Gene Symbol: Ctnnd1
Description: catenin delta 1
Alias: Catns, catenin delta-1, catenin (cadherin associated protein), delta 1, catenin src
Species: rat
Products:     Ctnnd1

Top Publications

  1. Golenhofen N, Drenckhahn D. The catenin, p120ctn, is a common membrane-associated protein in various epithelial and non-epithelial cells and tissues. Histochem Cell Biol. 2000;114:147-55 pubmed
    ..Whereas all epithelia assayed contained at least two isoforms, testis, heart, brain, and retina contained a single 110-kDa band that corresponds to isoform 1B in mice. ..
  2. Uehara K. Distribution of adherens junction mediated by VE-cadherin complex in rat spleen sinus endothelial cells. Cell Tissue Res. 2006;323:417-24 pubmed
    ..These data suggest that adherens junctions, whose formation appears to be mediated by VE-cadherin-catenin complexes, probably regulate the passage of blood cells through the spleen. ..
  3. Abu Elneel K, Ochiishi T, Medina M, Remedi M, Gastaldi L, Caceres A, et al. A delta-catenin signaling pathway leading to dendritic protrusions. J Biol Chem. 2008;283:32781-91 pubmed publisher
  4. Hsu K, Fan H, Chen Y, Huang Y, Chen C, Wu J, et al. Protein kinase C-Fyn kinase cascade mediates the oleic acid-induced disassembly of neonatal rat cardiomyocyte adherens junctions. Int J Biochem Cell Biol. 2009;41:1536-46 pubmed publisher
    ..Therefore, inhibitors of PKC-alpha/-epsilon and Src family kinase are potential candidates as cardioprotection agents against OA-induced heart injury during ischemia-reperfusion. ..
  5. Lehtonen S, Lehtonen E, Kudlicka K, Holthofer H, Farquhar M. Nephrin forms a complex with adherens junction proteins and CASK in podocytes and in Madin-Darby canine kidney cells expressing nephrin. Am J Pathol. 2004;165:923-36 pubmed
  6. Chen Y, Lee N, Mruk D, Lee W, Cheng C. Fer kinase/FerT and adherens junction dynamics in the testis: an in vitro and in vivo study. Biol Reprod. 2003;69:656-72 pubmed
    ..In summary, Fer kinase structurally associates with the N-cadherin/catenin protein complex in the testis and can possibly be used to mediate signaling function via the cadherin/catenin protein complex. ..
  7. Nunes F, Lopez L, Lin H, Davies C, Azevedo R, Gow A, et al. Distinct subdomain organization and molecular composition of a tight junction with adherens junction features. J Cell Sci. 2006;119:4819-27 pubmed
  8. Sallee J, Burridge K. Density-enhanced phosphatase 1 regulates phosphorylation of tight junction proteins and enhances barrier function of epithelial cells. J Biol Chem. 2009;284:14997-5006 pubmed publisher
    ..These data suggest that DEP-1 can modify the phosphorylation state of tight junction proteins and play a role in regulating permeability. ..
  9. Chauvet N, Privat A, Prieto M. Differential expression of p120 catenin in glial cells of the adult rat brain. J Comp Neurol. 2004;479:15-29 pubmed
    ..Moreover, the expression of p120ctn by various cell types and its differential subcellular distribution strongly suggest that p120ctn may serve multiple functions in the central nervous system. ..

