Gene Symbol: Ctnna1
Description: catenin alpha 1
Alias: Catna1, catenin alpha-1, catenin (cadherin associated protein), alpha 1, catenin (cadherin-associated protein), alpha 1, 102kDa
Species: rat
Products:     Ctnna1

Top Publications

  1. Watabe Uchida M, Uchida N, Imamura Y, Nagafuchi A, Fujimoto K, Uemura T, et al. alpha-Catenin-vinculin interaction functions to organize the apical junctional complex in epithelial cells. J Cell Biol. 1998;142:847-57 pubmed
    ..These results indicate that the alphaE-catenin-vinculin interaction plays a role in the assembly of the apical junctional complex in epithelia. ..
  2. Byers S, Sujarit S, Jegou B, Butz S, Hoschutzky H, Herrenknecht K, et al. Cadherins and cadherin-associated molecules in the developing and maturing rat testis. Endocrinology. 1994;134:630-9 pubmed
    ..As catenins are not present at these sites, our results suggest a catenin-independent role of cadherins in germ cell adhesion to Sertoli cells. ..
  3. Guillaume E, Comunale F, Do Khoa N, Planchon D, Bodin S, Gauthier Rouvière C. Flotillin microdomains stabilize cadherins at cell-cell junctions. J Cell Sci. 2013;126:5293-304 pubmed publisher
    ..Altogether, these data demonstrate that flotillin microdomains are required for cadherin stabilization at CCJs and for the formation of functional CCJs. ..
  4. Liu S, Gao Y, Yu X, Zhao B, Liu L, Zhao Y, et al. Annexin-1 Mediates Microglial Activation and Migration via the CK2 Pathway during Oxygen-Glucose Deprivation/Reperfusion. Int J Mol Sci. 2016;17: pubmed
    ..Our findings indicate that ANXA1 promotes microglial activation and migration during OGD/R via FPRs, and CK2 target ?-E-catenin phosphorylation is involved in this process. ..
  5. Desai R, Sarpal R, Ishiyama N, Pellikka M, Ikura M, Tepass U. Monomeric ?-catenin links cadherin to the actin cytoskeleton. Nat Cell Biol. 2013;15:261-73 pubmed publisher
  6. Fasen K, Beck H, Elger C, Lie A. Differential regulation of cadherins and catenins during axonal reorganization in the adult rat CNS. J Neuropathol Exp Neurol. 2002;61:903-13 pubmed
    ..Our results imply that members of the cadherin/catenin families undergo specific spatiotemporal patterns of regulation, which may be important in axon target recognition and synapse formation during lesion-induced sprouting. ..
  7. Higashi N, Kojima N, Miura M, Imai K, Sato M, Senoo H. Cell-cell junctions between mammalian (human and rat) hepatic stellate cells. Cell Tissue Res. 2004;317:35-43 pubmed
    ..This is the first description of the presence of cell-cell junctions between hepatic stellate cells in mammals at the fine structural and molecular levels. ..
  8. Lien W, Klezovitch O, Fernandez T, Delrow J, Vasioukhin V. alphaE-catenin controls cerebral cortical size by regulating the hedgehog signaling pathway. Science. 2006;311:1609-12 pubmed
    ..We propose that alphaE-catenin connects cell-density-dependent adherens junctions with the developmental hedgehog pathway and that this connection may provide a negative feedback loop controlling the size of developing cerebral cortex. ..
  9. Nakopoulou L, Gakiopoulou Givalou H, Karayiannakis A, Giannopoulou I, Keramopoulos A, Davaris P, et al. Abnormal alpha-catenin expression in invasive breast cancer correlates with poor patient survival. Histopathology. 2002;40:536-46 pubmed
    ..006 and P=0.04, respectively). alpha-Catenin, especially its cytoplasmic expression, seems to be a more sensitive prognostic marker than the other members of the E-cadherin complex in invasive breast cancer. ..

More Information


  1. Aaltomaa S, Kärjä V, Lipponen P, Isotalo T, Kankkunen J, Talja M, et al. Reduced alpha- and beta-catenin expression predicts shortened survival in local prostate cancer. Anticancer Res. 2005;25:4707-12 pubmed
    ..016) and low alpha-catenin expression (p = 0.049). Reduced alpha- or beta-catenin expressions are related to malignant phenotype in local prostate cancer and predict PSA failure as well as shortened survival. ..
  2. Khare L, Sabourin C, De Young B, Jamasbi R, Stoner G. Altered localization of E-cadherin and alpha-catenin in rat esophageal tumors. Int J Oncol. 1999;14:33-40 pubmed
  3. Shibata H, Takano H, Ito M, Shioya H, Hirota M, Matsumoto H, et al. Alpha-catenin is essential in intestinal adenoma formation. Proc Natl Acad Sci U S A. 2007;104:18199-204 pubmed
    ..Extensive genetic analysis identified a deletion in the alpha-catenin (Ctnna1) gene as the cause of this suppression...
