Cnr1

Summary

Gene Symbol: Cnr1
Description: cannabinoid receptor 1 (brain)
Alias: SKR6R, CB-R, CB1, brain-type cannabinoid receptor, cannabinoid receptor 1
Species: rat

Top Publications

  1. doi The endocannabinoid system is modulated in response to spinal cord injury in rats
    Daniel Garcia-Ovejero
    Laboratorio de Neuroinflamacion, Unidad de Neurología Experimental Research Unit associated to the Instituto Cajal, CSIC, Madrid, Hospital Nacional de Paraplejicos, Toledo, Spain
    Neurobiol Dis 33:57-71. 2009
  2. doi Anandamide-induced cell death: dual effects in primary rat decidual cell cultures
    B M Fonseca
    Serviço de Bioquímica, Faculdade de Farmacia, Universidade do Porto, Porto, Portugal
    Placenta 30:686-92. 2009
  3. ncbi Endocannabinoid signaling in rat somatosensory cortex: laminar differences and involvement of specific interneuron types
    Agnes L Bodor
    Department of Cellular and Network Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, H 1450 Budapest, Hungary
    J Neurosci 25:6845-56. 2005
  4. ncbi An essential role for constitutive endocytosis, but not activity, in the axonal targeting of the CB1 cannabinoid receptor
    Neil A McDonald
    Neurosciences Institute, Division of Pathology and Neuroscience, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, United Kingdom
    Mol Pharmacol 71:976-84. 2007
  5. ncbi Structure of a cannabinoid receptor and functional expression of the cloned cDNA
    L A Matsuda
    Laboratory of Cell Biology, National Institutes of Mental Health, Bethesda, Maryland 20892
    Nature 346:561-4. 1990
  6. doi Activation of PAR1 in the lateral hypothalamus of rats enhances food intake and REMS through CB1R
    Marcel Pérez-Morales
    Laboratory of Cannabinoids, Department of Physiology, School of Medicine, National Autonomus University of Mexico UNAM, DF, Mexico
    Neuroreport 23:814-8. 2012
  7. pmc Cannabinoid receptor agonists potentiate action potential-independent release of GABA in the dentate gyrus through a CB1 receptor-independent mechanism
    Mackenzie E Hofmann
    Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, USA
    J Physiol 589:3801-21. 2011
  8. doi Changes in the cannabinoid (CB1) receptor expression level and G-protein activation in kainic acid induced seizures
    Engin Bojnik
    Institute of Biochemistry, Biological Research Centre, Hungarian Academy of Sciences, Temesvari krt 62, 6726 Szeged, Hungary
    Epilepsy Res 99:64-8. 2012
  9. doi TRPV1-mediated calcium signal couples with cannabinoid receptors and sodium-calcium exchangers in rat odontoblasts
    Maki Tsumura
    Oral Health Science Center hrc8, Tokyo Dental College, Chiba, Japan
    Cell Calcium 52:124-36. 2012
  10. pmc Somatostatin receptor 5 and cannabinoid receptor 1 activation inhibit secretion of glucose-dependent insulinotropic polypeptide from intestinal K cells in rodents
    C E Moss
    Cambridge Institute for Medical Research, Wellcome Trust MRC Building, Addenbrooke s Hospital, Box 139, Hills Road, Cambridge CB2 0XY, UK
    Diabetologia 55:3094-103. 2012

Research Grants

Detail Information

Publications117 found, 100 shown here

  1. doi The endocannabinoid system is modulated in response to spinal cord injury in rats
    Daniel Garcia-Ovejero
    Laboratorio de Neuroinflamacion, Unidad de Neurología Experimental Research Unit associated to the Instituto Cajal, CSIC, Madrid, Hospital Nacional de Paraplejicos, Toledo, Spain
    Neurobiol Dis 33:57-71. 2009
    ..CB(2) receptor was strongly upregulated after lesion, and mostly expressed by immune infiltrates and astrocytes. The endocannabinoid system may represent an interesting target for new therapeutical approaches to spinal cord injury...
  2. doi Anandamide-induced cell death: dual effects in primary rat decidual cell cultures
    B M Fonseca
    Serviço de Bioquímica, Faculdade de Farmacia, Universidade do Porto, Porto, Portugal
    Placenta 30:686-92. 2009
    ..Moreover, these effects were attenuated by AM251, a selective antagonist for the cannabinoid receptor CB1. High concentrations induced a dramatic effect in cell viability and morphology, though methyl-beta-cyclodextrin (..
  3. ncbi Endocannabinoid signaling in rat somatosensory cortex: laminar differences and involvement of specific interneuron types
    Agnes L Bodor
    Department of Cellular and Network Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, H 1450 Budapest, Hungary
    J Neurosci 25:6845-56. 2005
    ..in the neocortex, the precise laminar, cellular, and subcellular localization of the type 1 cannabinoid receptor (CB1) as well as its function has been elusive...
  4. ncbi An essential role for constitutive endocytosis, but not activity, in the axonal targeting of the CB1 cannabinoid receptor
    Neil A McDonald
    Neurosciences Institute, Division of Pathology and Neuroscience, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, United Kingdom
    Mol Pharmacol 71:976-84. 2007
    ..These data are consistent with a revised model in which domain-specific endocytosis regulates the functional polarization of CB(1) receptors, but this process is distinct from constitutive activity...
  5. ncbi Structure of a cannabinoid receptor and functional expression of the cloned cDNA
    L A Matsuda
    Laboratory of Cell Biology, National Institutes of Mental Health, Bethesda, Maryland 20892
    Nature 346:561-4. 1990
    ..These findings suggest that this protein is involved in cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana...
  6. doi Activation of PAR1 in the lateral hypothalamus of rats enhances food intake and REMS through CB1R
    Marcel Pérez-Morales
    Laboratory of Cannabinoids, Department of Physiology, School of Medicine, National Autonomus University of Mexico UNAM, DF, Mexico
    Neuroreport 23:814-8. 2012
    ..synaptic retrograde signaling through the endocannabinoid 2-arachidonoylglycerol, thereby activating the cannabinoid receptor 1 (CB1R)...
