Gene Symbol: Creb1
Description: cAMP responsive element binding protein 1
Alias: Creb, cyclic AMP-responsive element-binding protein 1, CREB-1, Y protein, cAMP response element binding protein 1
Species: rat
Products:     Creb1

Top Publications

  1. Adamec R, Blundell J, Burton P. Phosphorylated cyclic AMP response element binding protein expression induced in the periaqueductal gray by predator stress: its relationship to the stress experience, behavior and limbic neural plasticity. Prog Neuropsychopharmacol Biol Psychiatry. 2003;27:1243-67 pubmed
    ..Finally, consistent with cat and human studies, the right hemisphere appears particularly important in long-term response to stress. ..
  2. Zhang X, Odom D, Koo S, Conkright M, Canettieri G, Best J, et al. Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues. Proc Natl Acad Sci U S A. 2005;102:4459-64 pubmed
    ..cellular gene expression by means of the PKA-mediated phosphorylation of cAMP-response element binding protein (CREB) at Ser-133...
  3. Hoeger Bement M, Sluka K. Phosphorylation of CREB and mechanical hyperalgesia is reversed by blockade of the cAMP pathway in a time-dependent manner after repeated intramuscular acid injections. J Neurosci. 2003;23:5437-45 pubmed
    ..nociceptive spinal neurons, and phosphorylates the transcription factor cAMP-responsive element binding protein (CREB), which initiates gene transcription...
  4. Ma W, Hatzis C, Eisenach J. Intrathecal injection of cAMP response element binding protein (CREB) antisense oligonucleotide attenuates tactile allodynia caused by partial sciatic nerve ligation. Brain Res. 2003;988:97-104 pubmed
    The transcription factor cAMP responsive element binding protein (CREB) is important in regulating immediate-early genes and some late-effector genes involved in neuroplasticity in response to peripheral injury and stressful insults...
  5. Maldonado C, Cea P, Adasme T, Collao A, Diaz Araya G, Chiong M, et al. IGF-1 protects cardiac myocytes from hyperosmotic stress-induced apoptosis via CREB. Biochem Biophys Res Commun. 2005;336:1112-8 pubmed
    ..IGF-1 induces intracellular Ca(2+) increase, we assessed whether the cyclic AMP response element-binding protein (CREB) is activated by IGF-1 through Ca(2+)-dependent signalling pathways...
  6. Hotte M, Thuault S, Lachaise F, Dineley K, Hemmings H, Nairn A, et al. D1 receptor modulation of memory retrieval performance is associated with changes in pCREB and pDARPP-32 in rat prefrontal cortex. Behav Brain Res. 2006;171:127-33 pubmed
    ..We analyzed the level of phosphorylation of both CREB (cAMP response element binding protein) and DARPP-32 (dopamine and cAMP-regulated phosphoprotein, 32 kDa) in (1) ..
  7. Blundell J, Adamec R. Elevated pCREB in the PAG after exposure to the elevated plus maze in rats previously exposed to a cat. Behav Brain Res. 2006;175:285-95 pubmed
    ..If what happens in animals also occurs in humans, the findings of this study suggest that neural mechanisms of prior traumatic stress may interact with subsequent stress to reinforce psychopathology. ..
  8. Lamas M, Lee Rivera I, Ramirez M, López Colomé A. D-serine regulates CREB phosphorylation induced by NMDA receptor activation in Müller glia from the retina. Neurosci Lett. 2007;427:55-60 pubmed
    ..modulates gene expression in Müller glial cells from the retina through the induction of transcription factor CREB phosphorylation and the expression of the immediate-early gene c-fos...
  9. Erion D, Ignatova I, Yonemitsu S, Nagai Y, Chatterjee P, Weismann D, et al. Prevention of hepatic steatosis and hepatic insulin resistance by knockdown of cAMP response element-binding protein. Cell Metab. 2009;10:499-506 pubmed publisher
    ..Since cAMP response element-binding protein (CREB) is a key regulator of gluconeogenic gene expression, we hypothesized that decreasing hepatic CREB expression would ..

More Information

Publications104 found, 100 shown here

  1. Choi K, Whisler K, Graham D, Self D. Antisense-induced reduction in nucleus accumbens cyclic AMP response element binding protein attenuates cocaine reinforcement. Neuroscience. 2006;137:373-83 pubmed
    ..cyclic AMP signaling and increases the transcriptional activity of cyclic AMP response element binding protein (CREB) in the nucleus accumbens...
  2. Peltier J, O Neill A, Schaffer D. PI3K/Akt and CREB regulate adult neural hippocampal progenitor proliferation and differentiation. Dev Neurobiol. 2007;67:1348-61 pubmed
    ..We also show that activation of the cAMP response element binding protein (CREB), which occurs in cells stimulated by FGF-2, is limited when Akt signaling is inhibited, demonstrating a link ..
  3. Sheng M, Thompson M, Greenberg M. CREB: a Ca(2+)-regulated transcription factor phosphorylated by calmodulin-dependent kinases. Science. 1991;252:1427-30 pubmed
    ..The adenosine 3',5'-monophosphate (cAMP) response element-binding protein (CREB) was shown to function as a Ca(2+)-regulated transcription factor and as a substrate for depolarization-activated ..
  4. Herzig S, Long F, Jhala U, Hedrick S, Quinn R, Bauer A, et al. CREB regulates hepatic gluconeogenesis through the coactivator PGC-1. Nature. 2001;413:179-83 pubmed
    ..Here we show that mice carrying a targeted disruption of the cyclic AMP (cAMP) response element binding (CREB) protein gene, or overexpressing a dominant-negative CREB inhibitor, exhibit fasting hypoglycaemia [corrected] and ..
