Gene Symbol: Crebbp
Description: CREB binding protein
Alias: CBP, RSTS, RTS, CREB-binding protein
Species: rat
Products:     Crebbp

Top Publications

  1. Kwok R, Lundblad J, Chrivia J, Richards J, Bachinger H, Brennan R, et al. Nuclear protein CBP is a coactivator for the transcription factor CREB. Nature. 1994;370:223-6 pubmed
    ..We have previously identified a nuclear protein of M(r)265K, CBP, that binds specifically to the PKA-phosphorylated form of CREB...
  2. Yang X, Ogryzko V, Nishikawa J, Howard B, Nakatani Y. A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A. Nature. 1996;382:319-24 pubmed
    The adenoviral oncoprotein E1A induces progression through the cell cycle by binding to the products of the p300/CBP and retinoblastoma gene families...
  3. Morikawa Y, Dai Y, Hao J, Bonin C, Hwang S, Cserjesi P. The basic helix-loop-helix factor Hand 2 regulates autonomic nervous system development. Dev Dyn. 2005;234:613-21 pubmed
    ..We show that this function is dependent on its interaction with the histone acetyltransferase p300/CBP, indicating that Hand 2 functions to promote ANS development as part of a larger transcriptional complex.
  4. Klevytska A, Tebbenkamp A, Savonenko A, Borchelt D. Partial depletion of CREB-binding protein reduces life expectancy in a mouse model of Huntington disease. J Neuropathol Exp Neurol. 2010;69:396-404 pubmed publisher
    ..reported that mutant huntingtin (htt) interferes with cyclic AMP response element binding protein binding protein (CBP)-mediated transcription, possibly by inhibiting the acetylation of histones...
  5. Bradney C, Hjelmeland M, Komatsu Y, Yoshida M, Yao T, Zhuang Y. Regulation of E2A activities by histone acetyltransferases in B lymphocyte development. J Biol Chem. 2003;278:2370-6 pubmed
    ..Gel filtration analysis of human pre-B cell nuclear extract showed that E2A co-elutes with the HATs p300, CBP, and PCAF...
  6. Lin C, Hare B, Wagner G, Harrison S, Maniatis T, Fraenkel E. A small domain of CBP/p300 binds diverse proteins: solution structure and functional studies. Mol Cell. 2001;8:581-90 pubmed
    The transcriptional coactivators CBP and p300 are critical regulators of metazoan gene expression. They associate with many different DNA-bound transcription factors through small, conserved domains...
  7. Pasheva E, Sarov M, Bidjekov K, Ugrinova I, Sarg B, Lindner H, et al. In vitro acetylation of HMGB-1 and -2 proteins by CBP: the role of the acidic tail. Biochemistry. 2004;43:2935-40 pubmed
    Histone acetyltransferases CBP, PCAF, and Tip60 have been tested for their ability to in vitro acetylate HMGB-1 and -2 proteins and their truncated forms lacking the C-terminal tail...
  8. Wu X, Zeng W, Jiang M, Qin J, Xu H. Effect of Oxymatrine on the TGFbeta-Smad signaling pathway in rats with CCl4-induced hepatic fibrosis. World J Gastroenterol. 2008;14:2100-5 pubmed
    ..The concentration of serum TGF-beta1 was assayed with ELISA. The gene expression of Smads and CBP (CREB binding protein) was detected with in situ hybridization (ISH) and immunohistochemistry (IH), respectively...
  9. Semenza G. Regulation of oxygen homeostasis by hypoxia-inducible factor 1. Physiology (Bethesda). 2009;24:97-106 pubmed publisher
    ..HIF-1 also mediates maladaptive responses to chronic continuous and intermittent hypoxia, which underlie the development of pulmonary and systemic hypertension, respectively. ..

More Information


  1. Sugawara A, Takeuchi K, Uruno A, Kudo M, Sato K, Ito S. Effects of mitogen-activated protein kinase pathway and co-activator CREP-binding protein on peroxisome proliferator-activated receptor-gamma-mediated transcription suppression of angiotensin II type 1 receptor gene. Hypertens Res. 2003;26:623-8 pubmed
    ..kinase pathway inhibits PPAR-gamma function through its phosphorylation, and co-activator CREB-binding protein (CBP)/p300 interacts with PPAR-gamma and modulates its activity...
  2. Yang J, Fuller P. Interactions of the mineralocorticoid receptor--within and without. Mol Cell Endocrinol. 2012;350:196-205 pubmed publisher
    ..This review will discuss the current understanding of interactions involving the MR and highlight their relevance to ligand- or tissue-specificity as well as their suitability as therapeutic targets. ..
