Cnr1

Summary

Gene Symbol: Cnr1
Description: cannabinoid receptor 1
Alias: SKR6R, cannabinoid receptor 1, CB-R, CB1, brain-type cannabinoid receptor, cannabinoid receptor 1 (brain)
Species: rat
Products:     Cnr1

Top Publications

  1. Casteels C, Lauwers E, Baitar A, Bormans G, Baekelandt V, Van Laere K. In vivo type 1 cannabinoid receptor mapping in the 6-hydroxydopamine lesion rat model of Parkinson's disease. Brain Res. 2010;1316:153-62 pubmed publisher
    Type 1 cannabinoid (CB1) receptors are expressed in high concentrations in the central nervous system, including the basal ganglia, and could have direct or indirect effects on motor behavior through modulation of dopaminergic, ..
  2. Timofeeva E, Baraboi E, Poulin A, Richard D. Palatable high-energy diet decreases the expression of cannabinoid type 1 receptor messenger RNA in specific brain regions in the rat. J Neuroendocrinol. 2009;21:982-92 pubmed publisher
    ..Altogether, the present results demonstrate that long-term PHED leads to an increase in the hypothalamic expression of SOCS-3 mRNA and a decrease in expression of CB1R mRNA in the Cg cortex and specific hypothalamic regions. ..
  3. Kawamura Y, Fukaya M, Maejima T, Yoshida T, Miura E, Watanabe M, et al. The CB1 cannabinoid receptor is the major cannabinoid receptor at excitatory presynaptic sites in the hippocampus and cerebellum. J Neurosci. 2006;26:2991-3001 pubmed
    ..It is generally accepted that the CB1 cannabinoid receptor (CB1) mediates the effects of endocannabinoid in inhibitory synapses...
  4. Falenski K, Carter D, Harrison A, Martin B, Blair R, Delorenzo R. Temporal characterization of changes in hippocampal cannabinoid CB(1) receptor expression following pilocarpine-induced status epilepticus. Brain Res. 2009;1262:64-72 pubmed publisher
    ..This suggests a role for dysregulation of the endocannabinoid system during epileptogenesis and indicates that the CB(1) receptor redistribution temporally correlates with the emergence of epileptic seizures. ..
  5. McDonald N, Henstridge C, Connolly C, Irving A. An essential role for constitutive endocytosis, but not activity, in the axonal targeting of the CB1 cannabinoid receptor. Mol Pharmacol. 2007;71:976-84 pubmed
    ..These data are consistent with a revised model in which domain-specific endocytosis regulates the functional polarization of CB(1) receptors, but this process is distinct from constitutive activity. ..
  6. Garcia Ovejero D, Arevalo Martin A, Petrosino S, Docagne F, Hagen C, Bisogno T, et al. The endocannabinoid system is modulated in response to spinal cord injury in rats. Neurobiol Dis. 2009;33:57-71 pubmed publisher
    ..CB(2) receptor was strongly upregulated after lesion, and mostly expressed by immune infiltrates and astrocytes. The endocannabinoid system may represent an interesting target for new therapeutical approaches to spinal cord injury. ..
  7. Singla S, Kreitzer A, Malenka R. Mechanisms for synapse specificity during striatal long-term depression. J Neurosci. 2007;27:5260-4 pubmed
    ..at excitatory synapses on medium spiny neurons in the striatum requires presynaptic activity coincident with CB1 receptor activation...
  8. Serpa A, Ribeiro J, Sebastião A. Cannabinoid CB(1) and adenosine A(1) receptors independently inhibit hippocampal synaptic transmission. Eur J Pharmacol. 2009;623:41-6 pubmed publisher
  9. Bodor A, Katona I, Nyiri G, Mackie K, Ledent C, Hajos N, et al. Endocannabinoid signaling in rat somatosensory cortex: laminar differences and involvement of specific interneuron types. J Neurosci. 2005;25:6845-56 pubmed
    ..in the neocortex, the precise laminar, cellular, and subcellular localization of the type 1 cannabinoid receptor (CB1) as well as its function has been elusive...

