Crhr2

Summary

Gene Symbol: Crhr2
Description: corticotropin releasing hormone receptor 2
Alias: Crf2r, CRF-R 2, CRF-R-2, CRF-R2, CRF2, CRFR-2, CRH-R 2, CRH-R-2, CRH-R2, corticotrophin releasing hormone receptor 2, corticotropin-releasing factor receptor 2, corticotropin-releasing factor receptor subtype 2, corticotropin-releasing hormone receptor 2
Species: rat

Top Publications

  1. ncbi Differential role of corticotrophin-releasing factor receptor types 1 and 2 in stress-induced suppression of pulsatile luteinising hormone secretion in the female rat
    X F Li
    Division of Reproductive Health, Endocrinology and Development, King s College London, Guy s Campus, London, UK
    J Neuroendocrinol 18:602-10. 2006
  2. ncbi Activation of the CRF 2 receptor modulates skeletal muscle mass under physiological and pathological conditions
    Richard T Hinkle
    Research Division, Procter and Gamble Pharmaceuticals, Health Care Research Center, 8700 Mason Montgomery Road, Mason, OH 45040 9317, USA
    Am J Physiol Endocrinol Metab 285:E889-98. 2003
  3. doi CRH-R1 and CRH-R2 differentially modulate dendritic outgrowth of hippocampal neurons
    Hui Sheng
    Department of Physiology, Second Military Medical University, 800 Xiangyin Road, Shanghai, 200433, People s Republic of China
    Endocrine 41:458-64. 2012
  4. doi Activation of CRHR2 exerts an inhibitory effect on the expression of collapsin response mediator protein 3 in hippocampal neurons
    Yanming Chen
    Department of Physiology and The Key Laboratory of Molecular Neurobiology of Ministry of Education, Second Military Medical University, Shanghai 200433, PR China
    Neuropeptides 46:93-8. 2012
  5. doi Sex differences in prenatally programmed anxiety behaviour in rats: differential corticotropin-releasing hormone receptor mRNA expression in the amygdaloid complex
    Paula J Brunton
    Laboratory of Neuroendocrinology, Centre for Integrative Physiology, University of Edinburgh, Edinburgh, UK
    Stress 14:634-43. 2011
  6. pmc Intravenous injection of urocortin 1 induces a CRF2 mediated increase in circulating ghrelin and glucose levels through distinct mechanisms in rats
    Lixin Wang
    CURE Digestive Diseases Research Center and Center for Neurobiology of Stress, Department of Medicine, Digestive Diseases Division at University of California Los Angeles, Los Angeles, CA 90073, USA
    Peptides 39:164-70. 2013
  7. doi Hypothalamic expression of urocortin 3 and the type 2 corticotropin-releasing factor receptor is regulated according to feeding state in lean but not obese Zucker rats
    Anne Marie Poulin
    Faculte de Medecine, Département Psychiatrie et Neurosciences, Centre de Recherche de l Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Universite Laval, Québec QC G1V 4G5, Canada
    Neuropharmacology 63:147-53. 2012
  8. pmc Quantitative trait locus for body weight identified on rat chromosome 4 in inbred alcohol-preferring and -nonpreferring rats: potential implications for neuropeptide Y and corticotrophin releasing hormone 2
    John Paul Spence
    Department of Psychiatry, Indiana University School of Medicine, Institute of Psychiatric Research, Indianapolis, IN 46202, USA
    Alcohol 47:63-7. 2013
  9. doi Cocaine withdrawal enhances long-term potentiation in rat hippocampus via changing the activity of corticotropin-releasing factor receptor subtype 2
    X Guan
    Department of Pharmacology, Nanjing Medical University, Nanjing 210029, China
    Neuroscience 161:665-70. 2009
  10. doi Corticotropin-releasing factor in the dorsal raphe nucleus increases medial prefrontal cortical serotonin via type 2 receptors and median raphe nucleus activity
    Gina L Forster
    Division of Basic Biomedical Sciences and Neuroscience Group, Sanford School of Medicine, University of South Dakota, 414 E Clark Street, Vermillion, SD 57069, USA
    Eur J Neurosci 28:299-310. 2008

Research Grants

Scientific Experts

Detail Information

Publications78

  1. ncbi Differential role of corticotrophin-releasing factor receptor types 1 and 2 in stress-induced suppression of pulsatile luteinising hormone secretion in the female rat
    X F Li
    Division of Reproductive Health, Endocrinology and Development, King s College London, Guy s Campus, London, UK
    J Neuroendocrinol 18:602-10. 2006
    ..These results suggest that hypoglycaemia and LPS stress-induced LH suppression involves activation of CRF(2) while restraint stress-induced inhibition of LH pulses involves both CRF(1) and CRF(2)...