  3. Hsieh Y, Chen Y, Jao H, Hsu H, Huang L, Hsu C. Role of cAMP-response element-binding protein phosphorylation in hepatic apoptosis under protein kinase C alpha suppression during sepsis. Shock. 2005;24:357-63 pubmed
    ..The in vivo and in vitro results suggest that the suppression of PKCalpha results in a decreased CREB phosphorylation and subsequent down-regulation of Bcl-xL, which may contribute to the hepatic apoptosis during sepsis. ..
  4. Li Q, Xiao H, Isobe K. Histone acetyltransferase activities of cAMP-regulated enhancer-binding protein and p300 in tissues of fetal, young, and old mice. J Gerontol A Biol Sci Med Sci. 2002;57:B93-8 pubmed
    b>CBP, a protein that binds to cyclic adenosine monophosphate-regulated enhancer-binding protein, and homologue protein, p300, have histone acetyltransferase (HAT) activity and are important in gene transcription, although their ..
  5. Zanger K, Cohen L, Hashimoto K, Radovick S, Wondisford F. A novel mechanism for cyclic adenosine 3',5'-monophosphate regulation of gene expression by CREB-binding protein. Mol Endocrinol. 1999;13:268-75 pubmed
    ..We show that CREB binding protein (CBP), through two cysteine-histidine rich domains (C/H1 and C/H3), specifically and constitutively ..
  6. Di Giulio C, Rapino M, Zingariello M, Antonucci A, Cataldi A. PKC alpha-mediated CREB activation is oxygen and age-dependent in rat myocardial tissue. Histochem Cell Biol. 2007;127:327-33 pubmed
  7. Cong S, Pepers B, Evert B, Rubinsztein D, Roos R, van Ommen G, et al. Mutant huntingtin represses CBP, but not p300, by binding and protein degradation. Mol Cell Neurosci. 2005;30:12-23 pubmed
    ..We now report that the transcriptional activity of CBP is already repressed in the early time points by soluble mutant huntingtin, whereas the histone acetylase activity ..
  8. Janaki Ramaiah M, Parnaik V. An essential GT motif in the lamin A promoter mediates activation by CREB-binding protein. Biochem Biophys Res Commun. 2006;348:1132-7 pubmed
    ..Further functional analysis by co-expression of recombinant proteins and ChIP assays has shown an important regulatory role for CREB-binding protein in promoter activation, which is mediated by the GT motif. ..
  9. Panagopoulos I, Isaksson M, Lindvall C, Hagemeijer A, Mitelman F, Johansson B. Genomic characterization of MOZ/CBP and CBP/MOZ chimeras in acute myeloid leukemia suggests the involvement of a damage-repair mechanism in the origin of the t(8;16)(p11;p13). Genes Chromosomes Cancer. 2003;36:90-8 pubmed
    ..erythrophagocytosis by the leukemic cells, and a poor response to chemotherapy, fuses the MOZ gene (8p11) with the CBP gene (16p13)...
  10. Chung Y, Kim E, Shin C, Joo K, Kim M, Woo H, et al. Age-related changes in CREB binding protein immunoreactivity in the cerebral cortex and hippocampus of rats. Brain Res. 2002;956:312-8 pubmed
    Although the role of cAMP-response-element-binding protein (CREB) binding protein (CBP) in the neuroprotective mechanisms has been the focus of many studies, very little is known about the expression or function of CBP in aged brains...
  11. Lee J, Kim C, Simon D, Aminova L, Andreyev A, Kushnareva Y, et al. Mitochondrial cyclic AMP response element-binding protein (CREB) mediates mitochondrial gene expression and neuronal survival. J Biol Chem. 2005;280:40398-401 pubmed
  12. Janknecht R, Wells N, Hunter T. TGF-beta-stimulated cooperation of smad proteins with the coactivators CBP/p300. Genes Dev. 1998;12:2114-9 pubmed
    ..We report that TGF-beta receptor phosphorylation of Smad3 promotes its interaction with the paralogous coactivators CBP and p300, whereas CBP/p300 binding to nonphosphorylated Smad3 or its oligomerization partner Smad4 is negatively ..
  13. Warner D, Pisano M, Greene R. Expression of the nuclear coactivators CBP and p300 in developing craniofacial tissue. In Vitro Cell Dev Biol Anim. 2002;38:48-53 pubmed
    cAMP regulatory element-binding protein (CREB)-binding protein (CBP) and its functional homolog, the adenovirus E1A -associated 300-kDa protein (p300) are nuclear coactivators and histone acetyltransferases that integrate signals from ..