  7. pmc Cannabinoid receptor agonists potentiate action potential-independent release of GABA in the dentate gyrus through a CB1 receptor-independent mechanism
    Mackenzie E Hofmann
    Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, USA
    J Physiol 589:3801-21. 2011
    ..The effect of WIN55,212-2 on mIPSCs is insensitive to AM251 and preserved in CB1 −/− animals,indicating that it does not depend on activation of CB1 receptors...
  8. doi Changes in the cannabinoid (CB1) receptor expression level and G-protein activation in kainic acid induced seizures
    Engin Bojnik
    Institute of Biochemistry, Biological Research Centre, Hungarian Academy of Sciences, Temesvari krt 62, 6726 Szeged, Hungary
    Epilepsy Res 99:64-8. 2012
    ..Furthermore, gene expression levels of the cannabinoid receptor 1 (CB1) receptor and cannabinoid receptor interacting protein 1 (CRIP1) were measured by RT-PCR, where both ..
  9. doi TRPV1-mediated calcium signal couples with cannabinoid receptors and sodium-calcium exchangers in rat odontoblasts
    Maki Tsumura
    Oral Health Science Center hrc8, Tokyo Dental College, Chiba, Japan
    Cell Calcium 52:124-36. 2012
    ..Increase in [Ca(2+)](i) by CB receptor agonist, 2-arachidonylglycerol, was inhibited by CB1 receptor antagonist or CPZ, as well as by adenylyl cyclase inhibitor...
  10. pmc Somatostatin receptor 5 and cannabinoid receptor 1 activation inhibit secretion of glucose-dependent insulinotropic polypeptide from intestinal K cells in rodents
    C E Moss
    Cambridge Institute for Medical Research, Wellcome Trust MRC Building, Addenbrooke s Hospital, Box 139, Hills Road, Cambridge CB2 0XY, UK
    Diabetologia 55:3094-103. 2012
    ..In view of the proadipogenic actions of GIP, this study aimed to identify pathways in K cells that lower cAMP levels and GIP secretion...
  11. pmc Angiotensin II induces vascular endocannabinoid release, which attenuates its vasoconstrictor effect via CB1 cannabinoid receptors
    Maria Szekeres
    Department of Physiology, Semmelweis University, H 1444 Budapest, Hungary
    J Biol Chem 287:31540-50. 2012
    ....
  12. pmc Distribution of CB1 cannabinoid receptors and their relationship with mu-opioid receptors in the rat periaqueductal gray
    A R Wilson-Poe
    Department of Neuroscience, Washington State University, 14204 NE Salmon Creek Avenue, Vancouver, WA 98686, USA
    Neuroscience 213:191-200. 2012
    ..Moreover, microinjection of the cannabinoid 1 (CB1) receptor agonist HU-210 into the PAG enhances the antinociceptive effect of subsequent morphine injections, ..
  13. pmc Striatal CB1 and D2 receptors regulate expression of each other, CRIP1A and δ opioid systems
    Lawrence C Blume
    Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    J Neurochem 124:808-20. 2013
    Although biochemical and physiological evidence suggests a strong interaction between striatal CB1 cannabinoid (CB1 R) and D2 dopamine (D2 R) receptors, the mechanisms are poorly understood...
  14. doi Intermittent ethanol consumption depresses endocannabinoid-signaling in the dorsolateral striatum of rat
    Louise Adermark
    Addiction Biology Unit, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, University of Gothenburg, Box 410, 405 30 Gothenburg, Sweden
    Neuropharmacology 61:1160-5. 2011
    ..In conclusion, alcohol consumption inhibits striatal eCB signaling in a way that could be of importance for understanding the neurological underpinnings of addictive behavior...
  15. pmc Cannabinoid receptor type 1 (CB1R) signaling regulates hepatic gluconeogenesis via induction of endoplasmic reticulum-bound transcription factor cAMP-responsive element-binding protein H (CREBH) in primary hepatocytes
    Dipanjan Chanda
    National Creative Research Initiatives Center for Nuclear Receptor Signals, Hormone Research Center, School of Biological Sciences and Technology, Chonnam National University, Gwangju 500 757, Republic of Korea
    J Biol Chem 286:27971-9. 2011
    ....
  16. doi Cannabinoid receptor 1 inhibition causes seizures during anesthesia induction in experimental sepsis
    Inga Küster
    Department of Anesthesiology and Intensive Care Medicine, Ernst Moritz Arndt University Greifswald, Greifswald, Germany
    Anesth Analg 114:1217-9. 2012
    We report on seizures during anesthesia induction in animals treated with a cannabinoid receptor 1 (CB1R) antagonist for experimental sepsis...
  17. pmc Cannabinoid CB1 receptors mediate the effects of corticotropin-releasing factor on the reinstatement of cocaine seeking and expression of cocaine-induced behavioural sensitization
    D A Kupferschmidt
    Centre for the Neurobiology of Stress, Department of Psychology, University of Toronto Scarborough, Toronto, ON, Canada
    Br J Pharmacol 167:196-206. 2012
    ..The present experiments were designed to probe functional interactions between endocannabinoids and CRF by testing the role of cannabinoid CB(1) receptors in cocaine-related behaviours induced or mediated by CRF...
  18. pmc Acute hypertension reveals depressor and vasodilator effects of cannabinoids in conscious rats
    W S Vanessa Ho
    School of Biomedical Sciences, University of Nottingham Medical School, Queen s Medical Centre, Nottingham, UK
    Br J Pharmacol 156:94-104. 2009
    ..The cardiovascular effects of cannabinoids can be influenced by anaesthesia and can differ in chronic hypertension, but the extent to which they are influenced by acute hypertension in conscious animals has not been determined...
  19. doi Antagonism of the cannabinoid CB-1 receptor protects rat liver against ischaemia-reperfusion injury complicated by endotoxaemia
    P Caraceni
    Department of Clinical Medicine, Alma Mater Studiorum, University of Bologna, Bologna, Italy
    Gut 58:1135-43. 2009
    ..Thus, we aimed to determine the effect of the endocannabinoid CB1-receptor antagonist Rimonabant in a model of hepatic IR injury complicated by endotoxaemia.
  20. doi Activation of CB1 cannabinoid receptors impairs memory consolidation and hippocampal polysialylated neural cell adhesion molecule expression in contextual fear conditioning
    M Mackowiak
    Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31 343 Krakow, Poland
    Neuroscience 158:1708-16. 2009
    We investigated the role of CB1 receptors in hippocampal-dependent memory consolidation mediated by polysialylated neural cell adhesion molecule (PSA-NCAM) during contextual fear conditioning (CFC)...
