Genomes and Genes
Gene Symbol: Ctbp1
Description: C-terminal binding protein 1
Alias: 50-kDaBFA-inducedADP-ribosylatedsubstrate, BARS-50, Bars, CtBP3/BARS, C-terminal-binding protein 1, 50 kDa BFA-dependent ADP-ribosylation substrate, 50-kDa BFA-induced ADP-ribosylated substrate, C-terminal-binding protein 3, C-terminus binding protein 3/brefeldin A (BFA) adenosine diphosphate-ribosylated substrate, brefeldin A-ADP-riboslyated substrate, ctBP3
- Stankiewicz T, Schroeder E, Kelsey N, Bouchard R, Linseman D. C-terminal binding proteins are essential pro-survival factors that undergo caspase-dependent downregulation during neuronal apoptosis. Mol Cell Neurosci. 2013;56:322-332 pubmed publisher..Moreover, antisense-mediated downregulation of CtBP1 is sufficient to cause CGN apoptosis...
- Dorman K, Shen Z, Yang C, Ezzat S, Asa S. CtBP1 interacts with Ikaros and modulates pituitary tumor cell survival and response to hypoxia. Mol Endocrinol. 2012;26:447-57 pubmed publisher..CtBP interacts with Ikaros isoforms in GH4 and AtT20 pituitary tumor cells. Ikaros and CtBP1 expression is coordinately induced by hypoxia, and this response is abrogated by CtBP1 deficiency...
- Quinlan K, Nardini M, Verger A, Francescato P, Yaswen P, Corda D, et al. Specific recognition of ZNF217 and other zinc finger proteins at a surface groove of C-terminal binding proteins. Mol Cell Biol. 2006;26:8159-72 pubmed..These results identify a new CtBP interaction motif and establish ZNF217 as a transcriptional repressor protein that functions, at least in part, by associating with CtBP. ..
- Perissi V, Scafoglio C, Zhang J, Ohgi K, Rose D, Glass C, et al. TBL1 and TBLR1 phosphorylation on regulated gene promoters overcomes dual CtBP and NCoR/SMRT transcriptional repression checkpoints. Mol Cell. 2008;29:755-66 pubmed publisher..Gene activation requires the release of both CtBP1/2- and NCoR/SMRT-dependent repression, through the coordinate action of two highly related exchange factors, the ..
- Spano S, Silletta M, Colanzi A, Alberti S, Fiucci G, Valente C, et al. Molecular cloning and functional characterization of brefeldin A-ADP-ribosylated substrate. A novel protein involved in the maintenance of the Golgi structure. J Biol Chem. 1999;274:17705-10 pubmed..BARS shares high homology with two known proteins, C-terminal-binding protein 1 (CtBP1) and CtBP2. It is therefore a third member of the CtBP family...
- Nardini M, Spanò S, Cericola C, Pesce A, Damonte G, Luini A, et al. Crystallization and preliminary X-ray diffraction analysis of brefeldin A-ADP ribosylated substrate (BARS). Acta Crystallogr D Biol Crystallogr. 2002;58:1068-70 pubmedBrefeldin A-ADP ribosylated substrate (BARS) is a newly discovered enzyme involved in membrane fission, catalyzing the formation of phosphatidic acid by transfer of an acyl group from acyl-CoA to lysophosphatidic acid...
- Belgrader P, Dey R, Berezney R. Molecular cloning of matrin 3. A 125-kilodalton protein of the nuclear matrix contains an extensive acidic domain. J Biol Chem. 1991;266:9893-9 pubmed..The corresponding human deduced partial amino acid sequence is 96% identical to the rat sequence, indicating that matrin 3 is a highly conserved protein. ..
- Oswald F, Winkler M, Cao Y, Astrahantseff K, Bourteele S, Knöchel W, et al. RBP-Jkappa/SHARP recruits CtIP/CtBP corepressors to silence Notch target genes. Mol Cell Biol. 2005;25:10379-90 pubmed..Furthermore, the endogenous Hey1 promoter is derepressed in CtBP-deficient cells. We propose that a corepressor complex containing CtIP/CtBP facilitates RBP-Jkappa/SHARP-mediated repression of Notch target genes. ..
- Li S, Weidenfeld J, Morrisey E. Transcriptional and DNA binding activity of the Foxp1/2/4 family is modulated by heterotypic and homotypic protein interactions. Mol Cell Biol. 2004;24:809-22 pubmed..These data reveal a complex regulatory mechanism underlying Foxp1, Foxp2, and Foxp4 activity, demonstrating that Foxp1, Foxp2, and Foxp4 are the first Fox proteins reported whose activity is regulated by homo- and heterodimerization. ..
- Riefler G, Firestein B. Binding of neuronal nitric-oxide synthase (nNOS) to carboxyl-terminal-binding protein (CtBP) changes the localization of CtBP from the nucleus to the cytosol: a novel function for targeting by the PDZ domain of nNOS. J Biol Chem. 2001;276:48262-8 pubmed..Taken together, our data suggest a new function for nNOS as a regulator of CtBP nuclear localization. ..
- Chinnadurai G. CtBP, an unconventional transcriptional corepressor in development and oncogenesis. Mol Cell. 2002;9:213-24 pubmed..CtBPs play important roles during development and oncogenesis. In this review, their unusual properties, the mechanisms of transcriptional repression, regulation, and their biological functions are discussed. ..
- Nardini M, Spanò S, Cericola C, Pesce A, Massaro A, Millo E, et al. CtBP/BARS: a dual-function protein involved in transcription co-repression and Golgi membrane fission. EMBO J. 2003;22:3122-30 pubmedC-terminal-binding protein/brefeldin A-ADP ribosylated substrate (CtBP/BARS) plays key roles in development and oncogenesis as a transcription co-repressor, and in intracellular traffic as a promoter of Golgi membrane fission...
- Hickabottom M, Parker G, Freemont P, Crook T, Allday M. Two nonconsensus sites in the Epstein-Barr virus oncoprotein EBNA3A cooperate to bind the co-repressor carboxyl-terminal-binding protein (CtBP). J Biol Chem. 2002;277:47197-204 pubmed
- Yang J, Everett A. Hepatoma-derived growth factor represses SET and MYND domain containing 1 gene expression through interaction with C-terminal binding protein. J Mol Biol. 2009;386:938-50 pubmed publisher..Because of moderate conservation of the CtBP binding motif in HDGF family members, trans-repressive activity mediated by CtBP may be a common function among HDGF proteins. ..