  14. Nakagawa Y, Kuwahara K, Takemura G, Akao M, Kato M, Arai Y, et al. p300 plays a critical role in maintaining cardiac mitochondrial function and cell survival in postnatal hearts. Circ Res. 2009;105:746-54 pubmed publisher
    ..Collectively, our findings suggest that p300 is essential for the maintenance of mitochondrial integrity and for myocyte survival in the postnatal left ventricular myocardium. ..
  15. Pulver Kaste R, Barlow C, Bond J, Watson A, Penar P, Tranmer B, et al. Ca2+ source-dependent transcription of CRE-containing genes in vascular smooth muscle. Am J Physiol Heart Circ Physiol. 2006;291:H97-105 pubmed
  16. Bartsch O, Wagner A, Hinkel G, Krebs P, Stumm M, Schmalenberger B, et al. FISH studies in 45 patients with Rubinstein-Taybi syndrome: deletions associated with polysplenia, hypoplastic left heart and death in infancy. Eur J Hum Genet. 1999;7:748-56 pubmed
    Rubinstein-Taybi syndrome (RTS) is a dominant Mendelian disorder characterised by mental retardation, a typical facies, broad thumbs and short stature. Previous reports indicated that 4-25% of RTS patients have a submicroscopic 16p13...
  17. Liu X, Sun S, Hassid A, Ostrom R. cAMP inhibits transforming growth factor-beta-stimulated collagen synthesis via inhibition of extracellular signal-regulated kinase 1/2 and Smad signaling in cardiac fibroblasts. Mol Pharmacol. 2006;70:1992-2003 pubmed
    ..Thus, cAMP-elevating agents inhibit the profibrotic effects of TGF-beta in cardiac fibroblasts largely through inhibiting ERK1/2 phosphorylation but also by reducing Smad-mediated recruitment of transcriptional coactivators. ..
  18. Cong S, Pepers B, Evert B, Rubinsztein D, Roos R, van Ommen G, et al. Mutant huntingtin represses CBP, but not p300, by binding and protein degradation. Mol Cell Neurosci. 2005;30:560-71 pubmed
    ..We now report that the transcriptional activity of CBP is already repressed in the early time points by soluble mutant huntingtin, whereas the histone acetylase activity ..
  19. Chang Y, Huang A, Kuo Y, Wang S, Chang Y, Huang C. Febrile seizures impair memory and cAMP response-element binding protein activation. Ann Neurol. 2003;54:706-18 pubmed
    ..These results raise concerns about the long-term cognitive consequences of even brief frequently repetitive FS during early brain development. ..
  20. Fonte C, Trousson A, Grenier J, Schumacher M, Massaad C. Opposite effects of CBP and p300 in glucocorticoid signaling in astrocytes. J Steroid Biochem Mol Biol. 2007;104:220-7 pubmed
    ..coactivators of the p160 family (SRCs), which are a docking platform for secondary coactivators like CBP, or its close homologue p300...
  21. Elliott A, De Miguel M, Rebel V, Donovan P. Identifying genes differentially expressed between PGCs and ES cells reveals a role for CREB-binding protein in germ cell survival. Dev Biol. 2007;311:347-58 pubmed
    ..Using this method, we identified the transcriptional coactivator/histone acetyltransferase CREB-binding protein (CBP) as being highly expressed in PGCs compared to ES cells...
  22. Hong W, Resnick R, Rakowski C, Shalloway D, Taylor S, Blobel G. Physical and functional interaction between the transcriptional cofactor CBP and the KH domain protein Sam68. Mol Cancer Res. 2002;1:48-55 pubmed
    b>CBP is a multifunctional transcriptional cofactor with tumor suppressor activity. The CH3 domain of CBP binds numerous transcription factors and several viral oncoproteins...
  23. Zhang J, Okutani F, Inoue S, Kaba H. Activation of the cyclic AMP response element-binding protein signaling pathway in the olfactory bulb is required for the acquisition of olfactory aversive learning in young rats. Neuroscience. 2003;117:707-13 pubmed
    ..These results show that the synthesis and phosphorylation of CREB are required for the acquisition of olfactory aversive learning in young rats, and that this requirement for the CREB signaling pathway has a critical time window. ..
  24. Tomás Pereira I, Coletta C, Perez E, Kim D, Gallagher M, Goldberg I, et al. CREB-binding protein levels in the rat hippocampus fail to predict chronological or cognitive aging. Neurobiol Aging. 2013;34:832-44 pubmed publisher
    ..We hypothesized that CREB-binding protein (CBP), a key histone acetyltransferase, may contribute to memory decline in normal aging...