  4. Park L, Gallo E, Anrather J, Wang G, Norris E, Paul J, et al. Key role of tissue plasminogen activator in neurovascular coupling. Proc Natl Acad Sci U S A. 2008;105:1073-8 pubmed publisher
    ..These findings unveil a previously unrecognized role of tPA in vital homeostatic mechanisms coupling NMDA receptor signaling with nitric oxide synthesis and local cerebral perfusion. ..
  5. Scholten A, Aliredjo R, Creutzberg C, Smit V. Combined E-cadherin, alpha-catenin, and beta-catenin expression is a favorable prognostic factor in endometrial carcinoma. Int J Gynecol Cancer. 2006;16:1379-85 pubmed
    ..02). Negative E-cadherin expression was found to be associated with histologic grade 3 and with NEEC. Combined positive E-cadherin, alpha-catenin, and beta-catenin expression was a significant prognostic factor. ..
  6. Zhang R, Yin J, Zhao Y, Guo Y, Wang Y, Yang Z. [Effect of intra-testicular testosterone withdrawal on the expression of alpha-catenin in the adult rat testis]. Zhonghua Nan Ke Xue. 2006;12:394-6, 400 pubmed
    ..Intra-testicular testosterone withdrawal-induced looser arrangement or sloughing of spermatogenic cells is not related to the adhesion molecule alpha-catenin. Alpha-catenin may be used as a cell identification marker for Leydig cells. ..
  7. Kashibuchi K, Tomita K, Schalken J, Kume H, Takeuchi T, Kitamura T. The prognostic value of E-cadherin, alpha-, beta- and gamma-catenin in bladder cancer patients who underwent radical cystectomy. Int J Urol. 2007;14:789-94 pubmed
    ..Alpha-catenin may not only be a good prognostic marker, but also one of key molecules that determine the chemosensitivities in patients with invasive bladder cancer. ..
  8. Gavard J, Lambert M, Grosheva I, Marthiens V, Irinopoulou T, Riou J, et al. Lamellipodium extension and cadherin adhesion: two cell responses to cadherin activation relying on distinct signalling pathways. J Cell Sci. 2004;117:257-70 pubmed
    ..These results provide additional information on the mechanisms by which cadherin coordinates adhesion with dynamic changes in the cytoskeleton to control cell shape and intercellular junction organization. ..
  9. Sacco P, McGranahan T, Wheelock M, Johnson K. Identification of plakoglobin domains required for association with N-cadherin and alpha-catenin. J Biol Chem. 1995;270:20201-6 pubmed
    ..Plakoglobin is an armadillo family member containing 13 weakly similar internal repeats. These data show that the alpha-catenin-binding region maps within the first repeat and the N-cadherin-binding region maps within repeats 7 and 8. ..
  10. She B, Liou G, Lin Chao S. Association of the growth-arrest-specific protein Gas7 with F-actin induces reorganization of microfilaments and promotes membrane outgrowth. Exp Cell Res. 2002;273:34-44 pubmed
    ..We propose that Gas7 localized near the plasma membrane induces the assembly of actin and the membrane outgrowth. ..
  11. Piedra J, Miravet S, Castaño J, Palmer H, Heisterkamp N, Garcia de Herreros A, et al. p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction. Mol Cell Biol. 2003;23:2287-97 pubmed
  12. Ha H, Park H, Park N. Expression of E-cadherin and ?-catenin in a varicocele-induced infertility rat model. Asian J Androl. 2011;13:470-5 pubmed publisher
    ..The results of this study suggest that damage to the blood-testis barrier (BTB) is associated with varicocele-induced male infertility, and that ROS may cause damage to the BTB. ..
  13. Jung K, Dean D, Jiang J, Gaylor S, Griffith W, Burghardt R, et al. Loss of N-cadherin and alpha-catenin in the proximal tubules of aging male Fischer 344 rats. Mech Ageing Dev. 2004;125:445-53 pubmed
    ..Taken together, these data suggest that aging is associated with decreased expression of N-cadherin and alpha-catenin and is associated with a loss of cell polarity. ..
  14. Wu J, Tsai R, Chung T. Role of catenins in the development of gap junctions in rat cardiomyocytes. J Cell Biochem. 2003;88:823-35 pubmed
    ..These results suggest the formation of a catenin-ZO-1-Cx43 complex in rat cardiomyocytes and that binding of catenins to ZO-1 is required for Cx43 transport to the plasma membrane during the assembly of gap junctions. ..