More Information

Publications62

  1. Bello N, Coughlin J, Redgrave G, Ladenheim E, Moran T, Guarda A. Dietary conditions and highly palatable food access alter rat cannabinoid receptor expression and binding density. Physiol Behav. 2012;105:720-6 pubmed publisher
    Endogenous cannabinoid signaling, mediated predominately by CB1 receptor activation, is involved in food intake control and body weight regulation...
  2. Wilson R, Nicoll R. Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses. Nature. 2001;410:588-92 pubmed
    Marijuana affects brain function primarily by activating the G-protein-coupled cannabinoid receptor-1 (CB1), which is expressed throughout the brain at high levels...
  3. Baek J, Zheng Y, Darlington C, Smith P. Cannabinoid CB(1) receptor expression and affinity in the rat hippocampus following bilateral vestibular deafferentation. Neurosci Lett. 2011;487:330-4 pubmed publisher
    ..These results suggest that the CB(1) receptor down-regulates in the CA3 region of the hippocampus following BVD, but with no changes in the affinity of the CB(1) receptor for WIN55,212-2. ..
  4. Fonseca B, Correia da Silva G, Teixeira N. Anandamide-induced cell death: dual effects in primary rat decidual cell cultures. Placenta. 2009;30:686-92 pubmed publisher
    ..Moreover, these effects were attenuated by AM251, a selective antagonist for the cannabinoid receptor CB1. High concentrations induced a dramatic effect in cell viability and morphology, though methyl-beta-cyclodextrin (..
  5. Niehaus J, Liu Y, Wallis K, Egertová M, Bhartur S, Mukhopadhyay S, et al. CB1 cannabinoid receptor activity is modulated by the cannabinoid receptor interacting protein CRIP 1a. Mol Pharmacol. 2007;72:1557-66 pubmed
    The CB1 cannabinoid receptor is a G-protein coupled receptor that has important physiological roles in synaptic plasticity, analgesia, appetite, and neuroprotection...
  6. Matsuda L, Lolait S, Brownstein M, Young A, Bonner T. Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature. 1990;346:561-4 pubmed
    ..These findings suggest that this protein is involved in cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. ..
  7. Flores L, Alzugaray M, Cubilla M, Raschia M, Del Zotto H, Román C, et al. Islet cannabinoid receptors: cellular distribution and biological function. Pancreas. 2013;42:1085-92 pubmed publisher
    ..chain reaction) and glucose-stimulated insulin secretion (GSIS) of isolated islets incubated with the CB1 antagonist rimonabant (R) and/or different CBs agonists...
  8. Ribeiro R, Wen J, Li S, Zhang Y. Involvement of ERK1/2, cPLA2 and NF-?B in microglia suppression by cannabinoid receptor agonists and antagonists. Prostaglandins Other Lipid Mediat. 2013;100-101:1-14 pubmed publisher
    ..molecular mechanisms and whether the action of cannabinoids is coupled to the activation of cannabinoid type 1 (CB1) and type 2 (CB2) receptors are still poorly defined...
  9. McLaughlin R, Hill M, Morrish A, Gorzalka B. Local enhancement of cannabinoid CB1 receptor signalling in the dorsal hippocampus elicits an antidepressant-like effect. Behav Pharmacol. 2007;18:431-8 pubmed
    Systemic administration of direct cannabinoid CB1 receptor agonists and inhibitors of the hydrolytic enzyme fatty acid amide hydrolase have been shown to elicit antidepressant effects...