  5. Miletic G, Hanson E, Miletic V. Brain-derived neurotrophic factor-elicited or sciatic ligation-associated phosphorylation of cyclic AMP response element binding protein in the rat spinal dorsal horn is reduced by block of tyrosine kinase receptors. Neurosci Lett. 2004;361:269-71 pubmed
    Brain-derived neurotrophic factor (BDNF) and cyclic AMP response element binding protein (CREB) may critically contribute to injury-associated plasticity and thus to the development of persistent pain...
  6. Wang L, Dong X, Zhou W, Zeng Q, Mao Y. PDGF-induced proliferation of smooth muscular cells is related to the regulation of CREB phosphorylation and Nur77 expression. J Huazhong Univ Sci Technolog Med Sci. 2011;31:169-173 pubmed publisher
    ..Quantitative PCR and Western blotting were used to determine the Nur77 protein and the CREB phosphorylation level, to observe their relations with PDGF-induced VSMC proliferation...
  7. Kim S, Jang S, Seo S. CREB-mediated Bcl-2 expression contributes to RCAN1 protection from hydrogen peroxide-induced neuronal death. J Cell Biochem. 2013;114:1115-23 pubmed publisher
    ..In contrast, RCAN1 significantly enhanced the activity of cAMP response element-binding protein (CREB). Furthermore, RCAN1 induced the expression of the CREB target gene, Bcl-2...
  8. Sun P, Enslen H, Myung P, Maurer R. Differential activation of CREB by Ca2+/calmodulin-dependent protein kinases type II and type IV involves phosphorylation of a site that negatively regulates activity. Genes Dev. 1994;8:2527-39 pubmed
    The cAMP response element-binding protein (CREB) has been shown to mediate transcriptional activation of genes in response to both cAMP and calcium influx signal transduction pathways...
  9. Nieto Bodelón M, Santpere G, Torrejón Escribano B, Puig B, Ferrer I. Expression of transcription factors c-Fos, c-Jun, CREB-1 and ATF-2, and caspase-3 in relation with abnormal tau deposits in Pick's disease. Acta Neuropathol. 2006;111:341-50 pubmed
    ..factors and members of the caspase family in cell death and cell survival, immunohistochemistry to c-Fos, c-Jun, CREB-1, ATF-2; c-Fos(P), c-Jun(P) and CREB-1(P); and procaspase-8, procaspase-3 and active (cleaved) caspase-3 ..
  10. Tardito D, Tiraboschi E, Kasahara J, Racagni G, Popoli M. Reduced CREB phosphorylation after chronic lithium treatment is associated with down-regulation of CaM kinase IV in rat hippocampus. Int J Neuropsychopharmacol. 2007;10:491-6 pubmed
    ..undertaken to assess the effects of prolonged lithium administration on cAMP responsive element-binding protein (CREB) phosphorylation and CaM kinase IV (CaMKIV), one of the main kinases phosphorylating CREB in neurons following ..
  11. Jiang Y, Fang H, Pang W, Liu J, Lu H, Ma Q, et al. Depressed hippocampal MEK/ERK phosphorylation correlates with impaired cognitive and synaptic function in zinc-deficient rats. Nutr Neurosci. 2011;14:45-50 pubmed publisher
    ..The results implicated a possibility that zinc deficiency-induced cognitive and synaptic impairment may be relevant to the MEK/ERK signaling pathway. ..
  12. Li M, Zhang D, Wang X, Xu T. NR2B-containing NMDA receptors promote neural progenitor cell proliferation through CaMKIV/CREB pathway. Biochem Biophys Res Commun. 2011;411:667-72 pubmed publisher
    ..levels of calcium/calmodulin-dependent protein kinase IV (CaMKIV) and cAMP response element binding protein (CREB) were increased by NMDA treatment, whereas Ro 25-6981 decreased them...
  13. Haghparast A, Fatahi Z, Alamdary S, Reisi Z, Khodagholi F. Changes in the levels of p-ERK, p-CREB, and c-fos in rat mesocorticolimbic dopaminergic system after morphine-induced conditioned place preference: the role of acute and subchronic stress. Cell Mol Neurobiol. 2014;34:277-88 pubmed publisher
    ..Stressful conditions can induce the activation of activate ERK, and its downstream targets, CREB and c-fos, in neural cells. Exposure to opioids has the same effect...
  14. Fukuchi M, Kirikoshi Y, Mori A, Eda R, Ihara D, Takasaki I, et al. Excitatory GABA induces BDNF transcription via CRTC1 and phosphorylated CREB-related pathways in immature cortical cells. J Neurochem. 2014;131:134-46 pubmed publisher
    ..The Bdnf-promoter IV (Bdnf-pIV) was activated by GABA, mainly via cAMP-response element (CRE)/CREB, and this was prevented by the over-expression of a dominant negative CREB...
  15. Arumugam H, Liu X, Colombo P, Corriveau R, Belousov A. NMDA receptors regulate developmental gap junction uncoupling via CREB signaling. Nat Neurosci. 2005;8:1720-6 pubmed
    ..of NMDA glutamate receptors, action potentials and the calcium-cyclic AMP response element binding protein (CREB), and are accelerated by CREB overexpression...