  2. ncbi Activation of the CRF 2 receptor modulates skeletal muscle mass under physiological and pathological conditions
    Richard T Hinkle
    Research Division, Procter and Gamble Pharmaceuticals, Health Care Research Center, 8700 Mason Montgomery Road, Mason, OH 45040 9317, USA
    Am J Physiol Endocrinol Metab 285:E889-98. 2003
    ..factor (CRF) family of peptides have been identified, the CRF 1 receptor (CRF1R) and the CRF 2 receptor (CRF2R). Of these, the CRF2R is expressed in skeletal muscle...
  3. doi CRH-R1 and CRH-R2 differentially modulate dendritic outgrowth of hippocampal neurons
    Hui Sheng
    Department of Physiology, Second Military Medical University, 800 Xiangyin Road, Shanghai, 200433, People s Republic of China
    Endocrine 41:458-64. 2012
    ..These effects can be reversed by the CRH-R2 antagonist astressin 2B. Our results suggest that CRH-R1 and CRH-R2 differentially modulate the dendritic growth of hippocampal neurons in culture...
  4. doi Activation of CRHR2 exerts an inhibitory effect on the expression of collapsin response mediator protein 3 in hippocampal neurons
    Yanming Chen
    Department of Physiology and The Key Laboratory of Molecular Neurobiology of Ministry of Education, Second Military Medical University, Shanghai 200433, PR China
    Neuropeptides 46:93-8. 2012
    ..In the present study, we determined the effects of CRHR1 and CRHR2 on CRMP3 expression in cultured hippocampal neurons...
  5. doi Sex differences in prenatally programmed anxiety behaviour in rats: differential corticotropin-releasing hormone receptor mRNA expression in the amygdaloid complex
    Paula J Brunton
    Laboratory of Neuroendocrinology, Centre for Integrative Physiology, University of Edinburgh, Edinburgh, UK
    Stress 14:634-43. 2011
    ..In conclusion, sex differences in anxiety-type behaviour in PNS rats may be explained by differential mRNA expression for CRH-R1 (pro-anxiogenic) and CRH-R2 (pro-anxiolytic) in the amygdaloid complex...
  6. pmc Intravenous injection of urocortin 1 induces a CRF2 mediated increase in circulating ghrelin and glucose levels through distinct mechanisms in rats
    Lixin Wang
    CURE Digestive Diseases Research Center and Center for Neurobiology of Stress, Department of Medicine, Digestive Diseases Division at University of California Los Angeles, Los Angeles, CA 90073, USA
    Peptides 39:164-70. 2013
    ....
  7. doi Hypothalamic expression of urocortin 3 and the type 2 corticotropin-releasing factor receptor is regulated according to feeding state in lean but not obese Zucker rats
    Anne Marie Poulin
    Faculte de Medecine, Département Psychiatrie et Neurosciences, Centre de Recherche de l Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Universite Laval, Québec QC G1V 4G5, Canada
    Neuropharmacology 63:147-53. 2012
    ..This article is part of a Special Issue entitled 'Central Control of Food Intake'...
  8. pmc Quantitative trait locus for body weight identified on rat chromosome 4 in inbred alcohol-preferring and -nonpreferring rats: potential implications for neuropeptide Y and corticotrophin releasing hormone 2
    John Paul Spence
    Department of Psychiatry, Indiana University School of Medicine, Institute of Psychiatric Research, Indianapolis, IN 46202, USA
    Alcohol 47:63-7. 2013
    ..Both Npy and Crfr2 have been previously identified as candidate genes of interest underlying the chromosome 4 QTL for alcohol consumption in iP and iNP rats...
  9. doi Cocaine withdrawal enhances long-term potentiation in rat hippocampus via changing the activity of corticotropin-releasing factor receptor subtype 2
    X Guan
    Department of Pharmacology, Nanjing Medical University, Nanjing 210029, China
    Neuroscience 161:665-70. 2009
    ..Our data suggest that short-term cocaine withdrawal treatment may cause synaptic plasticity in hippocampus partially via changing the activity of CRF(2) in the hippocampus...
  10. doi Corticotropin-releasing factor in the dorsal raphe nucleus increases medial prefrontal cortical serotonin via type 2 receptors and median raphe nucleus activity
    Gina L Forster
    Division of Basic Biomedical Sciences and Neuroscience Group, Sanford School of Medicine, University of South Dakota, 414 E Clark Street, Vermillion, SD 57069, USA
    Eur J Neurosci 28:299-310. 2008
    ..This response was blocked by CRF receptor type 2 antagonism in the dorsal raphe. Overall, these results highlight complex CRF modulation of medial prefrontal cortex serotonergic activity at the level of the raphe nuclei...
  11. doi Corticotropin-releasing hormone receptor subtypes in the rat anterior pituitary after two types of restraint stress
    Vera Klenerova
    Laboratory of Biochemical Neuropharmacology, Institute of Medical Biochemistry, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic
    Ann N Y Acad Sci 1148:415-20. 2008
    ..Our data demonstrated that these stressors did not change CRH-R2alpha mRNA, unlike the very significant response of CRH-R1 to IMO...