  10. Fonseca B, Correia da Silva G, Taylor A, Konje J, Bell S, Teixeira N. Spatio-temporal expression patterns of anandamide-binding receptors in rat implantation sites: evidence for a role of the endocannabinoid system during the period of placental development. Reprod Biol Endocrinol. 2009;7:121 pubmed publisher
    ..of the fetoplacental unit, the spatio-temporal pattern of expression of the anandamide-binding receptors, CB1, CB2 and the vanilloid receptor (TRPV1), were investigated by quantitative RT-PCR, western blot and ..
  11. Sachser R, Crestani A, Quillfeldt J, Mello e Souza T, de Oliveira Alvares L. The cannabinoid system in the retrosplenial cortex modulates fear memory consolidation, reconsolidation, and extinction. Learn Mem. 2015;22:584-8 pubmed publisher
    ..Finally, AM251 blocked extinction, whereas CP55940 facilitated it and maintained memory extinguished over time. Altogether, our data strongly suggest that the cannabinoid system of the RSC modulates emotional memory. ..
  12. Baek J, Zheng Y, Darlington C, Smith P. The CB1 receptor agonist, WIN 55,212-2, dose-dependently disrupts object recognition memory in adult rats. Neurosci Lett. 2009;464:71-3 pubmed publisher
    ..These results suggest that WIN can interfere with object recognition memory even in adult rats following a single injection of a low dose. ..
  13. Clayton N, Marshall F, Bountra C, O Shaughnessy C. CB1 and CB2 cannabinoid receptors are implicated in inflammatory pain. Pain. 2002;96:253-60 pubmed
    ..p. (in the carrageenan model). The selective CB1 antagonist, AM281 (0.5 microg/kg-1 i.p.) reversed effects of HU210 (10 and 30 microg/kg-1 i.p...
  14. Esposito G, Iuvone T, Savani C, Scuderi C, De Filippis D, Papa M, et al. Opposing control of cannabinoid receptor stimulation on amyloid-beta-induced reactive gliosis: in vitro and in vivo evidence. J Pharmacol Exp Ther. 2007;322:1144-52 pubmed
    ..Immunohistochemical and biochemical findings revealed that selective agonism at CB1 and antagonism at CB2 receptors was able to blunt A beta-induced reactive astrogliosis with subsequent ..
  15. Ferreira Junior N, Fedoce A, Alves F, Correa F, Resstel L. Medial prefrontal cortex endocannabinoid system modulates baroreflex activity through CB(1) receptors. Am J Physiol Regul Integr Comp Physiol. 2012;302:R876-85 pubmed publisher
    ..Taken together, our results support the view that the eCBs in the vMPFC is involved in the modulation of baroreflex activity through the activation of CB(1) receptors, which modulate local glutamate release. ..
  16. Lee T, Wainwright S, Hill M, Galea L, Gorzalka B. Sex, drugs, and adult neurogenesis: sex-dependent effects of escalating adolescent cannabinoid exposure on adult hippocampal neurogenesis, stress reactivity, and amphetamine sensitization. Hippocampus. 2014;24:280-92 pubmed publisher
    ..We investigated whether escalating doses of the cannabinoid receptor 1 (CB1 R) agonist, HU-210, in adolescence would affect adult hippocampal neurogenesis and behavioral ..
  17. Chanda D, Kim D, Li T, Kim Y, Koo S, Lee C, et al. Cannabinoid receptor type 1 (CB1R) signaling regulates hepatic gluconeogenesis via induction of endoplasmic reticulum-bound transcription factor cAMP-responsive element-binding protein H (CREBH) in primary hepatocytes. J Biol Chem. 2011;286:27971-9 pubmed publisher
  18. Martínez Vargas M, Murillo Rodriguez E, González Rivera R, Landa A, Méndez Díaz M, Prospro García O, et al. Sleep modulates cannabinoid receptor 1 expression in the pons of rats. Neuroscience. 2003;117:197-201 pubmed
    Endocannabinoids seem to play a role in the modulation of alertness. Therefore, we measured cannabinoid receptor 1 (CB1R) protein by Western blot and messenger RNA (mRNA) by reverse transcription-polymerase chain reaction in the pons of ..
