Gene Symbol: Cops8
Description: COP9 signalosome subunit 8
Alias: COP9 signalosome complex subunit 8, COP9 (constitutive photomorphogenic) homolog, subunit 8, COP9 homolog, JAB1-containing signalosome subunit 8, SGN8, signalosome subunit 8
Species: rat
Products:     Cops8

Top Publications

  1. Seeger M, Kraft R, Ferrell K, Bech Otschir D, Dumdey R, Schade R, et al. A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits. FASEB J. 1998;12:469-78 pubmed
    ..Considering the putative role of the complex in signal transduction and its widespread occurrence, we suggest the name JAB1-containing signalosome. ..
  2. Lykke Andersen K, Wei N. Gene structure and embryonic expression of mouse COP9 signalosome subunit 8 (Csn8). Gene. 2003;321:65-72 pubmed
    ..Immunostaining studies revealed that Csn8 is predominantly present in the inner cell mass (ICM) of E3.5 blastocyst and is widely expressed in E9.5-day embryos. ..
  3. Sharon M, Mao H, Boeri Erba E, Stephens E, Zheng N, Robinson C. Symmetrical modularity of the COP9 signalosome complex suggests its multifunctionality. Structure. 2009;17:31-40 pubmed publisher
    ..This suggests that the propensity of the CSN complex to change and adapt its subunit composition might underlie its ability to perform multiple functions in vivo. ..
  4. Crone S, Jacobsen A, Federspiel B, Bardram L, Krogh A, Lund A, et al. microRNA-146a inhibits G protein-coupled receptor-mediated activation of NF-?B by targeting CARD10 and COPS8 in gastric cancer. Mol Cancer. 2012;11:71 pubmed publisher
    ..identified two transcripts, caspase recruitment domain-containing protein 10 (CARD10) and COP9 signalosome complex subunit 8 (COPS8), as new miR-146a targets...
  5. Liu C, Guo L, Menon S, Jin D, Pick E, Wang X, et al. COP9 signalosome subunit Csn8 is involved in maintaining proper duration of the G1 phase. J Biol Chem. 2013;288:20443-52 pubmed publisher
    ..We conclude that CSN harbors both positive and negative regulators of the cell cycle and therefore is poised to influence the fate of a cell at the crossroad of cell division, differentiation, and senescence. ..