Gene Symbol: Col6a1
Description: collagen type VI alpha 1 chain
Alias: RGD1565398, collagen alpha-1(VI) chain, collagen, type VI, alpha 1, procollagen, type VI, alpha 1
Fitzgerald J, Rich C, Zhou F, Hansen U. Three novel collagen VI chains, alpha4(VI), alpha5(VI), and alpha6(VI). J Biol Chem. 2008;283:20170-80 pubmed publisher
..In summary, the discovery of three additional collagen VI chains doubles the collagen VI family and adds a layer of complexity to collagen VI assembly and function in the extracellular matrix. ..
Kohara Y, Soeta S, Izu Y, Arai K, Amasaki H. Distribution of type VI collagen in association with osteoblast lineages in the groove of Ranvier during rat postnatal development. Ann Anat. 2016;208:58-68 pubmed publisher
..These findings indicate that Col VI provided a characteristic microenvironment in the GOR and that NG2-Col VI interactions may regulate the differentiation of osteoblast lineages prior to terminal maturation. ..
Jobsis G, Keizers H, Vreijling J, de Visser M, Speer M, Wolterman R, et al
. Type VI collagen mutations in Bethlem myopathy, an autosomal dominant myopathy with contractures. Nat Genet. 1996;14:113-5 pubmed
..Nine kindreds show genetic linkage to the COL6A1-COL6A2 cluster on chromosome 21q22...
Dziadek M, Darling P, Bakker M, Overall M, Zhang R, Pan T, et al
. Deposition of collagen VI in the extracellular matrix during mouse embryogenesis correlates with expression of the alpha 3(VI) subunit gene. Exp Cell Res. 1996;226:302-15 pubmed
..This correlation is consistent with the proposal that expression of alpha 3(VI) chains regulates the formation and secretion of collagen VI trimers and collagen VI matrix deposition during development. ..
Lechner B, Lim J, Mercado M, Fallon J. Developmental regulation of biglycan expression in muscle and tendon. Muscle Nerve. 2006;34:347-55 pubmed
..These results suggest that biglycan has a particularly important function during muscle and connective tissue development. Moreover, biglycan may play a role in the pathogenesis of collagen VI-associated congenital muscular dystrophies. ..