Gene Symbol: Ctbp1
Description: C-terminal binding protein 1
Alias: 50-kDaBFA-inducedADP-ribosylatedsubstrate, BARS-50, Bars, CtBP3/BARS, C-terminal-binding protein 1, 50 kDa BFA-dependent ADP-ribosylation substrate, 50-kDa BFA-induced ADP-ribosylated substrate, C-terminal-binding protein 3, C-terminus binding protein 3/brefeldin A (BFA) adenosine diphosphate-ribosylated substrate, brefeldin A-ADP-riboslyated substrate, ctBP3
Species: rat
Products:     Ctbp1

Top Publications

  1. Schön C, Wochnik A, Rössner A, Donow C, Knöchel W. The FoxP subclass in Xenopus laevis development. Dev Genes Evol. 2006;216:641-6 pubmed
    ..Localised expression is found within the anterior neural fold, in the mid- and hindbrain, in the branchial arches as well as in the pancreas. ..
  2. Di L, Fernandez A, De Siervi A, Longo D, Gardner K. Transcriptional regulation of BRCA1 expression by a metabolic switch. Nat Struct Mol Biol. 2010;17:1406-13 pubmed publisher
    ..The active control of chromatin marks, DNA accessibility and gene expression at the BRCA1 promoter by this 'metabolic switch' provides an important molecular link between caloric intake and tumor suppressor expression in mammary cells. ..
  3. Ueda J, Tachibana M, Ikura T, Shinkai Y. Zinc finger protein Wiz links G9a/GLP histone methyltransferases to the co-repressor molecule CtBP. J Biol Chem. 2006;281:20120-8 pubmed
    ..These data indicate that Wiz not only contributes to the stability of G9a but also links the G9a/GLP heteromeric complex to the CtBP co-repressor machinery. ..
  4. Di Girolamo M, Silletta M, De Matteis M, Braca A, Colanzi A, Pawlak D, et al. Evidence that the 50-kDa substrate of brefeldin A-dependent ADP-ribosylation binds GTP and is modulated by the G-protein beta gamma subunit complex. Proc Natl Acad Sci U S A. 1995;92:7065-9 pubmed
    ..We report that the 50-kDa BFA-induced ADP-ribosylated substrate (BARS-50) has native forms of 170 and 130 kDa, as determined by gel filtration of rat brain cytosol, indicating that BARS-..
  5. Nardini M, Valente C, Ricagno S, Luini A, Corda D, Bolognesi M. CtBP1/BARS Gly172-->Glu mutant structure: impairing NAD(H)-binding and dimerization. Biochem Biophys Res Commun. 2009;381:70-4 pubmed publisher
    ..The results presented shed first light on the correlation between NAD(H)-binding and functional CtBP dimerization. ..
  6. Ivanova D, Dirks A, Montenegro Venegas C, Schöne C, Altrock W, Marini C, et al. Synaptic activity controls localization and function of CtBP1 via binding to Bassoon and Piccolo. EMBO J. 2015;34:1056-77 pubmed publisher
    ..Here, we report on a role of CtBP1, a transcriptional co-repressor enriched in presynapses and nuclei, in the activity-driven reconfiguration of gene ..
  7. Hidalgo Carcedo C, Bonazzi M, Spanò S, Turacchio G, Colanzi A, Luini A, et al. Mitotic Golgi partitioning is driven by the membrane-fissioning protein CtBP3/BARS. Science. 2004;305:93-6 pubmed
    ..We found that the protein CtBP3/BARS (BARS) was responsible for driving the fission of Golgi membranes during mitosis in vivo...
  8. Bai M, Gad H, Turacchio G, Cocucci E, Yang J, Li J, et al. ARFGAP1 promotes AP-2-dependent endocytosis. Nat Cell Biol. 2011;13:559-67 pubmed publisher
    ..The role of ARFGAP1 in AP-2-regulated endocytosis has mechanistic parallels with its roles in COPI transport, as both its GAP activity and coat function contribute to promoting AP-2 transport. ..
  9. Kajimura S, Seale P, Tomaru T, Erdjument Bromage H, Cooper M, Ruas J, et al. Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex. Genes Dev. 2008;22:1397-409 pubmed publisher
    ..These data show that the regulated docking of the CtBP proteins on PRDM16 controls the brown and white fat-selective gene programs. ..