  19. Spradley J, Davoodi A, Gee L, Carstens M, Carstens E. Differences in peripheral endocannabinoid modulation of scratching behavior in facial vs. spinally-innervated skin. Neuropharmacology. 2012;63:743-9 pubmed publisher
  20. Haghani M, Janahmadi M, Shabani M. Protective effect of cannabinoid CB1 receptor activation against altered intrinsic repetitive firing properties induced by A? neurotoxicity. Neurosci Lett. 2012;507:33-7 pubmed publisher
    ..Protective effect of cannabinoid CB1 receptor activation was also investigated against A?-induced alterations in evoked electrophysiological activities...
  21. Krylatov A, Maslov L, Ermakov S, Barzakh E, Lasukova O, Crawford D, et al. Negative chronotropic effect of cannabinoids and their water-soluble emulsion is related to activation of cardiac CB1 receptors. Bull Exp Biol Med. 2006;142:450-3 pubmed
    ..Selective CB1 and CB2 receptor antagonist HU-210 also induced a negative chronotropic effect in rats, while pre-injection of CB1 ..
  22. da Fonseca Pacheco D, Klein A, de Castro Perez A, da Fonseca Pacheco C, de Francischi J, Duarte I. The mu-opioid receptor agonist morphine, but not agonists at delta- or kappa-opioid receptors, induces peripheral antinociception mediated by cannabinoid receptors. Br J Pharmacol. 2008;154:1143-9 pubmed publisher
    ..The CB1-selective cannabinoid receptor antagonist AM251 completely reversed the peripheral antinociception induced by ..
  23. Di Francesco A, Falconi A, Di Germanio C, Micioni Di Bonaventura M, Costa A, Caramuta S, et al. Extravirgin olive oil up-regulates CB₁ tumor suppressor gene in human colon cancer cells and in rat colon via epigenetic mechanisms. J Nutr Biochem. 2015;26:250-8 pubmed publisher
    ..We observed a selective and transient up-regulation of CNR1 gene - encoding for type 1 cannabinoid receptor (CB₁) - that was evoked by exposure of Caco-2 cells to EVOO (..
  24. dos Anjos Garcia T, Ullah F, Falconi Sobrinho L, Coimbra N. CB1 cannabinoid receptor-mediated anandamide signalling reduces the defensive behaviour evoked through GABAA receptor blockade in the dorsomedial division of the ventromedial hypothalamus. Neuropharmacology. 2017;113:156-166 pubmed publisher
  25. Rosenstock J, Hollander P, Chevalier S, Iranmanesh A. SERENADE: the Study Evaluating Rimonabant Efficacy in Drug-naive Diabetic Patients: effects of monotherapy with rimonabant, the first selective CB1 receptor antagonist, on glycemic control, body weight, and lipid profile in drug-naive type 2 diabetes. Diabetes Care. 2008;31:2169-76 pubmed publisher
    ..Further ongoing studies will better establish the benefit-to-risk profile of rimonabant and define its place in type 2 diabetes management. ..
  26. de Oliveira Alvares L, Pasqualini Genro B, Diehl F, Molina V, Quillfeldt J. Opposite action of hippocampal CB1 receptors in memory reconsolidation and extinction. Neuroscience. 2008;154:1648-55 pubmed publisher
    ..Bilateral infusion of the CB1 cannabinoid receptor antagonist, N-(piperidin-1-yl)-5-(4-iodophenyl)-1-(2, 4-dichlorophenyl)-4-methyl-1H-pyrazole-3-..
  27. Bromberg K, Ma ayan A, Neves S, Iyengar R. Design logic of a cannabinoid receptor signaling network that triggers neurite outgrowth. Science. 2008;320:903-9 pubmed publisher
    b>Cannabinoid receptor 1 (CB1R) regulates neuronal differentiation...
