Gene Symbol: Cs
Description: citrate synthase
Alias: citrate synthase, mitochondrial, citrate (Si)-synthase
Species: rat
Products:     Cs

Top Publications

  1. Andersson U, Leighton B, Young M, Blomstrand E, Newsholme E. Inactivation of aconitase and oxoglutarate dehydrogenase in skeletal muscle in vitro by superoxide anions and/or nitric oxide. Biochem Biophys Res Commun. 1998;249:512-6 pubmed
    ..It is suggested that these effects may be responsible for some alterations in skeletal muscle metabolism, and these possibilities are discussed. ..
  2. Ramos A, Ferreira G, Carvalho Silva M, Furlanetto C, Gonçalves C, Ferreira G, et al. Acute administration of l-tyrosine alters energetic metabolism of hippocampus and striatum of infant rats. Int J Dev Neurosci. 2013;31:303-7 pubmed publisher
    ..If the same effects occur in the brain of the patients, it is possible that energy metabolism impairment may be contribute to possible damage in memory and cognitive processes in patients with tyrosinemia type II. ..
  3. Szczesny B, Brunyánszki A, Olah G, Mitra S, Szabo C. Opposing roles of mitochondrial and nuclear PARP1 in the regulation of mitochondrial and nuclear DNA integrity: implications for the regulation of mitochondrial function. Nucleic Acids Res. 2014;42:13161-73 pubmed publisher
    ..In summary, we conclude that mitochondrial PARP1, in opposite to nuclear PARP1, exerts a negative effect on several mitochondrial-specific transactions including the repair of the mitochondrial DNA. ..
  4. Mukherjee A, Srere P, Frenkel E. Studies of the mechanism by which hepatic citrate synthase activity increases in vitamin B12 deprivation. J Biol Chem. 1976;251:2155-60 pubmed
    ..The increased rate of synthesis appeared to explian the increased enzyme content. Finally, no change in specific activity of the enzyme was seen in brain, heart, or kidney in the B12-deprived animal. ..
  5. Lai J, Clark J. Preparation and properties of mitochondria derived from synaptosomes. Biochem J. 1976;154:423-32 pubmed
    ..5. The results are also discussed in the light of the suggested connection between the heterogeneity of brain mitochondria and metabolic compartmentation. ..
  6. Chow K, Ma Z, Cai J, Pierce W, Hersh L. Nardilysin facilitates complex formation between mitochondrial malate dehydrogenase and citrate synthase. Biochim Biophys Acta. 2005;1723:292-301 pubmed
    ..Using an immobilized nardilysin column, mitochondrial malate dehydrogenase (mMDH) and citrate synthase (CS) were isolated from a fractionated rat brain extract...
  7. Xu F, Ackerley C, Maj M, Addis J, Levandovskiy V, Lee J, et al. Disruption of a mitochondrial RNA-binding protein gene results in decreased cytochrome b expression and a marked reduction in ubiquinol-cytochrome c reductase activity in mouse heart mitochondria. Biochem J. 2008;416:15-26 pubmed publisher
    ..This defines the site for PTCD2 action in mammalian mitochondria and suggests a possible role for dysfunction of this protein in the aetiology of heart failure...
  8. Shepherd D, Garland P. The kinetic properties of citrate synthase from rat liver mitochondria. Biochem J. 1969;114:597-610 pubmed
    ..8. The sedimentation coefficient of the enzyme, as measured by activity sedimentation, is 6.3s, equivalent to molecular weight 95000. ..
  9. Marin Garcia J, Ananthakrishnan R, Goldenthal M. Human mitochondrial function during cardiac growth and development. Mol Cell Biochem. 1998;179:21-6 pubmed
    ..activity, mtDNA copy number and COX subunit II content remained unchanged in contrast to increased citrate synthase (CS) activity and content...

More Information


  1. Goldenthal M, Marin Garcia J, Ananthakrishnan R. Cloning and molecular analysis of the human citrate synthase gene. Genome. 1998;41:733-8 pubmed
    The nucleotide sequence encoding the citrate synthase (CS) gene was determined from the sequencing of the CS cDNA isolated from a human heart cDNA library...
  2. Ullian M, Gantt B, Ford A, Tholanikunnel B, Spicer E, Fitzgibbon W. Potential importance of glomerular citrate synthase activity in remnant nephropathy. Kidney Int. 2003;63:156-64 pubmed
  3. Esteva S, Panisello P, Ramon Torrella J, Pages T, Viscor G. Enzyme activity and myoglobin concentration in rat myocardium and skeletal muscles after passive intermittent simulated altitude exposure. J Sports Sci. 2009;27:633-40 pubmed publisher