  12. doi Novel action of pituitary urocortin 2 in the regulation of expression and secretion of gonadotropins
    Takahiro Nemoto
    Department of Physiology, Nippon Medical School, Tokyo, Japan
    J Endocrinol 201:105-14. 2009
    ..These findings suggest that pituitary Ucn 2 is involved in the regulatory mechanism of the expression and secretion of gonadotropins through its tonic and inhibitory action on gonadotrophs in a paracrine manner...
  13. pmc Restraint stress increases serotonin release in the central nucleus of the amygdala via activation of corticotropin-releasing factor receptors
    Bing Mo
    Biology Department and Neuroscience Group, University of South Dakota, 414 East Clark Street, Vermillion, SD 57069, USA
    Brain Res Bull 76:493-8. 2008
    ..Furthermore, the results imply that corticotropin-releasing factor mediated serotonergic activity in central nucleus of the amygdala may be an important component of a stress response...
  14. pmc Differential mechanisms of CRF1 and CRF2 receptor functions in the amygdala in pain-related synaptic facilitation and behavior
    Yu Fu
    Department of Neuroscience and Cell Biology, The University of Texas Medical Branch, Galveston, Texas 77555 1069, USA
    J Neurosci 28:3861-76. 2008
    ..site of extrahypothalamic expression of corticotropin-releasing factor (CRF) and its G-protein-coupled CRF1 and CRF2 receptors is the amygdala, a key player in emotions and affective disorders...
  15. ncbi Peripheral and central administration of exogenous urocortin 1 disrupts the fasted motility pattern of the small intestine in rats via the corticotrophin releasing factor receptor 2 and a cholinergic mechanism
    Yan Yin
    Department of Gastroenterology, The Second Affiliated Hospital of Xi an Jiaotong University, Xi an, China
    J Gastroenterol Hepatol 23:e79-87. 2008
    ..The present study aimed to determine the effects of urocortin 1 on small intestinal motility in rats and the CRF receptor subtypes and autonomic pathways mediating the effects...
  16. ncbi The type 2 corticotrophin-releasing hormone receptor mediates orexin A-induced luteinising hormone suppression in ovariectomised rats
    T Iwasa
    Department of Obstetrics and Gynecology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770 8503, Japan
    J Neuroendocrinol 19:732-8. 2007
    ..These findings suggest that CRH-R2 mediates orexin A-induced LH suppression and it is possible that CRH and UcnII in the hypothalamus are involved in this pathway...
  17. ncbi Central type 2 corticotropin-releasing hormone receptor mediates hypothalamic-pituitary-adrenocortical axis activation in the rat
    Hiroshi Maruyama
    Department of Endocrinology, Metabolism, and Nephrology, Kochi Medical School, Kochi University, Kochi, Japan
    Neuroendocrinology 86:1-16. 2007
    ..These results indicate that there is a CRHR-2-mediated mechanism in the brain that stimulates CRH- and AVP-producing neurons in the PVN which results in the promotion of plasma ACTH secretion...
  18. pmc A CRF(2) agonist administered into the central nucleus of the amygdala decreases ethanol self-administration in ethanol-dependent rats
    Cindy K Funk
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Brain Res 1155:172-8. 2007
    ..These data demonstrate an opposing role of the CRF(2) receptor subtype within the CeA in mediating ethanol self-administration in withdrawn, dependent and nondependent rats...
  19. ncbi Stress-induced relapse to cocaine seeking: roles for the CRF(2) receptor and CRF-binding protein in the ventral tegmental area of the rat
    Bin Wang
    Behavioral Neuroscience Branch, Intramural Research Program IRP, National Institute on Drug Abuse NIDA, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 193:283-94. 2007
    ..The effects of selective CRF antagonists have not yet been reported...
  20. ncbi Cocaine withdrawal enhances long-term potentiation induced by corticotropin-releasing factor at central amygdala glutamatergic synapses via CRF, NMDA receptors and PKA
    Sebastian Pollandt
    University of Texas Medical Branch, Department of Pharmacology and Toxicology, Galveston, TX 77555 1031, USA
    Eur J Neurosci 24:1733-43. 2006
    ..After prolonged withdrawal, CRF-induced LTP was dependent on activation of CRF2, CaV2...
  21. doi Urocortin induces interleukin-6 release from rat cardiomyocytes through p38 MAP kinase, ERK and NF-kappaB activation
    Man Huang
    Department of Pharmacology and Experimental Therapeutics Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, 27599 7178, USA
    J Mol Endocrinol 42:397-405. 2009
    ..The precise role of cardiac Ucn in vivo remains to be elucidated...
  22. doi Corticotropin-releasing hormone receptor-1 and 2 activity produces divergent resistance against stress-induced pulmonary Streptococcus pneumoniae infection
    Byung Jin Kim
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107, United States
    J Neuroimmunol 237:57-65. 2011
    ..CRH receptor-mediated effects on immune responses could prove valuable for novel therapeutics...
  23. pmc Topographical distribution of corticotropin-releasing factor type 2 receptor-like immunoreactivity in the rat dorsal raphe nucleus: co-localization with tryptophan hydroxylase
    J L Lukkes
    Department of Integrative Physiology and Center for Neuroscience, University of Colorado Boulder, Boulder, CO 80309, USA
    Neuroscience 183:47-63. 2011
    ....
