Cpeb1

Summary

Gene Symbol: Cpeb1
Description: cytoplasmic polyadenylation element binding protein 1
Alias: cytoplasmic polyadenylation element-binding protein 1, CPE-BP1, CPE-binding protein 1, CPEB, CPEB-1
Species: rat
Products:     Cpeb1

Top Publications

  1. Alarcon J, Hodgman R, Theis M, Huang Y, Kandel E, Richter J. Selective modulation of some forms of schaffer collateral-CA1 synaptic plasticity in mice with a disruption of the CPEB-1 gene. Learn Mem. 2004;11:318-27 pubmed
    b>CPEB-1 is a sequence-specific RNA binding protein that stimulates the polyadenylation-induced translation of mRNAs containing the cytoplasmic polyadenylation element (CPE)...
  2. Kim K, Hyun Joo S, Shin C. CPEB1 modulates lipopolysaccharide-mediated iNOS induction in rat primary astrocytes. Biochem Biophys Res Commun. 2011;409:687-92 pubmed publisher
    ..In this study, we investigated the role of cytoplasmic polyadenylation element binding protein 1 (CPEB1) in the regulation of inflammatory responses in a model of reactive gliosis, ..
  3. Kan M, Oruganty Das A, Cooper Morgan A, Jin G, Swanger S, Bassell G, et al. CPEB4 is a cell survival protein retained in the nucleus upon ischemia or endoplasmic reticulum calcium depletion. Mol Cell Biol. 2010;30:5658-71 pubmed publisher
    The RNA binding protein CPEB (cytoplasmic polyadenylation element binding) regulates cytoplasmic polyadenylation and translation in germ cells and the brain. In neurons, CPEB is detected at postsynaptic sites, as well as in the cell body...
  4. Tay J, Richter J. Germ cell differentiation and synaptonemal complex formation are disrupted in CPEB knockout mice. Dev Cell. 2001;1:201-13 pubmed
    b>CPEB is a sequence-specific RNA binding protein that regulates translation during vertebrate oocyte maturation...
  5. Cai C, Tamai K, Molyneaux K. KHDC1B is a novel CPEB binding partner specifically expressed in mouse oocytes and early embryos. Mol Biol Cell. 2010;21:3137-48 pubmed publisher
    ..Finally, KHDC1B levels and binding partners were shown to fluctuate with the cell cycle. KHDC1B, via its interaction with mCEPB1, may regulate translation of mRNA targets required for oocyte maturation. ..
  6. Oe S, Yoneda Y. Cytoplasmic polyadenylation element-like sequences are involved in dendritic targeting of BDNF mRNA in hippocampal neurons. FEBS Lett. 2010;584:3424-30 pubmed publisher
    ..In addition to the interaction with cytoplasmic polyadenylation element binding protein-1 (CPEB-1), depolarization enhanced CPEB-1 recruitment to the activity-dependent targeting element...
  7. Cao Q, Huang Y, Kan M, Richter J. Amyloid precursor proteins anchor CPEB to membranes and promote polyadenylation-induced translation. Mol Cell Biol. 2005;25:10930-9 pubmed
    The cytoplasmic polyadenylation element (CPE) binding factor, CPEB, is a sequence-specific RNA binding protein that controls polyadenylation-induced translation in germ cells and at postsynaptic sites of neurons...
  8. Tay J, Hodgman R, Sarkissian M, Richter J. Regulated CPEB phosphorylation during meiotic progression suggests a mechanism for temporal control of maternal mRNA translation. Genes Dev. 2003;17:1457-62 pubmed
    b>CPEB is an mRNA-binding protein that stimulates polyadenylation-induced translation of maternal mRNA once it is phosphorylated on Ser 174 or Thr 171 (species-dependent)...
  9. Wu L, Wells D, Tay J, Mendis D, Abbott M, Barnitt A, et al. CPEB-mediated cytoplasmic polyadenylation and the regulation of experience-dependent translation of alpha-CaMKII mRNA at synapses. Neuron. 1998;21:1129-39 pubmed
    ..translation of oocyte mRNAs requires the cis-acting CPE sequence and the CPE-binding protein CPEB. CPEB is also present in the dendritic layers of the hippocampus, at synapses in cultured neurons, and in ..