More Information


  1. Lee S, Peng I, Ng Y, Yanagisawa M, Bamji S, Elia L, et al. Synapses are regulated by the cytoplasmic tyrosine kinase Fer in a pathway mediated by p120catenin, Fer, SHP-2, and beta-catenin. J Cell Biol. 2008;183:893-908 pubmed publisher
    ..Our results indicate that a presynaptic signaling pathway through p120ctn, Fer, SHP-2, and beta-catenin promotes excitatory synapse development and function. ..
  2. Humtsoe J, Liu M, Malik A, Wary K. Lipid phosphate phosphatase 3 stabilization of beta-catenin induces endothelial cell migration and formation of branching point structures. Mol Cell Biol. 2010;30:1593-606 pubmed publisher
    ..Thus, our study identified a key role for LPP3 in orchestrating PTEN-mediated beta-catenin/LEF-1 signaling in EC migration, cell-cell adhesion, and formation of branching point structures. ..
  3. Gavard J, Lambert M, Grosheva I, Marthiens V, Irinopoulou T, Riou J, et al. Lamellipodium extension and cadherin adhesion: two cell responses to cadherin activation relying on distinct signalling pathways. J Cell Sci. 2004;117:257-70 pubmed
    ..These results provide additional information on the mechanisms by which cadherin coordinates adhesion with dynamic changes in the cytoskeleton to control cell shape and intercellular junction organization. ..
  4. Davis M, Reynolds A. Blocked acinar development, E-cadherin reduction, and intraepithelial neoplasia upon ablation of p120-catenin in the mouse salivary gland. Dev Cell. 2006;10:21-31 pubmed
    ..The data reveal an unexpected role for p120 in salivary acinar development and show that p120 ablation by itself induces effects consistent with a role in tumor progression. ..
  5. Wolf A, Keil R, Götzl O, Mun A, Schwarze K, Lederer M, et al. The armadillo protein p0071 regulates Rho signalling during cytokinesis. Nat Cell Biol. 2006;8:1432-40 pubmed
    ..These findings support an essential role for p0071 in spatially regulating restricted Rho signalling during cytokinesis. ..
  6. Chauvet N, Prieto M, Fabre C, Noren N, Privat A. Distribution of p120 catenin during rat brain development: potential role in regulation of cadherin-mediated adhesion and actin cytoskeleton organization. Mol Cell Neurosci. 2003;22:467-86 pubmed
  7. Hosking C, Ulloa F, Hogan C, Ferber E, Figueroa A, Gevaert K, et al. The transcriptional repressor Glis2 is a novel binding partner for p120 catenin. Mol Biol Cell. 2007;18:1918-27 pubmed
    ..These data indicate that p120 has additional novel functions in the nucleus together with Glis2. ..
  8. Holsinger L, Ward K, Duffield B, Zachwieja J, Jallal B. The transmembrane receptor protein tyrosine phosphatase DEP1 interacts with p120(ctn). Oncogene. 2002;21:7067-76 pubmed
    ..p120(ctn) was found to colocalize with these structures. Together these data suggest an important role for DEP-1 in the function of cell-cell contacts and adherens junctions. ..
  9. Strumane K, Bonnomet A, Stove C, Vandenbroucke R, Nawrocki Raby B, Bruyneel E, et al. E-cadherin regulates human Nanos1, which interacts with p120ctn and induces tumor cell migration and invasion. Cancer Res. 2006;66:10007-15 pubmed
    ..Targeting hNanos1 might be a promising strategy in the treatment of E-cadherin-negative tumors in particular. ..
  10. MARCIANO D, BRAKEMAN P, Lee C, Spivak N, Eastburn D, Bryant D, et al. p120 catenin is required for normal renal tubulogenesis and glomerulogenesis. Development. 2011;138:2099-109 pubmed publisher
    ..Taken together, our data show that p120ctn is required for early tubule and glomerular morphogenesis, as well as control of luminal diameter, probably through regulation of cadherins. ..
  11. Kelly K, Spring C, Otchere A, Daniel J. NLS-dependent nuclear localization of p120ctn is necessary to relieve Kaiso-mediated transcriptional repression. J Cell Sci. 2004;117:2675-86 pubmed
    ..Therefore, an intact NLS in p120(ctn) is requisite for its first identified regulatory role of the transcriptional repressor Kaiso. ..
  12. Oh M, Kim H, Yang I, Park J, Cong W, Baek M, et al. GSK-3 phosphorylates delta-catenin and negatively regulates its stability via ubiquitination/proteosome-mediated proteolysis. J Biol Chem. 2009;284:28579-89 pubmed publisher
    ..These results suggest that GSK-3 interacts with and phosphorylates delta-catenin and thereby negatively affects its stability by enabling its ubiquitination/proteosome-mediated proteolysis. ..
  13. Katafiasz B, Nieman M, Wheelock M, Johnson K. Characterization of cadherin-24, a novel alternatively spliced type II cadherin. J Biol Chem. 2003;278:27513-9 pubmed
    ..In addition, aggregation assays show that both forms of cadherin-24 mediate strong cell-cell adhesion. ..