  28. Wedzony K, Chocyk A. Cannabinoid CB1 receptors in rat medial prefrontal cortex are colocalized with calbindin- but not parvalbumin- and calretinin-positive GABA-ergic neurons. Pharmacol Rep. 2009;61:1000-7 pubmed
    In the present study, we investigate putative localization of cannabinoid receptors 1 (CB1) protein on a population of cortical gamma-aminobutyric acid (GABA) - positive interneurons characterized by expression of calcium-binding ..
  29. Mitrirattanakul S, Ramakul N, Guerrero A, Matsuka Y, Ono T, Iwase H, et al. Site-specific increases in peripheral cannabinoid receptors and their endogenous ligands in a model of neuropathic pain. Pain. 2006;126:102-14 pubmed
    Selective activation of the peripheral cannabinoid receptor 1 (CB1R) has been shown to suppress neuropathic pain symptoms in rodents...
  30. Friemel C, Zimmer A, Schneider M. The CB1 receptor as an important mediator of hedonic reward processing. Neuropsychopharmacology. 2014;39:2387-96 pubmed publisher
    ..Modulatory effects of the CB1 receptor antagonist/inverse agonist SR1411716 and the cannabinoid agonist WIN 55?212-2 on PAS were examined in rats...
  31. Fattore L, Vigano D, Fadda P, Rubino T, Fratta W, Parolaro D. Bidirectional regulation of mu-opioid and CB1-cannabinoid receptor in rats self-administering heroin or WIN 55,212-2. Eur J Neurosci. 2007;25:2191-200 pubmed
    ..either heroin or the cannabinoid receptor agonist WIN 55,212-2 on levels and functionality of mu-opioid (MOR) and CB1-cannabinoid receptors (CB1R) in reward-related brain areas, such as the prefrontal cortex (PFC), nucleus accumbens (..
  32. Tozzi A, de Iure A, Marsili V, Romano R, Tantucci M, Di Filippo M, et al. A2A adenosine receptor antagonism enhances synaptic and motor effects of cocaine via CB1 cannabinoid receptor activation. PLoS ONE. 2012;7:e38312 pubmed publisher
    ..of D2-like receptors and the release of endocannabinoids since it was prevented by L-sulpiride and reduced by a CB1 receptor antagonist...
  33. Zhu F, Wang X, Chen Y, Yang N, Lang S, Zuo P, et al. Changes and overlapping distribution in the expression of CB1/OX1-GPCRs in rat hippocampus by kainic acid-induced status epilepticus. Brain Res. 2015;1597:14-27 pubmed publisher
    ..Focus on the cannabinoid receptor and cannabinoid-related compounds might be a good option. Cannabinoid receptor 1 (CB1) and orexin receptor 1 (OX1) both belong to the GPCR superfamily and display "cross-talk" ..
  34. Mingorance C, Alvarez de Sotomayor M, Jiménez Palacios F, Callejón Mochón M, Casto C, Marhuenda E, et al. Effects of chronic treatment with the CB1 antagonist, rimonabant on the blood pressure, and vascular reactivity of obese Zucker rats. Obesity (Silver Spring). 2009;17:1340-7 pubmed publisher
    Rimonabant (RM) is a cannabinoid CB1 receptor antagonist useful in the treatment of obesity associated cardiovascular risk factors...
  35. Ramikie T, Nyilas R, Bluett R, Gamble George J, Hartley N, Mackie K, et al. Multiple mechanistically distinct modes of endocannabinoid mobilization at central amygdala glutamatergic synapses. Neuron. 2014;81:1111-1125 pubmed publisher
    ..Here we describe the subcellular localization of CB1 cannabinoid receptors and eCB synthetic machinery at glutamatergic synapses in the CeA and find that CeA neurons ..