  24. pmc Glucocorticoids differentially regulate the expression of CRFR1 and CRFR2α in MIN6 insulinoma cells and rodent islets
    M O Huising
    The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Endocrinology 152:138-50. 2011
    ..We postulate that differential effect of GCs on the expression of CRFR1 and CRFR2α in the endocrine pancreas represent a mechanism to shift sensitivity from CRFR1 to CRFR2 ligands...
  25. pmc The pseudo signal peptide of the corticotropin-releasing factor receptor type 2a decreases receptor expression and prevents Gi-mediated inhibition of adenylyl cyclase activity
    Katharina Schulz
    Leibniz Institut fur Molekulare Pharmakologie, Robert Rossle Strasse 10, 13125 Berlin, Germany
    J Biol Chem 285:32878-87. 2010
    ..In the case of the corticotropin-releasing factor receptor subtypes, the use of conventional and pseudo signal peptides have an unexpected influence on signal transduction...
  26. pmc CRF-1 antagonist and CRF-2 agonist decrease binge-like ethanol drinking in C57BL/6J mice independent of the HPA axis
    Emily G Lowery
    Department of Psychology, University of North Carolina, Chapel Hill, NC, USA
    Neuropsychopharmacology 35:1241-52. 2010
    ..Furthermore, normal HPA axis signaling is not necessary to achieve binge-like drinking behavior...
  27. doi Alterations in colonic corticotropin-releasing factor receptors in the maternally separated rat model of irritable bowel syndrome: differential effects of acute psychological and physical stressors
    Dervla O'Malley
    Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
    Peptides 31:662-70. 2010
    ..This study demonstrates that acute stressors alter colonic CRF receptor expression in a manner that is determined by the underlying stress sensitivity of the subject...
  28. pmc The serotonergic projection from the median raphe nucleus to the ventral hippocampus is involved in the retrieval of fear memory through the corticotropin-releasing factor type 2 receptor
    Yu Ohmura
    Department of Neuropharmacology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Neuropsychopharmacology 35:1271-8. 2010
    ..These results indicated that endogenous CRF and/or related ligands that were released in the MRN could activate the CRF(2) receptor and stimulate serotonin release in the ventral hippocampus, thereby inducing fear memory retrieval...
  29. doi Excitatory responses of cardiovascular activities to urocortin3 administration into the PVN of the rat
    Xia Li
    Department of Neurology, Huashan Hospital Affiliated to Fudan University, Shanghai, PR China
    Auton Neurosci 154:108-11. 2010
    Urocortin3 (Ucn3) is an endogenous ligand for corticotropin-releasing factor receptor subtype 2 (CRF2R)...
  30. pmc Local secretion of urocortin 1 promotes microvascular permeability during lipopolysaccharide-induced inflammation
    Elizabeth L Cureton
    Department of Surgery, University of California, San Francisco, San Francisco, California 94143, USA
    Endocrinology 150:5428-37. 2009
    ..Ucn1's effect on L(p) is partially mediated by the CRH-R(2) receptor and acts independently of the c-JUN N-terminal kinase signal transduction pathway...
  31. pmc Central nesfatin-1 reduces dark-phase food intake and gastric emptying in rats: differential role of corticotropin-releasing factor2 receptor
    Andreas Stengel
    Center for Neurovisceral Sciences and Women s Health CURE, Building 115, Room 117, Veterans Administration Greater Los Angeles Healthcare System, 11301 Wilshire Boulevard, Los Angeles, California 90073, USA
    Endocrinology 150:4911-9. 2009
    ..Activation of nesfatin-1 neurons by cholecystokinin at sites regulating food intake may suggest a role in gut peptide satiation effect...
  32. doi Activation of corticotropin-releasing factor 2 receptor inhibits Purkinje neuron P-type calcium currents via G(o)alpha-dependent PKC epsilon pathway
    Jin Tao
    Department of Neurobiology, Laboratory of Aging and Nervous Diseases, Medical College of Soochow University, Suzhou, PR China
    Cell Signal 21:1436-43. 2009
    ..In summary, activation of CRFR2 inhibits P-currents in Purkinje neurons via G(o)alpha-dependent PLC/PKCepsilon pathway, which might contribute to its physiological functions in the cerebellum...
  33. doi Gestational hypoxia alone or combined with restraint sensitizes the hypothalamic-pituitary-adrenal axis and induces anxiety-like behavior in adult male rat offspring
    J M Fan
    Division of Neurobiology and Physiology, College of Life Sciences, School of Medicine, Zhejiang University, Hangzhou, China
    Neuroscience 159:1363-73. 2009
    ..factor receptor type 1 (CRHR1) expression but decreased corticotropin-releasing factor receptor type 2 (CRHR2) in the paraventricular nucleus of the hypothalamus (PVN), enhanced CRHR1 mRNA and CRHR2 mRNA expression in the ..