  15. Rubinfeld B, Souza B, Albert I, Munemitsu S, Polakis P. The APC protein and E-cadherin form similar but independent complexes with alpha-catenin, beta-catenin, and plakoglobin. J Biol Chem. 1995;270:5549-55 pubmed
    ..Thus, APC forms distinct heteromeric complexes containing combinations of alpha-catenin, beta-catenin, and plakoglobin which are independent from the cadherin-catenin complexes. ..
  16. Wang X, Grunz Borgmann E, Parrish A. Loss of ?(E)-catenin potentiates cisplatin-induced nephrotoxicity via increasing apoptosis in renal tubular epithelial cells. Toxicol Sci. 2014;141:254-62 pubmed publisher
    ..Taken together, these data suggest that loss of ?(E)-catenin increases apoptosis of tubular epithelial cells which may contribute to the increased nephrotoxicity induced by cisplatin in aged kidney. ..
  17. Sundfeldt K, Piontkewitz Y, Billig H, Hedin L. E-cadherin-catenin complex in the rat ovary: cell-specific expression during folliculogenesis and luteal formation. J Reprod Fertil. 2000;118:375-85 pubmed
  18. Meng Q, Qi M, Chen D, Yuan R, Goldberg I, Rosen E, et al. Suppression of breast cancer invasion and migration by indole-3-carbinol: associated with up-regulation of BRCA1 and E-cadherin/catenin complexes. J Mol Med (Berl). 2000;78:155-65 pubmed
    ..Thus, clinical application of I3C may contribute to the potential benefit for suppression of breast cancer invasion and metastasis. ..
  19. Katafiasz B, Nieman M, Wheelock M, Johnson K. Characterization of cadherin-24, a novel alternatively spliced type II cadherin. J Biol Chem. 2003;278:27513-9 pubmed
    ..In addition, aggregation assays show that both forms of cadherin-24 mediate strong cell-cell adhesion. ..
  20. Carico E, Atlante M, Bucci B, Nofroni I, Vecchione A. E-cadherin and alpha-catenin expression during tumor progression of cervical carcinoma. Gynecol Oncol. 2001;80:156-61 pubmed
  21. Lallemand D, Curto M, Saotome I, Giovannini M, McClatchey A. NF2 deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctions. Genes Dev. 2003;17:1090-100 pubmed
    ..Our studies indicate that merlin functions as a tumor and metastasis suppressor by controlling cadherin-mediated cell:cell contact. ..
  22. Bear M, Liu T, Abualkhair S, Ghamloush M, Hill N, Preston I, et al. Alpha-Catulin Co-Localizes With Vimentin Intermediate Filaments and Functions in Pulmonary Vascular Endothelial Cell Migration via ROCK. J Cell Physiol. 2016;231:934-43 pubmed publisher
    ..J. Cell. Physiol. 231: 934-943, 2016. © 2015 Wiley Periodicals, Inc. ..
  23. Park D, Karesen R, Axcrona U, Noren T, Sauer T. Expression pattern of adhesion molecules (E-cadherin, alpha-, beta-, gamma-catenin and claudin-7), their influence on survival in primary breast carcinoma, and their corresponding axillary lymph node metastasis. APMIS. 2007;115:52-65 pubmed
  24. Goossens S, Janssens B, Bonne S, De Rycke R, Braet F, van Hengel J, et al. A unique and specific interaction between alphaT-catenin and plakophilin-2 in the area composita, the mixed-type junctional structure of cardiac intercalated discs. J Cell Sci. 2007;120:2126-36 pubmed
    ..This could explain the devastating effect of plakophilin-2 mutations on cell junction stability in intercalated discs, which lead to cardiac muscle malfunction. ..
  25. van Oort I, Tomita K, Van Bokhoven A, Bussemakers M, Kiemeney L, Karthaus H, et al. The prognostic value of E-cadherin and the cadherin-associated molecules alpha-, beta-, gamma-catenin and p120ctn in prostate cancer specific survival: a long-term follow-up study. Prostate. 2007;67:1432-8 pubmed
    ..Among these markers, alpha-catenin seems the best prognostic marker for prostate cancer specific survival. Larger studies are needed to confirm this result. ..
