Gene Symbol: Commd1
Description: copper metabolism domain containing 1
Alias: COMM domain-containing protein 1, copper metabolism (Murr1) domain containing 1
Species: rat
Products:     Commd1

Top Publications

  1. Biasio W, Chang T, McIntosh C, McDonald F. Identification of Murr1 as a regulator of the human delta epithelial sodium channel. J Biol Chem. 2004;279:5429-34 pubmed
    ..Murr1 also bound to the beta- and gammaENaC subunits and inhibited alphabetagammaENaC sodium current. Therefore, these results suggest that Murr1 is a novel regulator of ENaC. ..
  2. Burstein E, Hoberg J, Wilkinson A, Rumble J, Csomos R, Komarck C, et al. COMMD proteins, a novel family of structural and functional homologs of MURR1. J Biol Chem. 2005;280:22222-32 pubmed
    ..The prototype of this family, MURR1/COMMD1, suppresses NF-kappaB not by affecting nuclear translocation or binding of NF-kappaB to cognate motifs; rather, it ..
  3. Materia S, Cater M, Klomp L, Mercer J, La Fontaine S. Clusterin and COMMD1 independently regulate degradation of the mammalian copper ATPases ATP7A and ATP7B. J Biol Chem. 2012;287:2485-99 pubmed publisher
    ..Clusterin and COMMD1 were previously identified as interacting partners of these Cu-ATPases...
  4. Burstein E, Ganesh L, Dick R, van De Sluis B, Wilkinson J, Klomp L, et al. A novel role for XIAP in copper homeostasis through regulation of MURR1. EMBO J. 2004;23:244-54 pubmed
    ..These findings represent the first described phenotypic alteration in Xiap-deficient mice and demonstrate that XIAP can function through MURR1 to regulate copper homeostasis. ..
  5. Maine G, Mao X, Komarck C, Burstein E. COMMD1 promotes the ubiquitination of NF-kappaB subunits through a cullin-containing ubiquitin ligase. EMBO J. 2007;26:436-47 pubmed
    ..We have previously reported that COMMD1 represses kappaB-dependent transcription by negatively regulating NF-kappaB-chromatin interactions...
  6. van De Sluis B, Muller P, Duran K, Chen A, Groot A, Klomp L, et al. Increased activity of hypoxia-inducible factor 1 is associated with early embryonic lethality in Commd1 null mice. Mol Cell Biol. 2007;27:4142-56 pubmed
    b>COMMD1 (previously known as MURR1) belongs to a novel family of proteins termed the copper metabolism gene MURR1 domain (COMMD) family...
  7. Burkhead J, Morgan C, Shinde U, Haddock G, Lutsenko S. COMMD1 forms oligomeric complexes targeted to the endocytic membranes via specific interactions with phosphatidylinositol 4,5-bisphosphate. J Biol Chem. 2009;284:696-707 pubmed publisher
    Copper metabolism Murr1 domain 1 (COMMD1) is a 21-kDa protein involved in copper export from the liver, NF-kappaB signaling, HIV infection, and sodium transport...
  8. Narindrasorasak S, Kulkarni P, Deschamps P, She Y, Sarkar B. Characterization and copper binding properties of human COMMD1 (MURR1). Biochemistry. 2007;46:3116-28 pubmed
    b>COMMD1 (copper metabolism gene MURR1 (mouse U2af1-rs1 region1) domain) belongs to a family of multifunctional proteins that inhibit nuclear factor NF-kappaB...
  9. Chang T, Ke Y, Ly K, McDonald F. COMMD1 regulates the delta epithelial sodium channel (?ENaC) through trafficking and ubiquitination. Biochem Biophys Res Commun. 2011;411:506-11 pubmed publisher
    ..b>COMMD1 (copper metabolism Murr1 domain 1) was previously found to associate with and downregulate ?ENaC activity...

More Information


  1. Bartuzi P, Billadeau D, Favier R, Rong S, Dekker D, Fedoseienko A, et al. CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL. Nat Commun. 2016;7:10961 pubmed publisher
    ..patients with X-linked intellectual disability caused by mutations in CCDC22 are hypercholesterolaemic, and that COMMD1-deficient dogs and liver-specific Commd1 knockout mice have elevated plasma LDL cholesterol levels...
  2. de Bie P, van De Sluis B, Burstein E, Duran K, Berger R, Duckett C, et al. Characterization of COMMD protein-protein interactions in NF-kappaB signalling. Biochem J. 2006;398:63-71 pubmed
    ..The small ubiquitously expressed COMMD6 consists primarily of the COMM domain. Therefore COMMD1 and COMMD6 were analysed further as prototype members of the COMMD protein family...
  3. Ke Y, Butt A, Swart M, Liu Y, McDonald F. COMMD1 downregulates the epithelial sodium channel through Nedd4-2. Am J Physiol Renal Physiol. 2010;298:F1445-56 pubmed publisher
    ..Our previous studies demonstrated that Copper Metabolism Murr1 Domain-containing protein 1 (COMMD1; previously known as Murr1), a protein involved in copper metabolism, inhibited amiloride-sensitive current in ..
  4. Phillips Krawczak C, Singla A, Starokadomskyy P, Deng Z, Osborne D, Li H, et al. COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A. Mol Biol Cell. 2015;26:91-103 pubmed publisher
    b>COMMD1 deficiency results in defective copper homeostasis, but the mechanism for this has remained elusive...