  34. pmc Social defeat stress activates medial amygdala cells that express type 2 corticotropin-releasing factor receptor mRNA
    E M Fekete
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuroscience 162:5-13. 2009
    ..The results indicate CRF(2) receptor-positive neurons in the posterior medial amygdala are involved in the neural response to social defeat...
  35. ncbi Activation of corticotropin-releasing factor receptor-2 causes bronchorelaxation and inhibits pulmonary inflammation in mice
    James D Moffatt
    The Sackler Institute of Pulmonary Pharmacology, King s College London, Guy s Campus, London, UK
    FASEB J 20:1877-9. 2006
    ..Therefore, CRF(2) agonists appear to have both bronchorelaxant and anti-inflammatory activities and might represent an interesting therapeutic approach to the treatment of inflammatory lung diseases...
  36. pmc Cloning and characterization of a functionally distinct corticotropin-releasing factor receptor subtype from rat brain
    T W Lovenberg
    Department of Molecular Biology, Neurocrine Biosciences Inc, San Diego, CA 92121
    Proc Natl Acad Sci U S A 92:836-40. 1995
    ..clone that encodes a second member of the corticotropin-releasing factor (CRF) receptor family, designated as the CRF2 receptor. The cDNA was identified using oligonucleotides of degenerate sequence in a PCR paradigm...
  37. ncbi Role of corticotropin-releasing factor receptor-2 in stress-induced suppression of pulsatile luteinizing hormone secretion in the rat
    Xiao Feng Li
    Division of Reproductive Health, Endocrinology, and Development, New Hunt s House, King s College London, London SE1 1UL, United Kingdom
    Endocrinology 146:318-22. 2005
    ....
  38. ncbi CRF receptor type 1 and 2 expression and anatomical distribution in the rat colon
    Ekaterini Chatzaki
    Neurocrine Biosciences Inc, San Diego, CA 92121, USA
    J Neurochem 90:309-16. 2004
    ..These results demonstrate expression of both CRF receptor types in the rat colon and support a role for their involvement in regulating peripheral effects of CRF ligands...
  39. ncbi Increased anxiety-like behavior and ethanol self-administration in dependent rats: reversal via corticotropin-releasing factor-2 receptor activation
    Glenn R Valdez
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California, USA
    Alcohol Clin Exp Res 28:865-72. 2004
    ..characterization of these receptors, the objective of the following experiments was to characterize the role of CRF2 receptors in the interaction between alcohol and stress by examining the effects of CRF2 receptor activation in the ..
  40. pmc Differential expression of 5HT-1A, alpha 1b adrenergic, CRF-R1, and CRF-R2 receptor mRNA in serotonergic, gamma-aminobutyric acidergic, and catecholaminergic cells of the rat dorsal raphe nucleus
    Heidi E W Day
    Department of Psychology and Center for Neuroscience, University of Colorado, Boulder, Colorado 80309, USA
    J Comp Neurol 474:364-78. 2004
    ..The differential distribution of distinct neurochemical phenotypes lends support to the idea of functional differentiation of the DR...
  41. ncbi Alterations in central neuropeptide expression, release, and receptor binding in rats bred for high anxiety: critical role of vasopressin
    Alexandra Wigger
    Max Planck Institute of Psychiatry, Behavioural Neuroendocrinology, Munich, Germany
    Neuropsychopharmacology 29:1-14. 2004
    ....
  42. ncbi Corticotropin-releasing factor receptor types 1 and 2 are differentially expressed in pre- and post-synaptic elements in the post-natal developing rat cerebellum
    J D Swinny
    Laboratory for Cell Biology and Electron Microscopy, Department of Cell Biology, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Eur J Neurosci 18:549-62. 2003
    ..Finally, the distinct expression profiles of receptors along structural domains of Purkinje cells suggest that the role for these receptors is to modulate afferent inputs...
  43. ncbi Stimulation of neurons in rat ARC inhibits gastric acid secretion via hypothalamic CRF1/2- and NPY-Y1 receptors
    Johannes J Tebbe
    Division of Gastroenterology and Endocrinology, Department of Internal Medicine, Philipps Universitat Marburg, 35033 Marburg, Germany
    Am J Physiol Gastrointest Liver Physiol 285:G1075-83. 2003
    ..Our results indicate that activation of neurons in the ARC inhibits gastric acid secretion via CRF1/2 and NPY-Y1 receptor-mediated pathways in the PVN...
  44. ncbi Role of corticotropin-releasing factor receptors type 1 and 2 in modulating the rat adrenocorticotropin response to stressors
    Catherine L Rivier
    The Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, La Jolla, California 92037, USA
    Endocrinology 144:2396-403. 2003
    ..Finally, we showed that peripheral endogenous CRF restrains the ability of LPS to release cytokines...
  45. ncbi Corticotropin-releasing factor receptor type 2 messenger ribonucleic acid in rat pituitary: localization and regulation by immune challenge, restraint stress, and glucocorticoids
    Kazunori Kageyama
    The Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, La Jolla, California 92037, USA
    Endocrinology 144:1524-32. 2003
    CRF receptor 2 (CRF R2) has been identified in the rat pituitary. However, the cell types that express the receptor remained to be determined. In the present study, we localized CRF R2 mRNA in gonadotropes of the anterior pituitary...