  21. pmc Differential effects of the antidepressants tranylcypromine and fluoxetine on limbic cannabinoid receptor binding and endocannabinoid contents
    Matthew N Hill
    Department of Psychology, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada
    J Neural Transm 115:1673-9. 2008
    ..These data suggest that monoaminergic neurotransmission can regulate the endocannabinoid system and further indicates a role of the endocannabinoid system in affective illness and its treatment...
  22. doi Expression of type-1 cannabinoid receptor during rat postnatal testicular development: possible involvement in adult leydig cell differentiation
    Giovanna Cacciola
    Dipartimento di Medicina Sperimentale, Seconda Universita degli Studi di Napoli, 80138 Napoli, Italy
    Biol Reprod 79:758-65. 2008
    ..Two types of CNRs have been cloned, CNR1 (central) and CNR2 (peripheral)...
  23. ncbi A neutral CB1 receptor antagonist reduces weight gain in rat
    Adam P Chambers
    Hotchkiss Brain Institute, Department of Physiology and Biophysics, University of Calgary, Alberta, Canada
    Am J Physiol Regul Integr Comp Physiol 293:R2185-93. 2007
    ..Here, we examine the effect of a neutral CB1 antagonist, AM4113, on food intake, weight gain, and emesis...
  24. ncbi The effect of CB(1) receptor antagonism in the right basolateral amygdala on conditioned fear and associated analgesia in rats
    Michelle Roche
    Department of Pharmacology and Therapeutics, NCBES Neuroscience Cluster and Center for Pain Research, National University of Ireland, Galway, University Road, Galway, Ireland
    Eur J Neurosci 26:2643-53. 2007
    ..The results also enhance our understanding of endocannabinoid-monoamine interactions of relevance to conditioned fear and associated analgesia...
  25. ncbi CB1 receptor-mediated control of the release of endocannabinoids (as assessed by microdialysis coupled with LC/MS) in the rat hypothalamus
    Frédéric Béquet
    Discovery Analytics, sanofi aventis R and D, 195 route d Espagne, BP1169 31036 Toulouse cedex 1, France
    Eur J Neurosci 26:3458-64. 2007
    In the present study, we examined the occurrence and potential regulation of endocannabinoid release by cannabinoid CB1 receptors in the rat brain...
  26. pmc Hippocampal interneurons co-express transcripts encoding the alpha7 nicotinic receptor subunit and the cannabinoid receptor 1
    M Morales
    National Institute on Drug Abuse, Intramural Research Program, Cellular Neurophysiology Section, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Neuroscience 152:70-81. 2008
    ..Both the alpha7 nACh receptor and the cannabinoid receptor 1 (CB1) are highly expressed in the hippocampus...
  27. doi Pharmacological evaluation of LH-21, a newly discovered molecule that binds to cannabinoid CB1 receptor
    Richard Z Chen
    Department of Metabolic Disorders, Merck Research Laboratories, P O Box 2000, Rahway, NJ 07065, USA
    Eur J Pharmacol 584:338-42. 2008
    ..was previously reported as a neutral antagonist at the cannabinoid CB1 receptor which, despite its reported poor ability to penetrate into the brain, suppressed food intake and body ..
  28. doi CB1 cannabinoid receptor expression is regulated by glucose and feeding in rat pancreatic islets
    Alonso Vilches-Flores
    Unidad de Biomedicina, FES Iztacala, Universidad Nacional Autonoma de Mexico, Av de los Barrios 1, Los Reyes Iztacala, C P 54090, Tlalnepantla, Mexico
    Regul Pept 163:81-7. 2010
    ..Beside the hypothalamus, pancreatic islet also expresses CB1 cannabinoid receptor, however little is known about its physiological role and regulation...
  29. doi Reciprocal inhibition of G-protein signaling is induced by CB(1) cannabinoid and GABA(B) receptor interactions in rat hippocampal membranes
    Resat Cinar
    Institute of Biochemistry, Biological Research Center, Hungarian Academy of Sciences, Szeged, Hungary
    Neurochem Int 52:1402-9. 2008
    ....
  30. pmc The cannabinoid receptor-1 antagonist rimonabant inhibits platelet activation and reduces pro-inflammatory chemokines and leukocytes in Zucker rats
    A Schafer
    Department of Internal Medicine I Cardiology, University Hospital Wurzburg, Julius Maximilians University, Wurzburg, Germany
    Br J Pharmacol 154:1047-54. 2008
    ..We investigated the effect of rimonabant on inflammation and enhanced platelet reactivity in type 2 diabetic Zucker rats, an experimental model of impaired glucose tolerance and the metabolic syndrome...
  31. pmc Chronic stress differentially regulates cannabinoid CB1 receptor binding in distinct hippocampal subfields
    Matthew N Hill
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10065, USA
    Eur J Pharmacol 614:66-9. 2009
    ....
  32. pmc Differential effects of chronic unpredictable stress on hippocampal CB1 receptors in male and female rats
    Christian G Reich
    Department of Physiology, University of Maryland School of Medicine, 655 W Baltimore Street, Baltimore, MD 21201, USA
    Behav Brain Res 203:264-9. 2009
    Chronic unpredictable mild stress (CMS), an animal model of depression, downregulates hippocampal CB1 receptors in adult male rats...
  33. pmc The hypothermic response to bacterial lipopolysaccharide critically depends on brain CB1, but not CB2 or TRPV1, receptors
    Alexandre A Steiner
    St Joseph s Hospital and Medical Center, Phoenix, AZ 85013, USA
    J Physiol 589:2415-31. 2011
    ..lipopolysaccharide (LPS) is modulated by the endocannabinoid anandamide(AEA) and its receptors: cannabinoid-1 (CB1), cannabinoid-2 (CB2) and transient receptor potential vanilloid-1 (TRPV1)...
  34. doi Physical exercise in adolescence changes CB1 cannabinoid receptor expression in the rat brain
    Sergio Gomes da Silva
    Department of Physiology, Universidade Federal de Sao Paulo UNIFESP, Sao Paulo, Brazil
    Neurochem Int 57:492-6. 2010
    ..would promote changes the brain endocannabinoid system, we investigated the cannabinoid receptor type 1 (CB1) expression in the brain of rats trained during the adolescent period...