  16. Giampà C, DeMarch Z, D Angelo V, Morello M, Martorana A, Sancesario G, et al. Striatal modulation of cAMP-response-element-binding protein (CREB) after excitotoxic lesions: implications with neuronal vulnerability in Huntington's disease. Eur J Neurosci. 2006;23:11-20 pubmed
    Recent evidence has shown that the activity of cAMP responsive element-binding protein (CREB) and of CREB-binding protein (CBP) is decreased in Huntington's disease (HD) [Steffan et al. (2000)Proc. Natl Acad. Sci...
  17. Ramirez M, Lamas M. NMDA receptor mediates proliferation and CREB phosphorylation in postnatal Müller glia-derived retinal progenitors. Mol Vis. 2009;15:713-21 pubmed
    ..immunostaining, cell counting, and by immunolabeling of phosphorylated cAMP response element binding protein (P-CREB) transcription factor...
  18. Ishizu A, Abe A, Miyatake Y, Baba T, Iinuma C, Tomaru U, et al. Cyclic AMP response element-binding protein is implicated in IL-6 production from arthritic synovial cells. Mod Rheumatol. 2010;20:134-8 pubmed publisher
    ..Cyclic adenosine monophosphate (AMP) response element-binding protein (CREB), a leucine zipper transcription factor, is expressed at a high level in synovial cells of patients with RA...
  19. Liu H, Cao J, Dai P, Zheng G, Zeng Y. [Effects of intrathecal injection of U0126 on the expression of phospho-CREB in spinal cord of morphine-induced withdrawal rats]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2007;23:5-8 pubmed
    To explore effects of intrathecal injection of U0126 on morphine withdrawal response and the spinal Phospho-CREB expression in morphine-induced withdrawal rats...
  20. Li J, Zhao S, Wang P, Yu S, Zheng Z, Xu X. Calcium mediates high glucose-induced HIF-1? and VEGF expression in cultured rat retinal Müller cells through CaMKII-CREB pathway. Acta Pharmacol Sin. 2012;33:1030-6 pubmed publisher
    ..The levels of CaMKII, p-CaMKII, CREB, p-CREB, HIF-1?, and VEGF proteins were measured with Western blotting, while HIF-1á and VEGF mRNA levels were ..
  21. Sallaberry C, Nunes F, Costa M, Fioreze G, Ardais A, Botton P, et al. Chronic caffeine prevents changes in inhibitory avoidance memory and hippocampal BDNF immunocontent in middle-aged rats. Neuropharmacology. 2013;64:153-9 pubmed publisher
    ..solution for 30 days) on short- and long term memory and on levels of hippocampal proBDNF, mature BDNF, TrkB and CREB in young (3 month old) and middle-aged (12 month old) rats...
  22. Rossi M, Spichty M, Attorri L, Distante C, Nervi C, Salvati S, et al. Eicosapentaenoic acid modulates the synergistic action of CREB1 and ID/E2A family members in the rat pup brain and mouse embryonic stem cells. Biochim Biophys Acta Gene Regul Mech. 2017;1860:870-884 pubmed publisher
    ..The current study reveals that EPA modulates the exquisite interplay of interaction of CREB1 with the inhibitor of DNA binding (ID) and E2A family members, thereby delivering mechanistic insights into ..
  23. Redmond L, Kashani A, Ghosh A. Calcium regulation of dendritic growth via CaM kinase IV and CREB-mediated transcription. Neuron. 2002;34:999-1010 pubmed
    We report that CaM kinase IV and CREB play a critical role in mediating calcium-induced dendritic growth in cortical neurons...
  24. Fix C, Jordan C, Cano P, Walker W. Testosterone activates mitogen-activated protein kinase and the cAMP response element binding protein transcription factor in Sertoli cells. Proc Natl Acad Sci U S A. 2004;101:10919-24 pubmed
    ..These newly identified mechanisms of androgen action in Sertoli cells suggest new targets for developing male contraceptive agents. ..
  25. Li J, Li Y, Zhang X, Zhu X, Ge Y, Yuan X. [Changes in the phosphorylation of cAMP response element binding protein in the rat nucleus accumbens after acute and chronic ethanol administration]. Sheng Li Xue Bao. 2003;55:147-52 pubmed
    ..the molecular basis of ethanol dependence, changes in the phosphorylation of cAMP response element binding protein (CREB) in the nucleus accumbens of rats after acute and chronic ethanol administration were detected using ..
  26. Rodriguez A, Ferrer I. Expression of transcription factors CREB and c-Fos in the brains of terminal Creutzfeldt-Jakob disease cases. Neurosci Lett. 2007;421:10-5 pubmed
    Expression levels and localization of transcription factors cAMP response element binding protein (CREB(1) and CREB(2)) and c-Fos, as well as levels of up-stream mitogen-activated protein kinases/extracellular signal-regulated kinases (..
  27. Kodeboyina S, Balamurugan P, Liu L, Pace B. cJun modulates Ggamma-globin gene expression via an upstream cAMP response element. Blood Cells Mol Dis. 2010;44:7-15 pubmed publisher
    ..This effect is achieved via p38 mitogen activated protein kinase (MAPK)-dependent CREB1 and ATF-2 phosphorylation and G-CRE transactivation...
  28. Li X, Zhan X, Liu X, Wang X. CREB is a regulatory target for the protein kinase Akt/PKB in the differentiation of pancreatic ductal cells into islet ?-cells mediated by hepatocyte growth factor. Biochem Biophys Res Commun. 2011;404:711-6 pubmed publisher
    ..The transcription factor CREB is one of the downstream key effectors of the PI3K/Akt signaling pathway...