  46. ncbi The use of H-2 mutants as models for the study of T cell activation
    I F McKenzie
    Immunol Rev 35:179-230. 1977
  47. ncbi Leptin regulates appetite-related neuropeptides in the hypothalamus of developing rats without affecting food intake
    Karine Proulx
    McGill University, Department of Psychiatry, Douglas Hospital Research Center, Montreal, Quebec, Canada H4H 1R3
    Endocrinology 143:4683-92. 2002
    ..We conclude that despite adult-like effects of leptin on POMC, NPY, and CRFR-2 expression in neonates, leptin does not regulate food intake during early development...
  48. ncbi Antalarmin blockade of corticotropin releasing hormone-induced hypertension in rats
    R J Briscoe
    Department of Pharmacology, University of Michigan, 48109, Ann Arbor, MI, USA
    Brain Res 881:204-7. 2000
    ..of antalarmin, a novel, small molecule CRH1 receptor antagonist, and alpha-helical CRH(9-41), a peptidic CRHR1/CRHR2 antagonist to attempt to determine the receptor mechanisms through which CRH is acting in both of these situations...
  49. ncbi Deletion of crhr2 reveals an anxiolytic role for corticotropin-releasing hormone receptor-2
    T Kishimoto
    Howard Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, La Jolla, CA, USA
    Nat Genet 24:415-9. 2000
    ..hormone (Crh), a 41-residue polypeptide, activates two G-protein-coupled receptors, Crhr1 and Crhr2, causing (among other transductional events) phosphorylation of the transcription factor Creb...
  50. ncbi Abnormal adaptations to stress and impaired cardiovascular function in mice lacking corticotropin-releasing hormone receptor-2
    S C Coste
    Departments of Molecular Microbiology and Immunology, Oregon Health Sciences University, Portland, OR, USA
    Nat Genet 24:403-9. 2000
    ..to stress, and the related hormone urocortin (Ucn) are coordinated by two receptors, Crhr1 (encoded by Crhr) and Crhr2. These receptors may exhibit distinct functions due to unique tissue distribution and pharmacology...
  51. ncbi Labelling of CRF1 and CRF2 receptors using the novel radioligand, [3H]-urocortin
    J Gottowik
    Pharma Division, F Hoffmann La Roche Ltd, Basel, Switzerland
    Neuropharmacology 36:1439-46. 1997
    ....
  52. ncbi Cloning and characterization of human urocortin
    C J Donaldson
    Clayton Foundation Laboratories for Peptide Biology, Salk Institute, La Jolla 92037, USA
    Endocrinology 137:2167-70. 1996
    ..The inhibitory effect of the CRF-binding protein on human urocortin can be blocked by biologically inactive CRF fragments, such as CRF(9-33)...
  53. ncbi Peptide ligand binding properties of the corticotropin-releasing factor (CRF) type 2 receptor: pharmacology of endogenously expressed receptors, G-protein-coupling sensitivity and determinants of CRF2 receptor selectivity
    Sam R J Hoare
    Department of Pharmacology, Neurocrine Biosciences Inc, 12790 El Camino Real, San Diego, CA 92130, USA
    Peptides 26:457-70. 2005
    The CRF2 receptor is involved in stress responses, cardiovascular function and gastric motility...
  54. ncbi Chronic cocaine administration switches corticotropin-releasing factor2 receptor-mediated depression to facilitation of glutamatergic transmission in the lateral septum
    Jie Liu
    Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555 1031, USA
    J Neurosci 25:577-83. 2005
    ..CRF-related peptides that activate two different and synaptically localized G-protein-coupled receptors, CRF1 and CRF2. These peptides and their receptors have been implicated in stress responses and stress with cocaine abuse...
  55. ncbi Modulation of Ca2+ influx by corticotropin-releasing factor (CRF) family of peptides via CRF receptors in rat pancreatic beta-cells
    Kazunori Kageyama
    Department of Endocrinology, Metabolism and Infectious Diseases Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki, Aomori 036 8562, Japan
    Peptides 27:1814-9. 2006
    ..by the seven transmembrane-domain G-protein-coupled receptors, the CRF receptors type 1 (CRF1 receptor) and type 2 (CRF2 receptor)...
  56. ncbi Chronic disruption of body weight but not of stress peptides or receptors in rats exposed to repeated restraint stress
    Ruth B S Harris
    Department of Foods and Nutrition, Dawson Hall, University of Georgia, Athens, GA 30605, USA
    Horm Behav 49:615-25. 2006
    ....
  57. pmc Corticotropin-releasing factor 1 and 2 receptors in the dorsal raphé differentially affect serotonin release in the nucleus accumbens
    Jodi L Lukkes
    Neuroscience Group, Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, 414 East Clark Street, Vermillion, SD 57069 2390, USA
    Eur J Pharmacol 578:185-93. 2008
    ..These results suggest that the opposing effects of dorsal raphé CRF on 5-HT release in the nucleus accumbens are dependent on differential activation of CRF(1) and CRF(2) receptors in the dorsal raphé nucleus...