  35. pmc Expression of cannabinoid CB1 receptors by vagal afferent neurons: kinetics and role in influencing neurochemical phenotype
    Galina Burdyga
    Physiological Laboratory, School of Biomedical Sciences, Univ of Liverpool, Liverpool, L69 3BX, UK
    Am J Physiol Gastrointest Liver Physiol 299:G63-9. 2010
    ..Expression of CB1 in rat VAN was detectable by in situ hybridization or immunohistochemistry after 6 h of fasting and increased to a ..
  36. doi Diabetic thermal hyperalgesia: role of TRPV1 and CB1 receptors of periaqueductal gray
    Ahmad Mohammadi-Farani
    Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
    Brain Res 1328:49-56. 2010
    ..if diabetic hyperalgesia is related to changes in Transient Receptor Potential Vanilloid 1 (TRPV1) or Cannabinoid CB1 receptors of periaqueductal gray (PAG)...
  37. pmc Cannabinoid 1 receptor and interleukin-6 receptor together induce integration of protein kinase and transcription factor signaling to trigger neurite outgrowth
    Yana Zorina
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 285:1358-70. 2010
    ..These results provide a mechanism where multiple protein kinases and transcription factors interact to integrate signals from G protein-coupled and cytokine receptor to evoke neurite outgrowth in Neuro2A cells...
  38. doi Palatable high-energy diet decreases the expression of cannabinoid type 1 receptor messenger RNA in specific brain regions in the rat
    E Timofeeva
    Centre de Recherche de l Institut Universitaire de Cardiologie et de Pneumologie de Quebec, l Université Laval, Quebec, Canada
    J Neuroendocrinol 21:982-92. 2009
    ..Altogether, the present results demonstrate that long-term PHED leads to an increase in the hypothalamic expression of SOCS-3 mRNA and a decrease in expression of CB1R mRNA in the Cg cortex and specific hypothalamic regions...
  39. doi Sub-chronic administration of AM251, CB1 receptor antagonist, within the nucleus accumbens induced sensitization to morphine in the rat
    Abbas Haghparast
    Neuroscience Research Center, Shahid Beheshti University, M C, P O Box 19615 1178, Tehran, Iran
    Neurosci Lett 467:43-7. 2009
    It seems that there is a cross-talk between the cannabinoid CB1 and opioid receptors in the process of sensitization to opiates...
  40. doi Two opposite effects of Delta(9)-tetrahydrocannabinol on subthalamic nucleus neuron activity: involvement of GABAergic and glutamatergic neurotransmission
    Teresa Morera-Herreras
    Faculty of Medicine, Department of Pharmacology, University of the Basque Country, E 48940, Leioa, Vizcaya, Spain
    Synapse 64:20-9. 2010
    Activation of CB1 cannabinoid receptors in the basal ganglia interferes with movement regulation...
  41. pmc The CB1 antagonist rimonabant decreases insulin hypersecretion in rat pancreatic islets
    Lisa Getty-Kaushik
    Obesity Research Center, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA
    Obesity (Silver Spring) 17:1856-60. 2009
    ..The CB1 receptor antagonist, Rimonabant, has been shown to improve glucose tolerance and insulin sensitivity in vivo but ..
  42. doi The effect of leptin receptor deficiency and fasting on cannabinoid receptor 1 mRNA expression in the rat hypothalamus, brainstem and nodose ganglion
    Jacob Jelsing
    Rheoscience A S, Rødovre, Denmark Gubra, Copenhagen, Denmark
    Neurosci Lett 463:125-9. 2009
    ..control of appetite, food intake and energy balance, relatively little is known about the regulation of cannabinoid receptor 1 (CB(1)R) expression in respect to leptin signalling and fasting...
  43. doi Evidences of cannabinoids-induced modulation of paroxysmal events in an experimental model of partial epilepsy in the rat
    Valerio Rizzo
    Dipartimento di Medicina Sperimentale, Sezione di Fisiologia umana G Pagano, Universita degli Studi di Palermo, Corso Tukory, 129 90134 Palermo, Italy
    Neurosci Lett 462:135-9. 2009
    ....
  44. doi Effects of chronic treatment with the CB1 antagonist, rimonabant on the blood pressure, and vascular reactivity of obese Zucker rats
    Carmen Mingorance
    Department of Pharmacology, Faculty of Pharmacy, University of Seville, Seville, Spain
    Obesity (Silver Spring) 17:1340-7. 2009
    Rimonabant (RM) is a cannabinoid CB1 receptor antagonist useful in the treatment of obesity associated cardiovascular risk factors...
  45. doi Discovery of 2-[5-(4-chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-ethyl-1H-pyrazol-3-yl]-1,5,5-trimethyl-1,5-dihydro-imidazol-4-thione (BPR-890) via an active metabolite. A novel, potent and selective cannabinoid-1 receptor inverse agonist with high antiobesi
    Chien Huang Wu
    Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Zhunan Town, Miaoli County 35053, Taiwan, ROC
    J Med Chem 52:4496-510. 2009
    ..further structural modifications led to the identification of the titled compound 24 (BPR-890) as a highly potent CB1 inverse agonist possessing an excellent CB2/1 selectivity and remarkable in vivo efficacy in diet-induced obese ..
  46. ncbi CB1 cannabinoid receptor participates in the vascular hyporeactivity resulting from hemorrhagic shock in rats
    Li chao Hou
    Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi an, Shaanxi 710032, China
    Chin Med J (Engl) 122:950-4. 2009
    ..The present study was designed to examine whether the CB1 cannabinoid receptor (CB1R) was involved in the development of vascular hyporeactivity in rats suffering from ..
  47. doi Cannabinoid 1 receptor activation inhibits transient receptor potential vanilloid type 1 receptor-mediated cationic influx into rat cultured primary sensory neurons
    A Mahmud
    Department of Anaesthetics, Pain Medicine and Intensive Care, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
    Neuroscience 162:1202-11. 2009
    ....