  29. Chen D, Bambah Mukku D, Pollonini G, Alberini C. Glucocorticoid receptors recruit the CaMKII?-BDNF-CREB pathways to mediate memory consolidation. Nat Neurosci. 2012;15:1707-14 pubmed publisher
    ..long-term inhibitory avoidance memory in rats were coupled to the activation of CaMKII?, TrkB, ERK, Akt, PLC? and CREB, as well as a to a substantial induction of Arc and synaptic GluA1...
  30. Lee B, Sur B, Shim I, Lee H, Hahm D. Baicalin improves chronic corticosterone-induced learning and memory deficits via the enhancement of impaired hippocampal brain-derived neurotrophic factor and cAMP response element-binding protein expression in the rat. J Nat Med. 2014;68:132-43 pubmed publisher
    ..the hippocampal expression of brain-derived neurotrophic factor (BDNF) and cAMP response element-binding protein (CREB) was also investigated. For 21 days, male rats received daily doses of BAI (20, 50, and 100 mg/kg, i.p...
  31. Zuloaga R, Fuentes E, Molina A, Valdés J. The cAMP response element binding protein (CREB) is activated by insulin-like growth factor-1 (IGF-1) and regulates myostatin gene expression in skeletal myoblast. Biochem Biophys Res Commun. 2013;440:258-64 pubmed publisher
    ..Here we examined the activation of CREB transcription factor as downstream targets of IGF-1 during myoblast differentiation and its role as a regulator of ..
  32. Zhou L, Zhu Y. Changes of CREB in rat hippocampus, prefrontal cortex and nucleus accumbens during three phases of morphine induced conditioned place preference in rats. J Zhejiang Univ Sci B. 2006;7:107-13 pubmed
    To investigate the changes in CREB (cAMP response element binding protein) in hippocampus, PFC (prefrontal cortex) and NAc (nucleus accumbens) during three phases of morphine induced CPP (conditioned place preference) in rats, and to ..
  33. Raval A, Saul I, Dave K, DeFazio R, Perez Pinzon M, Bramlett H. Pretreatment with a single estradiol-17beta bolus activates cyclic-AMP response element binding protein and protects CA1 neurons against global cerebral ischemia. Neuroscience. 2009;160:307-18 pubmed publisher
    ..neurons against global cerebral ischemia via activation of the cyclic-AMP response element binding protein (CREB)-mediated signaling cascade...
  34. Leone V, D Angelo D, Ferraro A, Pallante P, Rubio I, Santoro M, et al. A TSH-CREB1-microRNA loop is required for thyroid cell growth. Mol Endocrinol. 2011;25:1819-30 pubmed publisher cAMP-responsive element binding protein (CREB)1, a thyrotropin-activated transcription factor, and that CREB1 binds the regulatory regions of the down-regulated miRNA...
  35. Rehfuss R, Walton K, Loriaux M, Goodman R. The cAMP-regulated enhancer-binding protein ATF-1 activates transcription in response to cAMP-dependent protein kinase A. J Biol Chem. 1991;266:18431-4 pubmed
    ..Of these CRE-binding proteins, only CREB has been shown to be activated by cAMP-dependent protein kinase A (PKA), and as such, CREB represents the only ..
  36. Saxlund M, Sadler Riggleman I, Skinner M. Role of basic helix-loop-helix (bHLH) and CREB transcription factors in the regulation of Sertoli cell androgen-binding protein expression. Mol Reprod Dev. 2004;68:269-78 pubmed the binding and interactions of basic helix-loop-helix (bHLH) and cAMP response element binding protein (CREB) to an E-box and cyclic AMP response element (CRE), respectively...
  37. McCauslin C, Heath V, Colangelo A, Malik R, Lee S, Mallei A, et al. CAAT/enhancer-binding protein delta and cAMP-response element-binding protein mediate inducible expression of the nerve growth factor gene in the central nervous system. J Biol Chem. 2006;281:17681-8 pubmed
    ..we have further defined the function of C/EBPdelta and identified a role for cAMP response element-binding protein (CREB) in NGF transcription...
  38. Li X, Liu R, Cao H, Li J. [Effects of curcumin on behavior and p-ERK, p-CREB, c-fos expression in dorsal root ganglion in chronic constrictive injury rats]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2009;25:418-22 pubmed
    To investigate the effects of curcumin on the behavior of chronic constrictive injury (CCI) rats and the p-ERK, p-CREB, c-fos expression in dorsal root ganglion...
  39. Liu Y, Zhao Z, Yang F, Gao Y, Song J, Wan Y. microRNA-181a is involved in insulin-like growth factor-1-mediated regulation of the transcription factor CREB1. J Neurochem. 2013;126:771-80 pubmed publisher
    ..studies have found that microRNA-181a is rich in mature nerve cells, and bioinformatics analysis shows that the CREB1 mRNA 3'-untranslated region (3'UTR) contains complementary sequence to the miR-181a seed region...
  40. Bustos F, Jury N, Martinez P, Ampuero E, Campos M, Abarzúa S, et al. NMDA receptor subunit composition controls dendritogenesis of hippocampal neurons through CAMKII, CREB-P, and H3K27ac. J Cell Physiol. 2017;232:3677-3692 pubmed publisher
    ..Among them, the activation of cAMP response element-binding protein (CREB-P) pathway triggers a plasticity-specific transcriptional program through unknown epigenetic mechanisms...
  41. Brightwell J, Gallagher M, Colombo P. Hippocampal CREB1 but not CREB2 is decreased in aged rats with spatial memory impairments. Neurobiol Learn Mem. 2004;81:19-26 pubmed
    ..Members of the CREB family of transcription factors contain enhancers (i.e., CREB1) and repressors (i.e...