  36. Richter H, Teixeira F, Ferreira S, Kittel A, Köfalvi A, Sperlagh B. Presynaptic ??-adrenoceptors control the inhibitory action of presynaptic CB? cannabinoid receptors on prefrontocortical norepinephrine release in the rat. Neuropharmacology. 2012;63:784-97 pubmed publisher
    ..Furthermore, idazoxan triggered a decrease in CB?R density in the PFC, suggesting that high extracellular level of norepinephrine downregulates CB?Rs. ..
  37. Leroy S, Griffon N, Bourdel M, Olie J, Poirier M, Krebs M. Schizophrenia and the cannabinoid receptor type 1 (CB1): association study using a single-base polymorphism in coding exon 1. Am J Med Genet. 2001;105:749-52 pubmed
    ..Cannabinoid receptor (CB1) is particularly concentrated in dopamine-modulated areas of the nervous system...
  38. Uliana D, Hott S, Lisboa S, Resstel L. Dorsolateral periaqueductal gray matter CB1 and TRPV1 receptors exert opposite modulation on expression of contextual fear conditioning. Neuropharmacology. 2016;103:257-69 pubmed publisher
    Cannabinoid type 1 (CB1) and Transient Potential Vanilloid type 1 (TRPV1) receptors in the dorsolateral periaqueductal gray (dlPAG) matter are involved in the modulation of conditioned response...
  39. Cinar R, Freund T, Katona I, Mackie K, Szucs M. Reciprocal inhibition of G-protein signaling is induced by CB(1) cannabinoid and GABA(B) receptor interactions in rat hippocampal membranes. Neurochem Int. 2008;52:1402-9 pubmed publisher
  40. Lim S, Park S. The high glucose-induced stimulation of B1R and B2R expression via CB(1)R activation is involved in rat podocyte apoptosis. Life Sci. 2012;91:895-906 pubmed publisher
    ..In addition, we studied the relationship of cannabinoid receptor 1 (CB(1)R) with high glucose and BK receptors...
  41. Tsumura M, Sobhan U, Muramatsu T, Sato M, Ichikawa H, Sahara Y, et al. TRPV1-mediated calcium signal couples with cannabinoid receptors and sodium-calcium exchangers in rat odontoblasts. Cell Calcium. 2012;52:124-36 pubmed publisher
    ..Increase in [Ca(2+)](i) by CB receptor agonist, 2-arachidonylglycerol, was inhibited by CB1 receptor antagonist or CPZ, as well as by adenylyl cyclase inhibitor...
  42. Thanos P, Ramalhete R, Michaelides M, Piyis Y, Wang G, Volkow N. Leptin receptor deficiency is associated with upregulation of cannabinoid 1 receptors in limbic brain regions. Synapse. 2008;62:637-42 pubmed publisher
    ..These results are consistent with prior findings showing increased levels of endogenous cannabinoids in the Ob rats corroborating the regulation of cannabinoid signaling by leptin. ..
  43. Steinmetz A, Freeman J. Central cannabinoid receptors modulate acquisition of eyeblink conditioning. Learn Mem. 2010;17:571-6 pubmed publisher
    ..The findings support the hypothesis that CB1Rs in the cerebellar cortex play an important role in plasticity mechanisms underlying eyeblink conditioning. ..
  44. De Filippis D, Russo A, D Amico A, Esposito G, Pietropaolo C, Concetta P, et al. Cannabinoids reduce granuloma-associated angiogenesis in rats by controlling transcription and expression of mast cell protease-5. Br J Pharmacol. 2008;154:1672-9 pubmed publisher
    ..Selective CB1 and CB2 receptor agonists(,) ACEA and JWH-015 (0.001-0...
  45. Slavic S, Lauer D, Sommerfeld M, Kemnitz U, Grzesiak A, Trappiel M, et al. Cannabinoid receptor 1 inhibition improves cardiac function and remodelling after myocardial infarction and in experimental metabolic syndrome. J Mol Med (Berl). 2013;91:811-23 pubmed publisher
    The cannabinoid receptors, CB1 and CB2, are expressed in the heart, but their role under pathological conditions remains controversial...