  48. pmc Spinal endocannabinoids and CB1 receptors mediate C-fiber-induced heterosynaptic pain sensitization
    Alejandro J Pernia-Andrade
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Science 325:760-4. 2009
    ..We found that endocannabinoids, produced upon strong nociceptive stimulation, activated type 1 cannabinoid (CB1) receptors on inhibitory dorsal horn neurons to reduce the synaptic release of gamma-aminobutyric acid and glycine ..
  49. ncbi No evidence for an involvement of variants in the cannabinoid receptor gene (CNR1) in obesity in German children and adolescents
    Timo Dirk Müller
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg Essen, Virchowstr 174, 45147 Essen, Germany
    Mol Genet Metab 90:429-34. 2007
    Studies in rodent models demonstrated that the central cannabinoid receptor (Cnr1) mediates the orexigenic effects of cannabinoids...
  50. ncbi Potential role of the cannabinoid receptor CB1 in rapid eye movement sleep rebound
    L Navarro
    Grupo de Neurociencias, Departamento de Fisiologia, Apdo Postal 70 250, Universidad Nacional Autonoma de Mexico, D F 04510, Mexico, Mexico
    Neuroscience 120:855-9. 2003
    ..One group deprived of REM sleep was treated with SR141716A, a cannabinoid receptor 1 (CB1) receptor antagonist and then allowed to sleep for the next 4 h...
  51. ncbi Upregulation of spinal cannabinoid-1-receptors following nerve injury enhances the effects of Win 55,212-2 on neuropathic pain behaviors in rats
    Grewo Lim
    Department of Anesthesia and Critical Care, MGH Pain Center, WACC 324, Massachusetts General Hospital, Harvard Medical School, 15 Parkman Street, Boston, MA 02114, USA
    Pain 105:275-83. 2003
    ..These results indicate that upregulation of spinal CB1Rs following peripheral nerve injury may contribute to the therapeutic effects of exogenous cannabinoids on neuropathic pain...
  52. ncbi CB1 receptors diminish both Ca(2+) influx and glutamate release through two different mechanisms active in distinct populations of cerebrocortical nerve terminals
    María Del Carmen Godino
    Departamento de Bioquimica, Facultad de Veterinaria, Universidad Complutense, Madrid, Spain
    J Neurochem 101:1471-82. 2007
    ..Furthermore, Ca(2+) imaging of single boutons demonstrated that the two pre-synaptic mechanisms by which cannabinoid receptors reduce glutamate release operate in distinct populations of nerve terminals...
  53. ncbi Lipid rafts control signaling of type-1 cannabinoid receptors in neuronal cells. Implications for anandamide-induced apoptosis
    Monica Bari
    Department of Biomedical Sciences, University of Teramo, 64100 Teramo, Italy
    J Biol Chem 280:12212-20. 2005
    ..Altogether, the present data suggest that lipid rafts control CB1R binding and signaling, and that CB1R activation underlies the protective effect of MCD against apoptosis...
  54. ncbi Mediation of amphetamine-induced long-term depression of synaptic transmission by CB1 cannabinoid receptors in the rat amygdala
    Ya Chun Huang
    Institute of Basic Medical Sciences, National Cheng Kung University, Tainan, Taiwan
    J Neurosci 23:10311-20. 2003
    ..by dopamine, serotonin 1A, and norepinephrine alpha2 receptor antagonists but is blocked by the cannabinoid CB1 receptor antagonist AM251...
  55. ncbi Cannabinoid CB1 receptor and serotonin 3 receptor subunit A (5-HT3A) are co-expressed in GABA neurons in the rat telencephalon
    Marisela Morales
    National Institute on Drug Abuse, Intramural Research Program, Cellular Neurophysiology, Baltimore, Maryland 21224, USA
    J Comp Neurol 468:205-16. 2004
    ..histochemistry, we found co-expression of the functional 5-HT3A subunit of the 5-HT3 receptor and the central CB1 cannabinoid receptor in neurons of the rat telencephalon...
  56. ncbi Cannabinoid receptor-mediated inhibition of calcium signaling in rat retinal ganglion cells
    Melanie R Lalonde
    Department of Physiology and Biophysics, Dalhousie University, Halifax, Nova Scotia, Canada
    Mol Vis 12:1160-6. 2006
    ..Here we investigate the actions of CB(1)R activation on high-voltage-activated (HVA) Ca(2+) channel currents in purified cultures of rat retinal ganglion cells (RGCs)...
  57. ncbi Evidence for an interaction between CB1 cannabinoid and melanocortin MCR-4 receptors in regulating food intake
    A N A Verty
    School of Psychology, University of New England, Armidale, New South Wales 2351, Australia
    Endocrinology 145:3224-31. 2004
    ..These results further suggested that CB(1) receptors are located downstream from melanocortin receptors and CB(1) receptor signaling is necessary to prevent the melanocortin system from altering food intake...
  58. ncbi The CB1 cannabinoid receptor is the major cannabinoid receptor at excitatory presynaptic sites in the hippocampus and cerebellum
    Yoshinobu Kawamura
    Department of Cellular Neuroscience, Graduate School of Medicine, Osaka University, Suita 565 0871, Japan
    J Neurosci 26:2991-3001. 2006
    ..It is generally accepted that the CB1 cannabinoid receptor (CB1) mediates the effects of endocannabinoid in inhibitory synapses...
  59. ncbi Cannabinoid CB1 receptor protein expression in the rat choroid plexus: a possible involvement of cannabinoids in the regulation of cerebrospinal fluid
    John C Ashton
    Department of Pharmacology and Toxicology, School of Medical Sciences, University of Otago Medical School, University of Otago, Dunedin, New Zealand
    Neurosci Lett 364:40-2. 2004
    Cannabinoid CB1 receptors in the brain are expressed on axon terminals presynaptic to neurons that express fatty acid amide hydrolase (FAAH). Postsynaptic FAAH catabolizes endocannabinoids which act as short-range transmitters...
  60. ncbi Subchronic haloperidol increases CB(1) receptor binding and G protein coupling in discrete regions of the basal ganglia
    Mikael Andersson
    Department of Integrative Medical Biology, Section for Histology and Cell Biology, Umea University, Umea, Sweden
    J Neurosci Res 82:264-72. 2005
    ..The results help to elucidate the underlying biochemical mechanism of CB(1) receptor supersensitivity after haloperidol treatment...