More Information


  1. Stankiewicz T, Schroeder E, Kelsey N, Bouchard R, Linseman D. C-terminal binding proteins are essential pro-survival factors that undergo caspase-dependent downregulation during neuronal apoptosis. Mol Cell Neurosci. 2013;56:322-332 pubmed publisher
    ..Moreover, antisense-mediated downregulation of CtBP1 is sufficient to cause CGN apoptosis...
  2. Dorman K, Shen Z, Yang C, Ezzat S, Asa S. CtBP1 interacts with Ikaros and modulates pituitary tumor cell survival and response to hypoxia. Mol Endocrinol. 2012;26:447-57 pubmed publisher
    ..CtBP interacts with Ikaros isoforms in GH4 and AtT20 pituitary tumor cells. Ikaros and CtBP1 expression is coordinately induced by hypoxia, and this response is abrogated by CtBP1 deficiency...
  3. Quinlan K, Nardini M, Verger A, Francescato P, Yaswen P, Corda D, et al. Specific recognition of ZNF217 and other zinc finger proteins at a surface groove of C-terminal binding proteins. Mol Cell Biol. 2006;26:8159-72 pubmed
    ..These results identify a new CtBP interaction motif and establish ZNF217 as a transcriptional repressor protein that functions, at least in part, by associating with CtBP. ..
  4. Perissi V, Scafoglio C, Zhang J, Ohgi K, Rose D, Glass C, et al. TBL1 and TBLR1 phosphorylation on regulated gene promoters overcomes dual CtBP and NCoR/SMRT transcriptional repression checkpoints. Mol Cell. 2008;29:755-66 pubmed publisher
    ..Gene activation requires the release of both CtBP1/2- and NCoR/SMRT-dependent repression, through the coordinate action of two highly related exchange factors, the ..
  5. Spano S, Silletta M, Colanzi A, Alberti S, Fiucci G, Valente C, et al. Molecular cloning and functional characterization of brefeldin A-ADP-ribosylated substrate. A novel protein involved in the maintenance of the Golgi structure. J Biol Chem. 1999;274:17705-10 pubmed
    ..BARS shares high homology with two known proteins, C-terminal-binding protein 1 (CtBP1) and CtBP2. It is therefore a third member of the CtBP family...
  6. Nardini M, Spanò S, Cericola C, Pesce A, Damonte G, Luini A, et al. Crystallization and preliminary X-ray diffraction analysis of brefeldin A-ADP ribosylated substrate (BARS). Acta Crystallogr D Biol Crystallogr. 2002;58:1068-70 pubmed
    Brefeldin A-ADP ribosylated substrate (BARS) is a newly discovered enzyme involved in membrane fission, catalyzing the formation of phosphatidic acid by transfer of an acyl group from acyl-CoA to lysophosphatidic acid...
  7. Belgrader P, Dey R, Berezney R. Molecular cloning of matrin 3. A 125-kilodalton protein of the nuclear matrix contains an extensive acidic domain. J Biol Chem. 1991;266:9893-9 pubmed
    ..The corresponding human deduced partial amino acid sequence is 96% identical to the rat sequence, indicating that matrin 3 is a highly conserved protein. ..
  8. Oswald F, Winkler M, Cao Y, Astrahantseff K, Bourteele S, Knöchel W, et al. RBP-Jkappa/SHARP recruits CtIP/CtBP corepressors to silence Notch target genes. Mol Cell Biol. 2005;25:10379-90 pubmed
    ..Furthermore, the endogenous Hey1 promoter is derepressed in CtBP-deficient cells. We propose that a corepressor complex containing CtIP/CtBP facilitates RBP-Jkappa/SHARP-mediated repression of Notch target genes. ..
  9. Li S, Weidenfeld J, Morrisey E. Transcriptional and DNA binding activity of the Foxp1/2/4 family is modulated by heterotypic and homotypic protein interactions. Mol Cell Biol. 2004;24:809-22 pubmed
    ..These data reveal a complex regulatory mechanism underlying Foxp1, Foxp2, and Foxp4 activity, demonstrating that Foxp1, Foxp2, and Foxp4 are the first Fox proteins reported whose activity is regulated by homo- and heterodimerization. ..
  10. Riefler G, Firestein B. Binding of neuronal nitric-oxide synthase (nNOS) to carboxyl-terminal-binding protein (CtBP) changes the localization of CtBP from the nucleus to the cytosol: a novel function for targeting by the PDZ domain of nNOS. J Biol Chem. 2001;276:48262-8 pubmed
    ..Taken together, our data suggest a new function for nNOS as a regulator of CtBP nuclear localization. ..
  11. Chinnadurai G. CtBP, an unconventional transcriptional corepressor in development and oncogenesis. Mol Cell. 2002;9:213-24 pubmed
    ..CtBPs play important roles during development and oncogenesis. In this review, their unusual properties, the mechanisms of transcriptional repression, regulation, and their biological functions are discussed. ..
  12. Nardini M, Spanò S, Cericola C, Pesce A, Massaro A, Millo E, et al. CtBP/BARS: a dual-function protein involved in transcription co-repression and Golgi membrane fission. EMBO J. 2003;22:3122-30 pubmed
    C-terminal-binding protein/brefeldin A-ADP ribosylated substrate (CtBP/BARS) plays key roles in development and oncogenesis as a transcription co-repressor, and in intracellular traffic as a promoter of Golgi membrane fission...
  13. Hickabottom M, Parker G, Freemont P, Crook T, Allday M. Two nonconsensus sites in the Epstein-Barr virus oncoprotein EBNA3A cooperate to bind the co-repressor carboxyl-terminal-binding protein (CtBP). J Biol Chem. 2002;277:47197-204 pubmed
  14. Yang J, Everett A. Hepatoma-derived growth factor represses SET and MYND domain containing 1 gene expression through interaction with C-terminal binding protein. J Mol Biol. 2009;386:938-50 pubmed publisher
    ..Because of moderate conservation of the CtBP binding motif in HDGF family members, trans-repressive activity mediated by CtBP may be a common function among HDGF proteins. ..