Gene Symbol: cortistatin
Description: cortistatin
Alias: cortistatin, Preprocortistatin
Species: rat
Products:     cortistatin

Top Publications

  1. Robas N, Mead E, Fidock M. MrgX2 is a high potency cortistatin receptor expressed in dorsal root ganglion. J Biol Chem. 2003;278:44400-4 pubmed
    ..Here we describe cortistatin, a neuropeptide for which no specific receptor has been identified previously, as a high potency ligand at ..
  2. Liu Y, Lin F, Fu Y, Chen W, Liu W, Chi J, et al. Cortistatin inhibits calcification of vascular smooth muscle cells by depressing osteoblastic differentiation and endoplasmic reticulum stress. Amino Acids. 2016;48:2671-2681 pubmed
    ..b>Cortistatin (CST), a novel bio-active peptide, has been shown to exert multiple protective effects on the cardiovascular ..
  3. de Lecea L, Criado J, Prospero Garcia O, Gautvik K, Schweitzer P, Danielson P, et al. A cortical neuropeptide with neuronal depressant and sleep-modulating properties. Nature. 1996;381:242-5 pubmed
    ..Here we report the cloning and initial characterization of cortistatin, a neuropeptide that exhibits strong structural similarity to somatostatin, although it is the product of a ..
  4. Deghenghi R, Avallone R, Torsello A, Muccioli G, Ghigo E, Locatelli V. Growth hormone-inhibiting activity of cortistatin in the rat. J Endocrinol Invest. 2001;24:RC31-3 pubmed
    b>Cortistatin-14 (CST-14) is an endogenous neuropeptide with notable structural similarities to native somatostatin-14 (SS-14), but different physiological functions...
  5. Xidakis C, Mastrodimou N, Notas G, Renieri E, Kolios G, Kouroumalis E, et al. RT-PCR and immunocytochemistry studies support the presence of somatostatin, cortistatin and somatostatin receptor subtypes in rat Kupffer cells. Regul Pept. 2007;143:76-82 pubmed
    ..investigated the presence of somatostatin receptor subtypes (ssts) and the endogenous peptides somatostatin and cortistatin in rat Kupffer cells, since modulation of these cells by somatostatin may be important for the beneficial ..
  6. Bourgin P, Fabre V, Huitron Resendiz S, Henriksen S, Prospero Garcia O, Criado J, et al. Cortistatin promotes and negatively correlates with slow-wave sleep. Eur J Neurosci. 2007;26:729-38 pubmed
    ..Steady-state levels of preprocortistatin mRNA oscillate during the light:dark cycle and are four-fold higher upon total 24-h sleep deprivation, ..
  7. Chen X, Xia J, Zhou T, Yuan Q, Zhang W, Hu C, et al. Involvement of DDAH/ADMA pathway in the pathogenesis of rheumatoid arthritis in rats. Int Immunopharmacol. 2013;16:322-31 pubmed publisher
    ..Moreover, the expression of anti-inflammatory factor cortistatin (CST) was markedly decreased in joint synovium of CIA rats...
  8. Fukusumi S, Kitada C, Takekawa S, Kizawa H, Sakamoto J, Miyamoto M, et al. Identification and characterization of a novel human cortistatin-like peptide. Biochem Biophys Res Commun. 1997;232:157-63 pubmed
    ..A protein coded by the cDNA showed 55% identity to rat preprocortistatin in amino acid...
  9. Yue M, Xia Y, Shi C, Guan C, Li Y, Liu R, et al. Berberine ameliorates collagen-induced arthritis in rats by suppressing Th17 cell responses via inducing cortistatin in the gut. FEBS J. 2017;284:2786-2801 pubmed publisher
    ..Further studies revealed that oral berberine selectively elevated the levels of cortistatin, of five gut-derived neuropeptides tested, in the intestines and sera of arthrititic rats...

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