  61. pmc Endocannabinoids acting at cannabinoid-1 receptors regulate cardiovascular function in hypertension
    Sandor Batkai
    Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892 8115, USA
    Circulation 110:1996-2002. 2004
    ..Endocannabinoids are novel lipid mediators with hypotensive and cardiodepressor activity. Here, we examined the possible role of the endocannabinergic system in cardiovascular regulation in hypertension...
  62. ncbi Involvement of CB1-receptors and beta-adrenoceptors in the regional hemodynamic responses to lipopolysaccharide infusion in conscious rats
    S M Gardiner
    Centre for Integrated Systems Biology and Medicine, School of Biomedical Sciences, Medical School, Queen s Medical Centre, University of Nottingham, United Kingdom
    Am J Physiol Heart Circ Physiol 288:H2280-8. 2005
    ..kg(-1).h(-1)) in conscious, male Sprague-Dawley rats, in the absence or presence of the cannabinoid (CB1) receptor antagonist AM-251 (3 mg/kg)...
  63. ncbi Homology model of the CB1 cannabinoid receptor: sites critical for nonclassical cannabinoid agonist interaction
    Joong Youn Shim
    Department of Basic Pharmaceutical Sciences, College of Pharmacy, University of South Carolina, Columbia, SC 29208, USA
    Biopolymers 71:169-89. 2003
    ..The present study provides a consistent framework for further investigation of the CB(1) receptor-ligand interaction and for the study of CB(1) receptor activation...
  64. ncbi Down-regulation of cannabinoid-1 (CB-1) receptors in specific extrahypothalamic regions of rats with dietary obesity: a role for endogenous cannabinoids in driving appetite for palatable food?
    Joanne A Harrold
    Diabetes Endocrinology Research Group, Department of Medicine, University of Liverpool, Duncan Building, Daulby Street, Liverpool L69 3GA, UK
    Brain Res 952:232-8. 2002
    ..However, cannabinoids in the hypothalamus do not appear to influence this aspect of eating behaviour...
  65. ncbi Schizophrenia and the cannabinoid receptor type 1 (CB1): association study using a single-base polymorphism in coding exon 1
    S Leroy
    INSERM E 0117 Université Paris V, Service Hospitalo Universitaire de Santé Mentale et Thérapeutique, Hopital Sainte Anne, Paris, France
    Am J Med Genet 105:749-52. 2001
    ..Cannabinoid receptor (CB1) is particularly concentrated in dopamine-modulated areas of the nervous system...
  66. ncbi CB1 and CB2 cannabinoid receptors are implicated in inflammatory pain
    N Clayton
    Department of Neurology, GlaxoWellcome Research and Development Ltd, Gunnels Wood Road, SG1 2NY, Stevenage, UK
    Pain 96:253-60. 2002
    ..p. (in the carrageenan model). The selective CB1 antagonist, AM281 (0.5 microg/kg-1 i.p.) reversed effects of HU210 (10 and 30 microg/kg-1 i.p...
  67. ncbi Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses
    R I Wilson
    Nature 410:588-92. 2001
    Marijuana affects brain function primarily by activating the G-protein-coupled cannabinoid receptor-1 (CB1), which is expressed throughout the brain at high levels...
  68. ncbi Cannabinoid receptor gene (CNR1): association with i.v. drug use
    D E Comings
    Department of Medical Genetics, City of Hope Medical Center, Duarte, CA 91010, USA
    Mol Psychiatry 2:161-8. 1997
    ..A microsatellite polymorphism (AAT)n at the cannabinoid CB1 (brain) receptor gene (CNR1) consists of 9 alleles...
  69. ncbi Neuronal and astrocytic localization of the cannabinoid receptor-1 in the dorsal horn of the rat spinal cord
    Chiara Salio
    CNRS UMR 7101, Neurobiologie des Signaux Intercellulaires, Universite Pierre et Marie Curie, 7 quai Saint Bernard, 75252 Cedex 05, Paris, France
    Neurosci Lett 329:13-6. 2002
    Cannabinoids are involved in the control of pain at the spinal level through the cannabinoid receptor-1 (CB1) localized pre- and postsynaptically on primary afferent fibres and dorsal horn interneurones, respectively...
  70. ncbi Bidirectional regulation of mu-opioid and CB1-cannabinoid receptor in rats self-administering heroin or WIN 55,212-2
    Liana Fattore
    Institute of Neuroscience, National Research Council CNR, Section of Cagliari, Italy
    Eur J Neurosci 25:2191-200. 2007
    ..either heroin or the cannabinoid receptor agonist WIN 55,212-2 on levels and functionality of mu-opioid (MOR) and CB1-cannabinoid receptors (CB1R) in reward-related brain areas, such as the prefrontal cortex (PFC), nucleus accumbens (..
  71. pmc An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors
    Susan M Huang
    Departments of Psychology and Neuroscience, Brown University, Providence, RI 02912, USA
    Proc Natl Acad Sci U S A 99:8400-5. 2002
    ..5 +/- 0.3 microg). Our data demonstrate the existence of a brain substance similar to capsaicin not only with respect to its chemical structure but also to its potency at VR1 receptors...
  72. ncbi Negative chronotropic effect of cannabinoids and their water-soluble emulsion is related to activation of cardiac CB1 receptors
    A V Krylatov
    Institute of Cardiology, Siberian Division of Russian Academy of Medical Sciences, Tomsk
    Bull Exp Biol Med 142:450-3. 2006
    ..Selective CB1 and CB2 receptor antagonist HU-210 also induced a negative chronotropic effect in rats, while pre-injection of CB1 ..
  73. ncbi Determination of the cannabinoid receptors in mouse x rat hybridoma NG108-15 cells and rat GH4C1 cells
    B Y Ho
    Department of Pharmacology, Medical College of Wisconsin, Milwaukee 53226, USA
    Neurosci Lett 212:123-6. 1996
    ..The CB1 but not the CB2 or CB1A cannabinoid receptor was found in both cell lines...
  74. ncbi Genetic variations at the endocannabinoid type 1 receptor gene (CNR1) are associated with obesity phenotypes in men
    Paola Russo
    Unit of Epidemiology and Population Genetics, Institute of Food Sciences, Consiglio Nazionale delle Ricerche, via Roma 52A C, Avellino, Italy
    J Clin Endocrinol Metab 92:2382-6. 2007
    ..The endocannabinoid system modulates food intake and body weight in animal models. Treatment with the cannabinoid type 1 receptor blocker, rimonabant, reduces body weight in obese individuals...