  25. Fang L, Wu J, Zhang X, Lin Q, Willis W. Calcium/calmodulin dependent protein kinase II regulates the phosphorylation of cyclic AMP-responsive element-binding protein of spinal cord in rats following noxious stimulation. Neurosci Lett. 2005;374:1-4 pubmed
    ..These results suggest that increased phosphorylation of CREB protein may contribute to central sensitization following acute peripheral noxious stimuli, and the effect may be regulated through the activation of CaM kinase cascades. ..
  26. Yang J, Chen L, Yang J, Ding J, Li S, Wu H, et al. MicroRNA-22 targeting CBP protects against myocardial ischemia-reperfusion injury through anti-apoptosis in rats. Mol Biol Rep. 2014;41:555-61 pubmed publisher
    ..Moreover, CREB binding protein (CBP) as a potential miR-22 target by bioinformatics was significantly inhibited after miR-22 transfection...
  27. Sriraman V, Richards J. Cathepsin L gene expression and promoter activation in rodent granulosa cells. Endocrinology. 2004;145:582-91 pubmed
  28. Guan H, Ishizuka T, Chui P, Lehrke M, Lazar M. Corepressors selectively control the transcriptional activity of PPARgamma in adipocytes. Genes Dev. 2005;19:453-61 pubmed
    ..Thus, selective modulation of adipocyte PPARgamma target genes by TZDs involves the dissociation of corepressors by direct and indirect mechanisms. ..
  29. Kitabayashi I, Aikawa Y, Nguyen L, Yokoyama A, Ohki M. Activation of AML1-mediated transcription by MOZ and inhibition by the MOZ-CBP fusion protein. EMBO J. 2001;20:7184-96 pubmed
    ..MOZ, as well as CBP and MOZ-CBP, can acetylate AML1 in vitro...
  30. Kruse J, Gu W. Modes of p53 regulation. Cell. 2009;137:609-22 pubmed publisher
    ..To reconcile these differences, we propose that antirepression, the release of p53 from repression by factors such as Mdm2 and MdmX, is a key step in the physiological activation of p53. ..
  31. Pentz E, Cordaillat M, Carretero O, Tucker A, Sequeira Lopez M, Gomez R. Histone acetyl transferases CBP and p300 are necessary for maintenance of renin cell identity and transformation of smooth muscle cells to the renin phenotype. Am J Physiol Heart Circ Physiol. 2012;302:H2545-52 pubmed publisher
    ..transcriptional effects are mediated by binding of cAMP responsive element binding protein with its co-activators, CBP and p300, to the cAMP response element in the renin promoter...
  32. Yuan S, Qiu Z, Ghosh A. TOX3 regulates calcium-dependent transcription in neurons. Proc Natl Acad Sci U S A. 2009;106:2909-14 pubmed publisher
    ..We find that TOX3 interacts with both cAMP response element (CRE)-binding protein (CREB) and CREB-binding protein (CBP), and knockdown of the endogenous TOX3 by RNAi leads to significant reduction of calcium-induced c-fos expression ..
  33. Mehra Chaudhary R, Matsui H, Raghow R. Msx3 protein recruits histone deacetylase to down-regulate the Msx1 promoter. Biochem J. 2001;353:13-22 pubmed
    ..promoter that can be relieved by exogenous expression of cAMP-response-element-binding protein-binding protein (CBP) and p300 in a dose-dependent manner...
  34. Molenda Figueira H, Williams C, Griffin A, Rutledge E, Blaustein J, Tetel M. Nuclear receptor coactivators function in estrogen receptor- and progestin receptor-dependent aspects of sexual behavior in female rats. Horm Behav. 2006;50:383-92 pubmed
    ..Nuclear receptor coactivators, including Steroid Receptor Coactivator-1 (SRC-1) and CREB Binding Protein (CBP), dramatically enhance ligand-dependent steroid receptor transcriptional activity in vitro...
  35. Nucifora F, Sasaki M, Peters M, Huang H, Cooper J, Yamada M, et al. Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity. Science. 2001;291:2423-8 pubmed
    ..with other proteins containing short polyglutamine tracts such as the transcriptional coactivator CREB binding protein, CBP...
  36. Castro Gomez S, Barrera Ocampo A, Machado Rodriguez G, Castro Alvarez J, Glatzel M, Giraldo M, et al. Specific de-SUMOylation triggered by acquisition of spatial learning is related to epigenetic changes in the rat hippocampus. Neuroreport. 2013;24:976-81 pubmed publisher
    Histone acetyltransferase activity by transcriptional cofactors such as CREB-binding protein (CBP) and post-translational modifications by small ubiquitin-like modifier-1 (SUMO-1) have shown to be relevant for synaptic and neuronal ..
  37. Mayr B, Guzman E, Montminy M. Glutamine rich and basic region/leucine zipper (bZIP) domains stabilize cAMP-response element-binding protein (CREB) binding to chromatin. J Biol Chem. 2005;280:15103-10 pubmed
    ..These results suggest a novel mechanism by which the family of glutamine-rich activators promotes cellular gene expression. ..