  42. Zubenko G, Hughes H. Effects of the G(-656)A variant on CREB1 promoter activity in a glial cell line: interactions with gonadal steroids and stress. Am J Med Genet B Neuropsychiatr Genet. 2008;147B:579-85 pubmed publisher
    ..Previous genetic studies have revealed significant evidence of linkage of the CREB1 region to mood disorders among women from families with recurrent, early-onset MDD (RE-MDD), a severe and familial ..
  43. Spencer T, Mellado W, Filbin M. BDNF activates CaMKIV and PKA in parallel to block MAG-mediated inhibition of neurite outgrowth. Mol Cell Neurosci. 2008;38:110-6 pubmed publisher
    ..and requires activation of several signaling pathways which converge at activation of the transcription factor, CREB. Here, we show that calcium/calmodulin-dependent kinase IV (CaMKIV) is necessary for the neurotrophin-induced ..
  44. Giampà C, Middei S, Patassini S, Borreca A, Marullo F, Laurenti D, et al. Phosphodiesterase type IV inhibition prevents sequestration of CREB binding protein, protects striatal parvalbumin interneurons and rescues motor deficits in the R6/2 mouse model of Huntington's disease. Eur J Neurosci. 2009;29:902-10 pubmed publisher
    The phosphodiesterase type IV inhibitor rolipram increases cAMP response element-binding protein (CREB) phosphorylation and exerts neuroprotective effects in both the quinolinic acid rat model of Huntington's disease (DeMarch et al...
  45. Schauer I, Knaub L, Lloyd M, Watson P, Gliwa C, Lewis K, et al. CREB downregulation in vascular disease: a common response to cardiovascular risk. Arterioscler Thromb Vasc Biol. 2010;30:733-41 pubmed publisher
    ..the impact of low-density lipoprotein (LDL), an established mediator of atherosclerosis, on the transcription factor cAMP-response element-binding protein (CREB), which is a regulator of vascular smooth muscle cell (VSMC) quiescence.
  46. Yu X, Curlik D, Oh M, Yin J, Disterhoft J. CREB overexpression in dorsal CA1 ameliorates long-term memory deficits in aged rats. elife. 2017;6: pubmed publisher
    ..Increasing activity of the transcription factor cAMP response element-binding protein (CREB) in young adult rodents facilitates cognition, and increases intrinsic excitability...
  47. Kruglov E, Ananthanarayanan M, Sousa P, Weerachayaphorn J, Guerra M, Nathanson M. Type 2 inositol trisphosphate receptor gene expression in hepatocytes is regulated by cyclic AMP. Biochem Biophys Res Commun. 2017;486:659-664 pubmed publisher
    ..Analysis of the IP3R2 promoter revealed five CREs, and CREB potently increased promoter activity...
  48. Chartoff E, Papadopoulou M, Konradi C, Carlezon W. Dopamine-dependent increases in phosphorylation of cAMP response element binding protein (CREB) during precipitated morphine withdrawal in primary cultures of rat striatum. J Neurochem. 2003;87:107-18 pubmed
    ..consequence of up-regulated cAMP signaling is increased phosphorylation of cAMP response element binding protein (CREB), a transcription factor that may regulate neuroadaptations related to morphine dependence...
  49. Lonze B, Riccio A, Cohen S, Ginty D. Apoptosis, axonal growth defects, and degeneration of peripheral neurons in mice lacking CREB. Neuron. 2002;34:371-85 pubmed
    CRE-binding protein (CREB) belongs to a family of transcription factors that mediates stimulus-dependent gene expression in neuronal and non-neuronal cells...
  50. Cox L, Hengst U, Gurskaya N, Lukyanov K, Jaffrey S. Intra-axonal translation and retrograde trafficking of CREB promotes neuronal survival. Nat Cell Biol. 2008;10:149-59 pubmed publisher
    ..that axons of developing mammalian neurons contain mRNA encoding the cAMP-responsive element (CRE)-binding protein (CREB)...
  51. Lund I, Hu Y, Raol Y, Benham R, Faris R, Russek S, et al. BDNF selectively regulates GABAA receptor transcription by activation of the JAK/STAT pathway. Sci Signal. 2008;1:ra9 pubmed publisher
    ..phosphorylation of STAT3 cause the adenosine 3',5'-monophosphate (cAMP) response element-binding protein (CREB) family member ICER (inducible cAMP early repressor) to bind with phosphorylated CREB at the Gabra1:CRE site...
  52. ROGGE G, Jones D, Green T, Nestler E, Kuhar M. Regulation of CART peptide expression by CREB in the rat nucleus accumbens in vivo. Brain Res. 2009;1251:42-52 pubmed publisher
    ..Since over expression of CREB was shown to decrease cocaine-mediated reward, we hypothesized that CART could be a target gene for CREB in the NAc ..
  53. Hang L, Yang J, Shao D, Chen Z, Wang H. Involvement of spinal PKA/CREB signaling pathway in the development of bone cancer pain. Pharmacol Rep. 2013;65:710-6 pubmed
    It has been shown that spinal PKA/CREB signaling pathway is involved in neuropathic and inflammatory pain, but its effects on bone cancer pain have not previously been investigated...
  54. Tischkau S, Mitchell J, Tyan S, Buchanan G, Gillette M. Ca2+/cAMP response element-binding protein (CREB)-dependent activation of Per1 is required for light-induced signaling in the suprachiasmatic nucleus circadian clock. J Biol Chem. 2003;278:718-23 pubmed
    ..Thus, Ca(2+)/cAMP response element-binding protein (CREB) and Per1 are integral components of the pathway transducing light-stimulated GLU neurotransmission into phase ..