  58. ncbi Evidence supporting a role for corticotropin-releasing factor type 2 (CRF2) receptors in the regulation of subpopulations of serotonergic neurons
    Daniel R Staub
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol, BS1 3NY, UK
    Brain Res 1070:77-89. 2006
    ..Some of these effects may be mediated via the CRF type 2 (CRF2) receptor on serotonergic neurons in the dorsal raphe nucleus (DR)...
  59. ncbi Endogenous expression and in vitro study of CRF-related peptides and CRF receptors in the rat gastric antrum
    Christophe Porcher
    Groupe d Etude du Stress et des Interactions Neuro Digestives GESIND, EA3744, CHRU Grenoble, BP 217, Grenoble 38043, France
    Peptides 27:1464-75. 2006
    ..CRF-like peptides, urocortin 1 (UCN 1) and UCN 2, inhibit gastric emptying and stimulate colonic motility through CRF2 and CRF1 receptors, respectively...
  60. pmc Corticotrophin-releasing factor receptors within the ventromedial hypothalamus regulate hypoglycemia-induced hormonal counterregulation
    Rory J McCrimmon
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8020, USA
    J Clin Invest 116:1723-30. 2006
    ..Our data suggest that regulation of the CRR is largely determined by the interaction between CRFR2-mediated suppression and CRFR1-mediated activation in the VMH...
  61. ncbi Des-acyl ghrelin acts by CRF type 2 receptors to disrupt fasted stomach motility in conscious rats
    Chih Yen Chen
    Division of Gastroenterology, Taipei Veterans General Hospital, Taiwan
    Gastroenterology 129:8-25. 2005
    ..Although it has been shown that des-acyl ghrelin decreases food intake and gastric emptying, no previous studies have examined the effects of des-acyl ghrelin on physiologic fed and fasted motor activity in the gastrointestinal tract...
  62. ncbi Lack of interaction between etifoxine and CRF1 and CRF2 receptors in rodents
    Marc Verleye
    Biocodex, Departement de Pharmacologie, Zac de Mercières, 60200 Compiegne, France
    Neurosci Res 56:53-60. 2006
    ..Blockade of CRF1 and CRF2 receptors can underlie the anxiolytic effects of drugs...
  63. ncbi The dynamic developmental localization of the full-length corticotropin-releasing factor receptor type 2 in rat cerebellum
    Natalia V Gounko
    Department of Cell Biology, Laboratory for Electron Microscopy, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, The Netherlands
    Eur J Neurosci 23:3217-24. 2006
    b>Corticotropin releasing factor receptor 2 (CRF-R2) is strongly expressed in the cerebellum and plays an important role in the development of the cerebellar circuitry, particularly in the development of the dendritic trees and afferent ..
  64. ncbi Urocortin stimulates tyrosine hydroxylase activity via the cAMP/protein kinase a pathway in rat Pheochromocytoma PC12 cells
    Toru Nanmoku
    Department of Clinical Pathology, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba, Ibaraki 305 8575, Japan
    Neurosci Lett 382:124-7. 2005
    ..In conclusion, we have demonstrated that urocortin stimulates catecholamine biosynthesis via the cAMP/protein kinase A pathway in PC12 cells, where both urocortin and its receptor, CRF-R2, are expressed...
  65. ncbi Regulation of corticotropin-releasing factor receptor type 2beta mRNA by mitogen-activated protein kinases in aortic smooth muscle cells
    Kazunori Kageyama
    The Third Department of Internal Medicine, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki, Aomori 036 8562, Japan
    Regul Pept 126:223-31. 2005
    ..Alternatively, anisomycin may increase CRFR2beta mRNA levels indirectly as a consequence of blocking protein synthesis...
  66. ncbi Expression of corticotropin-releasing factor and CRF receptors in micturition pathways after cyclophosphamide-induced cystitis
    Jennifer LaBerge
    Dept of Anatomy, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Am J Physiol Regul Integr Comp Physiol 291:R692-703. 2006
    ..CRF may contribute to urinary bladder overactivity and altered sensory processing with CYP-induced cystitis...
  67. pmc Delayed satiety-like actions and altered feeding microstructure by a selective type 2 corticotropin-releasing factor agonist in rats: intra-hypothalamic urocortin 3 administration reduces food intake by prolonging the post-meal interval
    Eva M Fekete
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuropsychopharmacology 32:1052-68. 2007
    ..The results implicate the VMN and PVN of the hypothalamus as sites for Ucn 3-CRF(2) control of food intake...
  68. ncbi Identification and characterization of multiple corticotropin-releasing factor type 2 receptor isoforms in the rat esophagus
    S Vincent Wu
    Center for Ulcer Research and Education, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles 90073, USA, and Division of Gastroenterology, Taipei Veterans General Hospital, Taiwan
    Endocrinology 148:1675-87. 2007
    ..skin squamous epithelium and striated muscle that express high levels of corticotropin-releasing factor type 2 (CRF2) receptors or their cognate ligand urocortin (Ucn) 1, 2, and 3...