  38. Lee S, Miller M, Shuman J, Johnson P. CCAAT/Enhancer-binding protein beta DNA binding is auto-inhibited by multiple elements that also mediate association with p300/CREB-binding protein (CBP). J Biol Chem. 2010;285:21399-410 pubmed publisher
    ..Thus, the N-terminal regulatory elements have dual roles in auto-inhibition and coactivator binding. ..
  39. Caccamo A, Maldonado M, Bokov A, Majumder S, Oddo S. CBP gene transfer increases BDNF levels and ameliorates learning and memory deficits in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A. 2010;107:22687-92 pubmed publisher
    ..We further show that restoring CREB function via brain viral delivery of the CREB-binding protein (CBP) improves learning and memory deficits in an animal model of AD...
  40. Ahluwalia A, Baatar D, Jones M, Tarnawski A. Novel mechanisms and signaling pathways of esophageal ulcer healing: the role of prostaglandin EP2 receptors, cAMP, and pCREB. Am J Physiol Gastrointest Liver Physiol. 2014;307:G602-10 pubmed publisher
    ..These results indicate that the EP2/cAMP/protein kinase A pathway mediates the stimulatory effect of PGEs on angiogenesis essential for tissue injury healing via the induction of CREB activity and VEGF expression. ..
  41. Yujnovsky I, Hirayama J, Doi M, Borrelli E, Sassone Corsi P. Signaling mediated by the dopamine D2 receptor potentiates circadian regulation by CLOCK:BMAL1. Proc Natl Acad Sci U S A. 2006;103:6386-91 pubmed
    ..Because dopamine is the major catecholamine in the retina, central for the neural adaptation to light, our findings establish a physiological link among photic input, dopamine signaling, and the molecular clock machinery. ..
  42. Hall J, McDonnell D. Coregulators in nuclear estrogen receptor action: from concept to therapeutic targeting. Mol Interv. 2005;5:343-57 pubmed
    ..This review also describes current efforts aimed at developing pharmaceutical agents that target ER-cofactor interactions as therapeutics for estrogen-associated pathologies. ..
  43. Kozak L, Britton J, Kozak U, Wells J. The mitochondrial uncoupling protein gene. Correlation of exon structure to transmembrane domains. J Biol Chem. 1988;263:12274-7 pubmed
    ..The 5'-untranslated region of the mRNA is composed of 231 nucleotides, and the 3'-untranslated region contains 81 nucleotides prior to addition of the poly(A) tail. ..
  44. Saha R, Ghosh A, Palencia C, Fung Y, Dudek S, Pahan K. TNF-alpha preconditioning protects neurons via neuron-specific up-regulation of CREB-binding protein. J Immunol. 2009;183:2068-78 pubmed publisher
    ..The present study identifies the importance of CREB-binding protein (CBP) in facilitating TNF-alpha-mediated preconditioning in neurons...
  45. Zhao Q, Cumming H, Cerruti L, Cunningham J, Jane S. Site-specific acetylation of the fetal globin activator NF-E4 prevents its ubiquitination and regulates its interaction with the histone deacetylase, HDAC1. J Biol Chem. 2004;279:41477-86 pubmed
    ..These results provide further demonstration that co-activators, such as PCAF, can influence individual transcription factor properties at multiple levels to alter their effects on gene expression. ..
  46. Gusterson R, Jazrawi E, Adcock I, Latchman D. The transcriptional co-activators CREB-binding protein (CBP) and p300 play a critical role in cardiac hypertrophy that is dependent on their histone acetyltransferase activity. J Biol Chem. 2003;278:6838-47 pubmed
    The CBP and p300 proteins are transcriptional co-activators that are involved in a variety of transcriptional pathways in development and in response to specific signaling pathways...
  47. Kung A, Rebel V, Bronson R, Ch Ng L, Sieff C, Livingston D, et al. Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP. Genes Dev. 2000;14:272-7 pubmed
    Mice with monoallelic inactivation of the CBP gene develop highly penetrant, multilineage defects in hematopoietic differentiation and, with advancing age, an increased incidence of hematologic malignancies...
  48. Massague J, Seoane J, Wotton D. Smad transcription factors. Genes Dev. 2005;19:2783-810 pubmed
    ..Our growing understanding of TGFbeta signaling through the Smad pathway provides general principles for how animal cells translate complex inputs into concrete behavior. ..