  55. Towns R, Azhar S, Peegel H, Menon K. LH/hCG-stimulated androgen production and selective HDL-cholesterol transport are inhibited by a dominant-negative CREB construct in primary cultures of rat theca-interstitial cells. Endocrine. 2005;27:269-77 pubmed
    ..Ad)-mediated introduction of a dominant-negative analog of cyclic AMP response element binding protein (A-CREB) inhibits the stimulatory effect of LH/hCG on the selective uptake of high-density lipoprotein (HDL)-cholesterol ..
  56. Lee C, Kim N, Choi H, Sun Y, Nam J, Rhee H, et al. Lysophosphatidic acid-induced c-fos up-regulation involves cyclic AMP response element-binding protein activated by mitogen- and stress-activated protein kinase-1. J Cell Biochem. 2008;104:785-94 pubmed publisher
    ..Recently, we reported that LPA stimulates cAMP response element-binding protein (CREB) through mitogen- and stress-activated protein kinase-1 (MSK1)...
  57. Chiamulera C, Di Chio M, Tedesco V, Cantù C, Formaggio E, Fumagalli G. Nicotine-induced phosphorylation of phosphorylated cyclic AMP response element-binding protein (pCREB) in hippocampal neurons is potentiated by agrin. Neurosci Lett. 2008;442:234-8 pubmed publisher
    ..These findings suggest that increasing the concentration of an ECM molecule, i.e. agrin, may enhance nicotine effects on pCREB and that both MAPK and CaMKII signalling may play a regulatory role. ..
  58. Hao J, Galindo C, Tran T, Sawyer D. Neuregulin-1? induces embryonic stem cell cardiomyogenesis via ErbB3/ErbB2 receptors. Biochem J. 2014;458:335-41 pubmed publisher
    ..PI3K (phosphoinositide 3-kinase), a known mediator of the NRG-1?/ErbB signalling pathway, as well as activation of CREB (cAMP-response-element-binding protein)...
  59. Coria Lucero C, Golini R, Ponce I, Deyurka N, Anzulovich A, Delgado S, et al. Rhythmic Bdnf and TrkB expression patterns in the prefrontal cortex are lost in aged rats. Brain Res. 2016;1653:51-58 pubmed publisher
    ..In this work, our objectives were: 1) to investigate whether Creb1, Bdnf and TrkB genes display endogenous circadian expression rhythms, in the prefrontal cortex of rats maintained ..
  60. Lee J, Kim C, Simon D, Aminova L, Andreyev A, Kushnareva Y, et al. Mitochondrial cyclic AMP response element-binding protein (CREB) mediates mitochondrial gene expression and neuronal survival. J Biol Chem. 2005;280:40398-401 pubmed
    Cyclic AMP response element-binding protein (CREB) is a widely expressed transcription factor whose role in neuronal protection is now well established...
  61. Li F, Zhang Y, Jing X, Yan C, Shen X. Memory impairment in early sensorimotor deprived rats is associated with suppressed hippocampal neurogenesis and altered CREB signaling. Behav Brain Res. 2010;207:458-65 pubmed publisher
    ..In this study we tested the hypothesis that altered cAMP response element binding (CREB) protein induction and activity-regulated cytoskeletal-associated gene (Arc) expression may underlie the ..
  62. Trofimiuk E, Holownia A, Braszko J. Activation of CREB by St. John's wort may diminish deletorious effects of aging on spatial memory. Arch Pharm Res. 2010;33:469-77 pubmed publisher
    ..impairments by increasing the levels of cyclic adenosine 3', 5'-monophosphate response element binding protein (CREB) and phosphorylated CREB (pCREB) in hippocampus...
  63. Ran I, Laplante I, Lacaille J. CREB-dependent transcriptional control and quantal changes in persistent long-term potentiation in hippocampal interneurons. J Neurosci. 2012;32:6335-50 pubmed publisher
    ..approaches to reveal the molecular mechanisms of transcriptional control via cAMP response element-binding protein (CREB) during induction, and (2) quantal analysis to identify synaptic changes during maintenance of cL-LTP(mGluR1) in ..
  64. Wang Y, Hu Z, Liu Z, Chen R, Peng H, Guo J, et al. MTOR inhibition attenuates DNA damage and apoptosis through autophagy-mediated suppression of CREB1. Autophagy. 2013;9:2069-86 pubmed publisher
    ..cAMP response element-binding protein 1 (CREB1), a nuclear transcription factor that regulates genes involved in survival and death, was positively regulated by ..
  65. Lu K, Huang T, Wang J, You Y, Chou J, Chan M, et al. NKCC1 mediates traumatic brain injury-induced hippocampal neurogenesis through CREB phosphorylation and HIF-1α expression. Pflugers Arch. 2015;467:1651-61 pubmed publisher
    ..The TBI-associated alternations in the expression of NKCC1, HIF-1α, VEGF, MAPK cascade, and CREB phosphorylation were analyzed by Western blot...
  66. Thomson D, Herway S, Fillmore N, Kim H, Brown J, Barrow J, et al. AMP-activated protein kinase phosphorylates transcription factors of the CREB family. J Appl Physiol (1985). 2008;104:429-38 pubmed
    ..Using radioisotopic kinase assays, we found that recombinant and rat liver and muscle AMPK phosphorylated CREB1 at the same site as cAMP-dependent protein kinase (PKA)...