  75. ncbi Mechanisms for the coupling of cannabinoid receptors to intracellular calcium mobilization in rat insulinoma beta-cells
    Luciano De Petrocellis
    Endocannabinoid Research Group, Institute of Cybernetics, National Research Council, Via Campi Flegrei 34, Comprensorio Olivetti, 80078 Pozzuoli, Naples, Italy
    Exp Cell Res 313:2993-3004. 2007
    ..These results suggest that, in RIN m5F cells, CB(1) receptors are coupled to PI-PLC-mediated mobilization of [Ca(2+)](i) and might inhibit bombesin signaling...
  76. doi The CB1 receptor agonist, WIN 55,212-2, dose-dependently disrupts object recognition memory in adult rats
    Jean Ha Baek
    Dept of Pharmacology and Toxicology, School of Medical Sciences, University of Otago Medical School, Dunedin, New Zealand
    Neurosci Lett 464:71-3. 2009
    ..These results suggest that WIN can interfere with object recognition memory even in adult rats following a single injection of a low dose...
  77. pmc Endogenous cannabinoids induce fever through the activation of CB1 receptors
    D Fraga
    Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
    Br J Pharmacol 157:1494-501. 2009
    ..Co., St. Louis, MO, USA) were investigated...
  78. doi Effects of the cannabinoid CB1 antagonist rimonabant on hepatic mitochondrial function in rats fed a high-fat diet
    Mélissa Flamment
    INSERM U694, CHU Angers, 4 rue Larrey, Angers, F 49033 France
    Am J Physiol Endocrinol Metab 297:E1162-70. 2009
    ..However, this increase of mitochondrial oxidation is regulated by a decrease of ATP synthase activity in order to have only ATP required for the cell function...
  79. ncbi Retroinhibition of presynaptic Ca2+ currents by endocannabinoids released via postsynaptic mGluR activation at a calyx synapse
    Christopher Kushmerick
    The Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Neurosci 24:5955-65. 2004
    We investigated the mechanisms by which activation of group I metabotropic glutamate receptors (mGluRs) and CB1 cannabinoid receptors (CB1Rs) leads to inhibition of synaptic currents at the calyx of Held synapse in the medial nucleus of ..
  80. ncbi Molecular interaction of the antagonist N-(piperidin-1-yl)-5-(4-chlorophenyl)-1- (2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide with the CB1 cannabinoid receptor
    Joong Youn Shim
    Department of Basic Pharmaceutical Sciences, College of Pharmacy, University of South Carolina, Columbia, South Carolina 29208, USA
    J Med Chem 45:1447-59. 2002
    ..SR141716; 1) is a potent and selective antagonist for the CB1 cannabinoid receptor...
  81. doi Integrated cannabinoid CB1 receptor transmission within the amygdala-prefrontal cortical pathway modulates neuronal plasticity and emotional memory encoding
    Huibing Tan
    Department of Anatomy and Cell Biology, The Schulich School of Medicine, University of Western Ontario, London, Ontario, Canada
    Cereb Cortex 20:1486-96. 2010
    The cannabinoid CB1 receptor system is functionally involved in the processing and encoding of emotionally salient sensory information, learning and memory...
  82. pmc Endocannabinoid signaling is required for development and critical period plasticity of the whisker map in somatosensory cortex
    Lu Li
    Department of Molecular and Cell Biology and Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA
    Neuron 64:537-49. 2009
    Type 1 cannabinoid (CB1) receptors mediate widespread synaptic plasticity, but how this contributes to systems-level plasticity and development in vivo is unclear...
  83. ncbi Cannabinoid CB1 receptors in rat medial prefrontal cortex are colocalized with calbindin- but not parvalbumin- and calretinin-positive GABA-ergic neurons
    Krzysztof Wedzony
    Laboratory of Pharmacology and Brain Biostructure, Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, Pl 31 343 Krakow, Poland
    Pharmacol Rep 61:1000-7. 2009
    In the present study, we investigate putative localization of cannabinoid receptors 1 (CB1) protein on a population of cortical gamma-aminobutyric acid (GABA) - positive interneurons characterized by expression of calcium-binding ..
  84. doi D2 receptor-mediated inhibition of dopamine release in the rat striatum in vitro is modulated by CB1 receptors: studies using fast cyclic voltammetry
    Carmel O'Neill
    UCD School of Biomolecular and Biomedical Science, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
    J Neurochem 108:545-51. 2009
    ..These effects were also antagonized by AM-251 (1 microM). This is the first report demonstrating a functional, antagonistic interaction between CB(1) receptors and D(2) autoreceptors in regulating rat striatal dopamine release...
  85. doi Colocalization of CB1 receptors with L1 and GAP-43 in forebrain white matter regions during fetal rat brain development: evidence for a role of these receptors in axonal growth and guidance
    M Gomez
    Departamento de Bioquimica y Biologia Molecular, Facultad de Medicina, Universidad Complutense de Madrid, 28040 Madrid, Spain
    Neuroscience 153:687-99. 2008
    ....
  86. ncbi Immunohistochemical localization of cannabinoid CB1 receptor in inhibitory interneurons in the cerebellum
    John C Ashton
    Department of Pharmacology and Toxicology, School of Medical Sciences, University of Otago Medical School, University of Otago, Dunedin, New Zealand
    Cerebellum 3:222-6. 2004
    ..contribute to cannabinoid-mediated cerebellar plasticity, consistent with the intense expression of cannabinoid CB1 receptor protein in the cerebellar molecular layer...
  87. doi Early maternal deprivation induces gender-dependent changes on the expression of hippocampal CB(1) and CB(2) cannabinoid receptors of neonatal rats
    Juan Suarez
    Laboratorio de Medicina Regenerativa, Fundacion IMABIS, Hospital Carlos Haya, 29010 Malaga, Spain
    Hippocampus 19:623-32. 2009
    ..The present MD procedure may provide an interesting experimental model to further address the role of the ECS in neurodevelopmental mental illnesses such as schizophrenia...