  49. Aizawa H, Hu S, Bobb K, Balakrishnan K, Ince G, Gurevich I, et al. Dendrite development regulated by CREST, a calcium-regulated transcriptional activator. Science. 2004;303:197-202 pubmed
    ..that interacts with adenosine 3',5'-monophosphate (cAMP) response element-binding protein (CREB)-binding protein (CBP) and is expressed in the developing brain...
  50. Imamura T, Imamura C, Iwamoto Y, Sandell L. Transcriptional Co-activators CREB-binding protein/p300 increase chondrocyte Cd-rap gene expression by multiple mechanisms including sequestration of the repressor CCAAT/enhancer-binding protein. J Biol Chem. 2005;280:16625-34 pubmed
    ..Fukui, N., and Sandell, L. J. (2002) J. Biol. Chem. 277, 31526-31533). The co-activators CREB-binding protein (CBP) and p300 are transcriptional co-regulators that participate in the activities of many different transcription ..
  51. Yuan W, Condorelli G, Caruso M, Felsani A, Giordano A. Human p300 protein is a coactivator for the transcription factor MyoD. J Biol Chem. 1996;271:9009-13 pubmed
    ..Consistent with its role as a coactivator, p300 potentiates MyoD-activated transcription. ..
  52. Wang W, Lee S, Palmer R, Ellisen L, Haber D. A functional interaction with CBP contributes to transcriptional activation by the Wilms tumor suppressor WT1. J Biol Chem. 2001;276:16810-6 pubmed
    ..We report here that WT1 binds to the transcriptional coactivator CBP, leading to synergistic activation of a physiologically relevant promoter...
  53. Chen L, Mu Y, Greene W. Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB. EMBO J. 2002;21:6539-48 pubmed
    ..We now demonstrate that the p300 and CBP acetyltransferases play a major role in the in vivo acetylation of RelA, principally targeting lysines 218, 221 and ..
  54. Radhakrishnan I, Pérez Alvarado G, Parker D, Dyson H, Montminy M, Wright P. Solution structure of the KIX domain of CBP bound to the transactivation domain of CREB: a model for activator:coactivator interactions. Cell. 1997;91:741-52 pubmed
    ..activates transcription of target genes in part through direct interactions with the KIX domain of the coactivator CBP in a phosphorylation-dependent manner...
  55. Pauleau A, Rutschman R, Lang R, Pernis A, Watowich S, Murray P. Enhancer-mediated control of macrophage-specific arginase I expression. J Immunol. 2004;172:7565-73 pubmed
    ..Identification of a powerful extrahepatic regulatory enhancer for arginase I provides potential to manipulate arginase I activity in immune cells while sparing liver urea cycle function. ..
  56. Gueorguiev V, Cheng S, Sabban E. Prolonged activation of cAMP-response element-binding protein and ATF-2 needed for nicotine-triggered elevation of tyrosine hydroxylase gene transcription in PC12 cells. J Biol Chem. 2006;281:10188-95 pubmed
    ..The results suggest that both ATF-2 and CREB mediate activation of TH gene transcription by nicotine. ..
  57. Xu T, Liu Y, Deng Y, Meng J, Li P, Xu X, et al. [Insulin combined with selenium inhibit p38MAPK/CBP pathway and suppresses cardiomyocyte apoptosis in rats with diabetic cardiomyopathy]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2016;32:926-30 pubmed
    ..of insulin in combination with selenium on p38-mitogen-activated protein kinase/CREB-binding protein (p38MAPK/CBP) pathway in rats with diabetic cardiomyopathy...
  58. Davies J, Klein D, Carter D. Selective genomic targeting by FRA-2/FOSL2 transcription factor: regulation of the Rgs4 gene is mediated by a variant activator protein 1 (AP-1) promoter sequence/CREB-binding protein (CBP) mechanism. J Biol Chem. 2011;286:15227-39 pubmed publisher protein complexes at the Rgs4 AP-1R sequence are associated with FRA-2-dependent dismissal of the co-activator, CBP; this provides a mechanistic basis for Rgs4 gene repression...
  59. Chen J, Jiang H, Yang J, Chen S, Xu L. Down-regulation of CREB-binding protein expression blocks thrombin-mediated endothelial activation by inhibiting acetylation of NF-?B. Int J Cardiol. 2012;154:147-52 pubmed publisher
    CREB-binding protein (CBP) belongs to a unique class of transcription co-activators possessing histone acetyltransferase (HAT) activity...
  60. Husse B, Isenberg G. CREB expression in cardiac fibroblasts and CREM expression in ventricular myocytes. Biochem Biophys Res Commun. 2005;334:1260-5 pubmed
    ..Our results suggest that the expression of CREB depends on the cell type and the age of the animal. We discuss that modulation of gene expression as it occurs with a age could be affected by the change within the CREB family members. ..