  67. Carloni S, Girelli S, Buonocore G, Longini M, Balduini W. Simvastatin acutely reduces ischemic brain damage in the immature rat via Akt and CREB activation. Exp Neurol. 2009;220:82-9 pubmed publisher
    ..Sim increased both Akt and CREB phosphorylation in neuronal cells and treatment with wortmannin completely blocked neuroprotection and p-Akt...
  68. Diamantopoulou A, Stamatakis A, Panagiotaropoulos T, Stylianopoulou F. Reward or its denial during the neonatal period affects adult spatial memory and hippocampal phosphorylated cAMP response element-binding protein levels of both the neonatal and adult rat. Neuroscience. 2011;181:89-99 pubmed publisher
    ..Furthermore, our data document a role of plasticity molecules like pCREB in mediating hippocampal dependent learning and detection of novelty not only in adulthood, but also more importantly in the neonatal period of the rat. ..
  69. Lubelski D, Ponzio T, Gainer H. Effects of A-CREB, a dominant negative inhibitor of CREB, on the expression of c-fos and other immediate early genes in the rat SON during hyperosmotic stimulation in vivo. Brain Res. 2012;1429:18-28 pubmed publisher
    ..These increases have usually been attributed to action of the cyclic-AMP Response Element Binding Protein (CREB)...
  70. Chen Y, Hsu W, Ma Y, Tai D, Lee E. CREB SUMOylation by the E3 ligase PIAS1 enhances spatial memory. J Neurosci. 2014;34:9574-89 pubmed publisher
    ..Here, we found that CREB1?, the short isoform of CREB, could be sumoylated by the small ubiquitin-like modifier (SUMO) E3 ligase protein ..
  71. Dworet J, Meinkoth J. Interference with 3',5'-cyclic adenosine monophosphate response element binding protein stimulates apoptosis through aberrant cell cycle progression and checkpoint activation. Mol Endocrinol. 2006;20:1112-20 pubmed
    ..Given the important role of cAMP response element binding protein (CREB) in mediating the transcriptional effects of protein kinase A, we explored whether interference with CREB family ..
  72. Ishida M, Mitsui T, Yamakawa K, Sugiyama N, Takahashi W, Shimura H, et al. Involvement of cAMP response element-binding protein in the regulation of cell proliferation and the prolactin promoter of lactotrophs in primary culture. Am J Physiol Endocrinol Metab. 2007;293:E1529-37 pubmed
    ..The PKA-downstream transcription factor cAMP response element (CRE)-binding protein (CREB) is an integrating molecule that is also activated by many other protein kinase pathways...
  73. Brightwell J, Smith C, Neve R, Colombo P. Transfection of mutant CREB in the striatum, but not the hippocampus, impairs long-term memory for response learning. Neurobiol Learn Mem. 2008;89:27-35 pubmed
    ..that rats using a response strategy to solve a cross maze task showed sustained phosphorylation of striatal CREB [Colombo, P. J., Brightwell, J. J., & Countryman, R. A. (2003)...
  74. Ma X, Zhang H, Yuan L, Jing H, Thacker P, Li D. CREBL2, interacting with CREB, induces adipogenesis in 3T3-L1 adipocytes. Biochem J. 2011;439:27-38 pubmed publisher
    ..In the present paper, we report that CREBL2 [CREB (cAMP-response-element-binding protein)-like 2], a novel bZIP_1 protein, is up-regulated during MDI-induced ..
  75. Chang S, Hwang C, Yin J, Chen S, Yang D. Oncostatin M-dependent Mcl-1 induction mediated by JAK1/2-STAT1/3 and CREB contributes to bioenergetic improvements and protective effects against mitochondrial dysfunction in cortical neurons. Biochim Biophys Acta. 2015;1853:2306-25 pubmed publisher
    ..signal transducer and activator of transcription-3 (STAT3), STAT1, and cAMP-response element-binding protein (CREB)...
  76. Griesbach G, Gomez Pinilla F, Hovda D. Time window for voluntary exercise-induced increases in hippocampal neuroplasticity molecules after traumatic brain injury is severity dependent. J Neurotrauma. 2007;24:1161-71 pubmed
    ..Rats were sacrificed at PID 7, 21, or 37. BDNF, synapsin I, and cyclic AMP response element binding protein (CREB) were analyzed within the ipsilateral hippocampus...
  77. Reynolds J, McCalmon S, Donaghey J, Naya F. Deregulated protein kinase A signaling and myospryn expression in muscular dystrophy. J Biol Chem. 2008;283:8070-4 pubmed publisher
    ..Our findings reveal for the first time abnormalities in the PKA signal transduction pathway and myospryn regulation in dystrophin deficiency. ..
  78. Chava K, Karpurapu M, Wang D, Bhanoori M, Kundumani Sridharan V, Zhang Q, et al. CREB-mediated IL-6 expression is required for 15(S)-hydroxyeicosatetraenoic acid-induced vascular smooth muscle cell migration. Arterioscler Thromb Vasc Biol. 2009;29:809-15 pubmed publisher
    ..cAMP response element binding protein (CREB) has been implicated in the regulation of VSMC growth and motility in response to thrombin and angiotensin II...
  79. Riccio A, Alvania R, Lonze B, Ramanan N, Kim T, Huang Y, et al. A nitric oxide signaling pathway controls CREB-mediated gene expression in neurons. Mol Cell. 2006;21:283-94 pubmed
    Prevailing views of neurotrophin action hold that the transcription factor CREB is constitutively bound to target genes with transcriptional activation occurring via CREB phosphorylation...