  69. pmc Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor
    K Lewis
    Clayton Foundation Laboratories for Peptide Biology and Laboratory of Neuronal Structure and Function, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 98:7570-5. 2001
    ..Urocortin III is selective for type 2 CRF receptors and thus represents another potential endogenous ligand for these receptors...
  70. ncbi Urocortin, but not urocortin II, protects cultured hippocampal neurons from oxidative and excitotoxic cell death via corticotropin-releasing hormone receptor type I
    Ward A Pedersen
    Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging, Baltimore, Maryland 21224, USA
    J Neurosci 22:404-12. 2002
    ..G-protein-coupled receptors have been identified that bind CRH and/or urocortin I and II, designated CRHR1 and CRHR2, both of which are present in hippocampal regions of mammalian brain...
  71. ncbi Type 1 corticotropin-releasing factor receptors in the ventromedial hypothalamus promote hypoglycemia-induced hormonal counterregulation
    Haiying Cheng
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Am J Physiol Endocrinol Metab 293:E705-12. 2007
    ..The balance between these two opposing CRFRs in this key glucose-sensing region may play an important role in determining the magnitude of CRRs to acute hypoglycemia...
  72. ncbi Presynaptic localization of a truncated isoform of the type 2 corticotropin releasing factor receptor in the cerebellum
    J B Tian
    Department of Neuroscience, The Ohio State University, 333 West 10th Avenue, Columbus, OH 43210, USA
    Neuroscience 138:691-702. 2006
    ....
  73. ncbi Differential profile of CRF receptor distribution in the rat stomach and duodenum assessed by newly developed CRF receptor antibodies
    Ekaterini Chatzaki
    Neurocrine Biosciences Inc, San Diego, California 92121, USA
    J Neurochem 88:1-11. 2004
    ..We mapped the distribution of CRF receptor type 1 (CRF1) and 2 (CRF2) in the rat upper GI...
  74. ncbi Neuronal activity and CRF receptor gene transcription in the brains of rats with colitis
    Christophe Porcher
    Groupe d Etude du Stress et des Interactions Neuro Digestives EA 3744, Hopital Albert Michallon, Centre Hospitalier Universitaire, 38043 Grenoble Cedex 09, France
    Am J Physiol Gastrointest Liver Physiol 287:G803-14. 2004
    ..No expression of CRF2 receptor transcripts was observed in the PVN, either in basal conditions or after TNBS...
  75. pmc Amphetamine treatment increases corticotropin-releasing factor receptors in the dorsal raphe nucleus
    Ronald B Pringle
    Division of Basic Biomedical Sciences and Neuroscience Group, Sanford School of Medicine, University of South Dakota, Vermillion, SD, USA
    Neurosci Res 62:62-5. 2008
    ..No changes in CRF(1) receptor densities were observed following amphetamine treatment or during withdrawal. Selective increases in dRN CRF(2) receptors may be related to increased anxiety-like behaviors following psychostimulant use...
  76. ncbi Dopamine-dependent responses to cocaine depend on corticotropin-releasing factor receptor subtypes
    Lin Lu
    Institute of Mental Health, West China University of Medical Sciences, Chengdu, China Medical Center of Fudan University, Shanghai, China
    J Neurochem 84:1378-86. 2003
    ..These results suggest that the CRF receptor antagonist, particularly the CRF receptor subtype 1 antagonist, might be of some value in the treatment of cocaine addiction and cocaine-related behavioral disorders...

Research Grants26

  1. Opioid and Dopamine Mechanisms of Heroin Relapse
    GLENN VALDEZ; Fiscal Year: 2006
    ....
  2. Role of AMPK in hypoglycemia-sensing in the ventromedial hypothalamus
    RORY MCCRIMMON; Fiscal Year: 2007
    ..Finally, the proposal aims to obtain data that will support the hypothesis that recurrent hypoglycemia induces mitochondrial biogenesis in the VMH, an effect that may be mediated by AMPK. ..
  3. A NOVEL NEURAL PATHWAY CONTROLS TESTOSTERONE RELEASE
    Catherine Rivier; Fiscal Year: 2007
    ..Collectively, these studies will advance our understanding of the effects of alcohol on male reproductive functions and the mechanisms that mediate them. ..
  4. NO AND CO MEDIATE MENTAL-NEUROENDOCRINE INTERACTIONS
    Catherine Rivier; Fiscal Year: 2004
    ..Collectively, these results will provide novel and comprehensive information regarding the neurocircuitries through which NO or CO modulate the response of the rat HPA to a neurogenic stress. ..
  5. A NOVEL NEURAL PATHWAY CONTROLS TESTOSTERONE RELEASE
    Catherine Rivier; Fiscal Year: 2003
    ..These experiments will provide the first morphological and functional evidence of the existence of a multisynaptic neural pathway between the testes and the CNS, that is influenced by alcohol. ..