  61. Burke S, Collier J, Scott D. cAMP opposes the glucose-mediated induction of the L-PK gene by preventing the recruitment of a complex containing ChREBP, HNF4alpha, and CBP. FASEB J. 2009;23:2855-65 pubmed publisher
    ..response element binding protein (ChREBP), hepatic nuclear factor 4alpha (HNF4alpha), and the coactivator CREB binding protein (CBP) are required for the glucose response of the L-PK gene and are recruited to the promoter by glucose...
  62. Kim S, Nian C, Widenmaier S, McIntosh C. Glucose-dependent insulinotropic polypeptide-mediated up-regulation of beta-cell antiapoptotic Bcl-2 gene expression is coordinated by cyclic AMP (cAMP) response element binding protein (CREB) and cAMP-responsive CREB coactivator 2. Mol Cell Biol. 2008;28:1644-56 pubmed
    ..The antiapoptotic effect of GIP in beta cells is therefore partially mediated through a novel mode of transcriptional regulation of Bcl-2 involving cAMP/PKA/AMPK-dependent regulation of CREB/TORC2 activity. ..
  63. Jenkins B, Pullen C, Darimont B. Novel glucocorticoid receptor coactivator effector mechanisms. Trends Endocrinol Metab. 2001;12:122-6 pubmed
    ..The emerging picture shows coactivators as flexible, but precise, coordinators of complex and dynamic networks, in which transcriptional regulation by GR and other NRs is linked to other signaling pathways. ..
  64. Bartsch O, Schmidt S, Richter M, Morlot S, Seemanova E, Wiebe G, et al. DNA sequencing of CREBBP demonstrates mutations in 56% of patients with Rubinstein-Taybi syndrome (RSTS) and in another patient with incomplete RSTS. Hum Genet. 2005;117:485-93 pubmed
    ..The RSTS can be caused by chromosomal microdeletions and molecular mutations in the CREBBP gene; however, relatively few mutations have been reported to date...
  65. von Mikecz A, Zhang S, Montminy M, Tan E, Hemmerich P. CREB-binding protein (CBP)/p300 and RNA polymerase II colocalize in transcriptionally active domains in the nucleus. J Cell Biol. 2000;150:265-73 pubmed
    ..Here we analyzed the nuclear distribution of the transcriptional coactivators CREB-binding protein (CBP)/p300 in situ by confocal laser scanning microscopy, and in vivo complex formation by coimmunoprecipitation...
  66. Mochizuki K, Suruga K, Sakaguchi N, Takase S, Goda T. Major intestinal coactivator p300 strongly activates peroxisome proliferator-activated receptor in intestinal cell line, Caco-2. Gene. 2002;291:271-7 pubmed
    ..encoding the nuclear receptor interaction domains of the two transcriptional coactivators, CREB-binding protein (CBP) and p300...
  67. Benlhabib H, Mendelson C. Epigenetic regulation of surfactant protein A gene (SP-A) expression in fetal lung reveals a critical role for Suv39h methyltransferases during development and hypoxia. Mol Cell Biol. 2011;31:1949-58 pubmed publisher
    ..that the developmental induction of SP-A was associated with increased recruitment of TTF-1, NF-?B, PCAF, and CBP, as well as enhanced acetylation and decreased methylation of histone H3K9 at the TBE...
  68. Ross S, Hill C. How the Smads regulate transcription. Int J Biochem Cell Biol. 2008;40:383-408 pubmed
    ..In this review we focus on the mechanisms whereby the Smads are modified and regulated. We then go on to discuss how the activated Smad complexes regulate transcription. ..
  69. Pradhan A, Liu Y. The calcium-responsive transactivator recruits CREB binding protein to nuclear bodies. Neurosci Lett. 2004;370:191-5 pubmed
    ..of CREST markedly increased the number of nuclear bodies positive for the histone acetyltransferase CREB binding protein (CBP)...
  70. Chmelar R, Buchanan G, Need E, Tilley W, Greenberg N. Androgen receptor coregulators and their involvement in the development and progression of prostate cancer. Int J Cancer. 2007;120:719-33 pubmed
  71. Chen J, Xu L, Chen S, Yang J, Jiang H. Transcriptional regulation of platelet-derived growth factor-B chain by thrombin in endothelial cells: involvement of Egr-1 and CREB-binding protein. Mol Cell Biochem. 2012;366:81-7 pubmed publisher
    ..To evaluate the function of CBP and Egr-1 involved in regulation of PDGF-B, small interfering RNA (siRNA) were used to down-regulate their ..
