Gene Symbol: Crhbp
Description: corticotropin releasing hormone binding protein
Alias: Crfbp, corticotropin-releasing factor-binding protein, CRF-BP, CRF-binding protein, CRH-BP
Species: rat
Products:     Crhbp

Top Publications

  1. Jahn O, Eckart K, Brauns O, Tezval H, Spiess J. The binding protein of corticotropin-releasing factor: ligand-binding site and subunit structure. Proc Natl Acad Sci U S A. 2002;99:12055-60 pubmed
    ..factor (CRF), recognized as an important stress factor, binds to a CRF receptor and a CRF-binding protein (CRFBP) that represents a reservoir of endogenous CRF...
  2. Slater P, Noches V, Gysling K. Corticotropin-releasing factor type-2 receptor and corticotropin-releasing factor-binding protein coexist in rat ventral tegmental area nerve terminals originated in the lateral hypothalamic area. Eur J Neurosci. 2016;43:220-9 pubmed publisher
    ..The results showing that CRF2R and CRF-BP are expressed in the LHA-VTA input give anatomical support to suggest that this input plays a role in stress-induced relapse to cocaine-seeking behaviour. ..
  3. Peto C, Arias C, Vale W, Sawchenko P. Ultrastructural localization of the corticotropin-releasing factor-binding protein in rat brain and pituitary. J Comp Neurol. 1999;413:241-54 pubmed
    ..In other areas of the central nervous system, the BP seems positioned to serve as a transmitter/modulator at conventional synapses or as an autocrine or paracrine modulator of local CRF effects. ..
  4. Pan Y, Wang F, Qiang L, Zhang D, Kong L. Icariin attenuates chronic mild stress-induced dysregulation of the LHPA stress circuit in rats. Psychoneuroendocrinology. 2010;35:272-83 pubmed publisher
    ..procedure and subsequent icariin treatment on mRNA and protein levels of CRF, CRF receptor 1 (CRFR1) and CRF binding protein (CRFBP), as well as sucrose intake in rats...
  5. Erb S, Funk D, Borkowski S, Watson S, Akil H. Effects of chronic cocaine exposure on corticotropin-releasing hormone binding protein in the central nucleus of the amygdala and bed nucleus of the stria terminalis. Neuroscience. 2004;123:1003-9 pubmed
  6. Cortright D, Goosens K, Lesh J, Seasholtz A. Isolation and characterization of the rat corticotropin-releasing hormone (CRH)-binding protein gene: transcriptional regulation by cyclic adenosine monophosphate and CRH. Endocrinology. 1997;138:2098-108 pubmed
    ..These studies suggest that CRH-BP transcription in vivo may be positively regulated by cAMP and CRH. ..
  7. Huising M, Vaughan J, Shah S, Grillot K, Donaldson C, Rivier J, et al. Residues of corticotropin releasing factor-binding protein (CRF-BP) that selectively abrogate binding to CRF but not to urocortin 1. J Biol Chem. 2008;283:8902-12 pubmed publisher
    ..Collectively our findings demonstrate that CRF-BP has distinct and separable binding surfaces for CRF and Ucn 1, opening new avenues for the design of ligand-specific antagonists based on CRF-BP. ..
  8. Smith M, Weiss S, Berry R, Zhang L, Clark M, Massenburg G, et al. Amygdala-kindled seizures increase the expression of corticotropin-releasing factor (CRF) and CRF-binding protein in GABAergic interneurons of the dentate hilus. Brain Res. 1997;745:248-56 pubmed
    ..These results suggest that CRF may contribute to the development of amygdala kindling. However, the compensatory induction of CRF-BP may serve to limit the excitatory effects of CRF in the dentate gyrus. ..
  9. Timofeeva E, Deshaies Y, Picard F, Richard D. Corticotropin-releasing hormone-binding protein in brain and pituitary of food-deprived obese (fa/fa) Zucker rats. Am J Physiol. 1999;277:R1749-59 pubmed

