem. 2001;268:6238-46 pubmed
    The molecular mechanism of the autolysis of rat alpha-chymotrypsin B was investigated. In addition to the two already known autolytic sites, Tyr146 and Asn147, a new site formed by Phe114 was identified...
  4. Miao Q, Sun Y, Wei T, Zhao X, Zhao K, Yan L, et al. Chymotrypsin B cached in rat liver lysosomes and involved in apoptotic regulation through a mitochondrial pathway. J Biol Chem. 2008;283:8218-28 pubmed publisher
    ..This protease was revealed as chymotrypsin B by biochemical and mass spectrometric analysis...
  5. Iovanna J, Dusetti N, Cadenas M, Mallmann M, Calvo E. Changes in pancreatic trophism and gene expression during a prolonged fasting period in rats. Int J Pancreatol. 1991;8:177-86 pubmed
    ..Total DNA, RNA, and proteins, and specific mRNAs for rat amylase, chymotrypsinogen B, trypsinogen I, proinsulin I, and actin (assessed by employing cloned cDNAs and dot-blot hybridization) were ..
  6. von Deimling O, Gröning J, Gaa A. Genetic and biochemical characterization of a new chymotrypsin isozyme of the house mouse, CTRA-1. Biochem Genet. 1991;29:545-57 pubmed
    ..From two backcross series, including a total of 274 animals, the gene order (Es-1, Es-9)-3.9 +/- 1.7%-Got-2-3.9 +/- 1.7%-(Es-2, Es-7, Es-23)-0.7 +/- 0.5%- Ctra-1-6.3 +/- 2.2%-Prt-2 was established. ..
  7. Lau P, Palmer R, Lambert H, Song C, Lutz F, Geokas M. Pseudomonas aeruginosa cytotoxin stimulates secretion of amylase and protease zymogens with a concomitant decrease of mRNA levels in isolated rat pancreatic acini. Biochem Biophys Res Commun. 1988;152:688-94 pubmed
    ..as measured by dot-blot hybridization with the cloned cDNAs of amylase, trypsinogen I, proelastase II, and chymotrypsinogen B of the rat, decreased with time and were significantly lower than in the untreated acini...
  8. Bell G, Quinto C, Quiroga M, Valenzuela P, Craik C, Rutter W. Isolation and sequence of a rat chymotrypsin B gene. J Biol Chem. 1984;259:14265-70 pubmed
    A cDNA clone encoding part of chymotrypsin B was isolated from a cDNA library prepared from rat pancreatic mRNA and used as a probe to isolate the chymotrypsin B gene. The nucleotide sequence of this gene is presented...
  9. Oppezzo O, Ventura S, Bergman T, Vendrell J, Jornvall H, Aviles F. Procarboxypeptidase in rat pancreas. Overall characterization and comparison of the activation processes. Eur J Biochem. 1994;222:55-63 pubmed
    ..Instead, we observed the presence of a binary complex between procarboxypeptidase A2 and chymotrypsinogen B. Among the major pancreatic endoproteinases, only trypsin was found to be a general activator of rat ..

More Information


  1. Rosewicz S, Lewis L, Wang X, Liddle R, Logsdon C. Pancreatic digestive enzyme gene expression: effects of CCK and soybean trypsin inhibitor. Am J Physiol. 1989;256:G733-8 pubmed
    ..examined in the rat using cloned cDNA probes to quantify changes in specific mRNAs (amylase, trypsinogen I, chymotrypsinogen B, and ribonuclease). Rats were administered intraduodenally an elemental liquid diet...
  2. Venekei I, Szilagyi L, Graf L, Rutter W. Attempts to convert chymotrypsin to trypsin. FEBS Lett. 1996;379:143-7 pubmed
    ..Our results indicate that in addition to structural elements already studied, further (chymotrypsin) specific sites have to be mutated to accomplish a chymotrypsin-->trypsin specificity conversion. ..