  80. Sekeres M, Mercaldo V, Richards B, Sargin D, Mahadevan V, Woodin M, et al. Increasing CRTC1 function in the dentate gyrus during memory formation or reactivation increases memory strength without compromising memory quality. J Neurosci. 2012;32:17857-68 pubmed publisher
    ..2004), disrupting the function of the transcription factor CREB impairs both processes (Kida et al., 2002; Mamiya et al., 2009)...
  81. Kemmerling U, Muñoz P, Müller M, Sanchez G, Aylwin M, Klann E, et al. Calcium release by ryanodine receptors mediates hydrogen peroxide-induced activation of ERK and CREB phosphorylation in N2a cells and hippocampal neurons. Cell Calcium. 2007;41:491-502 pubmed
    ..microM H2O2 elicited calcium signals, increased ryanodine receptor S-glutathionylation, and enhanced both ERK and CREB phosphorylation. In mouse hippocampal slices, H2O2 (1 microM) also stimulated ERK and CREB phosphorylation...
  82. Wheeler D, Barrett C, Groth R, Safa P, Tsien R. CaMKII locally encodes L-type channel activity to signal to nuclear CREB in excitation-transcription coupling. J Cell Biol. 2008;183:849-63 pubmed publisher
  83. Hua P, Feng W, Rezonzew G, Chumley P, Jaimes E. The transcription factor ETS-1 regulates angiotensin II-stimulated fibronectin production in mesangial cells. Am J Physiol Renal Physiol. 2012;302:F1418-29 pubmed publisher
    ..In addition, we identified the essential role of CREB and its coactivator p300 on the transcriptional activation of fibronectin by ETS-1...
  84. Bendova Z, Sladek M, Svobodova I. The expression of NR2B subunit of NMDA receptor in the suprachiasmatic nucleus of Wistar rats and its role in glutamate-induced CREB and ERK1/2 phosphorylation. Neurochem Int. 2012;61:43-7 pubmed publisher
    ..of extracellular-signal-regulated kinases 1/2 (ERK1/2) and cyclic AMP-responsive element binding protein (CREB)...
  85. Zhou X, Li J, Yang W. Calcium/calmodulin-dependent protein kinase II regulates cyclooxygenase-2 expression and prostaglandin E2 production by activating cAMP-response element-binding protein in rat peritoneal macrophages. Immunology. 2014;143:287-99 pubmed publisher
    ..activating Ca(2+) /Calmodulin (CaM)-dependent protein kinase II (CaMKII) and cAMP-response element-binding protein (CREB) in rat peritoneal macrophages...
  86. Fentzke R, Korcarz C, Lang R, Lin H, Leiden J. Dilated cardiomyopathy in transgenic mice expressing a dominant-negative CREB transcription factor in the heart. J Clin Invest. 1998;101:2415-26 pubmed
    ..Here we show that transgenic mice expressing a dominant-negative form of the CREB transcription factor (CREBA133) under the control of the cardiac myocyte-specific alpha-MHC promoter develop ..
  87. Terasaki Y, Sasaki T, Yagita Y, Okazaki S, Sugiyama Y, Oyama N, et al. Activation of NR2A receptors induces ischemic tolerance through CREB signaling. J Cereb Blood Flow Metab. 2010;30:1441-9 pubmed publisher
    ..We focused on the contribution of NR2A and cyclic-AMP response element (CRE)-binding protein (CREB) signaling to ischemic tolerance using primary cortical neurons...
  88. Ozgen N, Lau D, Shlapakova I, Sherman W, Feinmark S, Danilo P, et al. Determinants of CREB degradation and KChIP2 gene transcription in cardiac memory. Heart Rhythm. 2010;7:964-70 pubmed publisher a decrease in its transcription factor, cyclic adenosine monophosphate response element binding protein (CREB). This study sought to determine the mechanisms responsible for the CREB decrease that is initiated by LVP. CM was qu..
  89. Yang J, Tadokoro T, Keijzers G, Mattson M, Bohr V. Neurons efficiently repair glutamate-induced oxidative DNA damage by a process involving CREB-mediated up-regulation of apurinic endonuclease 1. J Biol Chem. 2010;285:28191-9 pubmed publisher
    ..A cAMP-response element-binding protein (CREB) binding sequence is present in the Ape1 gene (encodes APE1 protein) promoter and treatment of neurons with a Ca(2+)..
  90. Zhang E, Liu Y, Dentin R, Pongsawakul P, Liu A, Hirota T, et al. Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis. Nat Med. 2010;16:1152-6 pubmed publisher
    ..hepatic gluconeogenesis, trigger the cAMP-mediated phosphorylation of cAMP response element-binding protein (Creb) and dephosphorylation of the Creb-regulated transcription coactivator-2 (Crtc2)--two key transcriptional ..
  91. Neuschäfer Rube F, Lieske S, Kuna M, Henkel J, Perry R, Erion D, et al. The mammalian INDY homolog is induced by CREB in a rat model of type 2 diabetes. Diabetes. 2014;63:1048-57 pubmed publisher physiological concentrations of glucagon via a cAMP-dependent and cAMP-responsive element-binding protein (CREB)-dependent mechanism in primary rat hepatocytes...
  92. Xu Y, Ku B, Tie L, Yao H, Jiang W, Ma X, et al. Curcumin reverses the effects of chronic stress on behavior, the HPA axis, BDNF expression and phosphorylation of CREB. Brain Res. 2006;1122:56-64 pubmed
    ..BDNF) protein levels and reduced the ratio of phosphorylated cAMP response element-binding protein (pCREB) to CREB levels (pCREB/CREB) in the hippocampus and frontal cortex of stressed rats...