  72. Coudriet G, He J, Trucco M, Mars W, Piganelli J. Hepatocyte growth factor modulates interleukin-6 production in bone marrow derived macrophages: implications for inflammatory mediated diseases. PLoS ONE. 2010;5:e15384 pubmed publisher
    ..increased retention of the phosphorylated NF?B p65 subunit in the cytoplasm, and an enhanced interaction between CBP and phospho-CREB...
  73. Braganca J, Eloranta J, Bamforth S, Ibbitt J, Hurst H, Bhattacharya S. Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2. J Biol Chem. 2003;278:16021-9 pubmed
    The transcriptional co-activators and histone acetyltransferases p300/CREB-binding protein (CBP) interact with CITED2, a transcription factor AP-2 (TFAP2) co-activator...
  74. Jiang H, Chen J, Wang L, Zhu L, Wen H. Down-regulation of CREB-binding protein expression inhibits thrombin-induced proliferation of endothelial cells: possible relevance to PDGF-B. Cell Biol Int. 2010;34:1155-61 pubmed publisher
    ..b>CBP (CREB-binding protein), which functions as a transcriptional coactivator, links the changes in the extracellular ..
  75. Grummt I. The nucleolus—guardian of cellular homeostasis and genome integrity. Chromosoma. 2013;122:487-97 pubmed
    ..This review focuses on the mechanisms that link cell physiology to rDNA silencing, a prerequisite for nucleolar integrity and cell survival. ..
  76. Cazzalini O, Sommatis S, Tillhon M, Dutto I, Bachi A, Rapp A, et al. CBP and p300 acetylate PCNA to link its degradation with nucleotide excision repair synthesis. Nucleic Acids Res. 2014;42:8433-48 pubmed publisher
    ..Here we report that CREB-binding protein (CBP), and less efficiently p300, acetylated PCNA at lysine (Lys) residues Lys13,14,77 and 80, to promote removal of ..
  77. Marie H, Morishita W, Yu X, Calakos N, Malenka R. Generation of silent synapses by acute in vivo expression of CaMKIV and CREB. Neuron. 2005;45:741-52 pubmed
  78. Kalra I, Alam M, Choudhary P, Pace B. Krüppel-like Factor 4 activates HBG gene expression in primary erythroid cells. Br J Haematol. 2011;154:248-59 pubmed publisher
    ..using the ?-CACCC and ?-CACCC probes demonstrated KLF4 preferentially binds the endogenous ?-CACCC, while CREB binding protein (CREBBP) binding was not selective...
  79. Palomer E, Carretero J, Benvegnù S, Dotti C, Martin M. Neuronal activity controls Bdnf expression via Polycomb de-repression and CREB/CBP/JMJD3 activation in mature neurons. Nat Commun. 2016;7:11081 pubmed publisher
    ..of Bdnf promoters II and VI after neuronal stimulation is dependent on acetylation of histone H3K27 by CREB-p/CBP. Thus, regulatory mechanisms established during development seem to remain after differentiation controlling genes ..
  80. DasBanerjee T, Middleton F, Berger D, Lombardo J, Sagvolden T, Faraone S. A comparison of molecular alterations in environmental and genetic rat models of ADHD: a pilot study. Am J Med Genet B Neuropsychiatr Genet. 2008;147B:1554-63 pubmed publisher
    ..The epigenetic genes Crebbp, Mecp2, and Hdac5 are significantly altered in both models...
  81. Iioka T, Furukawa K, Yamaguchi A, Shindo H, Yamashita S, Tsukazaki T. P300/CBP acts as a coactivator to cartilage homeoprotein-1 (Cart1), paired-like homeoprotein, through acetylation of the conserved lysine residue adjacent to the homeodomain. J Bone Miner Res. 2003;18:1419-29 pubmed
    ..We describe here that the general coactivator p300/CBP controls the transcription activity of Cart1 through acetylation of a lysine residue that is highly conserved in ..
  82. Saifudeen Z, Dipp S, Fan H, El Dahr S. Combinatorial control of the bradykinin B2 receptor promoter by p53, CREB, KLF-4, and CBP: implications for terminal nephron differentiation. Am J Physiol Renal Physiol. 2005;288:F899-909 pubmed
    ..CREB, p53, and KLF-4 on chromatin at the endogenous B2R promoter is developmentally regulated and is accompanied by CBP recruitment and histone hyperacetylation; and 4) CREB and p53 occupancy of the B2R enhancer is cooperative...
  83. Demarest S, Martinez Yamout M, Chung J, Chen H, Xu W, Dyson H, et al. Mutual synergistic folding in recruitment of CBP/p300 by p160 nuclear receptor coactivators. Nature. 2002;415:549-53 pubmed
    ..response is mediated through recruitment of p160 receptor coactivators and the general transcriptional coactivator CBP/p300, which function synergistically to activate transcription...