Gene Symbol: Col10a1
Description: collagen type X alpha 1 chain
Alias: collagen alpha-1(X) chain, LOW QUALITY PROTEIN: collagen alpha-1(X) chain, collagen, type X, alpha 1, procollagen, type X, alpha 1
Species: rat
Products:     Col10a1

Top Publications

  1. McIntosh I, Abbott M, Warman M, Olsen B, Francomano C. Additional mutations of type X collagen confirm COL10A1 as the Schmid metaphyseal chondrodysplasia locus. Hum Mol Genet. 1994;3:303-7 pubmed
    ..All three mutations are in the carboxy-terminal non-collagenous domain suggesting that the effect of these mutations is to impair the mutant polypeptide's ability to participate in chain association and trimer formation. ..
  2. Shibata S, Fukada K, Suzuki S, Yamashita Y. Immunohistochemistry of collagen types II and X, and enzyme-histochemistry of alkaline phosphatase in the developing condylar cartilage of the fetal mouse mandible. J Anat. 1997;191 ( Pt 4):561-70 pubmed
    ..These findings strongly support a periosteal origin for the condylar cartilage of the fetal mouse mandible, and show that progenitor cells for condylar cartilage rapidly or directly differentiate into hypertrophic chondrocytes. ..
  3. Marks S, Lundmark C, Christersson C, Wurtz T, Odgren P, Seifert M, et al. Endochondral bone formation in toothless (osteopetrotic) rats: failures of chondrocyte patterning and type X collagen expression. Int J Dev Biol. 2000;44:309-16 pubmed
    ..The differences in patterning in the tl rat GP compared to direct Col X mutations may be explained by compensatory effects. ..
  4. Watanabe Y, Takeuchi K, Higa Onaga S, Sato M, Tsujita M, Abe M, et al. Chondroitin sulfate N-acetylgalactosaminyltransferase-1 is required for normal cartilage development. Biochem J. 2010;432:47-55 pubmed publisher
    ..Additionally, type-II collagen fibres in developing cartilage were abnormally aggregated and disarranged in the homozygous mutant mice. These results suggest that CSGalNAcT1 is required for normal CS production in developing cartilage. ..
  5. Plumb D, Ferrara L, Torbica T, Knowles L, Mironov A, Kadler K, et al. Collagen XXVII organises the pericellular matrix in the growth plate. PLoS ONE. 2011;6:e29422 pubmed publisher
    ..Collagen XXVII plays an important structural role in the pericellular extracellular matrix of the growth plate and is required for the organisation of the proliferative zone. ..
  6. Chung K, Park H, Ting K, Takita H, Apte S, Kuboki Y, et al. Modulated expression of type X collagen in Meckel's cartilage with different developmental fates. Dev Biol. 1995;170:387-96 pubmed
  7. Amling M, Neff L, Tanaka S, Inoue D, Kuida K, Weir E, et al. Bcl-2 lies downstream of parathyroid hormone-related peptide in a signaling pathway that regulates chondrocyte maturation during skeletal development. J Cell Biol. 1997;136:205-13 pubmed
    ..Thus, Bcl-2 lies downstream of PTHrP in a pathway that controls chondrocyte maturation and skeletal development. ..
  8. Römer P, Weingärtner J, Roldán J, Proff P, Reicheneder C. Development dependent collagen gene expression in the rat cranial base growth plate. Ann Anat. 2010;192:205-9 pubmed publisher
    ..Gene transcripts of type II and X collagen were most abundant at day 10 postnatally in the spheno-occipital synchondrosis. This observation is assumed to be due to intrinsic genetic factors and local environmental factors...
  9. Cancel M, Grimard G, Thuillard Crisinel D, Moldovan F, Villemure I. Effects of in vivo static compressive loading on aggrecan and type II and X collagens in the rat growth plate extracellular matrix. Bone. 2009;44:306-15 pubmed publisher

Scientific Experts

More Information


  1. Liang Q, Cui X, Xi Z, Bian Q, Hou W, Zhao Y, et al. Prolonged upright posture induces degenerative changes in intervertebral discs of rat cervical spine. Spine (Phila Pa 1976). 2011;36:E14-9 pubmed publisher
    ..Upright stance accelerates cervical disc degeneration in rats. ..
  2. Bo N, Peng W, Xinghong P, Ma R. Early cartilage degeneration in a rat experimental model of developmental dysplasia of the hip. Connect Tissue Res. 2012;53:513-20 pubmed publisher
    ..05). However, no change was observed in ADAMTS-4 expression. This study shows that degenerative cartilage changes occur at an early stage in the rat DDH model and become aggravated with age...