Gene Symbol: Cnmd
Alias: Chm-1, Lect1, leukocyte cell-derived chemotaxin 1, chM-I, chondromodulin-1, chondromodulin-I, leukocyte cell derived chemotaxin 1
Funaki H, Sawaguchi S, Yaoeda K, Koyama Y, Yaoita E, Funaki S, et al
. Expression and localization of angiogenic inhibitory factor, chondromodulin-I, in adult rat eye. Invest Ophthalmol Vis Sci. 2001;42:1193-200 pubmed
..Recombinant human ChM-I inhibited tube morphogenesis of human retinal endothelial cells in vitro. These observations indicate a potential role for ChM-I in inhibition of angiogenesis in the rat eye. ..
Yoshioka M, Yuasa S, Matsumura K, Kimura K, Shiomi T, Kimura N, et al
. Chondromodulin-I maintains cardiac valvular function by preventing angiogenesis. Nat Med. 2006;12:1151-9 pubmed
..These findings provide evidence that chondromodulin-I has a pivotal role in maintaining valvular normal function by preventing angiogenesis that may lead to VHD. ..
Oshima Y, Shukunami C, Honda J, Nishida K, Tashiro F, Miyazaki J, et al
. Expression and localization of tenomodulin, a transmembrane type chondromodulin-I-related angiogenesis inhibitor, in mouse eyes. Invest Ophthalmol Vis Sci. 2003;44:1814-23 pubmed
..These results indicate a potential role for TeM in prevention of vascular invasion in the mouse eye and the possibility of both TeM and ChM-I as candidates for use in gene therapy approaches to treatment of ocular angiogenesis. ..
Amil B, Fernandez Fuente M, Molinos I, Rodriguez J, Carbajo Perez E, Garcia E, et al
. Chondromodulin-I expression in the growth plate of young uremic rats. Kidney Int. 2004;66:51-9 pubmed
..b>Chondromodulin I (ChM-I) is a potent cartilage-specific angiostatic factor...
Watahiki J, Yamaguchi T, Enomoto A, Irie T, Yoshie K, Tachikawa T, et al
. Identification of differentially expressed genes in mandibular condylar and tibial growth cartilages using laser microdissection and fluorescent differential display: chondromodulin-I (ChM-1) and tenomodulin (TeM) are differentially expressed in mand. Bone. 2008;42:1053-60 pubmed publisher
..These observations demonstrated that gene expression in mandibular condylar cartilage differed from other types of cartilage such as articular and growth ones. ..
Miura S, Kondo J, Takimoto A, Sano Takai H, Guo L, Shukunami C, et al
. The N-terminal cleavage of chondromodulin-I in growth-plate cartilage at the hypertrophic and calcified zones during bone development. PLoS ONE. 2014;9:e94239 pubmed publisher
Xing S, DU L, Zhou W, Hu Y, Feng Y, Liang H, et al
. Proteomic analysis of chondromodulin-I-induced differentiation of mesenchymal stem cells into chondrocytes. J Proteomics. 2017;159:1-18 pubmed publisher
..These results demonstrate novel information about the molecular mechanism by which ChM-I induce MSCs to differentiate into chondrocytes. These results also provide a solid foundation for the development of tissue-engineered cartilage. ..
Kitahara H, Hayami T, Tokunaga K, Endo N, Funaki H, Yoshida Y, et al
. Chondromodulin-I expression in rat articular cartilage. Arch Histol Cytol. 2003;66:221-8 pubmed
..The avascular condition may be preserved by angiogenic inhibitors or mechanisms other than ChM-I in the mature articular cartilage. ..