Gene Symbol: Cops5
Description: COP9 signalosome subunit 5
Alias: COP9 signalosome complex subunit 5, COP9 (constitutive photomorphogenic) homolog, subunit 5
Species: rat
Products:     Cops5

Top Publications

  1. Luo W, Wang Y, Hanck T, Stricker R, Reiser G. Jab1, a novel protease-activated receptor-2 (PAR-2)-interacting protein, is involved in PAR-2-induced activation of activator protein-1. J Biol Chem. 2006;281:7927-36 pubmed
    ..Taken together, our data demonstrate that Jab1 is an important effector that mediates a novel signal transduction pathway for PAR-2-dependent gene expression. ..
  2. Sharon M, Mao H, Boeri Erba E, Stephens E, Zheng N, Robinson C. Symmetrical modularity of the COP9 signalosome complex suggests its multifunctionality. Structure. 2009;17:31-40 pubmed publisher
    ..This suggests that the propensity of the CSN complex to change and adapt its subunit composition might underlie its ability to perform multiple functions in vivo. ..
  3. Cooper E, Cutcliffe C, Kristiansen T, Pandey A, Pickart C, Cohen R. K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1. EMBO J. 2009;28:621-31 pubmed publisher
    ..Our results suggest that specificity for K63-linked polyubiquitin is a common property of the JAMM/MPN+ family of DUBs. ..
  4. Yun H, Baik J, Kang I, Jin C, Rhim H. Physical interaction of Jab1 with human serotonin 6 G-protein-coupled receptor and their possible roles in cell survival. J Biol Chem. 2010;285:10016-29 pubmed publisher
    ..These findings suggest that Jab1 provides a novel signal transduction pathway for 5-HT(6)R and may play an important role in 5-HT(6)R-mediated behavior changes in the brain. ..
  5. Merk M, Zierow S, Leng L, Das R, Du X, Schulte W, et al. The D-dopachrome tautomerase (DDT) gene product is a cytokine and functional homolog of macrophage migration inhibitory factor (MIF). Proc Natl Acad Sci U S A. 2011;108:E577-85 pubmed publisher
    ..These data indicate that D-DT is a MIF-like cytokine with an overlapping spectrum of activities that are important for our understanding of MIF-dependent physiology and pathology. ..
  6. Liu Y, Shah S, Xiang X, Wang J, Deng Z, Liu C, et al. COP9-associated CSN5 regulates exosomal protein deubiquitination and sorting. Am J Pathol. 2009;174:1415-25 pubmed publisher
    ..We propose that COP9-associated CSN5 regulates exosomal protein sorting in both a deubiquitinating activity-dependent and -independent manner, which is contrary to the current idea of ubiquitin-dependent sorting of proteins to exosomes. ..
  7. Granata A, Koo S, Haucke V, Schiavo G, Warner T. CSN complex controls the stability of selected synaptic proteins via a torsinA-dependent process. EMBO J. 2011;30:181-93 pubmed publisher
    ..Retrieval of surface-stranded synaptotagmin 1 is restored by overexpression of stonin 2 in ?E-TA-expressing cells, suggesting that the DYT1 mutation compromises the role of TA in protein stabilisation and synaptic vesicle recycling. ..
  8. Oono K, Yoneda T, Manabe T, Yamagishi S, Matsuda S, Hitomi J, et al. JAB1 participates in unfolded protein responses by association and dissociation with IRE1. Neurochem Int. 2004;45:765-72 pubmed
    ..These results suggested that JAB1 may act as a key molecule in selecting the UPR or cell death by association and dissociation with IRE1alpha. ..
  9. Tomoda K, Yoneda Kato N, Fukumoto A, Yamanaka S, Kato J. Multiple functions of Jab1 are required for early embryonic development and growth potential in mice. J Biol Chem. 2004;279:43013-8 pubmed
    ..Thus, Jab1 controls cell cycle progression and cell survival by regulating multiple cell cycle signaling pathways. ..

More Information


  1. Xiao S, Li D, Zhu H, Song M, Pan X, Jia P, et al. RIG-G as a key mediator of the antiproliferative activity of interferon-related pathways through enhancing p21 and p27 proteins. Proc Natl Acad Sci U S A. 2006;103:16448-53 pubmed
  2. Wang H, Song W, Hu T, Zhang N, Miao S, Zong S, et al. Fank1 interacts with Jab1 and regulates cell apoptosis via the AP-1 pathway. Cell Mol Life Sci. 2011;68:2129-39 pubmed publisher
    ..This process was shown to be Jab1 dependent. Taken together, our results indicated that by interacting with Jab1, Fank1 could suppress cell apoptosis by activating the AP-1-induced anti-apoptotic pathway. ..