Cstf2

Summary

Gene Symbol: Cstf2
Description: cleavage stimulation factor subunit 2
Alias: cleavage stimulation factor subunit 2, cleavage stimulation factor, 3' pre-RNA subunit 2
Species: rat
Products:     Cstf2

Top Publications

  1. Bleoo S, Sun X, Hendzel M, Rowe J, Packer M, Godbout R. Association of human DEAD box protein DDX1 with a cleavage stimulation factor involved in 3'-end processing of pre-MRNA. Mol Biol Cell. 2001;12:3046-59 pubmed
    ..These studies are the first to identify a DEAD box protein associating with factors involved in 3'-end cleavage and polyadenylation of pre-mRNAs. ..
  2. Chan S, Choi E, Shi Y. Pre-mRNA 3'-end processing complex assembly and function. Wiley Interdiscip Rev RNA. 2011;2:321-35 pubmed publisher
    ..In this article, we review what we have learned about this important cellular machine and discuss the remaining questions and future challenges. ..
  3. Gonzales M, Mellman D, Anderson R. CKIalpha is associated with and phosphorylates star-PAP and is also required for expression of select star-PAP target messenger RNAs. J Biol Chem. 2008;283:12665-73 pubmed publisher
    ..The Star-PAP complex therefore represents a location where multiple signaling pathways converge to regulate the expression of specific mRNAs. ..
  4. Laishram R, Anderson R. The poly A polymerase Star-PAP controls 3'-end cleavage by promoting CPSF interaction and specificity toward the pre-mRNA. EMBO J. 2010;29:4132-45 pubmed publisher
    ..The data support a model where Star-PAP binds to the RNA, recruits the CPSF complex to the 3'-end of pre-mRNA and then defines cleavage by CPSF 73 and subsequent polyadenylation of its target mRNAs. ..
  5. Shankarling G, MacDonald C. Polyadenylation site-specific differences in the activity of the neuronal ?CstF-64 protein in PC-12 cells. Gene. 2013;529:220-7 pubmed publisher
    ..Our data address the polyadenylation functions of ?CstF-64 for the first time, and provide initial insights into the mechanism of alternative poly(A) site selection in the nervous system. ..
  6. Takagaki Y, MacDonald C, Shenk T, Manley J. The human 64-kDa polyadenylylation factor contains a ribonucleoprotein-type RNA binding domain and unusual auxiliary motifs. Proc Natl Acad Sci U S A. 1992;89:1403-7 pubmed
  7. Gruber A, Martin G, Keller W, Zavolan M. Means to an end: mechanisms of alternative polyadenylation of messenger RNA precursors. Wiley Interdiscip Rev RNA. 2014;5:183-96 pubmed publisher
    ..Here, we review these approaches as well as the insights into the mechanisms of polyadenylation that emerged from genome-wide studies of polyadenylation across a range of cell types and states. ..