  26. Shimazui T, Bringuier P, van Berkel H, Ruijter E, Akaza H, Debruyne F, et al. Decreased expression of alpha-catenin is associated with poor prognosis of patients with localized renal cell carcinoma. Int J Cancer. 1997;74:523-8 pubmed
  27. Sorkin B, Wang M, Dobeck J, Albergo K, Skobe Z. The cadherin-catenin complex is expressed alternately with the adenomatous polyposis coli protein during rat incisor amelogenesis. J Histochem Cytochem. 2000;48:397-406 pubmed
  28. Tomlinson J, Alpaugh M, Barsky S. An intact overexpressed E-cadherin/alpha,beta-catenin axis characterizes the lymphovascular emboli of inflammatory breast carcinoma. Cancer Res. 2001;61:5231-41 pubmed
    ..A total of 90% of human IBCs showed increased membrane E-cadherin/alpha,beta-catenin immunoreactivity. These findings indicate that it is the gain and not the loss of the E-cadherin axis that contributes to the IBC phenotype. ..
  29. Uehara K, Uehara A. Localization of claudin-5 and ZO-1 in rat spleen sinus endothelial cells. Histochem Cell Biol. 2008;129:95-103 pubmed
    ..Thus, ZO-1 might play an important role in regulating the cell-cell junctions of sinus endothelial cells for blood-cell passage through splenic cords. ..
  30. Livshits G, Kobielak A, Fuchs E. Governing epidermal homeostasis by coupling cell-cell adhesion to integrin and growth factor signaling, proliferation, and apoptosis. Proc Natl Acad Sci U S A. 2012;109:4886-91 pubmed publisher
    ..The increased dependency of cells upon matrix interactions for their survival when cell-cell adhesions are destabilized has important implications for cancer progression and metastasis...
  31. Nozumi M, Togano T, Takahashi Niki K, Lu J, Honda A, Taoka M, et al. Identification of functional marker proteins in the mammalian growth cone. Proc Natl Acad Sci U S A. 2009;106:17211-6 pubmed publisher
    ..Most of the proteins we identified have not previously been implicated in axon growth and thus their identification presents a significant step forward, providing marker proteins and candidate neuronal growth-associated proteins. ..
  32. Kashibuchi K, Tomita K, Schalken J, Kume H, Yamaguchi T, Muto S, et al. The prognostic value of E-cadherin, alpha-, beta-, and gamma-catenin in urothelial cancer of the upper urinary tract. Eur Urol. 2006;49:839-45; discussion 845 pubmed
    ..Our data suggest E-cadherin may be a good prognostic marker for patients with upper urinary tract cancer. ..
  33. Sheth B, Fontaine J, Ponza E, McCallum A, Page A, Citi S, et al. Differentiation of the epithelial apical junctional complex during mouse preimplantation development: a role for rab13 in the early maturation of the tight junction. Mech Dev. 2000;97:93-104 pubmed
    ..Moreover, we propose a role for rab13 in the specification of the AJC site and the formation and segregation of the TJ. ..
  34. Sobarzo C, Lustig L, Ponzio R, Denduchis B. Effect of di-(2-ethylhexyl) phthalate on N-cadherin and catenin protein expression in rat testis. Reprod Toxicol. 2006;22:77-86 pubmed
    ..These findings demonstrate that DEHP induces an up-regulation of N-cadherin and alpha-catenin expression and may perturb cell-cell adhesion phenomena in the seminiferous tubule. ..
  35. Smythe W, Williams J, Wheelock M, Johnson K, Kaiser L, Albelda S. Cadherin and catenin expression in normal human bronchial epithelium and non-small cell lung cancer. Lung Cancer. 1999;24:157-68 pubmed
  36. Blanco D, Vicent S, Elizegi E, Pino I, Fraga M, Esteller M, et al. Altered expression of adhesion molecules and epithelial-mesenchymal transition in silica-induced rat lung carcinogenesis. Lab Invest. 2004;84:999-1012 pubmed
  37. Ohsugi M, Hwang S, Butz S, Knowles B, Solter D, Kemler R. Expression and cell membrane localization of catenins during mouse preimplantation development. Dev Dyn. 1996;206:391-402 pubmed
  38. Davies B, Worsley S, Ponder B. Expression of E-cadherin, alpha-catenin and beta-catenin in normal ovarian surface epithelium and epithelial ovarian cancers. Histopathology. 1998;32:69-80 pubmed
    ..It is likely that the catenins associate with membrane proteins other than E-cadherin in ovarian epithelium, and they may possibly function as tumour suppressors in this epithelium. ..
  39. Rangarajan E, Izard T. Dimer asymmetry defines ?-catenin interactions. Nat Struct Mol Biol. 2013;20:188-93 pubmed publisher
  40. Hertig C, Butz S, Koch S, Eppenberger Eberhardt M, Kemler R, Eppenberger H. N-cadherin in adult rat cardiomyocytes in culture. II. Spatio-temporal appearance of proteins involved in cell-cell contact and communication. Formation of two distinct N-cadherin/catenin complexes. J Cell Sci. 1996;109 ( Pt 1):11-20 pubmed