Gene Symbol: CSN2
Description: COP9 signalosome subunit 2
Alias: CSN2, Trip15, COP9 signalosome complex subunit 2, COP9 (constitutive photomorphogenic) homolog, subunit 2, JAB1-containing signalosome subunit 2, SGN2, TR-interacting protein 15, TRIP-15, alien homolog, signalosome subunit 2, thyroid receptor-interacting protein 15, tyroid receptor interacting protein 15
Akiyama H, Fujisawa N, Tashiro Y, Takanabe N, Sugiyama A, Tashiro F. The role of transcriptional corepressor Nif3l1 in early stage of neural differentiation via cooperation with Trip15/CSN2. J Biol Chem. 2003;278:10752-62 pubmed
..in retinoic acid-primed neural differentiation of P19 embryonic carcinoma cells through cooperation with Trip15/CSN2, a transcriptional corepressor/component of COP9 signalosome...
Akiyama H, Sugiyama A, Uzawa K, Fujisawa N, Tashiro Y, Tashiro F. Implication of Trip15/CSN2 in early stage of neuronal differentiation of P19 embryonal carcinoma cells. Brain Res Dev Brain Res. 2003;140:45-56 pubmed
b>Trip15/CSN2 is a transcriptional corepressor/a component of COP9 signalosome (CSN) and participates in various signaling pathways. However, participation of Trip15/CSN2 in neural differentiation is still obscure...
Tenbaum S, Juenemann S, Schlitt T, Bernal J, Renkawitz R, Munoz A, et al
. Alien/CSN2 gene expression is regulated by thyroid hormone in rat brain. Dev Biol. 2003;254:149-60 pubmed
..two Alien-specific proteins in vivo and in cell lines by Western analysis, one of the two forms representing the CSN2 subunit of the COP9 signalosome...
Lykke Andersen K, Schaefer L, Menon S, Deng X, Miller J, Wei N. Disruption of the COP9 signalosome Csn2 subunit in mice causes deficient cell proliferation, accumulation of p53 and cyclin E, and early embryonic death. Mol Cell Biol. 2003;23:6790-7 pubmed
Csn2 (Trip15/Cops2/Alien) encodes the second subunit of the COP9 signalosome (CSN), an eight-subunit heteromeric complex homologous to the lid subcomplex of the 26S proteasome...
Seeger M, Kraft R, Ferrell K, Bech Otschir D, Dumdey R, Schade R, et al
. A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits. FASEB J. 1998;12:469-78 pubmed
..It consists of at least eight different subunits including JAB1, the Jun activation-domain binding protein 1, and Trip15, the thyroid hormone receptor-interacting protein 15...
Eckey M, Tenbaum S, Munoz A, Baniahmad A. Mixed lineage kinase 2 enhances trans-repression of Alien and nuclear receptors. Mol Cell Endocrinol. 2003;213:71-8 pubmed
..This novel cross-talk may represent a link between MLK2-mediated signaling and transcriptional repression of target genes during neuronal differentiation processes. ..
Sharon M, Mao H, Boeri Erba E, Stephens E, Zheng N, Robinson C. Symmetrical modularity of the COP9 signalosome complex suggests its multifunctionality. Structure. 2009;17:31-40 pubmed publisher
..This suggests that the propensity of the CSN complex to change and adapt its subunit composition might underlie its ability to perform multiple functions in vivo. ..