  88. pmc Cannabinoid receptors are localized to noradrenergic axon terminals in the rat frontal cortex
    Veronica C Oropeza
    Department of Neurosurgery, Thomas Jefferson University, Farber Institute for Neurosciences, 900 Walnut St, Suite 400, Philadelphia, PA 19107, USA
    Brain Res 1127:36-44. 2007
    ..In an effort to elucidate whether cannabinoid (CB1) receptors are positioned to presynaptically modulate norepinephrine release in the frontal cortex, ..
  89. ncbi Local enhancement of cannabinoid CB1 receptor signalling in the dorsal hippocampus elicits an antidepressant-like effect
    Ryan J McLaughlin
    Department of Psychology, University of British Columbia, Vancouver, Canada
    Behav Pharmacol 18:431-8. 2007
    Systemic administration of direct cannabinoid CB1 receptor agonists and inhibitors of the hydrolytic enzyme fatty acid amide hydrolase have been shown to elicit antidepressant effects...
  90. ncbi Acute activation of CB1 cannabinoid receptors transiently decreases PSA-NCAM expression in the dentate gyrus of the rat hippocampus
    Marzena Mackowiak
    Laboratory of Pharmacology and Brain Biostructure, Institute of Pharmacology, Polish Academy of Sciences, 31 343 Krakow, 12 Smetna Street, Poland
    Brain Res 1148:43-52. 2007
    ..On the other hand, CB1 receptor activation is known to disturb some hippocampal processes involving plastic changes, such as learning and ..
  91. doi Identification of cannabinoid type 1 receptor expressing cocaine amphetamine-regulated transcript neurons in the rat hypothalamus and brainstem using in situ hybridization and immunohistochemistry
    J Jelsing
    Rheoscience A S, Basic Research, Glerupvej 2, Rødovre, Denmark
    Neuroscience 154:641-52. 2008
    ..that the neuropeptide cocaine amphetamine-regulated transcript (CART) may be a downstream mediator of the effect of CB1 receptor antagonist on appetite regulation...
  92. ncbi Opposing control of cannabinoid receptor stimulation on amyloid-beta-induced reactive gliosis: in vitro and in vivo evidence
    Giuseppe Esposito
    Department of Human Physiology and Pharmacology, University of Rome La Sapienza, Rome, Italy
    J Pharmacol Exp Ther 322:1144-52. 2007
    ..Immunohistochemical and biochemical findings revealed that selective agonism at CB1 and antagonism at CB2 receptors was able to blunt A beta-induced reactive astrogliosis with subsequent ..
  93. ncbi Attenuation of cue-induced heroin-seeking behavior by cannabinoid CB1 antagonist infusions into the nucleus accumbens core and prefrontal cortex, but not basolateral amygdala
    Lily Alvarez-Jaimes
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuropsychopharmacology 33:2483-93. 2008
    ..These findings provide new insights into the neural mechanisms through which CB(1) receptors modulate the motivational properties of heroin-associated cues inducing relapse...
  94. pmc Endocannabinoids acting at CB1 receptors mediate the cardiac contractile dysfunction in vivo in cirrhotic rats
    Sandor Batkai
    Section on Neuroendocrinology, Laboratory of Physiological Studies, NIAAA, National Institutes of Health, MSC 9413, Rm 2N17, 5625 Fishers Lane, Bethesda, MD 20892 9413, USA
    Am J Physiol Heart Circ Physiol 293:H1689-95. 2007
    ....
  95. ncbi Cannabinoid CB1 receptor stimulation affords neuroprotection in MPTP-induced neurotoxicity by attenuating S100B up-regulation in vitro
    Teresa Iuvone
    Department of Experimental Pharmacology, Faculty of Pharmacy, University of Naples Federico II, via D Montesano, 49, 80131, Naples, Italy
    J Mol Med (Berl) 85:1379-92. 2007
    ..Treatment with arachidonyl-2-chloroethylamide, a CB1 agonist, significantly inhibited MPTP-induced S100B density in C6 cells and protected co-cultured PC12 cells from ..
  96. ncbi The role of the cannabinoid type 1 receptor and down-stream cAMP/DARPP-32 signal in the nucleus accumbens of methamphetamine-sensitized rats
    Yao Chang Chiang
    Laboratory of Neuropharmacology, Department of Physiology and Pharmacology, Chang Gung University and Molecular Imaging Center, Chang Gung Hospital, Kwei Shan, Tao Yuan, Taiwan, Republic of China
    J Neurochem 103:2505-17. 2007
    ..Overall, we demonstrated that brain CB(1) receptor and its down-stream cAMP/DARPP-32/T34/PP-2B signaling are profoundly altered in methamphetamine-sensitized animals...
  97. doi CB1 receptor knockout mice are hyporesponsive to the behavior-stimulating actions of d-amphetamine: role of mGlu5 receptors
    Eleni T Tzavara
    Eli Lilly and Company, Lilly Corporate Center, Neuroscience Discovery Research, Indianapolis, IN 46285 0510, USA
    Eur Neuropsychopharmacol 19:196-204. 2009
    Blockade of the cannabinoid CB1 receptors (CB1R) has been shown to reduce psychostimulant-induced hyperactivity, an effect that we sought to further characterize here...
  98. pmc Cannabinoid CB1 receptor antagonists cause status epilepticus-like activity in the hippocampal neuronal culture model of acquired epilepsy
    Laxmikant S Deshpande
    Department of Neurology, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Neurosci Lett 411:11-6. 2007
    ..regulate synaptic transmission and dampen seizure activity via activation of the presynaptic cannabinoid receptor 1 (CB1)...
  99. pmc Anti-dyskinetic effects of cannabinoids in a rat model of Parkinson's disease: role of CB(1) and TRPV1 receptors
    Maria Grazia Morgese
    Department of Biomedical Sciences, University of Foggia, Viale Luigi Pinto 1, 71100 Foggia, Italy
    Exp Neurol 208:110-9. 2007
    ..Our data indicate that pharmacological blockade of TRPV1 receptors unmasks the anti-dyskinetic effects of FAAH inhibitors and that CB(1) and TRPV1 receptors play opposite roles in levodopa-induced dyskinesias...

Research Grants2

  1. CB1 Receptors: Cocaine Reinforcement and Relapse
    Sara Ward; Fiscal Year: 2007
    ..For example, mice in which the CB1 receptor has been altered can be used to assess the role of these receptors in the reinforcing effects of drugs of ..