More Information


  1. Eckart K, Jahn O, Radulovic J, Tezval H, van Werven L, Spiess J. A single amino acid serves as an affinity switch between the receptor and the binding protein of corticotropin-releasing factor: implications for the design of agonists and antagonists. Proc Natl Acad Sci U S A. 2001;98:11142-7 pubmed
    ..several brain functions through at least two subtypes of G protein-dependent receptors and a binding protein (CRFBP), we have developed synthetic strategies to provide enhanced binding specificity...
  2. Ungless M, Singh V, Crowder T, Yaka R, Ron D, Bonci A. Corticotropin-releasing factor requires CRF binding protein to potentiate NMDA receptors via CRF receptor 2 in dopamine neurons. Neuron. 2003;39:401-7 pubmed
    ..We also find that this potentiation requires CRF binding protein (CRF-BP)...
  3. Blanco E, Zúñiga J, Andrés M, Alvarez A, Gysling K. Corticotropin-releasing factor binding protein enters the regulated secretory pathway in neuroendocrine cells and cortical neurons. Neuropeptides. 2011;45:273-9 pubmed publisher
    b>Corticotropin releasing factor binding protein (CRF-BP) is a 37kDa glycoprotein that binds CRF with high affinity. CRF-BP controls CRF levels within plasma during human pregnancy...
  4. Wang H, Morales M. Corticotropin-releasing factor binding protein within the ventral tegmental area is expressed in a subset of dopaminergic neurons. J Comp Neurol. 2008;509:302-18 pubmed publisher
  5. Cortright D, Nicoletti A, Seasholtz A. Molecular and biochemical characterization of the mouse brain corticotropin-releasing hormone-binding protein. Mol Cell Endocrinol. 1995;111:147-57 pubmed
    ..Additional biochemical characterization of the binding activity of mCRH-BP indicates that CRH-BP and CRH receptor utilize different molecular interactions to bind CRH. ..
  6. Gammie S, Seasholtz A, Stevenson S. Deletion of corticotropin-releasing factor binding protein selectively impairs maternal, but not intermale aggression. Neuroscience. 2008;157:502-12 pubmed publisher
  7. Florio P, Romero R, Chaiworapongsa T, Kusanovic J, Torricelli M, Lowry P, et al. Amniotic fluid and umbilical cord plasma corticotropin-releasing factor (CRF), CRF-binding protein, adrenocorticotropin, and cortisol concentrations in intraamniotic infection and inflammation at term. J Clin Endocrinol Metab. 2008;93:3604-9 pubmed publisher
    ..CRF-BP may modulate CRF actions on ACTH and cortisol secretion, playing a pivotal role in limiting the inflammatory process and thus avoiding an overactivation of the fetal/placental hypothalamus-pituitary-adrenal axis at birth. ..
  8. Westphal N, Seasholtz A. Gonadotropin-releasing hormone (GnRH) positively regulates corticotropin-releasing hormone-binding protein expression via multiple intracellular signaling pathways and a multipartite GnRH response element in alphaT3-1 cells. Mol Endocrinol. 2005;19:2780-97 pubmed
    ..These data demonstrate novel regulation of pituitary CRH-BP, highlighting the importance of the pituitary gonadotrope as a potential interface between the stress and reproductive axes. ..
  9. Herringa R, Nanda S, Hsu D, Roseboom P, Kalin N. The effects of acute stress on the regulation of central and basolateral amygdala CRF-binding protein gene expression. Brain Res Mol Brain Res. 2004;131:17-25 pubmed
    ..Because CRF-BP can modulate CRF action, changes in amygdala CRF-BP levels after stress exposure may affect the ability of an organism to adapt to future stressors. ..
  10. van de Stolpe A, Slycke A, Reinders M, Zomer A, Goodenough S, Behl C, et al. Estrogen receptor (ER)-mediated transcriptional regulation of the human corticotropin-releasing hormone-binding protein promoter: differential effects of ERalpha and ERbeta. Mol Endocrinol. 2004;18:2908-23 pubmed
  11. Claes S, Villafuerte S, Forsgren T, Sluijs S, Del Favero J, Adolfsson R, et al. The corticotropin-releasing hormone binding protein is associated with major depression in a population from Northern Sweden. Biol Psychiatry. 2003;54:867-72 pubmed
    ..001). The corticotropin releasing hormone binding protein gene is likely to be involved in the genetic vulnerability for major depression. ..
  12. Hillhouse E, Grammatopoulos D. The molecular mechanisms underlying the regulation of the biological activity of corticotropin-releasing hormone receptors: implications for physiology and pathophysiology. Endocr Rev. 2006;27:260-86 pubmed
    ..The type of activating agonist, receptor, and target cell appears to play a major role in determining the overall signaling and biological responses in health and disease. ..
  13. Wang B, You Z, Rice K, Wise R. Stress-induced relapse to cocaine seeking: roles for the CRF(2) receptor and CRF-binding protein in the ventral tegmental area of the rat. Psychopharmacology (Berl). 2007;193:283-94 pubmed
    ..The present studies revealed a role of VTA CRF-BP and suggest an involvement of CRF(2)R in the effectiveness of stress in triggering glutamate and dopamine release and cocaine seeking in drug-experienced animals. ..
  14. Jahn O, Tezval H, van Werven L, Eckart K, Spiess J. Three-amino acid motifs of urocortin II and III determine their CRF receptor subtype selectivity. Neuropharmacology. 2004;47:233-42 pubmed
    ..4 nM) but not mUcnIII was identified as high-affinity ligand for the rat CRF binding protein. Such affinity had previously not been observed for the human version of this protein...
  15. Ray L. Stress-induced and cue-induced craving for alcohol in heavy drinkers: Preliminary evidence of genetic moderation by the OPRM1 and CRH-BP genes. Alcohol Clin Exp Res. 2011;35:166-74 pubmed publisher
    ..Larger studies are needed to validate these preliminary findings, which should also be extended to clinical samples. ..
  16. Glatt M. Klebsiella pneumonia treated with tetracycline (achromycin): a case presentation. Clin Proc Child Hosp Dist Columbia. 1954;10:25-8 pubmed
  17. Potter E, Behan D, Fischer W, Linton E, Lowry P, Vale W. Cloning and characterization of the cDNAs for human and rat corticotropin releasing factor-binding proteins. Nature. 1991;349:423-6 pubmed
    ..Both rat and human recombinant binding proteins inhibit CRF binding to a CRF antibody and inhibit CRF-induced ACTH release by pituitary cells in vitro. ..
  18. Slater P, Cerda C, Pereira L, Andrés M, Gysling K. CRF binding protein facilitates the presence of CRF type 2? receptor on the cell surface. Proc Natl Acad Sci U S A. 2016;113:4075-80 pubmed publisher
    b>Corticotropin releasing factor binding protein (CRF-BP) was originally recognized as CRF sequestering protein. However, its differential subcellular localization in different brain nuclei suggests that CRF-BP may have additional functions...