  46. Vechiato F, Rivas P, Ruginsk S, Borges B, Elias L, Antunes Rodrigues J. The type-1 cannabinoid receptor modulates the hydroelectrolytic balance independently of the energy homeostasis during salt load. Horm Behav. 2016;78:43-51 pubmed publisher
    ..These data indicate that CB1Rs modulate the hydroelectrolytic balance independently of the food intake during sustained hyperosmolality and hypovolemia. ..
  47. Inada H, Maejima T, Nakahata Y, Yamaguchi J, Nabekura J, Ishibashi H. Endocannabinoids contribute to metabotropic glutamate receptor-mediated inhibition of GABA release onto hippocampal CA3 pyramidal neurons in an isolated neuron/bouton preparation. Neuroscience. 2010;165:1377-89 pubmed publisher
    ..group I metabotropic glutamate receptors (mGluRs) and following presynaptic cannabinoid receptor type 1 (CB1 receptor) using mechanically dissociated rat hippocampal CA3 pyramidal neurons with adherent functional synaptic ..
  48. Rock E, Sticht M, Duncan M, Stott C, Parker L. Evaluation of the potential of the phytocannabinoids, cannabidivarin (CBDV) and ?(9) -tetrahydrocannabivarin (THCV), to produce CB1 receptor inverse agonism symptoms of nausea in rats. Br J Pharmacol. 2013;170:671-8 pubmed publisher
    The cannabinoid 1 (CB1 ) receptor inverse agonists/antagonists, rimonabant (SR141716, SR) and AM251, produce nausea and potentiate toxin-induced nausea by inverse agonism (rather than antagonism) of the CB1 receptor...
  49. Dasilva M, Grieve K, Cudeiro J, Rivadulla C. Endocannabinoid CB1 receptors modulate visual output from the thalamus. Psychopharmacology (Berl). 2012;219:835-45 pubmed publisher
    ..The present study aimed to characterize the effect of CB1-mediated activity in the visual thalamus...
  50. Hofmann M, Bhatia C, Frazier C. Cannabinoid receptor agonists potentiate action potential-independent release of GABA in the dentate gyrus through a CB1 receptor-independent mechanism. J Physiol. 2011;589:3801-21 pubmed publisher
    ..The effect of WIN55,212-2 on mIPSCs is insensitive to AM251 and preserved in CB1 ?/? animals,indicating that it does not depend on activation of CB1 receptors...
  51. Engel M, Izydorczyk I, Mueller Tribbensee S, Becker C, Neurath M, Reeh P. Inhibitory CB1 and activating/desensitizing TRPV1-mediated cannabinoid actions on CGRP release in rodent skin. Neuropeptides. 2011;45:229-37 pubmed publisher
    Cannabinoid-induced antinociception relies on activation of inhibitory cannabinoid receptors (CB1) in the peripheral and central nervous system...
  52. Lee S, Soltesz I. Requirement for CB1 but not GABAB receptors in the cholecystokinin mediated inhibition of GABA release from cholecystokinin expressing basket cells. J Physiol. 2011;589:891-902 pubmed publisher
    ..In contrast, cannabinoid type-1 (CB1) receptor blockade with AM251 (10 ?m) prevented the action of CCK on GABA release both from CCK+ basket cells and ..
  53. Ramirez B, Blazquez C, Gómez del Pulgar T, Guzman M, De Ceballos M. Prevention of Alzheimer's disease pathology by cannabinoids: neuroprotection mediated by blockade of microglial activation. J Neurosci. 2005;25:1904-13 pubmed
    ..Here, we show that senile plaques in AD patients express cannabinoid receptors CB1 and CB2, together with markers of microglial activation, and that CB1-positive neurons, present in high numbers in ..