More Information

Publications21

  1. Hägele S, Kuhn U, Böning M, Katschinski D. Cytoplasmic polyadenylation-element-binding protein (CPEB)1 and 2 bind to the HIF-1alpha mRNA 3'-UTR and modulate HIF-1alpha protein expression. Biochem J. 2009;417:235-46 pubmed publisher
    ..Overexpression of CPEB1 and CPEB2 affected HIF-1alpha protein levels mediated by the 3'-UTR of HIF-1alpha mRNA...
  2. Kundel M, Jones K, Shin C, Wells D. Cytoplasmic polyadenylation element-binding protein regulates neurotrophin-3-dependent beta-catenin mRNA translation in developing hippocampal neurons. J Neurosci. 2009;29:13630-9 pubmed publisher
    ..is protein synthesis dependent and requires the activity of cytoplasmic polyadenylation element-binding protein-1 (CPEB1), an mRNA-binding protein that regulates mRNA translation...
  3. Jones K, Korb E, Kundel M, Kochanek A, Kabraji S, McEvoy M, et al. CPEB1 regulates beta-catenin mRNA translation and cell migration in astrocytes. Glia. 2008;56:1401-13 pubmed publisher
    ..We now show that the CPE-binding protein (CPEB1) is expressed in astrocytes and that translation of beta-catenin mRNA is regulated by CPEB1...
  4. Huang Y, Carson J, Barbarese E, Richter J. Facilitation of dendritic mRNA transport by CPEB. Genes Dev. 2003;17:638-53 pubmed
    ..Here, we demonstrate that the CPE and its binding protein CPEB facilitate mRNA transport to dendrites...
  5. Kim K, Oh W, Ko K, Shin C, Wells D. Cyclin B1 expression regulated by cytoplasmic polyadenylation element binding protein in astrocytes. J Neurosci. 2011;31:12118-28 pubmed publisher
    ..In rat astrocytes, we now show that the mRNA binding protein cytoplasmic polyadenylation element binding protein 1 (CPEB1) is associated with cyclin B1 mRNA and that this interaction is enriched at the ..
  6. Grønli J, Dagestad G, Milde A, Murison R, Bramham C. Post-transcriptional effects and interactions between chronic mild stress and acute sleep deprivation: regulation of translation factor and cytoplasmic polyadenylation element-binding protein phosphorylation. Behav Brain Res. 2012;235:251-62 pubmed publisher
    ..phosphorylation of a major regulatory RNA-binding protein, cytoplasmic polyadenylation element-binding protein (CPEB) in the combined treatment. CMS had no effect on plasma corticosterone, but led to disruption of sleep...
  7. Kim K, Kim J, Choi C, Han S, Cheong J, Han S, et al. A role of CPEB1 in the modulation of proliferation and neuronal maturation of rat primary neural progenitor cells. Neurochem Res. 2013;38:1960-72 pubmed publisher
    Cytoplasmic polyadenylation binding protein 1 (CPEB1) is a RNA binding protein, which regulates translation of target mRNAs by regulating polyadenylation status...
  8. Huang Y, Kan M, Lin C, Richter J. CPEB3 and CPEB4 in neurons: analysis of RNA-binding specificity and translational control of AMPA receptor GluR2 mRNA. EMBO J. 2006;25:4865-76 pubmed
    b>CPEB is a sequence-specific RNA-binding protein that promotes polyadenylation-induced translation in oocytes and neurons. Vertebrates contain three additional genes that encode CPEB-like proteins, all of which are expressed in the brain...
  9. Bogen O, Alessandri Haber N, Chu C, Gear R, Levine J. Generation of a pain memory in the primary afferent nociceptor triggered by PKC? activation of CPEB. J Neurosci. 2012;32:2018-26 pubmed publisher
    ..injections of antisense oligodeoxynucleotides for the cytoplasmic polyadenylation element binding protein (CPEB) mRNA, a master regulator of protein translation that coimmunoprecipitated with PKC? and is almost exclusively ..
  10. Udagawa T, Swanger S, Takeuchi K, Kim J, Nalavadi V, Shin J, et al. Bidirectional control of mRNA translation and synaptic plasticity by the cytoplasmic polyadenylation complex. Mol Cell. 2012;47:253-66 pubmed publisher
    ..b>CPEB is an RNA-binding protein that regulates local translation in dendrites...
  11. Kochanek D, Wells D. CPEB1 regulates the expression of MTDH/AEG-1 and glioblastoma cell migration. Mol Cancer Res. 2013;11:149-60 pubmed publisher
    Cytoplasmic polyadenylation element-binding protein 1 (CPEB1) is an mRNA-binding protein present in both neurons and glia. CPEB1 is capable of both repressing mRNA translation and activating it depending upon its phosphorylation state...
  12. Calderone V, Gallego J, Fernández Miranda G, Garcia Pras E, Maillo C, Berzigotti A, et al. Sequential Functions of CPEB1 and CPEB4 Regulate Pathologic Expression of Vascular Endothelial Growth Factor and Angiogenesis in Chronic Liver Disease. Gastroenterology. 2016;150:982-97.e30 pubmed publisher
    ..the post-transcriptional regulation of VEGF by the cytoplasmic polyadenylation element-binding proteins CPEB1 and CPEB4 during development of portal hypertension and liver disease...